A role for Rho GTPases and cell–cell adhesion in single-cell motility in vivo

scientific article published on 13 December 2009

A role for Rho GTPases and cell–cell adhesion in single-cell motility in vivo is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NCB2003
P698PubMed publication ID20010816

P50authorCarl-Philipp HeisenbergQ33125331
Bijan BoldajipourQ56845662
Jean-Leon MaitreQ57908158
Elena KardashQ58778379
P2093author name stringErez Raz
Michal Reichman-Fried
Ekaterina Papusheva
Esther-Maria Messerschmidt
P2860cites workRegulation of cell-cell adhesion by the cadherin-catenin complexQ24609784
Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeletonQ24647442
Cell motility through plasma membrane blebbingQ24656957
Rho GTPases: biochemistry and biologyQ27860645
Cell migration: integrating signals from front to backQ27860670
Cell migration: a physically integrated molecular processQ27860682
A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell linesQ28240191
From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesionQ28256172
Control of chemokine-guided cell migration by ligand sequestrationQ28268329
Blebs lead the way: how to migrate without lamellipodiaQ28287258
Mutations in half baked/E-cadherin block cell behaviors that are necessary for teleost epibolyQ28305628
Evolutionary optimization of fluorescent proteins for intracellular FRETQ28306304
Inhibition of myosin light chain kinase by p21-activated kinaseQ28678502
Traction stress in focal adhesions correlates biphasically with actin retrograde flow speedQ29030465
Lifeact: a versatile marker to visualize F-actinQ29547604
Regulation of cadherin-mediated adhesion in morphogenesisQ29614940
Mammalian Rho GTPases: new insights into their functions from in vivo studiesQ29615191
Spatiotemporal dynamics of RhoA activity in migrating cellsQ29618433
Cell migrationQ30311876
Localized RhoA activation as a requirement for the induction of membrane rufflingQ30476117
Tre1 GPCR initiates germ cell transepithelial migration by regulating Drosophila melanogaster E-cadherinQ30483868
Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio)Q33247353
Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cellsQ34324446
Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migrationQ34543645
Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanismQ34574438
A zebrafish nanos-related gene is essential for the development of primordial germ cellsQ35082150
Activity of Rho-family GTPases during cell division as visualized with FRET-based probesQ36323206
In vivo migration: a germ cell perspective.Q36506792
Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independentQ37171607
The mechanical integrin cycle.Q37360851
Transition from non-motile behaviour to directed migration during early PGC development in zebrafishQ38321612
p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of SlugQ39850223
Enhanced adhesive capacities of the naturally occurring Ile249-Met280 variant of the chemokine receptor CX3CR1.Q40584646
Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behaviorQ40915141
Characterization of the interface between normal and transformed epithelial cellsQ42450915
Myosin VI is required for E-cadherin-mediated border cell migrationQ47070917
Invasive cell migration is initiated by guided growth of long cellular extensionsQ47070990
Autonomous modes of behavior in primordial germ cell migrationQ47073427
Guidance of primordial germ cell migration by the chemokine SDF-1.Q47073968
Migration of zebrafish primordial germ cells: a role for myosin contraction and cytoplasmic flow.Q53012779
P433issue1
P921main subjectcell adhesionQ187640
P304page(s)47-53; sup pp 1-11
P577publication date2009-12-13
P1433published inNature Cell BiologyQ1574111
P1476titleA role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo
P478volume12

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cites work (P2860)
Q40785765A GAL4-inducible transgenic tool kit for the in vivo modulation of Rho GTPase activity in zebrafish
Q27302113A Novel Role of E-Cadherin-Based Adherens Junctions in Neoplastic Cell Dissemination
Q33559900A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly
Q50495381Actin Filament Structures in Migrating Cells.
Q30536896Actomyosin-based self-organization of cell internalization during C. elegans gastrulation
Q41850717Adherens junction function and regulation during zebrafish gastrulation
Q28087050Adhesion in mammary development: novel roles for E-cadherin in individual and collective cell migration
Q30279018Allosteric Regulation of E-Cadherin Adhesion.
Q30854412An apicobasal gradient of Rac activity determines protrusion form and position
Q36685053Apoptotic cells are cleared by directional migration and elmo1- dependent macrophage engulfment
Q30525066Autonomy in specification of primordial germ cells and their passive translocation in the sea urchin
Q44652416Bcl-wav and the mitochondrial calcium uniporter drive gastrula morphogenesis in zebrafish
Q47366772Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations
Q38637064Cadherin-mediated cell-cell interactions in normal and cancer cells
Q61800906Caveolin-1α regulates primary cilium length by controlling RhoA GTPase activity
Q47436665Cdc42 regulates the cellular localization of Cdc42ep1 in controlling neural crest cell migration.
Q90781485Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo
Q90628778Cell confinement reveals a branched-actin independent circuit for neutrophil polarity
Q28581771Cell mechanics control rapid transitions between blebs and lamellipodia during migration
Q42032985Cell migration: fibroblasts find a new way to get ahead.
Q26766248Cell polarity signaling in the plasticity of cancer cell invasiveness
Q40732491Cellular regulation of extension and retraction of pseudopod-like blebs produced by nanosecond pulsed electric field (nsPEF).
Q41936228Central and C-terminal domains of heterotrimeric G protein gamma subunits differentially influence the signaling necessary for primordial germ cell migration
Q35819642Chemokine-guided cell migration and motility in zebrafish development
Q42734789Cleavage of E-Cadherin by Matrix Metalloproteinase-7 Promotes Cellular Proliferation in Nontransformed Cell Lines via Activation of RhoA.
Q30500161Completion of the epithelial to mesenchymal transition in zebrafish mesoderm requires Spadetail
Q60048013Contribution of epithelial-mesenchymal transitions to organogenesis and cancer metastasis
Q37776617Control of neural crest cell behavior and migration: Insights from live imaging
Q42062117Cortical contractility triggers a stochastic switch to fast amoeboid cell motility.
Q37830862Design and application of genetically encoded biosensors
Q37783941Development and application of probes for labeling the actin cytoskeleton in living plant cells
Q38205100Developments in preclinical cancer imaging: innovating the discovery of therapeutics.
Q64071276Distinct mesoderm migration phenotypes in extra-embryonic and embryonic regions of the early mouse embryo
Q40483221Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes
Q39177124Down expression of LRP1B promotes cell migration via RhoA/Cdc42 pathway and actin cytoskeleton remodeling in renal cell cancer
Q101237257E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow
Q50231309E-cadherin is required for cranial neural crest migration in Xenopus laevis
Q28079585E-cadherin roles in animal biology: A perspective on thyroid hormone-influence
Q26865483E-cadherin's dark side: possible role in tumor progression
Q50441456Early proliferation alteration and differential gene expression in human periodontal ligament cells subjected to cyclic tensile stress
Q39257853Effect of p120 catenin silencing on biological behaviors of PANC-1 cells
Q30547788Eph/Ephrin signalling maintains eye field segregation from adjacent neural plate territories during forebrain morphogenesis.
Q33780893Extra-embryonic tissue spreading directs early embryo morphogenesis in killifish
Q39436066FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion
Q38916447Finding their way: themes in germ cell migration
Q38121541From seeing to believing: labelling strategies for in vivo cell-tracking experiments.
Q38124184Genetic tools for multicolor imaging in zebrafish larvae
Q38311391Gβ1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium
Q38758135Gβ1 is required for neutrophil migration in zebrafish
Q35595462Gβγ signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity
Q27318761Haemodynamics-driven developmental pruning of brain vasculature in zebrafish
Q34211941Imaging molecular dynamics in vivo--from cell biology to animal models
Q51504985Imaging protein activity in live embryos using fluorescence resonance energy transfer biosensors.
Q39698278Individual cell movement, asymmetric colony expansion, rho-associated kinase, and E-cadherin impact the clonogenicity of human embryonic stem cells.
Q50760251Inflammatory breast cancer: unique biological and therapeutic considerations.
Q38151655Integration of anterior neural plate patterning and morphogenesis by the Wnt signaling pathway
Q55378989Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure.
Q34090534Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo
Q44050330Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions
Q30585627Mechanical feedback through E-cadherin promotes direction sensing during collective cell migration
Q28268441Mechanisms guiding primordial germ cell migration: strategies from different organisms
Q90468391Mechanisms of 3D cell migration
Q37791833Mechanisms of force generation and force transmission during interstitial leukocyte migration
Q37620886Mesenchymal morphogenesis of embryonic stem cells dynamically modulates the biophysical microtissue niche
Q47403051Mib1 contributes to persistent directional cell migration by regulating the Ctnnd1-Rac1 pathway
Q34181649Migration of sea urchin primordial germ cells.
Q30445718Migratory and adhesive properties of Xenopus laevis primordial germ cells in vitro
Q39013227Modeling, signaling and cytoskeleton dynamics: integrated modeling-experimental frameworks in cell migration
Q42483416N-cadherin is overexpressed in Crohn's stricture fibroblasts and promotes intestinal fibroblast migration
Q30524670Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1
Q100633469Non-junctional role of Cadherin3 in cell migration and contact inhibition of locomotion via domain-dependent, opposing regulation of Rac1
Q35925311Nonpolarized signaling reveals two distinct modes of 3D cell migration
Q47894525PI3K: A Crucial Piece in the RAS Signaling Puzzle
Q26823939Palatogenesis and cutaneous repair: A two-headed coin
Q38263780Physical influences of the extracellular environment on cell migration
Q47162542Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis
Q41087830Pou5f1-dependent EGF expression controls E-cadherin endocytosis, cell adhesion, and zebrafish epiboly movements.
Q47670930Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function
Q28080844Quantifying Modes of 3D Cell Migration
Q27320277RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression
Q57062655Rab GTPases take centre stage in understanding Entamoeba histolytica biology
Q30525522Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression
Q35057676Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo
Q52730585Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - The role of Hsp90.
Q50531441Reduction in E-cadherin expression fosters migration of Xenopus laevis primordial germ cells.
Q34629064Regulation of cell adhesions and motility during initiation of neural crest migration
Q37091348Resting microglia respond to and regulate neuronal activity in vivo
Q63408505Retrograde flow of cadherins in collective cell migration
Q57944920Review and perspective on soft matter modeling in cellular mechanobiology: cell contact, adhesion, mechanosensing, and motility
Q38284409Rho GTPase isoforms in cell motility: Don't fret, we have FRET.
Q26781332Rho GTPase signalling in cell migration
Q30572435Rho activation is apically restricted by Arhgap1 in neural crest cells and drives epithelial-to-mesenchymal transition
Q36887405RhoA is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis
Q50477773RhoA/ROCK pathway activity is essential for the correct localization of the germ plasm mRNAs in zebrafish embryos.
Q33658160RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6.
Q37770648Role of WASP in cell polarity and podosome dynamics of myeloid cells
Q89008449SAD-A Promotes Glucose-Stimulated Insulin Secretion Through Phosphorylation and Inhibition of GDIα in Male Islet β Cells
Q49853441Shedding new light on RhoA signalling as a drug target in vivo using a novel RhoA-FRET biosensor mouse.
Q37935313Shining light on Drosophila oogenesis: live imaging of egg development.
Q30498093Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53
Q27304862Steering cell migration by alternating blebs and actin-rich protrusions.
Q92846259Stepwise polarisation of developing bilayered epidermis is mediated by aPKC and E-cadherin in zebrafish
Q82502158Studying cell behavior in whole zebrafish embryos by confocal live imaging: application to hematopoietic stem cells
Q34025612Temporal control over the initiation of cell motility by a regulator of G-protein signaling
Q64245905The Functional Implications of Endothelial Gap Junctions and Cellular Mechanics in Vascular Angiogenesis
Q30276831The Molecular Basis of Radial Intercalation during Tissue Spreading in Early Development
Q30592319The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes
Q38786537The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues
Q37469449The Rho guanine nucleotide exchange factor Syx regulates the balance of dia and ROCK activities to promote polarized-cancer-cell migration
Q58613010The calcium-sensing receptor regulates epidermal intracellular Ca signaling and re-epithelialization after wounding
Q36147572The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment
Q38685677The front and rear of collective cell migration.
Q38321714The many faces of cell adhesion during Drosophila muscle development
Q37800262The nuts and bolts of germ-cell migration
Q26996410The role and regulation of blebs in cell migration
Q37909722The role of adhesion energy in controlling cell-cell contacts.
Q38124067Three functions of cadherins in cell adhesion
Q30659385Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos
Q33950292Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner.
Q50903485Volume Changes During Active Shape Fluctuations in Cells.
Q41215554Zygotic vinculin is not essential for embryonic development in zebrafish.
Q35655628αE-catenin regulates cell-cell adhesion and membrane blebbing during zebrafish epiboly

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