Broad HIV-1 neutralization mediated by CD4-binding site antibodies

scientific article published on 26 August 2007

Broad HIV-1 neutralization mediated by CD4-binding site antibodies is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NM1624
P932PMC publication ID2584972
P698PubMed publication ID17721546
P5875ResearchGate publication ID6117914

P50authorJohn R. MascolaQ63302442
George M. ShawQ78514357
Mark K. LouderQ87913394
Richard T. WyattQ96247131
P2093author name stringMark Connors
Xueling Wu
Stephen A Migueles
Brent Welcher
Krisha Svehla
Yuxing Li
Adhuna Phogat
P2860cites workThe HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and ImmunogensQ22242262
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Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolatesQ27629806
Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120.Q28217208
The antigenic structure of the HIV gp120 envelope glycoproteinQ28274698
Neutralizing antibodies from the sera of human immunodeficiency virus type 1-infected individuals bind to monomeric gp120 and oligomeric gp140Q30431941
Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitroQ33853775
Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donorsQ35857221
Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates.Q36600380
Identification of individual human immunodeficiency virus type 1 gp120 amino acids important for CD4 receptor bindingQ36795606
Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivityQ36797873
Neutralization of Divergent HIV-1 Isolates by Conformation-Dependent Human Antibodies to Gp120Q42129803
Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1. The National Institute of Allergy and Infectious Diseases AIDS Vaccine EvQ45771982
HIV vaccine design and the neutralizing antibody problemQ46474020
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressorsQ78342521
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
P304page(s)1032-1034
P577publication date2007-08-26
P1433published inNature medicineQ1633234
P1476titleBroad HIV-1 neutralization mediated by CD4-binding site antibodies
P478volume13

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Q27643993Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors
Q26829461Structural insights on the role of antibodies in HIV-1 vaccine and therapy
Q52338073Structure and Immune Recognition of the HIV Glycan Shield
Q27662155Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1
Q39602726Structure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble Trimers
Q40438707Structure-based Design of Cyclically Permuted HIV-1 gp120 Trimers That Elicit Neutralizing Antibodies
Q34987048Structure-based Vaccine Design in HIV: Blind Men and the Elephant?
Q33972838Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry
Q27316899Structure-based stabilization of HIV-1 gp120 enhances humoral immune responses to the induced co-receptor binding site
Q38811547Study of antibody repertoires to the CD4 binding site of gp120 of a Chinese HIV-1-infected elite neutralizer, using 454 sequencing and single-cell sorting
Q34312037Superinfection by Discordant Subtypes of HIV-1 Does Not Enhance the Neutralizing Antibody Response against Autologous Virus
Q59356767T-cell subset differentiation and antibody responses following antiretroviral therapy during simian immunodeficiency virus infection
Q37246321Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies
Q37179763Targeted deletion in the beta20-beta21 loop of HIV envelope glycoprotein gp120 exposes the CD4 binding site for antibody binding
Q33664910Temporal analysis of HIV envelope sequence evolution and antibody escape in a subtype A-infected individual with a broad neutralizing antibody response
Q64062652The HIV-1 Envelope Glycoprotein C3/V4 Region Defines a Prevalent Neutralization Epitope following Immunization
Q33504607The cat and mouse of HIV-1 antibody escape
Q30367176The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus.
Q36404101The changing face of HIV vaccine research
Q38019332The design and evaluation of HIV-1 vaccines
Q36155396The development of CD4 binding site antibodies during HIV-1 infection
Q26801603The evolution within us
Q37667754The implications of patterns in HIV diversity for neutralizing antibody induction and susceptibility.
Q38192357The past, present and future of neutralizing antibodies for hepatitis C virus
Q83601568The study of elite controllers: a pure academic exercise or a potential pathway to an HIV-1 vaccine?
Q37667360Thirty years of the human immunodeficiency virus epidemic and beyond
Q42185150Three amino acid residues in the envelope of human immunodeficiency virus type 1 CRF07_BC regulate viral neutralization susceptibility to the human monoclonal neutralizing antibody IgG1b12.
Q33614365Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodies
Q37431843Toward effective HIV vaccination: induction of binary epitope reactive antibodies with broad HIV neutralizing activity
Q33854841Transplanting supersites of HIV-1 vulnerability
Q38810452Tryptophan 375 stabilizes the outer-domain core of gp120 for HIV vaccine immunogen design
Q35076664Two Closely Related Env Antigens from the Same Patient Elicited Different Spectra of Neutralizing Antibodies against Heterologous HIV-1 Isolates
Q33826682Two N-linked glycosylation sites in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 regulate viral neutralization susceptibility to the human monoclonal antibody specific for the CD4 binding domain
Q35943810UCLA1, a synthetic derivative of a gp120 RNA aptamer, inhibits entry of human immunodeficiency virus type 1 subtype C
Q34441935Unique C2V3 sequence in HIV-1 envelope obtained from broadly neutralizing plasma of a slow progressing patient conferred enhanced virus neutralization
Q34203163Variations in autologous neutralization and CD4 dependence of b12 resistant HIV-1 clade C env clones obtained at different time points from antiretroviral naïve Indian patients with recent infection
Q37295534Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys
Q35192660epitopes immediately below the base of the V3 loop of gp120 as targets for the initial autologous neutralizing antibody response in two HIV-1 subtype B-infected individuals

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