Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem

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Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem is …
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P356DOI10.1016/BS.AI.2017.01.004
P932PMC publication ID5914178
P698PubMed publication ID28413022

P2093author name stringLaurent Verkoczy
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Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal miceQ37702078
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Correlates of protection induced by vaccinationQ37750121
Control systems and decision making for antibody production.Q37774242
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Mechanisms of programmed DNA lesions and genomic instability in the immune system.Q38078491
Insights into B cells and HIV-specific B-cell responses in HIV-infected individualsQ38114912
Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 AntibodiesQ38220506
A bacterial lipooligosaccharide that naturally mimics the epitope of the HIV-neutralizing antibody 2G12 as a template for vaccine design.Q38327409
Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody GenesQ38388195
Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potentialQ38414485
New approaches to HIV vaccine developmentQ38521826
Rheumatologic manifestations of infection with human immunodeficiency virus (HIV).Q38656282
HIV-1 envelope glycoprotein immunogens to induce broadly neutralizing antibodiesQ38665463
Selection of HIV vaccine candidates for concurrent testing in an efficacy trialQ38716886
Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor RepertoiresQ38747466
Humanized mice for HIV and AIDS researchQ38838864
Approaches to the induction of HIV broadly neutralizing antibodiesQ38936867
Differential reactivity of germ line allelic variants of a broadly neutralizing HIV-1 antibody to a gp41 fusion intermediate conformationQ38959483
Immunological Outcomes of Antibody Binding to Glycans Shared between Microorganisms and MammalsQ39013747
MK5 activates Rag transcription via Foxo1 in developing B cellsQ39121516
HIV-1 virus-like particles bearing pure env trimers expose neutralizing epitopes but occlude nonneutralizing epitopesQ39402539
Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin MiceQ39407795
Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagenQ39926777
Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodiesQ40103798
Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.Q40290511
Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.Q40290521
Identification of Common Features in Prototype Broadly Neutralizing Antibodies to HIV Envelope V2 Apex to Facilitate Vaccine DesignQ40296420
T cell independent antigensQ40404858
Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.Q40429324
HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism.Q40449984
Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimers.Q40471380
Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic miceQ40589505
Tolerance through indifference: autoreactive B cells to the nuclear antigen La show no evidence of tolerance in a transgenic model.Q40614137
Probing immune functions in RAG-deficient miceQ40661080
Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine DesignQ40679052
False-positive human immunodeficiency virus testing in patients with lupus erythematosusQ40777919
Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rateQ41027647
Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.Q41037927
Analysis of gene function in lymphocytes by RAG-2-deficient blastocyst complementation.Q41090386
Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigensQ41170875
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.Q41423746
VARIATIONS IN AFFINITIES OF ANTIBODIES DURING THE IMMUNE RESPONSEQ76969494
Antigen drives very low affinity B cells to become plasmacytes and enter germinal centersQ77573886
Chronic graft-versus-host in Ig knockin transgenic mice abrogates B cell tolerance in anti-double-stranded DNA B cellsQ77892659
Whole inactivated SIV virion vaccines with functional envelope glycoproteins: safety, immunogenicity, and activity against intrarectal challengeQ78402662
The PI3K p110delta is required for down-regulation of RAG expression in immature B cellsQ79717937
Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class AntibodiesQ27679353
Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10Q27680125
The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV AntibodiesQ27680688
Progress in HIV-1 vaccine development.Q27693849
PD-1 and its ligands in tolerance and immunityQ28131650
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunityQ28138855
Marginal-zone B cellsQ28201000
The future of immune checkpoint therapyQ28259862
Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing EpitopesQ28271300
GP120: target for neutralizing HIV-1 antibodiesQ28303124
Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunityQ28378893
Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC proteinQ28507678
Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogeniesQ28602877
HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimersQ28647225
High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH regionQ28709119
Antibody neutralization and escape by HIV-1Q29547345
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in ThailandQ29547531
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptorsQ29615065
Broad neutralization coverage of HIV by multiple highly potent antibodiesQ29615361
Immune-correlates analysis of an HIV-1 vaccine efficacy trialQ29617377
Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1Q29619511
Predominant autoantibody production by early human B cell precursorsQ29619656
Recombinase-mediated cassette exchange (RMCE) — A rapidly-expanding toolbox for targeted genomic modificationsQ30039990
Induction of broadly reactive anti-hemagglutinin stalk antibodies by an H5N1 vaccine in humansQ30207889
Affinity of antigen encounter and other early B-cell signals determine B-cell fateQ30436993
Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structuresQ30746440
Reassessment of autoreactivity of the broadly neutralizing HIV antibodies 4E10 and 2F5 and retrospective analysis of clinical safety dataQ31140424
Anergy and not clonal ignorance determines the fate of B cells that recognize a physiological autoantigenQ32024493
Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cellsQ33112697
Foxo1 directly regulates the transcription of recombination-activating genes during B cell developmentQ33333434
Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titersQ33444658
Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infectionQ33479167
Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic toleranceQ33591736
Optimality of mutation and selection in germinal centersQ33598442
Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infectionQ33702217
HIV-1 Envelope Trimer Design and Immunization Strategies To Induce Broadly Neutralizing AntibodiesQ33753573
Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelopeQ34991017
Polyreactivity and autoreactivity among HIV-1 antibodiesQ34992787
The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infectionQ35076717
Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaquesQ35101333
Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodiesQ35116581
Crystal structure of the HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomannoseQ35119778
Activation‐Induced Cytidine Deaminase Links Class Switch Recombination and Somatic HypermutationQ35119869
Genetic analysis of complex traits in the emerging Collaborative CrossQ35145475
Different sensitivity to receptor editing of B cells from mice hemizygous or homozygous for targeted Ig transgenesQ35160175
HIV-1 envelope gp41 broadly neutralizing antibodies: hurdles for vaccine developmentQ35172770
Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01.Q35192782
A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal centerQ35213561
Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controlsQ35336374
Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestorsQ35382871
DNA vaccine molecular adjuvants SP-D-BAFF and SP-D-APRIL enhance anti-gp120 immune response and increase HIV-1 neutralizing antibody titersQ35640984
Antibody-based protection against HIV infection by vectored immunoprophylaxisQ35658856
Autoreactivity in human IgG+ memory B cellsQ35729131
Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses.Q35731798
HIV-1 neutralization coverage is improved by combining monoclonal antibodies that target independent epitopesQ35826271
Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine designQ35868076
The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity.Q35930798
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogenQ35969973
Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activityQ35980902
BLyS-mediated modulation of naive B cell subsets impacts HIV Env-induced antibody responsesQ36016522
Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell developmentQ36041356
Activin A programs the differentiation of human TFH cellsQ36067435
Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.Q36112751
Transgenic mice and analysis of B-cell toleranceQ36135218
Restricted VH gene usage and generation of antibody diversity in rabbitQ36135235
Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin MiceQ36159067
Similarity and divergence in the development and expression of the mouse and human antibody repertoiresQ36220112
Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding proteinQ36227838
High affinity germinal center B cells are actively selected into the plasma cell compartment.Q36228042
Loss of the proapoptotic protein, Bim, breaks B cell anergyQ36228387
Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiationQ36228608
Characteristics of the earliest cross-neutralizing antibody response to HIV-1.Q33798076
Redemption of autoreactive B cellsQ33835034
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.Q33835200
Autoantigen discovery with a synthetic human peptidomeQ33908182
CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapyQ33937501
Relative roles of somatic and Darwinian evolution in shaping the antibody responseQ33941984
Modeling and optimization of populations subject to time-dependent mutationQ33958359
High-resolution description of antibody heavy-chain repertoires in humansQ33988374
Envelope deglycosylation enhances antigenicity of HIV-1 gp41 epitopes for both broad neutralizing antibodies and their unmutated ancestor antibodiesQ34016211
Autoreactivity in HIV-1 broadly neutralizing antibodies: implications for their function and induction by vaccinationQ34022578
Nonneutralizing functional antibodies: a new "old" paradigm for HIV vaccinesQ34057711
Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germlineQ34075820
Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodiesQ34114798
Tolerance to self gangliosides is the major factor restricting the antibody response to lipopolysaccharide core oligosaccharides in Campylobacter jejuni strains associated with Guillain-Barré syndromeQ34129949
AIDS/HIV. Host controls of HIV neutralizing antibodiesQ34170264
Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodiesQ34177732
Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genesQ34270980
B-cell-lineage immunogen design in vaccine development with HIV-1 as a case studyQ34273373
Broadly neutralizing antiviral antibodiesQ34323311
Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodiesQ34324992
Immune clearance of highly pathogenic SIV infectionQ34370314
Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbsQ34539819
Induction of immunity to human immunodeficiency virus type-1 by vaccinationQ34540645
miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell MaturationQ34545673
Human immunodeficiency virus infection and systemic lupus erythematosus. An unusual case and a review of the literatureQ34566963
The immune response during acute HIV-1 infection: clues for vaccine developmentQ34614862
B cell responses to HIV-1 infection and vaccination: pathways to preventing infectionQ34645502
Sequential immunization with V3 peptides from primary human immunodeficiency virus type 1 produces cross-neutralizing antibodies against primary isolates with a matching narrow-neutralization sequence motif.Q34648342
Mice transgenic for CD4-specific human CD4, CCR5 and cyclin T1 expression: a new model for investigating HIV-1 transmission and treatment efficacyQ34730602
Phase 1 safety and immunogenicity testing of DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particlesQ34772727
Structural evolution of glycan recognition by a family of potent HIV antibodiesQ34782382
HIV antibodies. Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies.Q34915786
Sequential immunization with a subtype B HIV-1 envelope quasispecies partially mimics the in vivo development of neutralizing antibodiesQ34982715
In-depth determination and analysis of the human paired heavy- and light-chain antibody repertoireQ41602128
Reconstructing a B-cell clonal lineage. I. Statistical inference of unobserved ancestorsQ41818598
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-toleranceQ41888015
CTCF-binding elements mediate control of V(D)J recombinationQ42145363
Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodiesQ42170932
Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responsesQ42278743
Strategies for selective priming of memory B cellsQ42577128
Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cellsQ42942148
Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic miceQ42947038
Preferrential rearrangement in normal rabbits of the 3' VHa allotype gene that is deleted in Alicia mutants; somatic hypermutation/conversion may play a major role in generating the heterogeneity of rabbit heavy chain variable region sequencesQ43446985
Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery.Q43646588
Breakdown of self-tolerance in anergic B lymphocytes.Q43668436
Unique signaling properties of B cell antigen receptor in mature and immature B cells: implications for tolerance and activationQ43760103
Editors and editing of anti-DNA receptors.Q43832072
Human antibody expression in transgenic rats: comparison of chimeric IgH loci with human VH, D and JH but bearing different rat C-gene regionsQ44182322
Selection of Ig μ Heavy Chains by Complementarity-Determining Region 3 Length and Amino Acid CompositionQ44625268
Generation of high-affinity antibody against T cell-dependent antigen in the Ganp gene-transgenic mouseQ44992122
Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations.Q45980652
A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain geneQ46098688
Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire.Q46109491
Antigen-induced B-cell death and elimination during germinal-centre immune responsesQ46147419
Development of the expressed Ig CDR-H3 repertoire is marked by focusing of constraints in length, amino acid use, and charge that are first established in early B cell progenitorsQ46535428
A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune functionQ46792429
Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimerQ47372605
The pre-B cell receptor: turning autoreactivity into self-defenseQ47398811
Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing.Q47713262
Memory B-cell persistence is independent of persisting immunizing antigen.Q47821945
A c-Myc/miR17-92/Pten Axis Controls PI3K-Mediated Positive and Negative Selection in B Cell Development and Reconstitutes CD19 Deficiency.Q50502479
Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination.Q51981842
Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.Q52053087
IgM heavy chain complementarity-determining region 3 diversity is constrained by genetic and somatic mechanisms until two months after birth.Q52177381
Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-xL transgene.Q52202641
The site and stage of anti-DNA B-cell deletion.Q52210540
Somatic hypermutation in B cells: an optimal control treatment.Q52390653
Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1.Q53592113
The Collaborative Cross, a community resource for the genetic analysis of complex traitsQ56896214
The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cellsQ56904544
Systemic and discoid lupus erythematosus in HIV-infected patients treated with highly active antiretroviral therapyQ57003999
Structural vaccinology starts to deliverQ57988219
Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA PolymeraseQ58424602
Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic miceQ59055762
Induction of self-tolerance in mature peripheral B lymphocytesQ59057608
Expression of anti-DNA immunoglobulin transgenes in non-autoimmune miceQ59065295
Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genesQ59098044
Only DFL16, DSP2, and DQ52 gene families exist in mouse immunoglobulin heavy chain diversity gene loci, of which DFL16 and DSP2 originate from the same primordial DH geneQ69384748
Immunoglobulin heavy chain gene replacement: a mechanism of receptor editingQ71457193
Deletion of the DQ52 element within the Ig heavy chain locus leads to a selective reduction in VDJ recombination and altered D gene usageQ73401098
High affinity rheumatoid factor transgenic B cells are eliminated in normal miceQ73535779
Negative selection at the pre-BCR checkpoint elicited by human mu heavy chains with unusual CDR3 regionsQ73923498
Report of a false-positive HIV test result and the potential use of additional tests in establishing HIV serostatusQ74116917
Role of BCR affinity in T cell dependent antibody responses in vivoQ74139589
A transgenic model of autoimmune hemolytic anemiaQ36230807
The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.Q36248087
Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodiesQ36262823
RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte developmentQ36303172
HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.Q36345558
Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutationQ36350233
Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cellsQ36360433
Sequential immunizations with rgp120s from independent isolates of human immunodeficiency virus type 1 induce the preferential expansion of broadly crossreactive B cellsQ36360966
Receptor editing: an approach by autoreactive B cells to escape toleranceQ36361497
Receptor editing in self-reactive bone marrow B cellsQ36361578
B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen.Q36367608
Autoreactive B cells in the marginal zone that express dual receptorsQ36369869
Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reducedQ36370154
Positive selection of anti-thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell developmentQ36370429
bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cellsQ36375912
Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escapeQ36388754
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.Q36403678
A molecular perspective of CTLA-4 functionQ36427322
Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 InfectionQ36444787
Antibody polyspecificity and neutralization of HIV-1: a hypothesisQ36487151
Confounding B-cell defences: lessons from a staphylococcal superantigenQ36488759
B-1 B cells: development, selection, natural autoantibody and leukemiaQ36552466
Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletionQ36559838
Mouse marginal zone B cells harbor specificities similar to human broadly neutralizing HIV antibodiesQ36568026
Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice.Q36627503
Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.Q36692987
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infectionQ36737159
Structural basis for germline antibody recognition of HIV-1 immunogensQ36739738
Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodiesQ36750045
Anti-HIV B Cell lines as candidate vaccine biosensorsQ36766704
Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease.Q36766872
Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursorsQ36775342
Long antibody HCDR3s from HIV-naïve donors presented on a PG9 neutralizing antibody background mediate HIV neutralizationQ36831651
Multistep pathogenesis of autoimmune disease.Q36882282
B-cell anergy: from transgenic models to naturally occurring anergic B cells?Q36887132
Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese DonorQ36888400
Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG.Q36895518
GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancyQ36906733
Understanding B-cell tolerance through the use of immunoglobulin transgenic modelsQ36974265
Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligationQ36977531
The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigensQ37012927
Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaquesQ37021717
Antibody and antiretroviral preexposure prophylaxis prevent cervicovaginal HIV-1 infection in a transgenic mouse modelQ37036786
Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10Q37049675
Sites and stages of autoreactive B cell activation and regulation.Q37058621
Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAsQ37153957
Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV antibody 4E10Q37171251
B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidatesQ37171260
Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.Q37183404
Peripheral deletion of self-reactive B cellsQ37209432
Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineagesQ37221575
Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing AntibodiesQ37246321
Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithmQ37247974
Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses.Q37252968
Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigmsQ37278451
HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing AntibodiesQ37293480
Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors.Q37318213
Optimal immunization cocktails can promote induction of broadly neutralizing Abs against highly mutable pathogensQ37417794
Regulatory T cells in the control of host-microorganism interactions (*).Q37419387
A single injection of anti-HIV-1 antibodies protects against repeated SHIV challengesQ37450695
Role of HIV membrane in neutralization by two broadly neutralizing antibodiesQ37453499
Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogensQ37456354
Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune diseaseQ37600558
Modulation of nonneutralizing HIV-1 gp41 responses by an MHC-restricted TH epitope overlapping those of membrane proximal external region broadly neutralizing antibodiesQ37607358
Checkpoints in lymphocyte development and autoimmune diseaseQ37657051
P304page(s)235-352
P577publication date2017-01-01
P1433published inAdvances in ImmunologyQ15752932
P1476titleHumanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem
P478volume134

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