Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists

scientific article published on 27 December 2018

Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/ACSMEDCHEMLETT.8B00459
P932PMC publication ID6466813
P698PubMed publication ID30996817

P50authorAntimo GioielloQ54379871
Andrea CarottiQ54379887
Alessandro Di MicheleQ59207110
Bruno CerraQ85945016
P2093author name stringAntonio Macchiarulo
Roberto Pellicciari
Roccaldo Sardella
Daniela Passeri
Giada Moroni
P2860cites workPregnane X receptor as a target for treatment of inflammatory bowel disordersQ26998347
Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonismQ27641100
Seamless integration of dose-response screening and flow chemistry: efficient generation of structure-activity relationship data of β-secretase (BACE1) inhibitorsQ30741444
Principles of early drug discoveryQ34150775
Integrated Platform for Expedited Synthesis-Purification-Testing of Small Molecule LibrariesQ36354649
Nuclear receptor PXR, transcriptional circuits and metabolic relevanceQ37835926
The Hitchhiker's Guide to Flow Chemistry ∥.Q39343669
Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform.Q42712714
Automating drug discoveryQ47780833
SpecDis: quantifying the comparison of calculated and experimental electronic circular dichroism spectraQ48968379
PXR: More Than Just a Master Xenobiotic ReceptorQ50117089
The Molecular Industrial Revolution: Automated Synthesis of Small MoleculesQ50420538
Expanding the medicinal chemistry synthetic toolboxQ56273707
Enantioresolution, stereochemical characterization and biological activity of a chiral large-conductance calcium-activated potassium channel openerQ56972498
What Makes a Great Medicinal Chemist? A Personal PerspectiveQ88624923
P433issue4
P304page(s)677-681
P577publication date2018-12-27
P1433published inACS Medicinal Chemistry LettersQ2819061
P1476titleExploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists
P478volume10

Reverse relations

cites work (P2860)
Q92219664Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines
Q89834926Flow Synthesis of Biologically-Relevant Compound Libraries
Q92634324Meroterpene-Like α-Glucosidase Inhibitors Based on Biomimetic Reactions Starting from β-Caryophyllene
Q93040134Minimal manual input
Q92259354New Polyketides from the Marine-Derived Fungus Letendraea sp. 5XNZ4-2
Q91657243Optimisation by Design of Experiment of Benzimidazol-2-One Synthesis under Flow Conditions

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