Rho activation is apically restricted by Arhgap1 in neural crest cells and drives epithelial-to-mesenchymal transition

scientific article

Rho activation is apically restricted by Arhgap1 in neural crest cells and drives epithelial-to-mesenchymal transition is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1242/DEV.095448
P932PMC publication ID3931734
P698PubMed publication ID23804498

P2093author name stringMary C Halloran
Matthew R Clay
P2860cites workEphrinB/EphB signaling controls embryonic germ layer separation by contact-induced cell detachmentQ21145780
Regulation of epithelial apical junctional complex by Rho family GTPasesQ22241271
Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticityQ24297858
Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domainQ24321803
Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanismQ24600173
From mechanical force to RhoA activationQ26824081
Epithelial-mesenchymal transitions in development and diseaseQ27860630
Rho GTPases: biochemistry and biologyQ27860645
Stages of embryonic development of the zebrafishQ27860947
The snail superfamily of zinc-finger transcription factorsQ28216843
Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasionQ28236067
The small GTPase RhoV is an essential regulator of neural crest induction in XenopusQ28243972
Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1Q28268049
Plakophilin 2 couples actomyosin remodeling to desmosomal plaque assembly via RhoA.Q28285534
Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesisQ28298687
Direct cadherin-activated cell signaling: a view from the plasma membraneQ28756060
Sec14 homology domain targets p50RhoGAP to endosomes and provides a link between Rab and Rho GTPasesQ28910420
The Small GTPases Rho and Rac Are Required for the Establishment of Cadherin-dependent Cell–Cell ContactsQ29042060
Regulation of cadherin-mediated adhesion in morphogenesisQ29614940
Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysisQ29616712
The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructsQ29618810
An overview of epithelio-mesenchymal transformationQ30014826
Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early developmentQ30311953
Cadherin 6B induces BMP signaling and de-epithelialization during the epithelial mesenchymal transition of the neural crestQ30431055
Regulation of cytokinesis by Rho GTPase fluxQ30439337
Integrin-dependent actomyosin contraction regulates epithelial cell scattering.Q30443410
Rho-kinase and myosin II affect dynamic neural crest cell behaviors during epithelial to mesenchymal transition in vivoQ30486278
The neural crest epithelial-mesenchymal transition in 4D: a 'tail' of multiple non-obligatory cellular mechanismsQ30487545
Versatile fluorescent probes for actin filaments based on the actin-binding domain of utrophinQ30629061
Concentric zones of active RhoA and Cdc42 around single cell woundsQ33211372
alpha-Catenin as a tension transducer that induces adherens junction developmentQ33572769
Action at a distance during cytokinesisQ33589990
Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cellsQ33727205
Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner.Q33950292
Cdc42GAP regulates c-Jun N-terminal kinase (JNK)-mediated apoptosis and cell number during mammalian perinatal growthQ34015919
Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membraneQ34049874
Novel direct targets of miR-19a identified in breast cancer cells by a quantitative proteomic approachQ34406228
A role for rhoB in the delamination of neural crest cells from the dorsal neural tube.Q34479565
Regulation of cell adhesions and motility during initiation of neural crest migrationQ34629064
Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling.Q34727905
Contact inhibition of locomotion in vivo controls neural crest directional migrationQ34902880
Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblastsQ35128385
Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftmentQ35848504
Rho/Rho-associated kinase-II signaling mediates disassembly of epithelial apical junctionsQ35949016
A microtubule-dependent zone of active RhoA during cleavage plane specificationQ36320722
Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulationQ36567245
Current knowledge of the large RhoGAP family of proteinsQ36707513
Cadherin switchingQ37102948
Distinct functions for Rho1 in maintaining adherens junctions and apical tension in remodeling epitheliaQ37264040
Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tensionQ37387859
Pulsation and stabilization: contractile forces that underlie morphogenesisQ37623993
Inflammation and EMT: an alliance towards organ fibrosis and cancer progressionQ37668231
The ins and outs of the epithelial to mesenchymal transition in health and diseaseQ37899185
Rho protein crosstalk: another social network?Q37933751
Neural crest delamination and migration: from epithelium-to-mesenchyme transition to collective cell migrationQ37977230
ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expressionQ38323022
ROCK cooperated with ET-1 to induce epithelial to mesenchymal transition through SLUG in human ovarian cancer cellsQ39414588
Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition.Q40457821
rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivoQ40874550
Epithelium-mesenchyme transition during neural crest development.Q41037607
Control of local Rho GTPase crosstalk by AbrQ41969752
A negative modulatory role for rho and rho-associated kinase signaling in delamination of neural crest cellsQ42085205
RhoA and microtubule dynamics control cell-basement membrane interaction in EMT during gastrulationQ42437398
Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.Q42492769
Live imaging of cell motility and actin cytoskeleton of individual neurons and neural crest cells in zebrafish embryosQ42920679
Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull.Q46038089
Directional migration of neural crest cells in vivo is regulated by Syndecan-4/Rac1 and non-canonical Wnt signaling/RhoA.Q46651779
Identification and regulation of a molecular module for bleb-based cell motilityQ47073298
N-cadherin is required for the polarized cell behaviors that drive neurulation in the zebrafishQ47073566
Antagonistic activities of Rho and Rac GTPases underlie the transition from neural crest delamination to migration.Q51787550
Dynamic expression patterns of RhoV/Chp and RhoU/Wrch during chicken embryonic development.Q51961614
VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension.Q52551401
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.Q53588886
A role for Rho GTPases and cell–cell adhesion in single-cell motility in vivoQ59314649
Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transitionQ78728261
Rho activation is required for transforming growth factor-beta-induced epithelial-mesenchymal transition in lens epithelial cellsQ80404965
A role for RhoA in the two-phase migratory pattern of post-otic neural crest cellsQ81363009
Effect of N-cadherin misexpression by the mammary epithelium in miceQ81663885
Activity of the RhoU/Wrch1 GTPase is critical for cranial neural crest cell migrationQ82878080
P433issue15
P407language of work or nameEnglishQ1860
P1104number of pages12
P304page(s)3198-3209
P577publication date2013-06-26
P1433published inDevelopmentQ3025404
P1476titleRho activation is apically restricted by Arhgap1 in neural crest cells and drives epithelial-to-mesenchymal transition
P478volume140

Reverse relations

cites work (P2860)
Q27334633A PTK7/Ror2 Co-Receptor Complex Affects Xenopus Neural Crest Migration
Q27312559Activator-inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium
Q47145373Apical Sarcomere-like Actomyosin Contracts Nonmuscle Drosophila Epithelial Cells
Q43274760Asymmetric localization of DLC1 defines avian trunk neural crest polarity for directional delamination and migration.
Q33731094Cadherin 6 promotes neural crest cell detachment via F-actin regulation and influences active Rho distribution during epithelial-to-mesenchymal transition
Q50026428Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A.
Q90480746Cellular organization and boundary formation in craniofacial development
Q99233893Collectively stabilizing and orienting posterior migratory forces disperses cell clusters in vivo
Q60048013Contribution of epithelial-mesenchymal transitions to organogenesis and cancer metastasis
Q38955852Divide or Conquer: Cell Cycle Regulation of Invasive Behavior.
Q26771793Epithelial-Mesenchymal Transitions during Neural Crest and Somite Development
Q34999153Establishing neural crest identity: a gene regulatory recipe
Q27311545Fascin1-dependent Filopodia are required for directional migration of a subset of neural crest cells
Q30583159In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity
Q48569187LKB1 signaling in cephalic neural crest cells is essential for vertebrate head development
Q39183594Modular regulation of Rho family GTPases in development.
Q52575478Neural crest delamination and migration: Looking forward to the next 150 years.
Q90578437Neural crest development: insights from the zebrafish
Q27335688Pard3 regulates contact between neural crest cells and the timing of Schwann cell differentiation but is not essential for neural crest migration or myelination
Q28833723Phenotypic chemical screening using a zebrafish neural crest EMT reporter identifies retinoic acid as an inhibitor of epithelial morphogenesis
Q33967288PleiotRHOpic: Rho pathways are essential for all stages of Neural Crest development
Q34109426ROCK Inhibition Extends Passage of Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium
Q30805064RhoA GTPase inhibition organizes contraction during epithelial morphogenesis.
Q58616049The RhoGAP myosin 9/HUM-7 integrates signals to modulate RhoA/RHO-1 during embryonic morphogenesis in
Q38170173The role of the non-canonical Wnt-planar cell polarity pathway in neural crest migration
Q28315755The significance and scope of evolutionary developmental biology: a vision for the 21st century
Q36128862miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways

Search more.