Progress in HIV-1 vaccine development.

scientific article

Progress in HIV-1 vaccine development. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JACI.2014.04.025
P932PMC publication ID4133697
P698PubMed publication ID25117798

P50authorBarton HaynesQ4865631
Guido FerrariQ56481169
Mattia BonsignoriQ56808332
Georgia D. TomarasQ63663866
M Anthony MoodyQ73297881
Hua-Xin LiaoQ88608388
Laurent VerkoczyQ88773002
Munir AlamQ89520930
P2093author name stringFeng Gao
Garnett Kelsoe
P2860cites workDesign and pre-clinical evaluation of a universal HIV-1 vaccineQ21092234
Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individualsQ24635002
HIV‐1 neutralizing antibodies: understanding nature's pathwaysQ27000480
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9Q27644478
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virusQ27644501
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan ShieldQ27675032
Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2Q27675879
Rational HIV Immunogen Design to Target Specific Germline B Cell ReceptorsQ27677104
Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding GlycansQ27678062
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120Q27678306
Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16Q27678312
Crystal Structure of a Soluble Cleaved HIV-1 Envelope TrimerQ27680496
Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope TrimerQ27680497
The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV AntibodiesQ27680688
A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodiesQ28299280
H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccinationQ28743596
Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trialQ28972526
Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine targetQ29547347
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in ThailandQ29547531
Immune-correlates analysis of an HIV-1 vaccine efficacy trialQ29617377
Predominant autoantibody production by early human B cell precursorsQ29619656
Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccineQ30578618
A method for identification of HIV gp140 binding memory B cells in human bloodQ33394829
Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic toleranceQ33591736
Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infectionQ33702217
Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeysQ33712291
Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeysQ33712578
Advancing Toward HIV-1 Vaccine Efficacy through the Intersections of Immune CorrelatesQ33742529
Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitutionQ33778466
Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccinationQ33977866
B-cell-lineage immunogen design in vaccine development with HIV-1 as a case studyQ34273373
Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2Q34298408
Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodiesQ34324992
Immune clearance of highly pathogenic SIV infectionQ34370314
Vaccine-induced IgG antibodies to V1V2 regions of multiple HIV-1 subtypes correlate with decreased risk of HIV-1 infectionQ34402934
Molecular structures of trimeric HIV-1 Env in complex with small antibody derivatives.Q34522657
Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbsQ34539819
N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of functionQ34594978
In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadthQ34937404
Is developing an HIV-1 vaccine possible?Q35043547
The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infectionQ35076717
Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodiesQ35116581
Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controlsQ35336374
Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestorsQ35382871
Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell developmentQ36041356
Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene familyQ36363231
Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escapeQ36388754
Antibody polyspecificity and neutralization of HIV-1: a hypothesisQ36487151
Risk behaviour and time as covariates for efficacy of the HIV vaccine regimen ALVAC-HIV (vCP1521) and AIDSVAX B/E: a post-hoc analysis of the Thai phase 3 efficacy trial RV 144.Q36489415
Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi-valent mosaic and consensus immunogensQ36638450
Broadly Neutralizing Antibodies Present New Prospects to Counter Highly Antigenically Diverse VirusesQ36693991
Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG.Q36895518
Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccineesQ36978671
Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infectionQ37033294
Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimerQ37049334
Common Tolerance Mechanisms, but Distinct Cross-Reactivities Associated with gp41 and Lipids, Limit Production of HIV-1 Broad Neutralizing Antibodies 2F5 and 4E10Q37049675
Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoproteinQ37123584
Immune Tolerance Negatively Regulates B Cells in Knock-In Mice Expressing Broadly Neutralizing HIV Antibody 4E10Q37171251
Cytomegalovirus Vectors Violate CD8 + T Cell Epitope Recognition ParadigmsQ37278451
Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors.Q37318213
T-cell vaccine strategies for human immunodeficiency virus, the virus with a thousand facesQ37333743
Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeysQ37355237
Isolation of HIV-1-reactive antibodies using cell surface-expressed gp160Δc(BaL.).Q37370393
Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogensQ37456354
Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.Q37625296
An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.Q37680009
Capacity for infectious HIV-1 virion capture differs by envelope antibody specificityQ37714023
Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.Q40429324
HIV-1 hides an Achilles' heel in virion lipidsQ42220533
HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineagesQ42270590
Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responsesQ42278743
Chemical synthesis of highly congested gp120 V1V2 N-glycopeptide antigens for potential HIV-1-directed vaccinesQ42279030
Stable docking of neutralizing human immunodeficiency virus type 1 gp41 membrane-proximal external region monoclonal antibodies 2F5 and 4E10 is dependent on the membrane immersion depth of their epitope regionsQ42561401
Role of antigen receptor affinity in T cell-independent antibody responses in vivoQ43918933
Progress in HIV-1 vaccine developmentQ56600657
Role of BCR affinity in T cell dependent antibody responses in vivoQ74139589
Antigen drives very low affinity B cells to become plasmacytes and enter germinal centersQ77573886
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectvaccineQ134808
P304page(s)3-10; quiz 11
P577publication date2014-06-26
P1433published inThe Journal of Allergy and Clinical ImmunologyQ7743550
P1476titleProgress in HIV-1 vaccine development
P478volume134

Reverse relations

cites work (P2860)
Q36337888Accurate predictions of population-level changes in sequence and structural properties of HIV-1 Env using a volatility-controlled diffusion model.
Q40748041An HIV gp120-CD4 Immunogen Does Not Elicit Autoimmune Antibody Responses in Cynomolgus Macaques
Q35641369Anti-V3/Glycan and Anti-MPER Neutralizing Antibodies, but Not Anti-V2/Glycan Site Antibodies, Are Strongly Associated with Greater Anti-HIV-1 Neutralization Breadth and Potency
Q36684710CXCL13 is a plasma biomarker of germinal center activity
Q38753943Changes in Structure and Antigenicity of HIV-1 Env Trimers Resulting from Removal of a Conserved CD4 Binding Site-Proximal Glycan.
Q35651494Characterization of a Large Panel of Rabbit Monoclonal Antibodies against HIV-1 gp120 and Isolation of Novel Neutralizing Antibodies against the V3 Loop
Q40452508Comparison of the patterns of antibody recall responses to HIV-1 gp120 and hepatitis B surface antigen in immunized mice.
Q30397595Current views on the potential for development of a HIV vaccine
Q40639803Cytokine-Independent Detection of Antigen-Specific Germinal Center T Follicular Helper Cells in Immunized Nonhuman Primates Using a Live Cell Activation-Induced Marker Technique
Q92740226Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape
Q40047250Development of an anti-HIV vaccine eliciting broadly neutralizing antibodies
Q38405470Evaluation of a novel multi-immunogen vaccine strategy for targeting 4E10/10E8 neutralizing epitopes on HIV-1 gp41 membrane proximal external region.
Q35913910Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody 2424 with Neutralizing Activity against HIV-1 JRFL
Q39454581Germinal center enhancement by extended antigen availability
Q47555844HIV-1 specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galcer Blocking and Phagocytosis
Q33753950HIV-Enhancing and HIV-Inhibiting Properties of Cationic Peptides and Proteins
Q39108735Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies
Q37045832Human Immunodeficiency Virus (HIV).
Q40942917Human immunodeficiency virus: position of Blood Working Group of the Federal Ministry of Health
Q30234773Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem
Q39108796Identification and specificity of broadly neutralizing antibodies against HIV
Q39108760Immunologic characteristics of HIV-infected individuals who make broadly neutralizing antibodies.
Q92210244Impact of HIV-1 Diversity on Its Sensitivity to Neutralization
Q36053149Interaction between unrelated viruses during in vivo co-infection to limit pathology and immunity
Q36246646Longitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants
Q59358562Neutralizing Antibody-Based Prevention of Cell-Associated HIV-1 Infection
Q37634061Ontogeny-based immunogens for the induction of V2-directed HIV broadly neutralizing antibodies
Q35855579Oral Delivery of a Novel Recombinant Streptococcus mitis Vector Elicits Robust Vaccine Antigen-Specific Oral Mucosal and Systemic Antibody Responses and T Cell Tolerance
Q33804531Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge
Q39108740Polyvalent vaccine approaches to combat HIV-1 diversity
Q40960044Tetraspanins displayed in retrovirus-derived virus-like particles and their immunogenicity.
Q39108730Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem
Q27000032The Role of Cationic Polypeptides in Modulating HIV-1 Infection of the Cervicovaginal Mucosa
Q27025177Virological features associated with the development of broadly neutralizing antibodies to HIV-1

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