Structure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble Trimers

scientific article published on 30 December 2015

Structure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble Trimers is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.02652-15
P8608Fatcat IDrelease_7xbzlu6xhzcaphpw7gnveir5mi
P932PMC publication ID4810649
P698PubMed publication ID26719252

P50authorAndrew B WardQ90160109
Richard T. WyattQ96247131
P2093author name stringNatalia de Val
Javier Guenaga
Viktoriya Dubrovskaya
Shailendra K Sharma
Barbara Carrette
P2860cites workCodon usage limitation in the expression of HIV-1 envelope glycoproteinQ24498729
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120Q27643185
Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 EnvQ27644383
Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopyQ27680442
Crystal Structure of a Soluble Cleaved HIV-1 Envelope TrimerQ27680496
Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope TrimerQ27680497
Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimersQ27683553
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibodyQ27759364
A new generation of the IMAGIC image processing systemQ28131751
A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodiesQ28299280
HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimersQ28647225
Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine targetQ29547347
Appion: an integrated, database-driven pipeline to facilitate EM image processingQ29614288
Automated molecular microscopy: the new Leginon systemQ29614290
Broad neutralization coverage of HIV by multiple highly potent antibodiesQ29615361
Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1Q29619511
A clustering approach to multireference alignment of single-particle projections in electron microscopyQ33548939
Modifications that stabilize human immunodeficiency virus envelope glycoprotein trimers in solutionQ33804811
Characterization of stable, soluble trimers containing complete ectodomains of human immunodeficiency virus type 1 envelope glycoproteinsQ33806056
Immunogenicity and protective efficacy of oligomeric human immunodeficiency virus type 1 gp140.Q33835295
Improved elicitation of neutralizing antibodies against primary human immunodeficiency viruses by soluble stabilized envelope glycoprotein trimersQ33836042
Biochemical and immunogenic characterization of soluble human immunodeficiency virus type 1 envelope glycoprotein trimers expressed by semliki forest virusQ33930424
Enhancing the proteolytic maturation of human immunodeficiency virus type 1 envelope glycoproteinsQ34332728
Stabilization of the soluble, cleaved, trimeric form of the envelope glycoprotein complex of human immunodeficiency virus type 1.Q34361680
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apexQ34709433
A trimeric, V2-deleted HIV-1 envelope glycoprotein vaccine elicits potent neutralizing antibodies but limited breadth of neutralization in human volunteersQ34743297
Stable, uncleaved HIV-1 envelope glycoprotein gp140 forms a tightly folded trimer with a native-like structureQ34831341
Highly stable trimers formed by human immunodeficiency virus type 1 envelope glycoproteins fused with the trimeric motif of T4 bacteriophage fibritinQ34999293
A native-like SOSIP.664 trimer based on an HIV-1 subtype B env geneQ35110976
Structure and immune recognition of trimeric pre-fusion HIV-1 Env.Q35142291
Well-ordered trimeric HIV-1 subtype B and C soluble spike mimetics generated by negative selection display native-like propertiesQ35540033
Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env.Q35641498
Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogensQ36102994
HIV-1 Neutralizing Antibodies Display Dual Recognition of the Primary and Coreceptor Binding Sites and Preferential Binding to Fully Cleaved Envelope GlycoproteinsQ36276274
Native oligomeric human immunodeficiency virus type 1 envelope glycoprotein elicits diverse monoclonal antibody reactivities.Q36633402
Broad HIV-1 neutralization mediated by CD4-binding site antibodiesQ36977635
Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoproteinQ37123584
DoG Picker and TiltPicker: software tools to facilitate particle selection in single particle electron microscopyQ37401395
Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group m consensus envelope glycoproteinQ37742876
Purification, Characterization, and Immunogenicity of a Soluble Trimeric Envelope Protein Containing a Partial Deletion of the V2 Loop Derived from SF162, an R5-Tropic Human Immunodeficiency Virus Type 1 IsolateQ39484956
A recombinant human immunodeficiency virus type 1 envelope glycoprotein complex stabilized by an intermolecular disulfide bond between the gp120 and gp41 subunits is an antigenic mimic of the trimeric virion-associated structureQ39588870
Cleavage-independent HIV-1 Env trimers engineered as soluble native spike mimetics for vaccine designQ41042362
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)2806-2817
P577publication date2015-12-30
P1433published inJournal of VirologyQ1251128
P1476titleStructure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble Trimers
P478volume90

Reverse relations

cites work (P2860)
Q54237723A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers
Q40463159An HIV-1 Env-Antibody Complex Focuses Antibody Responses to Conserved Neutralizing Epitopes.
Q59351009An HIV-1 broadly neutralizing antibody from a clade C infected pediatric elite neutralizer potently neutralizes the contemporaneous and autologous evolving viruses
Q36267348Antigenic characterization of the human immunodeficiency virus (HIV-1) envelope glycoprotein precursor incorporated into nanodiscs
Q61795909Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide
Q40108631Characterization of a stable HIV-1 B/C recombinant, soluble and trimeric envelope glycoprotein (Env) highly resistant to CD4-induced conformational changes
Q91427933Characterization of native-like HIV-1 gp140 glycoprotein expressed in insect cells
Q95627977Controlling the SARS-CoV-2 Spike Glycoprotein Conformation
Q97652986Controlling the SARS-CoV-2 spike glycoprotein conformation
Q37695592Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers
Q37482035Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer
Q92932198Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements
Q36194234Diversification in the HIV-1 Envelope Hyper-variable Domains V2, V4, and V5 and Higher Probability of Transmitted/Founder Envelope Glycosylation Favor the Development of Heterologous Neutralization Breadth
Q92828111Effects of the SOS (A501C/T605C) and DS (I201C/A433C) Disulfide Bonds on HIV-1 Membrane Envelope Glycoprotein Conformation and Function
Q33830824Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches
Q90182956Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
Q37300461Epitope-Independent Purification of Native-Like Envelope Trimers from Diverse HIV-1 Isolates
Q88985874Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1
Q37649155Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein.
Q38992740Evolution of B cell analysis and Env trimer redesign
Q36003168Evolution of coreceptor utilization to escape CCR5 antagonist therapy.
Q41924154Functional Stability of HIV-1 Envelope Trimer Affects Accessibility to Broadly Neutralizing Antibodies at its Apex
Q47096121Glutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice
Q33711154Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein
Q95323134Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help
Q46454115HIV Envelope Glycoform Heterogeneity and Localized Diversity Govern the Initiation and Maturation of a V2 Apex Broadly Neutralizing Antibody Lineage
Q40073016HIV-1 Cross-reactive Primary Virus Neutralizing Antibody Response Elicited by Immunization in Non-human Primate
Q39365785HIV-1 Escape from a Peptidic Anchor Inhibitor through Stabilization of the Envelope Glycoprotein Spike
Q89746983HIV-1 gp120-CD4-Induced Antibody Complex Elicits CD4 Binding Site-Specific Antibody Response in Mice
Q59339672HIV-1 vaccine design through minimizing envelope metastability
Q59360730Harnessing post-translational modifications for next-generation HIV immunogens
Q40061438Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer
Q46272894High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers
Q38708708Improving the Expression and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers by Targeted Sequence Changes.
Q47364595Increased surface expression of HIV-1 envelope is associated with improved antibody response in vaccinia prime/protein boost immunization
Q37633417Native-like Env trimers as a platform for HIV-1 vaccine design
Q91691714Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization
Q40198048Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach
Q37549777Progress toward active or passive HIV-1 vaccination
Q53081267Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity
Q38712684Stabilization of a soluble, native-like trimeric form of an efficiently cleaved Indian HIV-1 clade C envelope glycoprotein
Q47313525Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers
Q30490942Stabilized HIV-1 envelope glycoprotein trimers for vaccine use.
Q57091049Stabilizing HIV-1 envelope glycoprotein trimers to induce neutralizing antibodies
Q98384046Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens
Q37376640Structural basis for membrane anchoring of HIV-1 envelope spike
Q52338073Structure and Immune Recognition of the HIV Glycan Shield
Q92382176Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence
Q90675709Structure-Guided Redesign Improves NFL HIV Env Trimer Integrity and Identifies an Inter-Protomer Disulfide Permitting Post-Expression Cleavage
Q46631754Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding.
Q40043429Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response
Q39108730Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem
Q39108789The HIV-1 envelope glycoprotein structure: nailing down a moving target
Q28553360Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies
Q37060986Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.

Search more.