Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2-hydroxylation, results in penicillin overproduction

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Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2-hydroxylation, results in penicillin overproduction is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.274.21.14545
P698PubMed publication ID10329644
P5875ResearchGate publication ID12968354

P50authorJosé Manuel Fernández-CañónQ67931018
P2093author name stringM A Peñalva
J M Mingot
P2860cites workFunctional analysis of ARGRI and ARGRIII regulatory proteins involved in the regulation of arginine metabolism in Saccharomyces cerevisiaeQ27930392
Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologueQ28118834
Fungal metabolic model for human type I hereditary tyrosinaemiaQ33887444
Functional and evolutionary relationships among diverse oxygenasesQ33972461
Molecular characterization of the phenylacetic acid catabolic pathway in Pseudomonas putida U: the phenylacetyl-CoA catabolonQ37418572
Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulansQ37716071
P450 genes: structure, evolution, and regulationQ39664988
Toluene-4-monooxygenase, a three-component enzyme system that catalyzes the oxidation of toluene to p-cresol in Pseudomonas mendocina KR1.Q39941504
7 Purification and properties of NADPH-Cytochrome P-450 reductaseQ40161368
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.Q41142872
Cytochrome P450 enzyme systems in fungiQ41720643
Oxidation of phenylacetic acid by Penicillium chrysogenumQ42020946
Immunochemical characterization of NADPH-cytochrome P-450 reductase from Jerusalem artichoke and other higher plantsQ42272847
Molecular Characterization of a Gene Encoding a Homogentisate Dioxygenase from Aspergillus nidulans and Identification of Its Human and Plant HomologuesQ42277901
Molecular cloning and expression in different microbes of the DNA encoding Pseudomonas putida U phenylacetyl-CoA ligase. Use of this gene to improve the rate of benzylpenicillin biosynthesis in Penicillium chrysogenum.Q48056552
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectpenicillinQ12190
Aspergillus nidulansQ683881
Phenylacetate 2-hydroxylaseQ62650258
Putative cytochrome P450 monooxygenase involved in the catabolism of aromatic compoundsQ62665807
P304page(s)14545-14550
P577publication date1999-05-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleDisruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2-hydroxylation, results in penicillin overproduction
P478volume274

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