In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth

scientific article

In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.02631-08
P932PMC publication ID2663270
P698PubMed publication ID19193787

P50authorBarton HaynesQ4865631
Beatrice H. HahnQ55293537
David C. MontefioriQ63302725
Georgia D. TomarasQ63663866
Brandon KeeleQ68690678
George M. ShawQ78514357
Kent J. WeinholdQ109935303
Jennifer L KirchherrQ114406376
P2093author name stringFeng Gao
Xiaoying Shen
William A Blattner
Julie M Decker
Michael L Greenberg
Charles B Hicks
Robert J Parks
P2860cites workA fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodiesQ27485578
Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidatesQ27489000
Antigenicity and immunogenicity of the HIV-1 gp41 epitope ELDKWA inserted into permissive sites of the MalE proteinQ28140278
Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodiesQ29619015
Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infectionQ29619510
Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.Q31016954
An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10Q33272711
Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysisQ33592278
Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitopeQ34348303
Nature of nonfunctional envelope proteins on the surface of human immunodeficiency virus type 1.Q34434854
Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donorsQ35857221
Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infectionQ35857268
In vivo and in vitro escape from neutralizing antibodies 2G12, 2F5, and 4E10.Q35947769
Human immunodeficiency virus type 1 gp41 antibodies that mask membrane proximal region epitopes: antibody binding kinetics, induction, and potential for regulation in acute infectionQ36423897
4E10-resistant variants in a human immunodeficiency virus type 1 subtype C-infected individual with an anti-membrane-proximal external region-neutralizing antibody responseQ36483956
Antibody polyspecificity and neutralization of HIV-1: a hypothesisQ36487151
The membrane-proximal external region of the human immunodeficiency virus type 1 envelope: dominant site of antibody neutralization and target for vaccine designQ36497712
Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C.Q36974754
Broad HIV-1 neutralization mediated by CD4-binding site antibodiesQ36977635
Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infectionQ37033294
Analysis of neutralization specificities in polyclonal sera derived from human immunodeficiency virus type 1-infected individualsQ37033400
Analysis of the human immunodeficiency virus type 1 gp41 membrane proximal external region arrayed on hepatitis B surface antigen particlesQ37251390
Neutralization profiles of newly transmitted human immunodeficiency virus type 1 by monoclonal antibodies 2G12, 2F5, and 4E10.Q37683080
Simian immunodeficiency virus engrafted with human immunodeficiency virus type 1 (HIV-1)-specific epitopes: replication, neutralization, and survey of HIV-1-positive plasmaQ40311562
Neutralization of HIV-1 primary isolate by ELDKWA-specific murine monoclonal antibodiesQ40344651
Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.Q40429324
Immunogenic presentation of a conserved gp41 epitope of human immunodeficiency virus type 1 on recombinant surface antigen of hepatitis B virus.Q41171978
Generation of Human Monoclonal Antibodies against HIV-1 Proteins; Electrofusion and Epstein-Barr Virus Transformation for Peripheral Blood Lymphocyte ImmortalizationQ41478638
Rapid clearance of virus after acute HIV-1 infection: correlates of risk of AIDS.Q45644537
Restricted antigenic variability of the epitope recognized by the neutralizing gp41 antibody 2F5Q58038933
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectmonoclonal antibodyQ422248
antibodyQ79460
P304page(s)3617-3625
P577publication date2009-02-04
P1433published inJournal of VirologyQ1251128
P1476titleIn vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth
P478volume83

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cites work (P2860)
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