Autologous transplantation of GDNF-expressing mesenchymal stem cells protects against MPTP-induced damage in cynomolgus monkeys

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Autologous transplantation of GDNF-expressing mesenchymal stem cells protects against MPTP-induced damage in cynomolgus monkeys is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1012727457
P356DOI10.1038/SREP02786
P8608Fatcat IDrelease_ak7yvpcbrff5fggeqogm5iemfy
P932PMC publication ID4070584
P698PubMed publication ID24071770
P5875ResearchGate publication ID257135104

P50authorZhiguo ChenQ59694220
P2093author name stringXiaobo Li
Jiayin Wang
Chunlin Zou
Shuyan Wang
Yunqian Guan
Y Alex Zhang
Zhenhua Ren
P2860cites workSpontaneous transformation of adult mesenchymal stem cells from cynomolgus macaques in vitroQ85026343
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A chronic MPTP model reproducing the slow evolution of Parkinson's disease: evolution of motor symptoms in the monkeyQ48635335
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Comparison of growth and differentiation of fetal and adult rhesus monkey mesenchymal stem cells.Q51214960
Motor slowing and parkinsonian signs in aging rhesus monkeys mirror human aging.Q52164243
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Spontaneous transformation of cynomolgus mesenchymal stem cells in vitro: further confirmation by short tandem repeat analysisQ83153283
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The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's diseaseQ33656315
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GDNF-secreting human neural progenitor cells increase tyrosine hydroxylase and VMAT2 expression in MPTP-treated cynomolgus monkeysQ39975890
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Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson diseaseQ40326219
Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primatesQ40339968
Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease.Q40464992
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Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD.Q40678042
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GDNF induces a dystonia-like state in neonatal rats and stimulates dopamine and serotonin synthesisQ41221025
Multiple neurogenic and neurorescue effects of human mesenchymal stem cell after transplantation in an experimental model of Parkinson's disease.Q43234179
99mTc-TRODAT-1 SPECT in healthy and 6-OHDA lesioned parkinsonian monkeys: comparison with 18F-FDOPA PET.Q44261629
A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's diseaseQ44571920
Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion modelQ45178238
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 UnportedQ19125045
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectmesenchymal stem cellQ1922379
P304page(s)2786
P577publication date2013-09-27
P1433published inScientific ReportsQ2261792
P1476titleAutologous transplantation of GDNF-expressing mesenchymal stem cells protects against MPTP-induced damage in cynomolgus monkeys
P478volume3

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cites work (P2860)
Q36882491Autologous iPSC-derived dopamine neuron transplantation in a nonhuman primate Parkinson's disease model
Q38194531Challenges and promises in the development of neurotrophic factor-based therapies for Parkinson's disease.
Q47941437Functional role of mesenchymal stem cells in the treatment of chronic neurodegenerative diseases.
Q38201685Preconditioning as a potential strategy for the prevention of Parkinson's disease.
Q64237799Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid-Lesioned Parkinson's Disease Models
Q41913461The phosphodiesterase inhibitor, ibudilast, attenuates neuroinflammation in the MPTP model of Parkinson's disease.
Q89942957Transplantation in the nonhuman primate MPTP model of Parkinson's disease: update and perspectives
Q38181868Use of genetically modified mesenchymal stem cells to treat neurodegenerative diseases