Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B.

scientific article

Solid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/JM0110901
P698PubMed publication ID11985465
P5875ResearchGate publication ID11385277

P50authorMorten P. MeldalQ6914509
Jeremy C. MottramQ41417991
Jorge ArevaloQ56483707
Phaedria M St HilaireQ114674245
P2093author name stringGraham H Coombs
Luiz Juliano
Maria A Juliano
Manat Renil
Sanya J Sanderson
Fatima Herrera
Lira C Alves
P2860cites workEvidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors.Q37568159
Potency comparison of peptidomimetic inhibitors against HIV-1 and HIV-2 proteinases: design of equipotent lead compoundsQ39444912
New mechanisms of drug resistance in parasitic protozoaQ40945183
Analysis of the roles of cysteine proteinases of Leishmania mexicana in the host-parasite interactionQ43407501
Identification of peptides inhibitory to recombinant cysteine proteinase, CPB, of Leishmania mexicanaQ43610414
Substrate specificity of recombinant cysteine proteinase, CPB, of Leishmania mexicanaQ43681684
The crystal structure of cruzain: a therapeutic target for Chagas' diseaseQ46209844
The multiple cpb cysteine proteinase genes of Leishmania mexicana encode isoenzymes that differ in their stage regulation and substrate preferencesQ48049558
Solid-phase synthesis and biological properties of psi [CH2NH] pseudopeptide analogues of a highly potent somatostatin octapeptide.Q52488662
Color test for detection of free terminal amino groups in the solid-phase synthesis of peptidesQ56390180
New coupling reagents in peptide chemistryQ59382410
Anthranilamide and nitrotyrosine as a donor-acceptor pair in internally quenched fluorescent substrates for endopeptidases: multicolumn peptide synthesis of enzyme substrates for subtilisin Carlsberg and pepsinQ67967631
Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sitesQ68927791
Solid phase synthesis of peptides containing the CH2NH peptide bond isostereQ69001709
Combinatorial library of serine and cysteine protease inhibitors that interact with both the S and S' binding sitesQ73046590
Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivoQ73077056
Mechanism of inhibition of cathepsin K by potent, selective 1, 5-diacylcarbohydrazides: a new class of mechanism-based inhibitors of thiol proteasesQ73334004
Structure of papain refined at 1.65 A resolutionQ27729147
Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin KQ27765282
Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsitesQ27765850
Drug resistance in leishmaniasis: its implication in systemic chemotherapy of cutaneous and mucocutaneous diseaseQ28326560
Protease inhibitors: current status and future prospectsQ28370172
Cyanohydridoborate anion as a selective reducing agentQ29028927
Solid phase combinatorial library of phosphinic peptides for discovery of matrix metalloproteinase inhibitorsQ30642555
Phosphinic peptide inhibitors of macrophage metalloelastase (MMP-12). Selectivity and mechanism of bindingQ30670896
Potent, low-molecular-weight non-peptide inhibitors of malarial aspartyl protease plasmepsin II.Q30672366
Combinatorial library of peptide isosters based on Diels-Alder reactions: identification of novel inhibitors against a recombinant cysteine protease from Leishmania mexicanaQ30713686
Fluorescence-quenched solid phase combinatorial libraries in the characterization of cysteine protease substrate specificityQ30854464
Inhibition of cruzipain visualized in a fluorescence quenched solid-phase inhibitor library assay. D-amino acid inhibitors for cruzipain, cathepsin B and cathepsin L.Q32061568
Generation and use of synthetic peptide combinatorial libraries for basic research and drug discoveryQ33267847
Multiple high activity cysteine proteases of Leishmania mexicana are encoded by the Imcpb gene arrayQ34341002
Cysteine protease inhibitors as chemotherapy: lessons from a parasite targetQ36176812
BIA/MS: interfacing biomolecular interaction analysis with mass spectrometryQ36845637
Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitorsQ36891348
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P433issue10
P407language of work or nameEnglishQ1860
P921main subjectLeishmania mexicanaQ2493771
P304page(s)1971-1982
P577publication date2002-05-01
P1433published inJournal of Medicinal ChemistryQ900316
P1476titleSolid-phase library synthesis, screening, and selection of tight-binding reduced peptide bond inhibitors of a recombinant Leishmania mexicana cysteine protease B.
P478volume45

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cites work (P2860)
Q33202737Combinatorial library of peptidotriazoles: identification of [1,2,3]-triazole inhibitors against a recombinant Leishmania mexicana cysteine protease
Q44949896Cyclic, linear, cycloretro-isomer, and cycloretro-inverso peptides derived from the C-terminal sequence of bradykinin as substrates or inhibitors of serine and cysteine proteases
Q40517959Differences in substrate specificities between cysteine protease CPB isoforms of Leishmania mexicana are mediated by a few amino acid changes
Q35053473Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8.
Q36288119Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families
Q37947476Microwave heating in solid-phase peptide synthesis
Q36033291Peptides and Peptide Analogs to Inhibit Protein-Protein Interactions
Q37708228Ralph F. Hirschmann award address 2009: Merger of organic chemistry with peptide diversity.
Q37780442Solid-phase synthesis of N-substituted glycine oligomers (alpha-peptoids) and derivatives.
Q33355343Synthesis, screening, and sequencing of cysteine-rich one-bead one-compound peptide libraries
Q33184660The one-bead two-compound assay for solid phase screening of combinatorial libraries

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