Identification of a new quaternary neutralizing epitope on human immunodeficiency virus type 1 virus particles

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Identification of a new quaternary neutralizing epitope on human immunodeficiency virus type 1 virus particles is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.79.8.5232-5237.2005
P932PMC publication ID1069558
P698PubMed publication ID15795308

P50authorLeonidas StamatatosQ89197121
P2093author name stringMiroslaw K Gorny
Susan Zolla-Pazner
Barbara Volsky
Constance Williams
Kathy Revesz
Xiao-Hong Wang
Sandra Cohen
Robert Staudinger
P2860cites workAccess of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1Q24645530
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibodyQ27759364
Human immunodeficiency virus (HIV) envelope binds to CXCR4 independently of CD4, and binding can be enhanced by interaction with soluble CD4 or by HIV envelope deglycosylation.Q28646878
Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibodyQ29618366
Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1Q29619512
Generation of neutralizing human monoclonal antibodies against parvovirus B19 proteinsQ33653001
Neutralization Profiles of Primary Human Immunodeficiency Virus Type 1 Isolates in the Context of Coreceptor UsageQ33783714
An Envelope Modification That Renders a Primary, Neutralization-Resistant Clade B Human Immunodeficiency Virus Type 1 Isolate Highly Susceptible to Neutralization by Sera from Other CladesQ33784679
Mapping of epitopes exposed on intact human immunodeficiency virus type 1 (HIV-1) virions: a new strategy for studying the immunologic relatedness of HIV-1.Q33785510
Conserved and exposed epitopes on intact, native, primary human immunodeficiency virus type 1 virions of group M.Q33809112
Identification of gp120 regions targeted by a highly potent neutralizing antiserum elicited in a chimpanzee inoculated with a primary human immunodeficiency virus type 1 isolateQ33811940
Generation of human monoclonal antibodies to human immunodeficiency virusQ33841011
Production of site-selected neutralizing human monoclonal antibodies against the third variable domain of the human immunodeficiency virus type 1 envelope glycoproteinQ34097650
Human monoclonal antibodies specific for conformation-sensitive epitopes of V3 neutralize human immunodeficiency virus type 1 primary isolates from various clades.Q34145199
Human anti-V2 monoclonal antibody that neutralizes primary but not laboratory isolates of human immunodeficiency virus type 1Q34292765
A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1Q34306804
The V1/V2 domain of gp120 is a global regulator of the sensitivity of primary human immunodeficiency virus type 1 isolates to neutralization by antibodies commonly induced upon infectionQ34317025
The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.Q34342352
Serotyping of primary human immunodeficiency virus type 1 isolates from diverse geographic locations by flow cytometry.Q35839973
Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein.Q35857331
Constitutive cell surface association between CD4 and CCR5.Q36397946
Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1.Q36623941
Immunochemical analysis of the gp120 surface glycoprotein of human immunodeficiency virus type 1: probing the structure of the C4 and V4 domains and the interaction of the C4 domain with the V3 loopQ36651187
Genetic and functional analysis of full-length human immunodeficiency virus type 1 env genes derived from brain and blood of patients with AIDS.Q36890344
The v3 loop is accessible on the surface of most human immunodeficiency virus type 1 primary isolates and serves as a neutralization epitope.Q36954472
Another discontinuous epitope on glycoprotein gp120 that is important in human immunodeficiency virus type 1 neutralization is identified by a monoclonal antibodyQ37603996
Small amino acid sequence changes within the V2 domain can affect the function of a T-cell line-tropic human immunodeficiency virus type 1 envelope gp120.Q39143635
V2 loop glycosylation of the human immunodeficiency virus type 1 SF162 envelope facilitates interaction of this protein with CD4 and CCR5 receptors and protects the virus from neutralization by anti-V3 loop and anti-CD4 binding site antibodiesQ39592261
Induction and characterization of neutralizing antibodies against a human immunodeficiency virus type 1 primary isolateQ39603619
Distinct modes of human immunodeficiency virus type 1 proviral latency revealed by superinfection of nonproductively infected cell lines with recombinant luciferase-encoding viruses.Q40038787
Relationship of the human immunodeficiency virus type 1 gp120 third variable loop to a component of the CD4 binding site in the fourth conserved regionQ40061779
Generation of Human Monoclonal Antibodies against HIV-1 Proteins; Electrofusion and Epstein-Barr Virus Transformation for Peripheral Blood Lymphocyte ImmortalizationQ41478638
An IgG human monoclonal antibody that reacts with HIV-1/GP120, inhibits virus binding to cells, and neutralizes infectionQ41679452
Pre- and postexposure protection against human immunodeficiency virus type 1 infection mediated by a monoclonal antibodyQ44781672
V3-Specific Polyclonal Antibodies Affinity Purified from Sera of Infected Humans Effectively Neutralize Primary Isolates of Human Immunodeficiency Virus Type 1Q45734123
Passive immunization with a human immunodeficiency virus type 1-neutralizing monoclonal antibody in Hu-PBL-SCID mice: isolation of a neutralization escape variantQ45756890
Prevention of HIV-1 infection in chimpanzees by gpl20 V3 domain-specific monoclonal antibodyQ46352552
Prevention of HIV infection by passive immunization with HIV immunoglobulinQ47571809
Repertoire of neutralizing human monoclonal antibodies specific for the V3 domain of HIV-1 gp120Q72067428
Neutralization of animal virusesQ72886254
Characterization of human monoclonal antibodies selected with a hypervariable loop-deleted recombinant HIV-1(IIIB) gp120Q74618553
Evidence for CD4-enchanced signaling through the chemokine receptor CCR5Q78806608
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectvirusQ808
P304page(s)5232-5237
P577publication date2005-04-01
P1433published inJournal of VirologyQ1251128
P1476titleIdentification of a new quaternary neutralizing epitope on human immunodeficiency virus type 1 virus particles
P478volume79

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cites work (P2860)
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