Broadly Neutralizing Antibodies against HIV: Back to Blood

scientific article published on 18 February 2019

Broadly Neutralizing Antibodies against HIV: Back to Blood is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MOLMED.2019.01.007
P932PMC publication ID6401214
P698PubMed publication ID30792120

P2093author name stringGeorge K Lewis
Anthony L DeVico
Mohammad M Sajadi
Amir Dashti
P2860cites workPotent and broad HIV-neutralizing antibodies in memory B cells and plasmaQ40092127
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Superinfection Drives HIV Neutralizing Antibody Responses from Several B Cell Lineages that Contribute to a Polyclonal RepertoireQ52718554
Immune systems rather than antigenic epitopes elicit and produce protective antibodies against HIV.Q54686508
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HIV broadly neutralizing antibody targetsQ27026662
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Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic AntibodyQ27644415
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virusQ27644501
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodiesQ27644515
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Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 BindingQ27670829
Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep SequencingQ27671696
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodiesQ27674878
Broad and potent neutralization of HIV-1 by a gp41-specific human antibodyQ27675131
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Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 NeutralizationQ27677117
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120Q27678306
Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class AntibodiesQ27679353
Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptorQ27684529
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Cross-clade neutralization patterns among HIV-1 strains from the six major clades of the pandemic evaluated and compared in two different models.Q30369026
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Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.Q31016954
Measuring HIV neutralization in a luciferase reporter gene assayQ39914262
Discordant memory B cell and circulating anti-Env antibody responses in HIV-1 infectionQ33410222
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Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodiesQ33614365
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Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens.Q33636347
Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1.Q33693391
Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infectionQ33702217
HIV-1 Envelope Trimer Design and Immunization Strategies To Induce Broadly Neutralizing AntibodiesQ33753573
Early development of broadly neutralizing antibodies in HIV-1-infected infantsQ33764917
Characteristics of the earliest cross-neutralizing antibody response to HIV-1.Q33798076
Human immunodeficiency virus (HIV)-positive sera obtained shortly after seroconversion neutralize autologous HIV type 1 isolates on primary macrophages but not on lymphocytesQ33805324
Epitope specificities of broadly neutralizing plasmas from HIV-1 infected subjectsQ33888559
Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.Q34009945
Memory B cell antibodies to HIV-1 gp140 cloned from individuals infected with clade A and B virusesQ34023249
A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individualsQ34047445
Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodiesQ34114798
Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaquesQ34230556
Identification of a new quaternary neutralizing epitope on human immunodeficiency virus type 1 virus particlesQ34406977
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interfaceQ34473958
HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruptionQ34531858
Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivoQ34593860
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apexQ34709433
Evidence for a Continuous Drift of the HIV-1 Species towards Higher Resistance to Neutralizing Antibodies over the Course of the EpidemicQ34819651
Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremiaQ34848486
Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individualsQ34962766
Polyreactivity and autoreactivity among HIV-1 antibodiesQ34992787
Correlation between circulating HIV-1 RNA and broad HIV-1 neutralizing antibody activity.Q35034034
Mechanism of Neutralization by the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01Q35192782
Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutatedQ35441583
Sustained Delivery of a Broadly Neutralizing Antibody in Nonhuman Primates Confers Long-Term Protection against Simian/Human Immunodeficiency Virus InfectionQ35641234
Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-DependentQ35686912
Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal AntibodiesQ35743897
Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donorsQ35857221
Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine designQ35868076
Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection CohortQ35894094
Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus InfectionQ35914292
Signature biochemical properties of broadly cross-reactive HIV-1 neutralizing antibodies in human plasma.Q35943730
Features of Recently Transmitted HIV-1 Clade C Viruses that Impact Antibody Recognition: Implications for Active and Passive ImmunizationQ36081789
Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120Q36132925
The development of CD4 binding site antibodies during HIV-1 infectionQ36155396
HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.Q36345558
λ Light Chain Bias Associated With Enhanced Binding and Function of Anti-HIV Env Glycoprotein AntibodiesQ36365309
Antigenic conservation and immunogenicity of the HIV coreceptor binding siteQ36403587
Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivoQ36414891
Crystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10.Q36485204
Antibody polyspecificity and neutralization of HIV-1: a hypothesisQ36487151
Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1.Q36623941
Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.Q36961578
Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodiesQ37033269
Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individualsQ37033400
Visualizing antibody affinity maturation in germinal centersQ37078589
Recent advances in the characterization of HIV-1 neutralization assays for standardized evaluation of the antibody response to infection and vaccinationQ37119451
Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithmQ37247974
Antibody specificities associated with neutralization breadth in plasma from human immunodeficiency virus type 1 subtype C-infected blood donorsQ37333772
Breadth of neutralizing antibody response to human immunodeficiency virus type 1 is affected by factors early in infection but does not influence disease progressionQ37356036
High titer HIV-1 V3-specific antibodies with broad reactivity but low neutralizing potency in acute infection and following vaccinationQ37471315
Antigenic properties of the HIV envelope on virions in solutionQ37547245
Mechanism of HIV-1 neutralization by antibodies targeting a membrane-proximal region of gp41.Q37547462
Effect of HIV Antibody VRC01 on Viral Rebound after Treatment InterruptionQ37624842
Native-like Env trimers as a platform for HIV-1 vaccine designQ37633417
Accessing the human repertoire for broadly neutralizing HIV antibodiesQ37694976
Polyreactive antibodies in adaptive immune responses to virusesQ37951868
Basic research in HIV vaccinology is hampered by reductionist thinkingQ38025633
Simple, rapid, quantitative, syncytium-forming microassay for the detection of human immunodeficiency virus neutralizing antibodyQ38476940
Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimersQ39001126
Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infectionQ39278529
CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.Q39605077
P433issue3
P304page(s)228-240
P577publication date2019-02-18
P1433published inTrends in Molecular MedicineQ15265842
P1476titleBroadly Neutralizing Antibodies against HIV: Back to Blood
P478volume25

Reverse relations

cites work (P2860)
Q91636324Long-Term Delivery of an Anti-SIV Monoclonal Antibody With AAV
Q89803127Shortening HIV vaccine regimens to achieve high coverage
Q91609981Strategies for inducing effective neutralizing antibody responses against HIV-1
Q92538999Update on Fc-Mediated Antibody Functions Against HIV-1 Beyond Neutralization

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