Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity.

scientific article published on November 1993

Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.67.11.6365-6378.1993
P932PMC publication ID238071
P698PubMed publication ID8411338

P2093author name stringMartin MA
Purcell DF
P2860cites workHigh levels of HIV-1 in plasma during all stages of infection determined by competitive PCRQ22242246
Regulation of human immunodeficiency virus env expression by the rev gene productQ24646216
A novel human immunodeficiency virus type 1 protein, tev, shares sequences with tat, env, and rev proteinsQ28246228
HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element regionQ28256243
HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of diseaseQ28267375
The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNAQ28279502
rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNAQ28279513
Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigensQ28647265
Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular cloneQ29547734
Importance of the nef gene for maintenance of high virus loads and for development of AIDSQ29618369
Regulation of tissue-specific alternative splicing: exon-specific cis-elements govern the splicing of leukocyte common antigen pre-mRNAQ33561177
Missense mutations in an infectious human immunodeficiency viral genome: functional mapping of tat and identification of the rev splice acceptorQ33681763
Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: mapping cryptic functions of the arginine-rich motifQ33831166
A tripartite HIV-1 tat-env-rev fusion proteinQ33918908
HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA.Q34186306
Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitorQ34323995
The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env regionQ34544493
Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.Q34564460
Alternative mRNA splicingQ35237442
Molecular profile of human immunodeficiency virus type 1 infection in symptomless patients and in patients with AIDSQ36687307
Control of retroviral RNA splicing through maintenance of suboptimal processing signalsQ36717739
Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus.Q36770468
Alternative splice acceptor utilization during human immunodeficiency virus type 1 infection of cultured cellsQ36782518
Characterization and expression of novel singly spliced RNA species of human immunodeficiency virus type 1Q36783395
Env and Vpu proteins of human immunodeficiency virus type 1 are produced from multiple bicistronic mRNAsQ36793376
Human immunodeficiency virus rev protein recognizes a target sequence in rev-responsive element RNA within the context of RNA secondary structureQ36796081
Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1Q36806618
Mechanism of translation of monocistronic and multicistronic human immunodeficiency virus type 1 mRNAsQ36808350
Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophagesQ36810554
In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivityQ36825840
Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expressionQ36830303
The Rev protein of human immunodeficiency virus type 1 promotes polysomal association and translation of gag/pol and vpu/env mRNAsQ36964078
Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA SplicingQ37132263
Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virusQ37412665
Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytesQ37528880
Specific regulation of mRNA splicing in vitro by a peptide from HIV-1 Rev.Q38332969
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donorQ40170620
Human growth hormone DNA sequence and mRNA structure: possible alternative splicingQ40499454
The role of the tnv protein and tnv RNA splicing signals in replication of HIV-1 IIIB isolatesQ41609512
Identification of two novel human immunodeficiency virus type 1 splice acceptor sites in infected T cell linesQ41614884
Analysis of alternatively spliced human immunodeficiency virus type-1 mRNA species, one of which encodes a novel tat-env fusion proteinQ41657615
Rev is necessary for translation but not cytoplasmic accumulation of HIV-1 vif, vpr, and env/vpu 2 RNAsQ41686213
Functional analysis of CAR, the target sequence for the Rev protein of HIV-1.Q41757816
Regulation by HIV Rev depends upon recognition of splice sitesQ41758926
A novel gene of HIV-1, vpu, and its 16-kilodalton productQ42656133
Nucleic acid structure and expression of the human AIDS/lymphadenopathy retrovirusQ43563098
The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localizationQ44022521
The trans-activator gene of the human T cell lymphotropic virus type III is required for replicationQ44579665
Secondary structure is the major determinant for interaction of HIV rev protein with RNA.Q45129827
Mutations within the human immunodeficiency virus type 1 gp160 envelope glycoprotein alter its intracellular transport and processingQ45252128
Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator proteinQ45830211
The HIV 'A' (sor) gene product is essential for virus infectivityQ45847960
A general method for rapid site-directed mutagenesis using the polymerase chain reaction.Q48247178
Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDSQ59057787
Tissue-specific and allelic expression of the complement regulator CD46 is controlled by alternative splicingQ61779875
Interactions of small nuclear RNA's with precursor messenger RNA during in vitro splicingQ64378031
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectvirusQ808
infectivityQ1662346
alternative mRNA splicing, via spliceosomeQ21114084
P304page(s)6365-6378
P577publication date1993-11-01
P1433published inJournal of VirologyQ1251128
P1476titleAlternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity
P478volume67

Reverse relations

cites work (P2860)
Q37361258A 5'UTR-spliced mRNA isoform is specialized for enhanced HIV-2 gag translation
Q40375793A Cytoplasmic RNA Virus Alters the Function of the Cell Splicing Protein SRSF2.
Q52548171A Janus splicing regulatory element modulates HIV-1 tat and rev mRNA production by coordination of hnRNP A1 cooperative binding.
Q30381208A Naturally Occurring rev1-vpu Fusion Gene Does Not Confer a Fitness Advantage to HIV-1.
Q57086517A Rev–CBP80–eIF4AI complex drives Gag synthesis from the HIV-1 unspliced mRNA
Q24563281A bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates human immunodeficiency virus type 1 rev, env, vpu, and nef gene expression
Q38961890A functional conserved intronic G run in HIV-1 intron 3 is critical to counteract APOBEC3G-mediated host restriction.
Q30407389A long-awaited structure is rev-ealed
Q42613411A minimal uORF within the HIV-1 vpu leader allows efficient translation initiation at the downstream env AUG.
Q35883049A model system for human cytomegalovirus-mediated modulation of human immunodeficiency virus type 1 long terminal repeat activity in brain cells
Q39882220A naturally arising mutation of a potential silencer of exon splicing in human immunodeficiency virus type 1 induces dominant aberrant splicing and arrests virus production
Q34970601A new generation of HIV vaccines
Q33556837A novel HIV-1-encoded microRNA enhances its viral replication by targeting the TATA box region
Q37331638A novel approach for inhibition of HIV-1 by RNA interference: counteracting viral escape with a second generation of siRNAs
Q34365863A novel function for Sam68: enhancement of HIV-1 RNA 3' end processing
Q33653774A rev1-vpu polymorphism unique to HIV-1 subtype A and C strains impairs envelope glycoprotein expression from rev-vpu-env cassettes and reduces virion infectivity in pseudotyping assays
Q90218662A scale-free analysis of the HIV-1 genome demonstrates multiple conserved regions of structural and functional importance
Q25255588A suboptimal 5' splice site downstream of HIV-1 splice site A1 is required for unspliced viral mRNA accumulation and efficient virus replication
Q35094890A truncated hnRNP A1 isoform, lacking the RGG-box RNA binding domain, can efficiently regulate HIV-1 splicing and replication
Q33236503Acetylated Tat regulates human immunodeficiency virus type 1 splicing through its interaction with the splicing regulator p32.
Q33911993An exonic splicing silencer downstream of the 3' splice site A2 is required for efficient human immunodeficiency virus type 1 replication
Q36637774An integration-defective U5 deletion mutant of human immunodeficiency virus type 1 reverts by eliminating additional long terminal repeat sequences
Q39222999An intronic G run within HIV-1 intron 2 is critical for splicing regulation of vif mRNA.
Q38705930Analysis of Competing HIV-1 Splice Donor Sites Uncovers a Tight Cluster of Splicing Regulatory Elements within Exon 2/2b
Q42654734Analysis of Jembrana disease virus mRNA transcripts produced during acute infection demonstrates a complex transcription pattern
Q35149006Analysis of human immunodeficiency virus type 1 gene expression in latently infected resting CD4+ T lymphocytes in vivo
Q37348552Analysis of human immunodeficiency virus type 1 transcriptional elongation in resting CD4+ T cells in vivo
Q35088292Analysis of multiply spliced transcripts in lymphoid tissue reservoirs of rhesus macaques infected with RT-SHIV during HAART
Q24498349Architecture and secondary structure of an entire HIV-1 RNA genome
Q33580330Argonaute proteins regulate HIV-1 multiply spliced RNA and viral production in a Dicer independent manner
Q35575811Balanced splicing at the Tat-specific HIV-1 3'ss A3 is critical for HIV-1 replication
Q50176880Behind the scenes of HIV-1 replication: Alternative splicing as the dependency factor on the quiet.
Q61443390Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing
Q35857341Both linear and discontinuous ribosome scanning are used for translation initiation from bicistronic human immunodeficiency virus type 1 env mRNAs
Q36289312CDK11 in TREX/THOC Regulates HIV mRNA 3' End Processing
Q39764495CDK13, a new potential human immunodeficiency virus type 1 inhibitory factor regulating viral mRNA splicing
Q39194586Can the HIV-1 splicing machinery be targeted for drug discovery?
Q37012917Cell type specificity and structural determinants of IRES activity from the 5' leaders of different HIV-1 transcripts
Q36798408Cell-associated HIV RNA: a dynamic biomarker of viral persistence
Q35837198Changes in the viral mRNA expression pattern correlate with a rapid rate of CD4+ T-cell number decline in human immunodeficiency virus type 1-infected individuals
Q37584186Chapter 1. Regulation of HIV-1 alternative RNA splicing and its role in virus replication
Q37271140Characterization of novel inhibitors of HIV-1 replication that function via alteration of viral RNA processing and rev function
Q36364322Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.
Q38721805Characterizing HIV-1 Splicing by Using Next-Generation Sequencing
Q34309004Co-expression of HIV-1 virus-like particles and granulocyte-macrophage colony stimulating factor by GEO-D03 DNA vaccine
Q34671913Comparison of SIV and HIV-1 genomic RNA structures reveals impact of sequence evolution on conserved and non-conserved structural motifs
Q34260427Conserved stem-loop structures in the HIV-1 RNA region containing the A3 3' splice site and its cis-regulatory element: possible involvement in RNA splicing
Q33816167Contributions of viral splice sites and cis-regulatory elements to lentivirus vector function
Q35261679Converging strategies in expression of human complex retroviruses
Q39362365Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape.
Q35841354Defective accessory genes in a human immunodeficiency virus type 1-infected long-term survivor lacking recoverable virus
Q54225233Defining the molecular mechanisms of HIV-1 Tat secretion: PtdIns(4,5)P2 at the epicenter.
Q89086874Design of Gaussia luciferase-based bioluminescent stem-loop probe for sensitive detection of HIV-1 nucleic acids
Q96577275Determination of RNA structural diversity and its role in HIV-1 RNA splicing
Q33787285Development of multigene and regulated lentivirus vectors
Q35630437Differential Effects of Tra2ß Isoforms on HIV-1 RNA Processing and Expression
Q35143725Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy
Q41834943Differential effects of hnRNP D/AUF1 isoforms on HIV-1 gene expression.
Q33639362Diminished production of human immunodeficiency virus type 1 in astrocytes results from inefficient translation of gag, env, and nef mRNAs despite efficient expression of Tat and Rev
Q39608862Direct participation of Sam68, the 68-kilodalton Src-associated protein in mitosis, in the CRM1-mediated Rev nuclear export pathway
Q36672092Discovery and in vitro development of AIDS antiviral drugs as biopharmaceuticals
Q40410691Disruption of the putative splice acceptor site for SIV(mac239)Vif reveals tight control of SIV splicing and impaired replication in Vif non-permissive cells
Q21245209Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion production
Q38212068Dynamic Post-Transcriptional Regulation of HIV-1 Gene Expression
Q36368754Dynamic regulation of HIV-1 mRNA populations analyzed by single-molecule enrichment and long-read sequencing.
Q35871860Dynamics and modulation of human immunodeficiency virus type 1 transcripts in vitro and in vivo
Q57490234Dynamics of the Gene Regulatory Network of HIV-1 and the Role of Viral Non-coding RNAs on Latency Reversion
Q36390805Ectopic expression of anti-HIV-1 shRNAs protects CD8(+) T cells modified with CD4ζ CAR from HIV-1 infection and alleviates impairment of cell proliferation
Q40704048Efficient transcription through an intron requires the binding of an Sm-type U1 snRNP with intact stem loop II to the splice donor
Q47094347Elucidating the in vivo interactome of HIV-1 RNA by hybridization capture and mass spectrometry
Q52592924Emerging Roles of N6-Methyladenosine on HIV-1 RNA Metabolism and Viral Replication.
Q21133769Engineering HIV-1-resistant T-cells from short-hairpin RNA-expressing hematopoietic stem/progenitor cells in humanized BLT mice
Q61447142Epitranscriptomics: Correlation of N6-methyladenosine RNA methylation and pathway dysregulation in the hippocampus of HIV transgenic rats
Q35034904Evaluation of alignment algorithms for discovery and identification of pathogens using RNA-Seq
Q34416441Excessive RNA Splicing and Inhibition of HIV-1 Replication Induced by Modified U1 Small Nuclear RNAs
Q49674917Experiment Design for Early Molecular Events in HIV Infection.
Q92071667Expression Level of HIV-1 Vif Can Be Fluctuated by Natural Nucleotide Variations in the vif-Coding and Regulatory SA1D2prox Sequences of the Proviral Genome
Q35549754Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cells
Q33635315Expression of Herpes Simplex Virus Thymidine Kinase/Ganciclovir by RNA Trans-Splicing Induces Selective Killing of HIV-Producing Cells.
Q36479939Feline immunodeficiency virus OrfA alters gene expression of splicing factors and proteasome-ubiquitination proteins
Q43577959Focal glomerulosclerosis in proviral and c-fms transgenic mice links Vpr expression to HIV-associated nephropathy
Q60927723Focus on Translation Initiation of the HIV-1 mRNAs
Q30374877Functional bottlenecks for generation of HIV-1 intersubtype Env recombinants.
Q34239843Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag-encoded RNA.
Q36071452Gene activity in primary T cells infected with HIV89.6: intron retention and induction of genomic repeats.
Q35206871Gene transcription in HIV infection
Q92135927Genetic variation and function of the HIV-1 Tat protein
Q92623317Genome-Wide Analysis of Heterogeneous Nuclear Ribonucleoprotein (hnRNP) Binding to HIV-1 RNA Reveals a Key Role for hnRNP H1 in Alternative Viral mRNA Splicing
Q34249488Genomic HEXploring allows landscaping of novel potential splicing regulatory elements.
Q47548285Global synonymous mutagenesis identifies cis-acting RNA elements that regulate HIV-1 splicing and replication.
Q64071106Gymnotic Delivery of LNA Mixmers Targeting Viral SREs Induces HIV-1 mRNA Degradation
Q35829334HIV controls the selective packaging of genomic, spliced viral and cellular RNAs into virions through different mechanisms.
Q54214251HIV latency reversing agents act through Tat post translational modifications.
Q34033160HIV-1 Nef: a critical factor in viral-induced pathogenesis
Q30488459HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA.
Q36496484HIV-1 infection induces changes in expression of cellular splicing factors that regulate alternative viral splicing and virus production in macrophages
Q45372623HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3.
Q41705374HIV-1 splicing at the major splice donor site is restricted by RNA structure
Q40058710HIV-1 tolerates changes in A-count in a small segment of the pol gene
Q38234190HIV-1 translation and its regulation by cellular factors PKR and PACT.
Q64121615Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability
Q37062073Human Immunodeficiency Virus Type 1 hnRNP A/B-Dependent Exonic Splicing Silencer ESSV Antagonizes Binding of U2AF65 to Viral Polypyrimidine Tracts
Q89522955Human Tat-specific factor 1 binds the HIV-1 genome and selectively transports HIV-1 RNAs
Q24320192Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity
Q35835206Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines.
Q35835327Human immunodeficiency virus type 1 cellular RNA load and splicing patterns predict disease progression in a longitudinally studied cohort.
Q34353549Human immunodeficiency virus type 1 incorporated with fusion proteins consisting of integrase and the designed polydactyl zinc finger protein E2C can bias integration of viral DNA into a predetermined chromosomal region in human cells
Q40667670Human immunodeficiency virus type 1 latency model for high-throughput screening
Q42800068Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells
Q24599767Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles
Q42633019Identification of a novel splice acceptor in the HIV-1 genome: independent expression of the cytoplasmic tail of the envelope protein
Q39173758Identification of new and unusual rev and nef transcripts expressed by an HIV type 1 primary isolate
Q30413474Identification of new splice sites used for generation of rev transcripts in human immunodeficiency virus type 1 subtype C primary isolates
Q37607805Identification of small molecule modulators of HIV-1 Tat and Rev protein accumulation
Q40189962In vitro dimerization of human immunodeficiency virus type 1 (HIV-1) spliced RNAs
Q35066359In vivo SELEX of single-stranded domains in the HIV-1 leader RNA.
Q40739621Inhibition of HIV-1 replication by novel lentiviral vectors expressing transdominant Rev and HIV-1 env antisense
Q36850296Inhibition of HIV-1 transcription and replication by a newly identified cyclin T1 splice variant.
Q33827664Inhibition of splicing by serine-arginine rich protein 55 (SRp55) causes the appearance of partially spliced HIV-1 mRNAs in the cytoplasm
Q28083335Insights into the nuclear export of murine leukemia virus intron-containing RNA
Q43029724Insights into the selective activation of alternatively used splice acceptors by the human immunodeficiency virus type-1 bidirectional splicing enhancer
Q39804536Insulin-like growth factor II mRNA binding protein 1 modulates Rev-dependent human immunodeficiency virus type 1 RNA expression
Q33812392Integrase-lexA fusion proteins incorporated into human immunodeficiency virus type 1 that contains a catalytically inactive integrase gene are functional to mediate integration
Q89685622Integrated assessment of viral transcription, antigen presentation, and CD8+ T cell function reveal multiple limitations of class I selective HDACi during HIV-1 latency reversal
Q33340808Integration site selection by retroviral vectors: molecular mechanism and clinical consequences
Q28078564Interactions between the HIV-1 Unspliced mRNA and Host mRNA Decay Machineries
Q37194255Intracellular transport of human immunodeficiency virus type 1 genomic RNA and viral production are dependent on dynein motor function and late endosome positioning
Q52672265Intron retention in viruses and cellular genes: Detention, border controls and passports.
Q38635966Iron overload down-regulates the expression of the HIV-1 Rev cofactor eIF5A in infected T lymphocytes
Q35944232Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts
Q38188271Life of psi: how full-length HIV-1 RNAs become packaged genomes in the viral particles
Q39783741Limited complementarity between U1 snRNA and a retroviral 5' splice site permits its attenuation via RNA secondary structure
Q30373903Long lasting control of viral rebound with a new drug ABX464 targeting Rev - mediated viral RNA biogenesis.
Q61796320Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion
Q36858478MS3D structural elucidation of the HIV-1 packaging signal
Q35004179Mathematical model of the Tat-Rev regulation of HIV-1 replication in an activated cell predicts the existence of oscillatory dynamics in the synthesis of viral components
Q37131965Mechanisms employed by retroviruses to exploit host factors for translational control of a complicated proteome.
Q34063962Molecular genetics and target site specificity of retroviral integration
Q33565157Multi-Faceted Post-Transcriptional Functions of HIV-1 Rev.
Q38379102Multiple Origins of Virus Persistence during Natural Control of HIV Infection
Q38316167Multiple copies of the Mason-Pfizer monkey virus constitutive RNA transport element lead to enhanced HIV-1 Gag expression in a context-dependent manner.
Q43902042Mutational analysis of the internal membrane proximal domain of the HIV glycoprotein C-terminus.
Q34138829Mutations in matrix and SP1 repair the packaging specificity of a Human Immunodeficiency Virus Type 1 mutant by reducing the association of Gag with spliced viral RNA
Q36811895Natural Single-Nucleotide Variations in the HIV-1 Genomic SA1prox Region Can Alter Viral Replication Ability by Regulating Vif Expression Levels
Q37713854Natural single-nucleotide polymorphisms in the 3' region of the HIV-1 pol gene modulate viral replication ability
Q36633545Naturally occurring genotypes of the human immunodeficiency virus type 1 long terminal repeat display a wide range of basal and Tat-induced transcriptional activities.
Q38269023Nef of HIV-1 interacts directly with calcium-bound calmodulin
Q36540041Negative and positive mRNA splicing elements act competitively to regulate human immunodeficiency virus type 1 vif gene expression
Q41775010New way of regulating alternative splicing in retroviruses: the promoter makes a difference
Q22252434Newly identified host factors modulate HIV replication
Q89685656Next Generation Sequencing in a direct model of HIV infection reveals important parallels and differences to in vivo reservoir dynamics
Q35219990Next-generation sequencing reveals HIV-1-mediated suppression of T cell activation and RNA processing and regulation of noncoding RNA expression in a CD4+ T cell line
Q34381398Nuclear transport of human immunodeficiency virus type 1, visna virus, and equine infectious anemia virus Rev proteins: identification of a family of transferable nuclear export signals.
Q59131677Nucleolar Localization of HIV-1 Rev Is Required, Yet Insufficient for Production of Infectious Viral Particles
Q43727649Numerical modelling of the perturbation of HIV-1 during combination anti-retroviral therapy.
Q91804744On the generation of the MSD-Ѱ class of defective HIV proviruses
Q41851074On the role of four small hairpins in the HIV-1 RNA genome
Q43124783Optimization of human immunodeficiency virus type 1 envelope glycoproteins with V1/V2 deleted, using virus evolution
Q24291820Organization of the human tarbp2 gene reveals two promoters that are repressed in an astrocytic cell line
Q38982524Pokeweed antiviral protein alters splicing of HIV-1 RNAs, resulting in reduced virus production
Q36857076Posttranscriptional control of HIV-1 and other retroviruses and its practical applications
Q37261090Posttranscriptional regulation of retroviral gene expression: primary RNA transcripts play three roles as pre-mRNA, mRNA, and genomic RNA.
Q36554054Presence of exon splicing silencers within human immunodeficiency virus type 1 tat exon 2 and tat-rev exon 3: evidence for inhibition mediated by cellular factors
Q30450216Presence of negative and positive cis-acting RNA splicing elements within and flanking the first tat coding exon of human immunodeficiency virus type 1
Q47554842Production of HIV-1 vif mRNA Is Modulated by Natural Nucleotide Variations and SLSA1 RNA Structure in SA1D2prox Genomic Region
Q37272747Prolonged persistence of a novel replication-defective HIV-1 variant in plasma of a patient on suppressive therapy
Q40089005Puralpha as a cellular co-factor of Rev/RRE-mediated expression of HIV-1 intron-containing mRNA.
Q39084005RNA helicase MOV10 functions as a co-factor of HIV-1 Rev to facilitate Rev/RRE-dependent nuclear export of viral mRNAs
Q35652119RNA interference approaches for treatment of HIV-1 infection
Q33854295RNA splicing at human immunodeficiency virus type 1 3' splice site A2 is regulated by binding of hnRNP A/B proteins to an exonic splicing silencer element
Q28262840RNA structure modulates splicing efficiency at the human immunodeficiency virus type 1 major splice donor
Q39816401RNAi-mediated inhibition of HIV-1 by targeting partially complementary viral sequences
Q42148114RRE-deleting self-inactivating and self-activating HIV-1 vectors for improved safety
Q37538638Randomized Trial of Food Effect on Pharmacokinetic Parameters of ABX464 Administered Orally to Healthy Male Subjects
Q37204580Regulation of Vif mRNA splicing by human immunodeficiency virus type 1 requires 5' splice site D2 and an exonic splicing enhancer to counteract cellular restriction factor APOBEC3G
Q34546893Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression
Q33640055Regulation of virus release by the macrophage-tropic human immunodeficiency virus type 1 AD8 isolate is redundant and can be controlled by either Vpu or Env.
Q33839005Repair of a Rev-minus human immunodeficiency virus type 1 mutant by activation of a cryptic splice site.
Q36546903Replication of human immunodeficiency virus type 1 from entry to exit
Q36447124Retrovirus translation initiation: Issues and hypotheses derived from study of HIV-1
Q34033155Rev protein and its cellular partners
Q35634169Rev-dependent lentiviral expression vector
Q35079162Rev-ing up post-transcriptional HIV-1 RNA expression
Q39577905Ribosomal scanning on the 5'-untranslated region of the human immunodeficiency virus RNA genome
Q34351276Robust growth of human immunodeficiency virus type 1 (HIV-1)
Q35468374Role of HIV-1 RNA and protein determinants for the selective packaging of spliced and unspliced viral RNA and host U6 and 7SL RNA in virus particles
Q37033364Role of cellular RNA processing factors in human immunodeficiency virus type 1 mRNA metabolism, replication, and infectivity
Q35040210Roles of the linker region of RNA helicase A in HIV-1 RNA metabolism
Q39646678SR proteins and hnRNP H regulate the splicing of the HIV-1 tev-specific exon 6D.
Q35760531SRSF1 RNA Recognition Motifs Are Strong Inhibitors of HIV-1 Replication.
Q36975224Selective translational repression of HIV-1 RNA by Sam68DeltaC occurs by altering PABP1 binding to unspliced viral RNA
Q34351941Selectively reduced tat mRNA heralds the decline in productive human immunodeficiency virus type 1 infection in monocyte-derived macrophages
Q36063873Sequence Analysis of In Vivo-Expressed HIV-1 Spliced RNAs Reveals the Usage of New and Unusual Splice Sites by Viruses of Different Subtypes.
Q33649436Serine- and Arginine-rich Proteins 55 and 75 (SRp55 and SRp75) Induce Production of HIV-1 vpr mRNA by Inhibiting the 5′-Splice Site of Exon 3
Q45784451Single cell transcript analysis of human immunodeficiency virus gene expression in the transition from latent to productive infection
Q27319151Single-Cell and Single-Cycle Analysis of HIV-1 Replication
Q24682936Small interfering RNAs against the TAR RNA binding protein, TRBP, a Dicer cofactor, inhibit human immunodeficiency virus type 1 long terminal repeat expression and viral production
Q36518316Solution Structure of the HIV-1 Intron Splicing Silencer and Its Interactions with the UP1 Domain of Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A1
Q24807291Splicing of human immunodeficiency virus RNA is position-dependent suggesting sequential removal of introns from the 5' end
Q33824324Splicing regulatory elements within tat exon 2 of human immunodeficiency virus type 1 (HIV-1) are characteristic of group M but not group O HIV-1 strains.
Q97528833Stress proteins: the biological functions in virus infection, present and challenges for target-based antiviral drug development
Q38367292Targeting the HIV RNA genome: high-hanging fruit only needs a longer ladder
Q92240525Tat IRES modulator of tat mRNA (TIM-TAM): a conserved RNA structure that controls Tat expression and acts as a switch for HIV productive and latent infection
Q33455685Tat-SF1 is not required for Tat transactivation but does regulate the relative levels of unspliced and spliced HIV-1 RNAs
Q40628737The 0.3-kb fragment containing the R-U5-5'leader sequence of Friend murine leukemia virus influences the level of protein expression from spliced mRNA.
Q39237000The Alphabet Soup of HIV Reservoir Markers
Q34469824The HIV-1 Rev protein enhances encapsidation of unspliced and spliced, RRE-containing lentiviral vector RNA
Q30300217The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication
Q54216806The HIV-1 Tat protein enhances splicing at the major splice donor site.
Q45219002The HIV-1 major splice donor D1 is activated by splicing enhancer elements within the leader region and the p17-inhibitory sequence
Q92881205The Impact of Cellular Proliferation on the HIV-1 Reservoir
Q28076985The Life-Cycle of the HIV-1 Gag-RNA Complex
Q35888172The Vif and Gag proteins of human immunodeficiency virus type 1 colocalize in infected human T cells
Q35854386The envelope glycoprotein of human immunodeficiency virus type 2 enhances viral particle release: a Vpu-like factor?
Q33778676The exon splicing silencer in human immunodeficiency virus type 1 Tat exon 3 is bipartite and acts early in spliceosome assembly
Q32061728The expression of the essential nuclear splicing factor SC35 is altered by human immunodeficiency virus infection
Q38356070The hepatitis B virus posttranscriptional regulatory element is composed of two subelements
Q34362436The leader of the HIV-1 RNA genome forms a compactly folded tertiary structure
Q34667412The retrovirus RNA trafficking granule: from birth to maturity
Q34361775The role of overlapping U1 and U11 5' splice site sequences in a negative regulator of splicing
Q30440740The secondary structure of the human immunodeficiency virus type 1 transcript modulates viral splicing and infectivity
Q35220043The strength of the HIV-1 3' splice sites affects Rev function.
Q33700143The transcriptional transactivator Tat selectively regulates viral splicing.
Q38732658Thermodynamic and phylogenetic insights into hnRNP A1 recognition of the HIV-1 exon splicing silencer 3 element
Q33489159Thermodynamic profiling of HIV RREIIB RNA-zinc finger interactions
Q36607087Tra2-mediated recognition of HIV-1 5' splice site D3 as a key factor in the processing of vpr mRNA
Q30439325Trafficking through the Rev/RRE pathway is essential for efficient inhibition of human immunodeficiency virus type 1 by an antisense RNA derived from the envelope gene
Q39611742Transcription of preintegrated HIV-1 cDNA modulates cell surface expression of major histocompatibility complex class I via Nef.
Q34071895Transcription through the HIV-1 nucleosomes: effects of the PBAF complex in Tat activated transcription
Q34030804Transcriptional and posttranscriptional regulation of HIV-1 gene expression
Q26801493Translational Control of the HIV Unspliced Genomic RNA
Q33832420Translational regulation of HIV-1 replication by HIV-1 Rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3.
Q37247695Treatment with the fusion inhibitor enfuvirtide influences the appearance of mutations in the human immunodeficiency virus type 1 regulatory protein rev.
Q33653701U1 small nuclear ribonucleoprotein and splicing inhibition by the rous sarcoma virus negative regulator of splicing element.
Q35828687Unique insertion sequence and pattern of CD4 expression in variants selected with immunotoxins from human immunodeficiency virus type 1-infected T cells.
Q39101871Unusual Fusion Proteins of HIV-1
Q40198557Use of modified U1 snRNAs to inhibit HIV-1 replication
Q34983999Utilization of host SR protein kinases and RNA-splicing machinery during viral replication
Q33850355Vaccination with attenuated simian immunodeficiency virus by DNA inoculation
Q38739273Various plus unique: Viral protein U as a plurifunctional protein for HIV-1 replication
Q47548192What do we measure when we measure cell-associated HIV RNA.
Q35864679cis-acting elements in human immunodeficiency virus type 1 RNAs direct viral transcripts to distinct intranuclear locations.
Q33782866gag, vif, and nef genes contribute to the homologous viral interference induced by a nonproducer human immunodeficiency virus type 1 (HIV-1) variant: identification of novel HIV-1-inhibiting viral protein mutants
Q42621995hnRNP A1 controls HIV-1 mRNA splicing through cooperative binding to intron and exon splicing silencers in the context of a conserved secondary structure
Q35778000hnRNP E1 and E2 have distinct roles in modulating HIV-1 gene expression
Q58604866mA: Widespread regulatory control in virus replication

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