The strength of the HIV-1 3' splice sites affects Rev function.

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The strength of the HIV-1 3' splice sites affects Rev function. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1011683853
P356DOI10.1186/1742-4690-3-89
P932PMC publication ID1697824
P698PubMed publication ID17144911
P5875ResearchGate publication ID6653988

P50authorJørgen KjemsQ55277197
Marianne OtteQ57404647
P2093author name stringHeiner Schaal
Ilona Hauber
Joachim Hauber
Susanne Kammler
P2860cites workControl of HIV-1 env RNA splicing and transport: investigating the role of hnRNP A1 in exon splicing silencer (ESS3a) functionQ79096514
Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion productionQ21245209
HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim.Q24543241
A bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates human immunodeficiency virus type 1 rev, env, vpu, and nef gene expressionQ24563281
Splicing of human immunodeficiency virus RNA is position-dependent suggesting sequential removal of introns from the 5' endQ24807291
Extended base pair complementarity between U1 snRNA and the 5' splice site does not inhibit splicing in higher eukaryotes, but rather increases 5' splice site recognitionQ24812684
A suboptimal 5' splice site downstream of HIV-1 splice site A1 is required for unspliced viral mRNA accumulation and efficient virus replicationQ25255588
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
A novel human immunodeficiency virus type 1 protein, tev, shares sequences with tat, env, and rev proteinsQ28246228
In vitro interaction between human immunodeficiency virus type 1 Rev protein and splicing factor ASF/SF2-associated protein, p32Q28278287
Requirement of N-terminal amino acid residues of gp41 for human immunodeficiency virus type 1-mediated cell fusionQ28646837
Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNAQ28646843
CRM1 is responsible for intracellular transport mediated by the nuclear export signalQ29547861
ESEfinder: A web resource to identify exonic splicing enhancersQ29616126
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brainQ29618472
Exon Identity Established through Differential Antagonism between Exonic Splicing Silencer-Bound hnRNP A1 and Enhancer-Bound SR ProteinsQ30040281
Presence of negative and positive cis-acting RNA splicing elements within and flanking the first tat coding exon of human immunodeficiency virus type 1Q30450216
Intragenic cis-acting art gene-responsive sequences of the human immunodeficiency virusQ33562331
The exon splicing silencer in human immunodeficiency virus type 1 Tat exon 3 is bipartite and acts early in spliceosome assemblyQ33778676
U1 small nuclear RNA plays a direct role in the formation of a rev-regulated human immunodeficiency virus env mRNA that remains unsplicedQ33821654
Splicing regulatory elements within tat exon 2 of human immunodeficiency virus type 1 (HIV-1) are characteristic of group M but not group O HIV-1 strains.Q33824324
Selective modification of alternative splicing by indole derivatives that target serine-arginine-rich protein splicing factorsQ33853846
RNA splicing at human immunodeficiency virus type 1 3' splice site A2 is regulated by binding of hnRNP A/B proteins to an exonic splicing silencer elementQ33854295
An exonic splicing silencer downstream of the 3' splice site A2 is required for efficient human immunodeficiency virus type 1 replicationQ33911993
A second exon splicing silencer within human immunodeficiency virus type 1 tat exon 2 represses splicing of Tat mRNA and binds protein hnRNP H.Q33954292
SC35 and heterogeneous nuclear ribonucleoprotein A/B proteins bind to a juxtaposed exonic splicing enhancer/exonic splicing silencer element to regulate HIV-1 tat exon 2 splicingQ33974928
SF2/ASF binds to a splicing enhancer in the third HIV-1 tat exon and stimulates U2AF binding independently of the RS domain.Q34092879
Conserved stem-loop structures in the HIV-1 RNA region containing the A3 3' splice site and its cis-regulatory element: possible involvement in RNA splicingQ34260427
The sequence complementarity between HIV-1 5' splice site SD4 and U1 snRNA determines the steady-state level of an unstable env pre-mRNA.Q34363471
Solution structure of the pseudo-5' splice site of a retroviral splicing suppressorQ34365986
Splicing efficiency of human immunodeficiency virus type 1 tat RNA is determined by both a suboptimal 3' splice site and a 10 nucleotide exon splicing silencer element located within tat exon 2.Q34626299
The retrovirus RNA trafficking granule: from birth to maturityQ34667412
Mechanism of HIV-1 viral protein R-induced apoptosisQ35120771
Three recognition events at the branch-site adenine.Q35846398
Exon 1 leader sequences downstream of U5 are important for efficient human immunodeficiency virus type 1 gene expressionQ35880472
The spliceosome: a novel multi-faceted target for therapyQ36189908
Role of viral splicing elements and cellular RNA binding proteins in regulation of HIV-1 alternative RNA splicingQ36384842
Identification of positive and negative splicing regulatory elements within the terminal tat-rev exon of human immunodeficiency virus type 1.Q36554047
Presence of exon splicing silencers within human immunodeficiency virus type 1 tat exon 2 and tat-rev exon 3: evidence for inhibition mediated by cellular factorsQ36554054
Elements distinct from human immunodeficiency virus type 1 splice sites are responsible for the Rev dependence of env mRNA.Q36633363
Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity.Q36654112
Mutational inactivation of an inhibitory sequence in human immunodeficiency virus type 1 results in Rev-independent gag expressionQ36687102
Scanning and competition between AGs are involved in 3' splice site selection in mammalian intronsQ36695561
Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1Q36806618
Structure and expression of tat-, rev-, and nef-specific transcripts of human immunodeficiency virus type 1 in infected lymphocytes and macrophagesQ36810554
A functional interaction between Rev and yeast pre-mRNA is related to splicing complex formationQ37635903
Substrate specificities of SR proteins in constitutive splicing are determined by their RNA recognition motifs and composite pre-mRNA exonic elementsQ39444777
The hnRNP A1 protein regulates HIV-1 tat splicing via a novel intron silencer element.Q39645951
SR proteins and hnRNP H regulate the splicing of the HIV-1 tev-specific exon 6D.Q39646678
A naturally arising mutation of a potential silencer of exon splicing in human immunodeficiency virus type 1 induces dominant aberrant splicing and arrests virus productionQ39882220
A novel splice donor site in the gag-pol gene is required for HIV-1 RNA stabilityQ40283703
A novel approach to describe a U1 snRNA binding site.Q40315328
Two strong 5' splice sites and competing, suboptimal 3' splice sites involved in alternative splicing of human immunodeficiency virus type 1 RNA.Q41271968
Analysis of alternatively spliced human immunodeficiency virus type-1 mRNA species, one of which encodes a novel tat-env fusion proteinQ41657615
hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicingQ41679293
Regulation by HIV Rev depends upon recognition of splice sitesQ41758926
hnRNP A1 controls HIV-1 mRNA splicing through cooperative binding to intron and exon splicing silencers in the context of a conserved secondary structureQ42621995
The D1-A2 and D2-A2 pairs of splice sites from human immunodeficiency virus type 1 are highly efficient in vitro, in spite of an unusual branch siteQ45761048
The HIV 'A' (sor) gene product is essential for virus infectivityQ45847960
Use of DNA end joining activity of a Xenopus laevis egg extract for construction of deletions and expression vectors for HIV-1 Tat and Rev proteinsQ49152914
A Janus splicing regulatory element modulates HIV-1 tat and rev mRNA production by coordination of hnRNP A1 cooperative binding.Q52548171
Interactions of INS (CRS) elements and the splicing machinery regulate the production of Rev-responsive mRNAsQ71020737
Inefficient spliceosome assembly and abnormal branch site selection in splicing of an HIV-1 transcript in vitroQ71823431
Overlapping cis sites used for splicing of HIV-1 env/nef and rev mRNAsQ77678068
P304page(s)89
P577publication date2006-12-04
P1433published inRetrovirologyQ15793508
P1476titleThe strength of the HIV-1 3' splice sites affects Rev function
P478volume3

Reverse relations

cites work (P2860)
Q38961890A functional conserved intronic G run in HIV-1 intron 3 is critical to counteract APOBEC3G-mediated host restriction.
Q90218662A scale-free analysis of the HIV-1 genome demonstrates multiple conserved regions of structural and functional importance
Q37677066Alternative splicing: regulation of HIV-1 multiplication as a target for therapeutic action
Q39222999An intronic G run within HIV-1 intron 2 is critical for splicing regulation of vif mRNA.
Q38705930Analysis of Competing HIV-1 Splice Donor Sites Uncovers a Tight Cluster of Splicing Regulatory Elements within Exon 2/2b
Q35575811Balanced splicing at the Tat-specific HIV-1 3'ss A3 is critical for HIV-1 replication
Q50176880Behind the scenes of HIV-1 replication: Alternative splicing as the dependency factor on the quiet.
Q39194586Can the HIV-1 splicing machinery be targeted for drug discovery?
Q37584186Chapter 1. Regulation of HIV-1 alternative RNA splicing and its role in virus replication
Q34671913Comparison of SIV and HIV-1 genomic RNA structures reveals impact of sequence evolution on conserved and non-conserved structural motifs
Q35261679Converging strategies in expression of human complex retroviruses
Q34169373Correct mRNA processing at a mutant TT splice donor in FANCC ameliorates the clinical phenotype in patients and is enhanced by delivery of suppressor U1 snRNAs.
Q35143725Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy
Q92071667Expression Level of HIV-1 Vif Can Be Fluctuated by Natural Nucleotide Variations in the vif-Coding and Regulatory SA1D2prox Sequences of the Proviral Genome
Q37152994Extensive purifying selection acting on synonymous sites in HIV-1 Group M sequences
Q36479939Feline immunodeficiency virus OrfA alters gene expression of splicing factors and proteasome-ubiquitination proteins
Q34249488Genomic HEXploring allows landscaping of novel potential splicing regulatory elements.
Q47548285Global synonymous mutagenesis identifies cis-acting RNA elements that regulate HIV-1 splicing and replication.
Q37323917HIV-1 Vpr N-terminal tagging affects alternative splicing of the viral genome
Q41591221Heterogenous nuclear ribonucleoprotein Q increases protein expression from HIV-1 Rev-dependent transcripts
Q39790727Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV Rev protein
Q43029724Insights into the selective activation of alternatively used splice acceptors by the human immunodeficiency virus type-1 bidirectional splicing enhancer
Q39783741Limited complementarity between U1 snRNA and a retroviral 5' splice site permits its attenuation via RNA secondary structure
Q64072075Modulation of HIV-1 gene expression by binding of a ULM motif in the Rev protein to UHM-containing splicing factors
Q33565157Multi-Faceted Post-Transcriptional Functions of HIV-1 Rev.
Q36811895Natural Single-Nucleotide Variations in the HIV-1 Genomic SA1prox Region Can Alter Viral Replication Ability by Regulating Vif Expression Levels
Q37713854Natural single-nucleotide polymorphisms in the 3' region of the HIV-1 pol gene modulate viral replication ability
Q36540041Negative and positive mRNA splicing elements act competitively to regulate human immunodeficiency virus type 1 vif gene expression
Q36481243Position-dependent splicing activation and repression by SR and hnRNP proteins rely on common mechanisms.
Q47554842Production of HIV-1 vif mRNA Is Modulated by Natural Nucleotide Variations and SLSA1 RNA Structure in SA1D2prox Genomic Region
Q52423047Programmable design of functional ribonucleoprotein complexes.
Q35079162Rev-ing up post-transcriptional HIV-1 RNA expression
Q42247651Stable assembly of HIV-1 export complexes occurs cotranscriptionally.
Q38286131The HIV-1 Tat protein has a versatile role in activating viral transcription
Q45219002The HIV-1 major splice donor D1 is activated by splicing enhancer elements within the leader region and the p17-inhibitory sequence
Q36515503The impact of multiple splice sites in human L1 elements
Q36368449The influenza A virus spliced messenger RNA M mRNA3 is not required for viral replication in tissue culture
Q36607087Tra2-mediated recognition of HIV-1 5' splice site D3 as a key factor in the processing of vpr mRNA
Q34030804Transcriptional and posttranscriptional regulation of HIV-1 gene expression
Q37349210Transcriptional errors in human immunodeficiency virus type 1 generate targets for T-cell responses

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