Characterization of the interface between normal and transformed epithelial cells

scientific article published on 15 March 2009

Characterization of the interface between normal and transformed epithelial cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NCB1853
P698PubMed publication ID19287376
P5875ResearchGate publication ID24201877

P50authorEugenia PiddiniQ56853234
Yoshifumi ItohQ58809398
Andrew E. PellingQ42808292
Franck PichaudQ46578249
P2093author name stringMark Norman
Mihoko Kajita
Yasuyuki Fujita
Hiroshi Hosoya
Jean-Paul Vincent
Catherine Hogan
Sophie Dupré-Crochet
Luis Alberto Baena-López
Carola Zimmermann
P2860cites workThe Hallmarks of CancerQ221226
Wg and Egfr signalling antagonise the development of the peripodial epithelium in Drosophila wing discs.Q52096638
Differential influence of adjacent normal cells on the proliferation of mammalian cells transformed by the viral oncogenes myc, ras and src.Q53522409
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)Q24319737
Rho GTPases: biochemistry and biologyQ27860645
Clonal origin of human tumorsQ28144871
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by RasQ28238120
The clonal evolution of tumor cell populationsQ28271546
Ras oncogenes: split personalitiesQ29615405
Phosphoinositide 3-kinase signalling pathwaysQ33940898
Multilayering and loss of apical polarity in MDCK cells transformed with viral K-rasQ36529343
Rho GTPases in cancer cell biologyQ37156024
scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in DrosophilaQ37367551
Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motilityQ39714519
Rap1 regulates the formation of E-cadherin-based cell-cell contacts.Q40535764
Ras-like GTPasesQ41659022
An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanismQ43812071
Growth inhibition of polyoma-transformed cells by contact with static normal fibroblastsQ45132458
Drosophila myc regulates organ size by inducing cell competitionQ47071644
Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosisQ47071947
dMyc transforms cells into super-competitorsQ47072112
Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migrationQ48009008
Normal cells control the growth of neighboring transformed cells independent of gap junctional communication and SRC activity.Q51029512
P433issue4
P304page(s)460-467
P577publication date2009-03-15
P1433published inNature Cell BiologyQ1574111
P1476titleCharacterization of the interface between normal and transformed epithelial cells
P478volume11

Reverse relations

cites work (P2860)
Q27302113A Novel Role of E-Cadherin-Based Adherens Junctions in Neoplastic Cell Dissemination
Q28304367A PAK6-IQGAP1 complex promotes disassembly of cell-cell adhesions
Q34016436A positive role of cadherin in Wnt/β-catenin signalling during epithelial-mesenchymal transition
Q59314649A role for Rho GTPases and cell–cell adhesion in single-cell motility in vivo
Q33882575A role for the epithelial microenvironment at tumor boundaries: evidence from Drosophila and human squamous cell carcinomas.
Q38382450A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC).
Q55428649ADAM-like Decysin-1 (ADAMDEC1) is a positive regulator of Epithelial Defense Against Cancer (EDAC) that promotes apical extrusion of RasV12-transformed cells.
Q38939314AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival.
Q28082719Actin cytoskeletal control during epithelial to mesenchymal transition: focus on the pancreas and intestinal tract
Q92594793Actin dynamics and the Bmp pathway drive apical extrusion of proepicardial cells
Q38222722Activated K-RAS and its effect on morphological appearance.
Q41871045Activated Ras protein accelerates cell cycle progression to perturb Madin-Darby canine kidney cystogenesis
Q35158071Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer
Q42479243Active deformation of apoptotic intestinal epithelial cells with adhesion-restricted polarity contributes to apoptotic clearance
Q39022773An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition
Q24323326Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein
Q47844438Apical constriction is driven by a pulsatile apical myosin network in delaminating Drosophila neuroblasts.
Q27305890Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling
Q30572504Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P
Q33832727Basal but not luminal mammary epithelial cells require PI3K/mTOR signaling for Ras-driven overgrowth.
Q28487942Basolateral BMP signaling in polarized epithelial cells
Q38679713Beyond a tumor suppressor: Soluble E-cadherin promotes the progression of cancer.
Q24622900Biological influence of Hakai in cancer: a 10-year review
Q52342162Biophysical characteristics of hematopoietic cells during division.
Q34319959Bringing balance by force: live cell extrusion controls epithelial cell numbers
Q92262729CBLL1 is highly expressed in non-small cell lung cancer and promotes cell proliferation and invasion
Q50168938Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis.
Q37478763Cell competition and its implications for development and cancer
Q38834617Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes
Q67228058Cell sheet integrity and nanomechanical breakdown during programmed cell death
Q49557534Cellular responses and gene expression profiles of colonic Lgr5+ stem cells after low-dose/low-dose-rate radiation exposure
Q38064445Collective epithelial and mesenchymal cell migration during gastrulation
Q35208467Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype.
Q34042307Competition between human cells by entosis
Q28539643Conserved mechanisms of tumorigenesis in the Drosophila adult midgut
Q39653631Conversion of Helicobacter pylori CagA from senescence inducer to oncogenic driver through polarity-dependent regulation of p21
Q51124393Cortical F-actin stabilization generates apical-lateral patterns of junctional contractility that integrate cells into epithelia.
Q60932989Culling Less Fit Neurons Protects against Amyloid-β-Induced Brain Damage and Cognitive and Motor Decline
Q37429822DAAM1 stabilizes epithelial junctions by restraining WAVE complex-dependent lateral membrane motility.
Q55286883Differential Expression Patterns of Eph Receptors and Ephrin Ligands in Human Cancers.
Q36420075Directing the assembly of spatially organized multicomponent tissues from the bottom up.
Q36827924Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1.
Q37673448Dissecting social cell biology and tumors using Drosophila genetics
Q90103107Drosophila Models of Cell Polarity and Cell Competition in Tumourigenesis
Q37950977Drosophila cancer models.
Q38449977E-cadherin junctions as active mechanical integrators in tissue dynamics
Q38705672Elimination of LMP1-expressing cells from a monolayer of gastric cancer AGS cells
Q92916660Elimination of oncogenic cells that regulate epithelial homeostasis in Drosophila
Q98303503Emerging mechanisms of cell competition
Q93025337Enforcement is central to the evolution of cooperation
Q38841415Epithelial cell extrusion: Pathways and pathologies.
Q42536370Epithelial cell translocation: new insights into mechanisms of tumor initiation.
Q37916077Epithelial delamination and migration: lessons from Drosophila
Q26864115Epithelial homeostasis
Q39360620Epithelial self-defense against cancer
Q36124331Epstein-Barr virus mRNA profiles and viral DNA methylation status in nasopharyngeal brushings from nasopharyngeal carcinoma patients reflect tumor origin
Q39533666Evidence for the transmission of neoplastic properties from transformed to normal human stem cells.
Q36039749Expression of Cell Competition Markers at the Interface between p53 Signature and Normal Epithelium in the Human Fallopian Tube
Q53044996Extracellular cleavage of E-cadherin promotes epithelial cell extrusion.
Q38969932Filamin acts as a key regulator in epithelial defence against transformed cells
Q36051086Flower-deficient mice have reduced susceptibility to skin papilloma formation
Q38093768Force nanoscopy of cell mechanics and cell adhesion
Q39145987Functional exploration of colorectal cancer genomes using Drosophila
Q34066321Hakai reduces cell-substratum adhesion and increases epithelial cell invasion
Q37105376Haploinsufficiency in the prometastasis Kiss1 receptor Gpr54 delays breast tumor initiation, progression, and lung metastasis
Q93073427Harnessing epithelial homeostatic mechanisms to fight cancer
Q27323156Human mutations affect the epigenetic/bookmarking function of HNF1B
Q37923836Impact of interactions between normal and transformed epithelial cells and the relevance to cancer
Q52763280In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosis.
Q51812009Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia.
Q30496969Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells
Q37892645Interface between normal and transformed epithelial cells: a road to a novel type of cancer prevention and treatment
Q24339418Involvement of Lgl and Mahjong/VprBP in cell competition
Q87201501Lateral junction dynamics lead the way out
Q47680095Local cellular neighborhood controls proliferation in cell competition.
Q39411256Loss of Scribble causes cell competition in mammalian cells.
Q99560435MAPK activity dynamics regulate non-cell autonomous effects of oncogene expression
Q42578908MDCK cells expressing constitutively active Yes-associated protein (YAP) undergo apical extrusion depending on neighboring cell status
Q37322180MIP-1α/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia
Q27319472Mechanical cell competition kills cells via induction of lethal p53 levels
Q36695589Mechanisms of cell competition: themes and variations
Q87925960Metabolic changes promote rejection of oncogenic cells
Q51793774Micro and nanotechnology for biological and biomedical applications.
Q90646258Mutations in the Drosophila tricellular junction protein M6 synergize with RasV12 to induce apical cell delamination and invasion
Q100945987Neuroepithelial cell competition triggers loss of cellular juvenescence
Q37995989New frontiers in cell competition
Q42509412Non-muscle myosin II deletion in the developing kidney causes ureter-bladder misconnection and apical extrusion of the nephric duct lineage epithelia
Q54354622Normal epithelial cells trigger EphA2-dependent RasV12 cell repulsion at the single cell level.
Q27015094Normal morphogenesis of epithelial tissues and progression of epithelial tumors
Q52563487Obesity Suppresses Cell-Competition-Mediated Apical Elimination of RasV12-Transformed Cells from Epithelial Tissues.
Q42619130Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with αV-Class integrins to promote EMT.
Q92610926Outcompeting cancer
Q39399468Outgrowth of single oncogene-expressing cells from suppressive epithelial environments.
Q91813983Ovarian Cancer Dissemination-A Cell Biologist's Perspective
Q37342456P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium
Q34043214PKA-regulated VASP phosphorylation promotes extrusion of transformed cells from the epithelium
Q38160892Patterns in space: coordinating adhesion and actomyosin contractility at E-cadherin junctions.
Q47240974Physiological and pathological relevance of cell competition in fly to mammals.
Q42317205Plectin is a novel regulator for apical extrusion of RasV12-transformed cells
Q26830318Polarity in mammalian epithelial morphogenesis
Q49555404Policing Tumorigenesis within the Skin: Good Outs Bad.
Q34305530Programmed cell death: a new way worms get rid of unwanted cells
Q36790728Programmed cell-to-cell variability in Ras activity triggers emergent behaviors during mammary epithelial morphogenesis
Q92988169Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP-mediated cell competition
Q36292389Proteomic and histopathological characterization of the interface between oral squamous cell carcinoma invasion fronts and non-cancerous epithelia.
Q54520178ROCK1 and ROCK2 regulate epithelial polarisation and geometric cell shape.
Q40501653Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma
Q34062605Rab11 regulates E-cadherin expression and induces cell transformation in colorectal carcinoma
Q41710038Rab5-regulated endocytosis plays a crucial role in apical extrusion of transformed cells.
Q89587304Rho-ROCK Signaling in Normal Physiology and as a Key Player in Shaping the Tumor Microenvironment
Q51247891Slit-Robo Repulsive Signaling Extrudes Tumorigenic Cells from Epithelia.
Q55210240Somatic clones heterozygous for recessive disease alleles of BMPR1A exhibit unexpected phenotypes in Drosophila.
Q53209256Somatic mosaicism: on the road to cancer.
Q51521605Spatiotemporal control of gene expression using microfluidics.
Q58586457Src-transformed cells hijack mitosis to extrude from the epithelium
Q90438593The COX-2/PGE2 pathway suppresses apical elimination of RasV12-transformed cells from epithelia
Q55081275The Hippo-YAP Pathway Regulates 3D Organ Formation and Homeostasis.
Q35813043The cell competition-based high-throughput screening identifies small compounds that promote the elimination of RasV12-transformed cells from epithelia
Q93270879The duality of human oncoproteins: drivers of cancer and congenital disorders
Q88571481The forces and fates of extruding cells
Q42504319The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition
Q49390116The paxillin-plectin-EPLIN complex promotes apical elimination of RasV12-transformed cells by modulating HDAC6-regulated tubulin acetylation
Q90731397These secret battles between your body's cells might just save your life
Q50457231Tissue normalizing capacity as a key determinant of carcinogenesis: an in silico simulation
Q39441362Tissue-Intrinsic Tumor Hotspots: Terroir for Tumorigenesis.
Q42171388Topological defects in epithelia govern cell death and extrusion
Q34425577Tumour cell invasion: an emerging role for basal epithelial cell extrusion
Q52746331[How epithelium gets rid of weird cells].
Q30275107p53 pathway is involved in cell competition during mouse embryogenesis

Search more.