Characteristics of the earliest cross-neutralizing antibody response to HIV-1.

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Characteristics of the earliest cross-neutralizing antibody response to HIV-1. is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1001251
P932PMC publication ID3020924
P698PubMed publication ID21249232
P5875ResearchGate publication ID49768997

P50authorMarcus AltfeldQ72531060
Galit AlterQ88683228
Leonidas StamatatosQ89197121
Noah SatherQ92365148
Spyros A KalamsQ95979306
P2093author name stringIliyana Mikell
P2860cites workCross‐Reactive Neutralizing Humoral Immunity Does Not Protect from HIV Type 1 Disease ProgressionQ56886558
Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral loadQ58034113
Repertoire of neutralizing human monoclonal antibodies specific for the V3 domain of HIV-1 gp120Q72067428
Neutralization of HIV-1 primary isolates by polyclonal and monoclonal human antibodiesQ73732889
Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodiesQ24561905
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineagesQ24642180
Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120Q27658449
T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cellsQ28268047
Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine targetQ29547347
Rapid evolution of the neutralizing antibody response to HIV type 1 infectionQ29618603
Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodiesQ29619015
Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1Q29619512
Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics.Q30843874
Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.Q31016954
An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10Q33272711
Efficient recovery of high-affinity antibodies from a single-chain Fab yeast display libraryQ33431668
Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individualsQ33526340
Breadth of human immunodeficiency virus-specific neutralizing activity in sera: clustering analysis and association with clinical variablesQ33614495
Anti-gp41 antibodies cloned from HIV-infected patients with broadly neutralizing serologic activityQ33826951
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cellsQ33866996
Epitope specificities of broadly neutralizing plasmas from HIV-1 infected subjectsQ33888559
A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individualsQ34047445
A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitopeQ34078521
Human anti-HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitnessQ34096475
Variable loop glycan dependency of the broad and potent HIV-1-neutralizing antibodies PG9 and PG16.Q34178201
The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120.Q34341843
The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.Q34342352
Identification of a new quaternary neutralizing epitope on human immunodeficiency virus type 1 virus particlesQ34406977
Evidence for potent autologous neutralizing antibody titers and compact envelopes in early infection with subtype C human immunodeficiency virus type 1Q34648079
Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responsesQ34651668
Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremiaQ34848486
In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadthQ34937404
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individualsQ34962766
Antibody responses elicited in macaques immunized with human immunodeficiency virus type 1 (HIV-1) SF162-derived gp140 envelope immunogens: comparison with those elicited during homologous simian/human immunodeficiency virus SHIVSF162P4 and heteroloQ35024202
Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivityQ35101464
Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in Southern AfricaQ35140032
Role of V1V2 and other human immunodeficiency virus type 1 envelope domains in resistance to autologous neutralization during clade C infectionQ35635163
Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donorsQ35857221
Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infectionQ35857268
Isolation and characterization of monoclonal antibodies elicited by trimeric HIV-1 Env gp140 protein immunogensQ36103090
The c3-v4 region is a major target of autologous neutralizing antibodies in human immunodeficiency virus type 1 subtype C infectionQ36483346
Development of the anti-gp120 antibody response during seroconversion to human immunodeficiency virus type 1Q36625449
Human antibody responses to HIV type 1 glycoprotein 41 cloned in phage display libraries suggest three major epitopes are recognized and give evidence for conserved antibody motifs in antigen bindingQ36818811
Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C.Q36974754
Broad HIV-1 neutralization mediated by CD4-binding site antibodiesQ36977635
Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodiesQ37033269
Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infectionQ37033294
Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individualsQ37033400
Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithmQ37247974
Breadth of neutralizing antibody response to human immunodeficiency virus type 1 is affected by factors early in infection but does not influence disease progressionQ37356036
Broad neutralization of human immunodeficiency virus type 1 mediated by plasma antibodies against the gp41 membrane proximal external regionQ37410792
Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine?Q37519312
Quaternary epitope specificities of anti-HIV-1 neutralizing antibodies generated in rhesus macaques infected by the simian/human immunodeficiency virus SHIVSF162P4Q39610645
Nonneutralizing antibodies to the CD4-binding site on the gp120 subunit of human immunodeficiency virus type 1 do not interfere with the activity of a neutralizing antibody against the same siteQ39699375
Assessment of antibody responses against gp41 in HIV-1-infected patients using soluble gp41 fusion proteins and peptides derived from M group consensus envelopeQ40145762
Anti-human immunodeficiency virus type 1 (HIV-1) antibodies 2F5 and 4E10 require surprisingly few crucial residues in the membrane-proximal external region of glycoprotein gp41 to neutralize HIV-1.Q40721814
Independent evolution of human immunodeficiency virus type 1 env V1/V2 and V4/V5 hypervariable regions during chronic infectionQ42737939
Epitopes for broad and potent neutralizing antibody responses during chronic infection with human immunodeficiency virus type 1.Q42959357
HIV type 1 variants transmitted to women in Kenya require the CCR5 coreceptor for entry, regardless of the genetic complexity of the infecting virusQ45732337
Prevalence of cross-reactive HIV-1-neutralizing activity in HIV-1-infected patients with rapid or slow disease progression.Q45948731
HIV-1 subtype A envelope variants from early in infection have variable sensitivity to neutralization and to inhibitors of viral entryQ46170039
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
P304page(s)e1001251
P577publication date2011-01-13
P1433published inPLOS PathogensQ283209
P1476titleCharacteristics of the earliest cross-neutralizing antibody response to HIV-1.
P478volume7

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