Cell-to-cell spread of HIV-1 and evasion of neutralizing antibodies

scientific article published on 17 October 2013

Cell-to-cell spread of HIV-1 and evasion of neutralizing antibodies is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.VACCINE.2013.10.020
P698PubMed publication ID24140477
P5875ResearchGate publication ID258059770

P50authorQuentin J SattentauQ59822898
P2093author name stringChristopher J A Duncan
Torben Schiffner
P2860cites workEfficient HIV-1 transmission from macrophages to T cells across transient virological synapsesQ44307172
Multiple proviral integration events after virological synapse-mediated HIV-1 spreadQ44571430
Follicular dendritic cells and human immunodeficiency virus infectivityQ45080369
Recruitment of HIV and its receptors to dendritic cell-T cell junctionsQ47563778
Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses.Q55239314
Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodiesQ57226425
Antigp41 antibodies fail to block early events of virological synapses but inhibit HIV spread between T cellsQ58023483
Neutralizing antibodies inhibit HIV-1 transfer from primary dendritic cells to autologous CD4 T lymphocytesQ84943267
Cryo-electron tomographic structure of an immunodeficiency virus envelope complex in situQ21090535
Structural mechanism of trimeric HIV-1 envelope glycoprotein activationQ21131394
High multiplicity HIV-1 cell-to-cell transmission from macrophages to CD4+ T cells limits antiretroviral efficacyQ22242698
HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapseQ22242967
Avoiding the void: cell-to-cell spread of human virusesQ22251022
In vivo imaging of virological synapsesQ22251074
Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapyQ22251085
Endocytosis of HIV: anything goesQ22251441
Dimeric association and segmental variability in the structure of human CD4Q24324340
Structural definition of a conserved neutralization epitope on HIV-1 gp120Q24655948
Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1Q24670055
Redefining the viral reservoirs that prevent HIV-1 eradicationQ26827255
A Blueprint for HIV Vaccine DiscoveryQ26829865
Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structureQ27312441
Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosidesQ27318429
HIV traffics through a specialized, surface-accessible intracellular compartment during trans-infection of T cells by mature dendritic cellsQ27318551
The regulated secretory pathway in CD4(+) T cells contributes to human immunodeficiency virus type-1 cell-to-cell spread at the virological synapseQ27349077
Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolatesQ27629806
Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine designQ27634018
Antibody domain exchange is an immunological solution to carbohydrate cluster recognitionQ27641517
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9Q27644478
HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membraneQ27649531
Molecular architecture of native HIV-1 gp120 trimersQ27651385
Crystallographic Definition of the Epitope Promiscuity of the Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2F5: Vaccine Design ImplicationsQ27657377
Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01Q27663293
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan ShieldQ27675032
Broad and potent neutralization of HIV-1 by a gp41-specific human antibodyQ27675131
Crystallographic structure of an intact IgG1 monoclonal antibodyQ27748871
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibodyQ27759364
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cellsQ28138968
Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogeniesQ28602877
Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine targetQ29547347
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in ThailandQ29547531
Broad neutralization coverage of HIV by multiple highly potent antibodiesQ29615361
Immune-correlates analysis of an HIV-1 vaccine efficacy trialQ29617377
Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibodyQ29618366
Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1Q29619511
Targeting early infection to prevent HIV-1 mucosal transmission.Q30386549
Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapsesQ30480959
Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapsesQ30487819
Quantitative 3D video microscopy of HIV transfer across T cell virological synapsesQ30490761
Virological synapse-mediated spread of human immunodeficiency virus type 1 between T cells is sensitive to entry inhibitionQ30493649
3D visualization of HIV transfer at the virological synapse between dendritic cells and T cellsQ30496061
Multiploid inheritance of HIV-1 during cell-to-cell infectionQ30501773
Cell-to-cell transfer of HIV-1 via virological synapses leads to endosomal virion maturation that activates viral membrane fusionQ30505286
Macrophage internal HIV-1 is protected from neutralizing antibodiesQ30510067
Neutralization resistance of virological synapse-mediated HIV-1 Infection is regulated by the gp41 cytoplasmic tailQ30524110
Antiretroviral agents effectively block HIV replication after cell-to-cell transferQ30524224
In vitro derived dendritic cells trans-infect CD4 T cells primarily with surface-bound HIV-1 virionsQ33269795
Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitroQ33853775
Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12.Q34015978
Maturation-induced cloaking of neutralization epitopes on HIV-1 particlesQ34023008
Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodiesQ34229664
Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimerQ34292319
The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120.Q34341843
Cell-to-cell transmission can overcome multiple donor and target cell barriers imposed on cell-free HIV.Q34544718
Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibodyQ34630446
Dendritic Cells and HIV-1 Trans-InfectionQ34632997
The infectious synapse formed between mature dendritic cells and CD4(+) T cells is independent of the presence of the HIV-1 envelope glycoproteinQ34650563
Redox-Triggered Infection by Disulfide-Shackled Human Immunodeficiency Virus Type 1 PseudovirionsQ34977075
Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-LQ35012462
Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestorsQ35382871
Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophagesQ35826158
HIV cell-to-cell transmission requires the production of infectious virus particles and does not proceed through env-mediated fusion poresQ35826780
Transmembrane domain membrane proximal external region but not surface unit-directed broadly neutralizing HIV-1 antibodies can restrict dendritic cell-mediated HIV-1 trans-infectionQ35842299
PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4.Q35868102
Selection pressure on HIV-1 envelope by broadly neutralizing antibodies to the conserved CD4-binding siteQ35943521
Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escapeQ36000736
Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope proteinQ36131738
HIV-infected T cells are migratory vehicles for viral disseminationQ36315429
Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivoQ36414891
A fusion inhibitor prevents spread of immunodeficiency viruses, but not activation of virus-specific T cells, by dendritic cells.Q36673272
Broad HIV-1 neutralization mediated by CD4-binding site antibodiesQ36977635
Development of prophylactic vaccines against HIV-1.Q37042563
Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithmQ37247974
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.Q37259407
Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infectionQ37273158
Cell-to-cell HIV-1 spread and its implications for immune evasionQ37429751
Infection of specific dendritic cells by CCR5-tropic human immunodeficiency virus type 1 promotes cell-mediated transmission of virus resistant to broadly neutralizing antibodiesQ37583414
Virus cell-to-cell transmission.Q37726587
HIV-1 Virological Synapse is not Simply a Copycat of the Immunological SynapseQ37796606
Cell-to-Cell Spread of RetrovirusesQ37945208
The HTLV-1 Virological Synapse.Q38615502
A cell-to-cell HIV transfer assay identifies humoral responses with broad neutralization activity.Q39537121
Neutralizing monoclonal antibodies block human immunodeficiency virus type 1 infection of dendritic cells and transmission to T cells.Q39583017
Human immunodeficiency virus type 1 attachment, coreceptor, and fusion inhibitors are active against both direct and trans infection of primary cellsQ39700360
Efficient capture of antibody neutralized HIV-1 by cells expressing DC-SIGN and transfer to CD4+ T lymphocytesQ40168741
Preparation and characterization of human HIV type 1 neutralizing reference seraQ41332501
Epitope exposure on functional, oligomeric HIV-1 gp41 moleculesQ41381359
Generation of Human Monoclonal Antibodies against HIV-1 Proteins; Electrofusion and Epstein-Barr Virus Transformation for Peripheral Blood Lymphocyte ImmortalizationQ41478638
pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membraneQ41764642
Architecture and regulation of the HIV-1 assembly and holding compartment in macrophagesQ42140364
Structural comparison of HIV-1 envelope spikes with and without the V1/V2 loopQ42707235
Adhesion molecule interactions facilitate human immunodeficiency virus type 1-induced virological synapse formation between T cellsQ42910380
Inefficient human immunodeficiency virus replication in mobile lymphocytesQ42957159
Infection of macaques after vaginal exposure to cell-associated simian immunodeficiency virusQ43009530
P433issue49
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
P304page(s)5789-5797
P577publication date2013-10-17
P1433published inVaccineQ7907941
P1476titleCell-to-cell spread of HIV-1 and evasion of neutralizing antibodies
P478volume31

Reverse relations

cites work (P2860)
Q30596957A comparison of elasticities of viral levels to specific immune response mechanisms in human immunodeficiency virus infection.
Q34180174Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice
Q34262089Broadly neutralizing antibody VRC01 prevents HIV-1 transmission from plasmacytoid dendritic cells to CD4 T lymphocytes
Q35686912Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent
Q37182721Cell-Free versus Cell-to-Cell Infection by Human Immunodeficiency Virus Type 1 and Human T-Lymphotropic Virus Type 1: Exploring the Link among Viral Source, Viral Trafficking, and Viral Replication.
Q37347313Chimeric Antigen Receptor T Cells Guided by the Single-Chain Fv of a Broadly Neutralizing Antibody Specifically and Effectively Eradicate Virus Reactivated from Latency in CD4+ T Lymphocytes Isolated from HIV-1-Infected Individuals Receiving Suppres
Q38231405DC-T cell virological synapses and the skin: novel perspectives in dermatology
Q38515936Dynamics of virus-receptor interactions in virus binding, signaling, and endocytosis
Q37154783Encoded novel forms of HSP70 or a cytolytic protein increase DNA vaccine potency
Q40794254Exploring the benefits of antibody immune response in HIV-1 infection using a discrete model.
Q60951107Gene Editing of HIV-1 Co-receptors to Prevent and/or Cure Virus Infection
Q27681313HIV Cell-to-Cell Spread Results in Earlier Onset of Viral Gene Expression by Multiple Infections per Cell
Q36269097HIV transmission biology: translation for HIV prevention
Q57030223HIV-1 cell-to-cell transmission and broadly neutralizing antibodies
Q30570557High-multiplicity HIV-1 infection and neutralizing antibody evasion mediated by the macrophage-T cell virological synapse.
Q37593177Identification of Human Anti-HIV gp160 Monoclonal Antibodies That Make Effective Immunotoxins
Q58724429Importance of Fc-mediated functions of anti-HIV-1 broadly neutralizing antibodies
Q35861276Inhibitory Effect of Individual or Combinations of Broadly Neutralizing Antibodies and Antiviral Reagents against Cell-Free and Cell-to-Cell HIV-1 Transmission
Q42638889Maternal but Not Infant Anti-HIV-1 Neutralizing Antibody Response Associates with Enhanced Transmission and Infant Morbidity
Q39578041Molecular Determinants Directing HIV-1 Gag Assembly to Virus-Containing Compartments in Primary Macrophages
Q40295939Neutralization of Virus Infectivity by Antibodies: Old Problems in New Perspectives
Q59358562Neutralizing Antibody-Based Prevention of Cell-Associated HIV-1 Infection
Q40312301New Connections: Cell-to-Cell HIV-1 Transmission, Resistance to Broadly Neutralizing Antibodies, and an Envelope Sorting Motif
Q35745453Novel CD4-Based Bispecific Chimeric Antigen Receptor Designed for Enhanced Anti-HIV Potency and Absence of HIV Entry Receptor Activity
Q40088529Partial efficacy of a broadly neutralizing antibody against cell-associated SHIV infection
Q34309493Partial rescue of V1V2 mutant infectivity by HIV-1 cell-cell transmission supports the domain's exceptional capacity for sequence variation
Q30754418Porcine Reproductive and Respiratory Syndrome Virus Utilizes Nanotubes for Intercellular Spread
Q100535027Preferential recognition and antagonism of SARS-CoV-2 spike glycoprotein binding to 3- O -sulfated heparan sulfate
Q58569712Recent progress in broadly neutralizing antibodies to HIV
Q36294727Short Communication: Exploring Antibody Potential as Prophylactic/Therapeutic Strategies for Prevention of Early Mucosal HIV-1 Infection
Q41924135T cell-macrophage fusion triggers multinucleated giant cell formation for HIV-1 spreading.
Q95602650TMPRSS2 and TMPRSS4 mediate SARS-CoV-2 infection of human small intestinal enterocytes
Q94670006TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes
Q37415455The Glycosylphosphatidylinositol-Anchored Variable Region of Llama Heavy Chain-Only Antibody JM4 Efficiently Blocks both Cell-Free and T Cell-T Cell Transmission of Human Immunodeficiency Virus Type 1.
Q92881205The Impact of Cellular Proliferation on the HIV-1 Reservoir
Q40190061The pentameric complex drives immunologically covert cell-cell transmission of wild-type human cytomegalovirus
Q41102793Vpr Promotes Macrophage-Dependent HIV-1 Infection of CD4+ T Lymphocytes
Q33772637Which Antibody Functions are Important for an HIV Vaccine?

Search more.