Seamless integration of dose-response screening and flow chemistry: efficient generation of structure-activity relationship data of β-secretase (BACE1) inhibitors

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Seamless integration of dose-response screening and flow chemistry: efficient generation of structure-activity relationship data of β-secretase (BACE1) inhibitors is …
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scholarly articleQ13442814

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P356DOI10.1002/ANIE.201309301
P698PubMed publication ID24458566

P50authorRainer E MartinQ87506723
P2093author name stringHorst Vogel
Alexander I Alanine
Christoph Kuratli
David Wechsler
Michael Werner
Remo Hochstrasser
Thilo Enderle
P2860cites workFlow chemistry synthesis of zolpidem, alpidem and other GABAAagonists and their biological evaluation through the use of in-line frontal affinity chromatographyQ56951708
The flow synthesis of heterocycles for natural product and medicinal chemistry applicationsQ56951891
β-Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s DiseaseQ27684422
Hit and lead generation: beyond high-throughput screeningQ28204526
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Substrate and Inhibitor Profile of BACE (β-Secretase) and Comparison with Other Mammalian Aspartic ProteasesQ31032457
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Continuous-flow organic synthesis: a tool for the modern medicinal chemistQ37855814
The productivity crisis in pharmaceutical R&D.Q37883027
Continuous Flow Synthesis. A Pharma PerspectiveQ37979238
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Novel Process Windows for Enabling, Accelerating, and Uplifting Flow ChemistryQ38100756
Integrated Synthesis and Testing of Substituted Xanthine Based DPP4 Inhibitors: Application to Drug DiscoveryQ39771545
Microfluidic gradient-generating device for pharmacological profilingQ40403674
Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform.Q42712714
Characterization of sensitivity and specificity in leaky droplet-based assaysQ51536122
Droplet-based microfluidic flow injection system with large-scale concentration gradient by a single nanoliter-scale injection for enzyme inhibition assayQ51544050
Dispersion of Soluble Matter in Solvent Flowing Slowly through a TubeQ56553507
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1704-1708
P577publication date2014-01-23
P1433published inAngewandte Chemie International EditionQ62023953
P1476titleSeamless integration of dose-response screening and flow chemistry: efficient generation of structure-activity relationship data of β-secretase (BACE1) inhibitors
P478volume53

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Q38209736Accessing new chemical entities through microfluidic systems
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