The Impact of Cellular Proliferation on the HIV-1 Reservoir

scientific article published on 21 January 2020

The Impact of Cellular Proliferation on the HIV-1 Reservoir is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3390/V12020127
P932PMC publication ID7077244
P698PubMed publication ID31973022

P2093author name stringKathleen L Collins
Maria C Virgilio
P2860cites workVpr Promotes Macrophage-Dependent HIV-1 Infection of CD4+ T LymphocytesQ41102793
Cell-to-cell spread of HIV-1 occurs within minutes and may not involve the participation of virus particlesQ41642255
Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.Q41880147
Quiescence promotes latent HIV infection and resistance to reactivation from latency with histone deacetylase inhibitorsQ41918740
Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2sQ42115088
Rapid turnover of effector-memory CD4(+) T cells in healthy humansQ42134878
HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects.Q43130032
Conversion rate towards a syncytium-inducing (SI) phenotype during different stages of human immunodeficiency virus type 1 infection and prognostic value of SI phenotype for survival after AIDS diagnosisQ43581702
Efficient HIV-1 transmission from macrophages to T cells across transient virological synapsesQ44307172
Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4+ T Cells Permissive for Latent HIV-1 InfectionQ44876281
Enhanced culture assay for detection and quantitation of latently infected, resting CD4+ T-cells carrying replication-competent virus in HIV-1-infected individualsQ45428919
Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infectionQ45854138
Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants.Q46281767
Class 1-selective histone deacetylase inhibitors enhance HIV latency reversal while preserving the activity of HDAC isoforms necessary for maximal HIV gene expressionQ47234362
HIV integration sites and implications for maintenance of the reservoirQ47329569
Digital PCR as a tool to measure HIV persistenceQ47548213
Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy.Q49059122
Measuring replication competent HIV-1: advances and challenges in defining the latent reservoir.Q49298325
Re-evaluating evolution in the HIV reservoir.Q49715245
Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signalingQ22009382
HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapseQ22242967
Avoiding the void: cell-to-cell spread of human virusesQ22251022
Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cellsQ24548940
Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferencesQ24798872
The analysis, roles and regulation of quiescence in hematopoietic stem cellsQ26998160
HIV-1 reverse transcriptionQ27023387
Bottlenecks in HIV-1 transmission: insights from the study of founder virusesQ28082862
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cellsQ28212168
A human memory T cell subset with stem cell-like propertiesQ28248395
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapyQ28253761
Residual Viremia in Treated HIV+ IndividualsQ28552126
Retroviral DNA IntegrationQ28596842
The biology of CCR5 and CXCR4Q29012920
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infectionQ29547852
Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor geneQ29614892
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infectionQ29614956
Central memory and effector memory T cell subsets: function, generation, and maintenanceQ29615097
Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapyQ29615992
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapyQ29615993
Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and diseaseQ29616432
HIV-1 integration in the human genome favors active genes and local hotspotsQ29618457
Decay characteristics of HIV-1-infected compartments during combination therapyQ29619375
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferationQ29619611
High-multiplicity HIV-1 infection and neutralizing antibody evasion mediated by the macrophage-T cell virological synapse.Q30570557
Homeostatic proliferation fails to efficiently reactivate HIV-1 latently infected central memory CD4+ T cellsQ31036545
Human nucleoporins promote HIV-1 docking at the nuclear pore, nuclear import and integrationQ31103609
Retroviral DNA integration: viral and cellular determinants of target-site selectionQ33247467
Multiple, linked human immunodeficiency virus type 1 drug resistance mutations in treatment-experienced patients are missed by standard genotype analysisQ33592278
Weak palindromic consensus sequences are a common feature found at the integration target sites of many retrovirusesQ33724262
A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors.Q33906477
HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs.Q33941997
HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostatQ34106191
Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans.Q51415097
Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection.Q51966653
Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.Q52007779
In vivo fate of HIV-1-infected T cells: quantitative analysis of the transition to stable latency.Q52050894
Sex Differences in HIV Infection.Q52674721
Expanded cellular clones carrying replication-competent HIV-1 persist, wax, and wane.Q52684425
Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural GeneQ56591978
Improved assays to measure and characterize the inducible HIV reservoirQ57477977
Ongoing HIV Replication During ART ReconsideredQ57498730
The role of integration and clonal expansion in HIV infection: live long and prosperQ57799661
Sex-Based Differences in HIV-1 Reservoir Activity and Residual Immune ActivationQ58104425
A majority of HIV persistence during antiretroviral therapy is due to infected cell proliferationQ59136614
Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoirQ59355676
Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansionQ61796320
Haematopoiesis in the era of advanced single-cell technologiesQ64008432
Entry of Polarized Effector Cells into Quiescence Forces HIV LatencyQ64120094
HIV-1 infection in an individual homozygous for the CCR5 deletion alleleQ73122336
Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4+ T CellsQ88866382
Hematopoietic Hierarchy - An Updated RoadmapQ89216358
Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individualsQ90694289
Transportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoatingQ90703720
Hematopoietic Stem and Progenitor Cells Are a Distinct HIV Reservoir that Contributes to Persistent Viremia in Suppressed PatientsQ90776929
Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapyQ91247946
A quantitative approach for measuring the reservoir of latent HIV-1 provirusesQ91284113
Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestorsQ91496007
Clones of infected cells arise early in HIV-infected individualsQ92884455
The role of interleukin-2 during homeostasis and activation of the immune systemQ34255232
Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapyQ34290545
Genotypic analysis of HIV-1 drug resistance at the limit of detection: virus production without evolution in treated adults with undetectable HIV loadsQ34312257
A human immunodeficiency virus type 1 isolate from an infected person homozygous for CCR5Delta32 exhibits dual tropism by infecting macrophages and MT2 cells via CXCR4.Q34333673
Effect of raltegravir-containing intensification on HIV burden and T-cell activation in multiple gut sites of HIV-positive adults on suppressive antiretroviral therapyQ34384143
Engineering designer transcription activator-like effector nucleases (TALENs) by REAL or REAL-Fast assemblyQ34425833
In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression.Q34445208
Nuclear architecture dictates HIV-1 integration site selection.Q34465264
HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infectionQ34502840
Recurrent HIV-1 integration at the BACH2 locus in resting CD4+ T cell populations during effective highly active antiretroviral therapyQ34607544
AIDS-related cancer and severity of immunosuppression in persons with AIDS.Q34636933
HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cellsQ34672568
A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell responseQ34743336
Single cell analysis of lymph node tissue from HIV-1 infected patients reveals that the majority of CD4+ T-cells contain one HIV-1 DNA moleculeQ34789289
HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cellsQ35007831
Integration of human immunodeficiency virus type 1 in untreated infection occurs preferentially within genesQ35023783
Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cellsQ35076645
Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA moleculeQ35091012
Chromatin organization at the nuclear pore favours HIV replicationQ35196941
HIV-1 integration landscape during latent and active infectionQ35211469
Key determinants of target DNA recognition by retroviral intasomesQ35577172
Absence of HIV-1 evolution in the gut-associated lymphoid tissue from patients on combination antiviral therapy initiated during primary infection.Q35729054
A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected IndividualsQ36038655
Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation.Q36155046
Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cellsQ36228932
Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoirQ36318184
Dynamic regulation of HIV-1 mRNA populations analyzed by single-molecule enrichment and long-read sequencing.Q36368754
Change in coreceptor use correlates with disease progression in HIV-1--infected individualsQ36376800
Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patientQ36383594
An increasing proportion of monotypic HIV-1 DNA sequences during antiretroviral treatment suggests proliferation of HIV-infected cellsQ36559821
Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivoQ36607484
Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity.Q36654112
Quantitation of human immunodeficiency virus type 1 infection kineticsQ36686530
Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptorsQ36733787
Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1Q36806618
Interleukin-7 promotes HIV persistence during antiretroviral therapyQ36873277
Persistent HIV-1 replication maintains the tissue reservoir during therapyQ36897321
HIV rebounds from latently infected cells, rather than from continuing low-level replicationQ36954950
Retrovirus Integration Database (RID): a public database for retroviral insertion sites into host genomesQ37064393
Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapyQ37200979
HIV-1 infection of hematopoietic progenitor cells in vivo in humanized miceQ37202288
Defective proviruses rapidly accumulate during acute HIV-1 infectionQ37239064
Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infectionQ37273158
IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic ActivityQ37592618
HIV-1 persistence in CD4+ T cells with stem cell-like propertiesQ37646541
Proliferation of latently infected CD4+ T cells carrying replication-competent HIV-1: Potential role in latent reservoir dynamicsQ37737052
Origins of CD4(+) effector and central memory T cellsQ37899115
Mutation rates and intrinsic fidelity of retroviral reverse transcriptases.Q37945186
Cell-to-cell spread of HIV-1 and evasion of neutralizing antibodiesQ38154038
The who's who of T-cell differentiation: human memory T-cell subsetsQ38164599
Cancer risk in HIV-infected people in the USA from 1996 to 2012: a population-based, registry-linkage studyQ38399107
HIV-1 drug resistance profiles in children and adults with viral load of <50 copies/ml receiving combination therapyQ38460522
CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo.Q38667923
Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cellsQ38719409
Broader tropism and higher cytopathicity for CD4+ T cells of a syncytium-inducing compared to a non-syncytium-inducing HIV-1 isolate as a mechanism for accelerated CD4+ T cell decline in vivoQ39009407
Persistence of dual-tropic HIV-1 in an individual homozygous for the CCR5 Delta 32 allele.Q39029428
Minimal requirement for a lentivirus vector based on human immunodeficiency virus type 1.Q39577503
Characterization of chemokine receptor utilization of viruses in the latent reservoir for human immunodeficiency virus type 1.Q39592932
Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infectionQ39686599
HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells.Q40050048
Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexesQ40075873
Resting CD4+ T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals carry integrated HIV-1 genomes within actively transcribed host genesQ40886843
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue2
P921main subjectcell population proliferationQ189101
P577publication date2020-01-21
P1433published inVirusesQ7935305
P1476titleThe Impact of Cellular Proliferation on the HIV-1 Reservoir
P478volume12

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