Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm

scientific article published on 13 May 2009

Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.00110-09
P932PMC publication ID2704778
P698PubMed publication ID19439467
P5875ResearchGate publication ID24424699

P50authorPascal PoignardQ72530329
Linda-Gail BekkerQ30001903
Walter JaokoQ37383427
Dennis R. BurtonQ56331320
Etienne KaritaQ72386151
P2093author name stringRobert Paris
Punnee Pitisuttithum
Anton Pozniak
Laura M Walker
Wayne C Koff
Tony Tarragona-Fiol
Patricia E Fast
André Inwoley
Jack Dehovitz
Terri Wrin
Josephine Birungi
Olivier Manigart
Dagna S Laufer
Dale A McPhee
Emily Carrow
Frances H Priddy
George Miiro
Jennifer K Lehrman
Mark Boaz
Melissa D Simek
Pham Pung
Wasima Rida
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Age‐Dependent Differences in IgG Isotype and Avidity Induced by Measles Vaccine Received during the First Year of LifeQ58218799
Repertoire of neutralizing human monoclonal antibodies specific for the V3 domain of HIV-1 gp120Q72067428
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectvirusQ808
P304page(s)7337-7348
P577publication date2009-05-13
P1433published inJournal of VirologyQ1251128
P1476titleHuman immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm
P478volume83

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Q47575476Moving ahead an HIV vaccine: To neutralize or not, a key HIV vaccine question
Q38120526Multiantibody strategies for HIV.
Q27679353Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies
Q39845890Multiple tandem copies of conserved gp41 epitopes incorporated in gag virus-like particles elicit systemic and mucosal antibodies in an optimized heterologous vector delivery regimen
Q35864051N463 Glycosylation Site on V5 Loop of a Mutant gp120 Regulates the Sensitivity of HIV-1 to Neutralizing Monoclonal Antibodies VRC01/03
Q37633417Native-like Env trimers as a platform for HIV-1 vaccine design
Q37619134Natural infection as a blueprint for rational HIV vaccine design
Q91582856Neutralization and beyond: Antibodies and HIV-1 acquisition
Q47562235Neutralization tiers of HIV-1.
Q36837324Neutralizing Antibody Response and Antibody-Dependent Cellular Cytotoxicity in HIV-1-Infected Individuals from Guinea-Bissau and Denmark
Q53693698Neutralizing Antibody Responses following Long-Term Vaccination with HIV-1 Env gp140 in Guinea Pigs
Q34550046Neutralizing Monoclonal Antibodies to Fight HIV-1: On the Threshold of Success
Q33887693Neutralizing antibodies against HIV-1: can we elicit them with vaccines and how much do we need?
Q37519312Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine?
Q36603515Neutralizing antibodies to HIV-1 induced by immunization.
Q36433894New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency
Q36011269New Paradigms for HIV/AIDS Vaccine Development
Q34344323New templates for HIV-1 antibody-based vaccine design
Q41924059Non-neutralizing Antibodies Targeting the V1V2 Domain of HIV Exhibit Strong Antibody-Dependent Cell-mediated Cytotoxic Activity.
Q50617948Opening Fronts in HIV Vaccine Development: Tracking the development of broadly neutralizing antibodies
Q35868102PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4.
Q92327047Parallel Induction of CH505 B Cell Ontogeny-Guided Neutralizing Antibodies and tHIVconsvX Conserved Mosaic-Specific T Cells against HIV-1
Q30358434Passive immunization against HIV/AIDS by antibody gene transfer.
Q47548101Passive immunotherapy of viral infections: 'super-antibodies' enter the fray
Q34230556Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques
Q30402036Phylogenetic structure in African HIV-1 subtype C revealed by selective sequential pruning
Q38023086Plant made anti-HIV microbicides--a field of opportunity
Q24635002Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals
Q42265635Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans
Q34742533Potent and broad neutralization of HIV-1 subtype C by plasma antibodies targeting a quaternary epitope including residues in the V2 loop
Q35665921Potent intratype neutralizing activity distinguishes human immunodeficiency virus type 2 (HIV-2) from HIV-1
Q35124761Predicting HIV-1 broadly neutralizing antibody epitope networks using neutralization titers and a novel computational method
Q33638320Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters.
Q33702217Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection
Q38206519Preventive and therapeutic applications of neutralizing antibodies to Human Immunodeficiency Virus Type 1 (HIV-1).
Q57093617Preventive and therapeutic features of broadly neutralising monoclonal antibodies against HIV-1
Q64080897Prime-Boost Immunizations with DNA, Modified Vaccinia Virus Ankara, and Protein-Based Vaccines Elicit Robust HIV-1 Tier 2 Neutralizing Antibodies against the CAP256 Superinfecting Virus
Q37785949Prime-boost immunization with poxvirus or adenovirus vectors as a strategy to develop a protective vaccine for HIV-1.
Q39315316Profiles of neutralizing antibody response in chronically human immunodeficiency virus type 1 clade B′-infected former plasma donors from China naïve to antiretroviral therapy
Q37741310Profiling the neutralizing antibody response in chronically HIV-1 CRF07_BC-infected intravenous drug users naïve to antiretroviral therapy
Q56970600Progress in HIV vaccine development
Q56600657Progress in HIV-1 vaccine development
Q37549777Progress toward active or passive HIV-1 vaccination
Q42215329Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV.
Q38534943Prospects for a globally effective HIV-1 vaccine
Q37625877Protein engineering strategies for the development of viral vaccines and immunotherapeutics
Q37584635Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif.
Q39610645Quaternary epitope specificities of anti-HIV-1 neutralizing antibodies generated in rhesus macaques infected by the simian/human immunodeficiency virus SHIVSF162P4
Q35973587Rapid Development of gp120-Focused Neutralizing B Cell Responses during Acute Simian Immunodeficiency Virus Infection of African Green Monkeys
Q35647701Rapid development of glycan-specific, broad, and potent anti–HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque
Q33725673Rapid escape from preserved cross-reactive neutralizing humoral immunity without loss of viral fitness in HIV-1-infected progressors and long-term nonprogressors
Q42726161Rational design of HIV vaccines and microbicides: report of the EUROPRISE network annual conference 2010.
Q29619511Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1
Q35603504Rational design of vaccines to elicit broadly neutralizing antibodies to HIV-1.
Q30235024Recent Insights into the HIV/AIDS Pandemic
Q30353580Recent advances on the use of structural biology for the design of novel envelope immunogens of HIV-1
Q58569712Recent progress in broadly neutralizing antibodies to HIV
Q34539819Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs
Q34709433Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
Q38656764Regulation of Subunit-Specific Germinal Center B Cell Responses to the HIV-1 Envelope Glycoproteins by Antibody-Mediated Feedback.
Q34225659Requirements for empirical immunogenicity trials, rather than structure-based design, for developing an effective HIV vaccine
Q58382398Retroviral Pseudotypes - From Scientific Tools to Clinical Utility
Q36670538Role of IL-21 and IL-21 Receptor on B Cells in HIV Infection
Q38046828Role of human immunodeficiency virus type 1 envelope structure in the induction of broadly neutralizing antibodies.
Q33898131Role of humoral immunity in host defense against HIV.
Q41019767Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults
Q35943521Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding Site
Q58598623Sensitivity to Broadly Neutralizing Antibodies of Recently Transmitted HIV-1 Clade CRF02_AG Viruses with a Focus on Evolution over Time
Q34397758Sequences in Glycoprotein gp41, the CD4 Binding Site, and the V2 Domain Regulate Sensitivity and Resistance of HIV-1 to Broadly Neutralizing Antibodies
Q41876895Sequential Evolution and Escape from Neutralization of Simian Immunodeficiency Virus SIVsmE660 Clones in Rhesus Macaques
Q34456367Serum neutralizing activities from a Beijing homosexual male cohort infected with different subtypes of HIV-1 in China
Q34096530Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates
Q27677117Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization
Q36231944Somatic Populations of PGT135-137 HIV-1-Neutralizing Antibodies Identified by 454 Pyrosequencing and Bioinformatics
Q43454270Specific antibody-dependent cellular cytotoxicity responses associated with slow progression of HIV infection
Q30385813Status of vaccine research and development of vaccines for HIV-1.
Q36559665Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and coreceptor binding sites of HIV-1 gp120
Q57093739Structural Insights from HIV-Antibody Coevolution and Related Immunization Studies
Q37123501Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers
Q27683553Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers
Q38050485Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA.
Q26829461Structural insights on the role of antibodies in HIV-1 vaccine and therapy
Q27662155Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1
Q37409244Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site
Q34987048Structure-based Vaccine Design in HIV: Blind Men and the Elephant?
Q35196671Structure-function relationships of HIV-1 envelope sequence-variable regions refocus vaccine design
Q41835711Synthesis of multivalent glycopeptide conjugates that mimic an HIV epitope
Q52657148T Cell Subsets in the Germinal Center: Lessons from the Macaque Model
Q36157711Targeting a Neutralizing Epitope of HIV Envelope Gp120 by Immune Complex Vaccine
Q64060305The Antibodiome-Mapping the Humoral Immune Response to HIV
Q27000889The Antibody Response against HIV-1
Q36276632The Breadth and Titer of Maternal HIV-1-Specific Heterologous Neutralizing Antibodies Are Not Associated with a Lower Rate of Mother-to-Child Transmission of HIV-1
Q27680688The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
Q52584646The Hard Way towards an Antibody-Based HIV-1 Env Vaccine: Lessons from Other Viruses
Q54987756The Janus Face of Follicular T Helper Cells in Chronic Viral Infections.
Q26797466The role of Fc-FcγR interactions in IgG-mediated microbial neutralization
Q37547702The selection of low envelope glycoprotein reactivity to soluble CD4 and cold during simian-human immunodeficiency virus infection of rhesus macaques.
Q38046109Tools to therapeutically harness the human antibody response
Q36972591Toward a more accurate view of human B-cell repertoire by next-generation sequencing, unbiased repertoire capture and single-molecule barcoding
Q33854841Transplanting supersites of HIV-1 vulnerability
Q34991017Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope
Q34441935Unique C2V3 sequence in HIV-1 envelope obtained from broadly neutralizing plasma of a slow progressing patient conferred enhanced virus neutralization
Q92479131Unusual Cysteine Content in V1 Region of gp120 From an Elite Suppressor That Produces Broadly Neutralizing Antibodies
Q38764543Use of broadly neutralizing antibodies for HIV-1 prevention
Q61448102VH1-69 Utilizing Antibodies Are Capable of Mediating Non-neutralizing Fc-Mediated Effector Functions Against the Transmitted/Founder gp120
Q33612459Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates
Q34203163Variations in autologous neutralization and CD4 dependence of b12 resistant HIV-1 clade C env clones obtained at different time points from antiretroviral naïve Indian patients with recent infection
Q92883419Viral Characteristics Associated with Maintenance of Elite Neutralizing Activity in Chronically HIV-1 Clade C-Infected Monozygotic Pediatric Twins
Q27676728Viral Escape from Neutralizing Antibodies in Early Subtype A HIV-1 Infection Drives an Increase in Autologous Neutralization Breadth
Q27025177Virological features associated with the development of broadly neutralizing antibodies to HIV-1
Q40346802Virus-driven Inflammation Is Associated With the Development of bNAbs in Spontaneous Controllers of HIV.
Q35641144What Do Chaotrope-Based Avidity Assays for Antibodies to HIV-1 Envelope Glycoproteins Measure?
Q47561102What Is the most Important for Elite Control: Genetic Background of Patient, Genetic Background of Partner, both or neither? Description of Complete Natural History within a Couple of MSM.
Q33772637Which Antibody Functions are Important for an HIV Vaccine?
Q39160496Will studies in individuals with systemic lupus erythematosus be the key to future HIV vaccine design?
Q35192660epitopes immediately below the base of the V3 loop of gp120 as targets for the initial autologous neutralizing antibody response in two HIV-1 subtype B-infected individuals

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