Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.

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Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics. is …
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scholarly articleQ13442814

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P356DOI10.1016/J.VIROL.2008.04.005
P8608Fatcat IDrelease_yuvsduyuwbasldmk565hfmqo6e
P932PMC publication ID2493441
P698PubMed publication ID18499210
P5875ResearchGate publication ID5351375

P50authorDennis R. BurtonQ56331320
G. Marius CloreQ19864601
P2093author name stringJohn M Louis
Philip E Dawson
Douglas D Richman
Rose G Mage
Michael B Zwick
Richard Jensen
Katherine Bowdish
Toshiaki Maruyama
Carole A Bewley
Florence M Brunel
Shana Frederickson
Heather Kinkead
Josh D Nelson
Dan Leaman
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Cross-reactive HIV-1 neutralizing monoclonal antibodies selected by screening of an immune human phage library against an envelope glycoprotein (gp140) isolated from a patient (R2) with broadly HIV-1 neutralizing antibodiesQ33274285
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Differential inhibition of HIV-1 and SIV envelope-mediated cell fusion by C34 peptides derived from the C-terminal heptad repeat of gp41 from diverse strains of HIV-1, HIV-2, and SIV.Q40435668
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Expression and characterization of HIV type 1 envelope protein associated with a broadly reactive neutralizing antibody responseQ47968718
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Analysis of the neutralizing antibody response elicited in rabbits by repeated inoculation with trimeric HIV-1 envelope glycoproteinsQ53877712
Structural basis for HIV-1 neutralization by a gp41 fusion intermediate-directed antibody.Q54040210
A trimeric structural domain of the HIV-1 transmembrane glycoproteinQ54155492
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
P1104number of pages14
P304page(s)170-183
P577publication date2008-05-21
P1433published inVirologyQ7934867
P1476titleAntibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics
P478volume377

Reverse relations

cites work (P2860)
Q33523258Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41
Q33495440Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 [...]
Q33946158Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization
Q35689608Binding of Anti-Membrane-Proximal gp41 Monoclonal Antibodies to CD4-Liganded and -Unliganded Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus Virions
Q34020570Binding of HIV-1 gp41-directed neutralizing and non-neutralizing fragment antibody binding domain (Fab) and single chain variable fragment (ScFv) antibodies to the ectodomain of gp41 in the pre-hairpin and six-helix bundle conformations
Q33798076Characteristics of the earliest cross-neutralizing antibody response to HIV-1.
Q27303525Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41
Q27666159Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41
Q36057328Design and characterization of a peptide mimotope of the HIV-1 gp120 bridging sheet
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Q40387378The C34 Peptide Fusion Inhibitor Binds to the Six-Helix Bundle Core Domain of HIV-1 gp41 by Displacement of the C-Terminal Helical Repeat Region
Q33935016Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates

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