4E10-resistant variants in a human immunodeficiency virus type 1 subtype C-infected individual with an anti-membrane-proximal external region-neutralizing antibody response

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4E10-resistant variants in a human immunodeficiency virus type 1 subtype C-infected individual with an anti-membrane-proximal external region-neutralizing antibody response is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.02161-07
P932PMC publication ID2258954
P698PubMed publication ID18094155

P50authorFrederic Bibollet-RucheQ47006522
Penny MooreQ55079169
Elin S GrayQ56637089
Lynn MorrisQ70377150
George M. ShawQ78514357
Hui LiQ131372534
P2093author name stringTammy Meyers
Julie M Decker
P2860cites workComprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodiesQ24561905
Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41Q28236154
Determinants of Human Immunodeficiency Virus Type 1 Resistance to gp41-Derived Inhibitory PeptidesQ28379310
Insensitivity of paediatric HIV-1 subtype C viruses to broadly neutralising monoclonal antibodies raised against subtype BQ28469023
Effects of amino acid changes in the extracellular domain of the human immunodeficiency virus type 1 gp41 envelope glycoproteinQ28646850
Molecular cloning and analysis of functional envelope genes from human immunodeficiency virus type 1 sequence subtypes A through G. The WHO and NIAID Networks for HIV Isolation and Characterization.Q30423779
Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.Q31016954
An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10Q33272711
A conserved tryptophan-rich motif in the membrane-proximal region of the human immunodeficiency virus type 1 gp41 ectodomain is important for Env-mediated fusion and virus infectivity.Q33654081
Antibody neutralization escape mediated by point mutations in the intracytoplasmic tail of human immunodeficiency virus type 1 gp41Q33781344
Identification of two sequences in the cytoplasmic tail of the human immunodeficiency virus type 1 envelope glycoprotein that inhibit cell surface expressionQ33851952
Regulation of human immunodeficiency virus type 1 envelope glycoprotein fusion by a membrane-interactive domain in the gp41 cytoplasmic tailQ33984243
Virion envelope content, infectivity, and neutralization sensitivity of simian immunodeficiency virusQ33984296
A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1Q34306804
Truncation of the cytoplasmic domain induces exposure of conserved regions in the ectodomain of human immunodeficiency virus type 1 envelope proteinQ34332519
Cytosolic domain of the human immunodeficiency virus envelope glycoproteins binds to calmodulin and inhibits calmodulin-regulated proteins.Q34343793
Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitopeQ34348303
Rational site-directed mutations of the LLP-1 and LLP-2 lentivirus lytic peptide domains in the intracytoplasmic tail of human immunodeficiency virus type 1 gp41 indicate common functions in cell-cell fusion but distinct roles in virion envelope incQ34741962
Redox-Triggered Infection by Disulfide-Shackled Human Immunodeficiency Virus Type 1 PseudovirionsQ34977075
Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infectionQ35857268
In vivo and in vitro escape from neutralizing antibodies 2G12, 2F5, and 4E10.Q35947769
Dynamics of HIV-1 recombination in its natural target cellsQ37356815
The cytoplasmic tail slows the folding of human immunodeficiency virus type 1 Env from a late prebundle configuration into the six-helix bundleQ37747105
Enfuvirtide resistance mutations: impact on human immunodeficiency virus envelope function, entry inhibitor sensitivity, and virus neutralizationQ39389791
Sensitivity of human immunodeficiency virus type 1 to the fusion inhibitor T-20 is modulated by coreceptor specificity defined by the V3 loop of gp120Q39612212
Simian immunodeficiency virus engrafted with human immunodeficiency virus type 1 (HIV-1)-specific epitopes: replication, neutralization, and survey of HIV-1-positive plasmaQ40311562
HIV-1 mutants escaping neutralization by the human antibodies 2F5, 2G12, and 4E10: in vitro experiments versus clinical studiesQ40356059
Multiple domains of the SIV Env protein determine virus replication efficiency and neutralization sensitivity.Q40468605
Role of the fusion peptide and membrane-proximal domain in HIV-1 envelope glycoprotein-mediated membrane fusionQ40613093
Anti-human immunodeficiency virus type 1 (HIV-1) antibodies 2F5 and 4E10 require surprisingly few crucial residues in the membrane-proximal external region of glycoprotein gp41 to neutralize HIV-1.Q40721814
A potent cross-clade neutralizing human monoclonal antibody against a novel epitope on gp41 of human immunodeficiency virus type 1.Q40757568
The membrane-proximal external region of HIV-1 gp41: a vaccine target worth exploringQ44830344
In vitro generation of HIV type 1 subtype C isolates resistant to enfuvirtideQ46211850
Genotypic and phenotypic characterization of viral isolates from HIV-1 subtype C-infected children with slow and rapid disease progressionQ48087904
Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.Q51100729
Differential functional phenotypes of two primary HIV-1 strains resulting from homologous point mutations in the LLP domains of the envelope gp41 intracytoplasmic domain.Q55508034
Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodiesQ57226425
P433issue5
P407language of work or nameEnglishQ1860
P1104number of pages9
P304page(s)2367-2375
P577publication date2007-12-19
P1433published inJournal of VirologyQ1251128
P1476title4E10-resistant variants in a human immunodeficiency virus type 1 subtype C-infected individual with an anti-membrane-proximal external region-neutralizing antibody response
P478volume82

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cites work (P2860)
Q335474514E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphisms
Q27655865A Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing Antibodies
Q34463861A single amino acid substitution in the C4 region in gp120 confers enhanced neutralization of HIV-1 by modulating CD4 binding sites and V3 loop
Q91473474An MPER antibody neutralizes HIV-1 using germline features shared among donors
Q33946158Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization
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Q38025633Basic research in HIV vaccinology is hampered by reductionist thinking
Q37410792Broad neutralization of human immunodeficiency virus type 1 mediated by plasma antibodies against the gp41 membrane proximal external region
Q30428089Closing the door to human immunodeficiency virus
Q36694111Conformational Epitope-Specific Broadly Neutralizing Plasma Antibodies Obtained from an HIV-1 Clade C-Infected Elite Neutralizer Mediate Autologous Virus Escape through Mutations in the V1 Loop
Q21090520Cryoelectron tomography of HIV-1 envelope spikes: further evidence for tripod-like legs
Q42850455Direct antibody access to the HIV-1 membrane-proximal external region positively correlates with neutralization sensitivity
Q33518005Evolution of antibody landscape and viral envelope escape in an HIV-1 CRF02_AG infected patient with 4E10-like antibodies
Q35289861Genotypic and functional properties of early infant HIV-1 envelopes
Q35173635HIV Type 1 Env Precursor Cleavage State Affects Recognition by Both Neutralizing and Nonneutralizing gp41 Antibodies
Q37179996Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India
Q37051645Human immunodeficiency virus type 2 (HIV-2)/HIV-1 envelope chimeras detect high titers of broadly reactive HIV-1 V3-specific antibodies in human plasma
Q36673288Importance of the membrane-perturbing properties of the membrane-proximal external region of human immunodeficiency virus type 1 gp41 to viral fusion
Q34937404In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth
Q33916676Induction of HIV neutralizing antibodies against the MPER of the HIV envelope protein by HA/gp41 chimeric protein-based DNA and VLP vaccines
Q24635002Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals
Q34742533Potent and broad neutralization of HIV-1 subtype C by plasma antibodies targeting a quaternary epitope including residues in the V2 loop
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Q34397758Sequences in Glycoprotein gp41, the CD4 Binding Site, and the V2 Domain Regulate Sensitivity and Resistance of HIV-1 to Broadly Neutralizing Antibodies
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Q34203163Variations in autologous neutralization and CD4 dependence of b12 resistant HIV-1 clade C env clones obtained at different time points from antiretroviral naïve Indian patients with recent infection

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