Vaccine-induced V1V2-specific antibodies control and or protect against infection with HIV, SIV and SHIV

scientific article published on 01 July 2019

Vaccine-induced V1V2-specific antibodies control and or protect against infection with HIV, SIV and SHIV is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1097/COH.0000000000000551
P932PMC publication ID6542703
P698PubMed publication ID30994501

P50authorXiang-Peng KongQ41629080
P2093author name stringSusan Zolla-Pazner
Raymond Alvarez
Svenja Weiss
P2860cites workHIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cellsQ22251066
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9Q27644478
Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2Q27675879
Functional and immunochemical cross-reactivity of V2-specific monoclonal antibodies from HIV-1-infected individualsQ27677941
Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loopsQ27678226
Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine targetQ29547347
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in ThailandQ29547531
HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation timeQ29547822
Immune-correlates analysis of an HIV-1 vaccine efficacy trialQ29617377
The V1V2 Region of HIV-1 gp120 Forms a Five-Stranded Beta BarrelQ30152923
Antibodies with high avidity to the gp120 envelope protein in protection from simian immunodeficiency virus SIV(mac251) acquisition in an immunization regimen that mimics the RV-144 Thai trialQ30532861
A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin StructureQ33592001
Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challengeQ33804531
Conserved and exposed epitopes on intact, native, primary human immunodeficiency virus type 1 virions of group M.Q33809112
Detection of antibody-dependent complement-mediated inactivation of both autologous and heterologous virus in primary human immunodeficiency virus type 1 infectionQ33834852
Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems SerologyQ33851717
V1V2-specific complement activating serum IgG as a correlate of reduced HIV-1 infection risk in RV144.Q33874253
HIV-1 Vpu antagonism of tetherin inhibits antibody-dependent cellular cytotoxic responses by natural killer cells.Q33887674
HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activitiesQ33900395
Multiple vaccine-elicited nonneutralizing antienvelope antibody activities contribute to protective efficacy by reducing both acute and chronic viremia following simian/human immunodeficiency virus SHIV89.6P challenge in rhesus macaquesQ33966586
Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccinationQ33977866
Nonneutralizing functional antibodies: a new "old" paradigm for HIV vaccinesQ34057711
Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimerQ34292319
Human anti-V2 monoclonal antibody that neutralizes primary but not laboratory isolates of human immunodeficiency virus type 1Q34292765
Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2Q34298408
The V1/V2 domain of gp120 is a global regulator of the sensitivity of primary human immunodeficiency virus type 1 isolates to neutralization by antibodies commonly induced upon infectionQ34317025
Activation of complement on the surface of cells infected by human immunodeficiency virusQ41744013
Non-neutralizing Antibodies Targeting the V1V2 Domain of HIV Exhibit Strong Antibody-Dependent Cell-mediated Cytotoxic Activity.Q41924059
Polyfunctional Fc-effector profiles mediated by IgG subclass selection distinguish RV144 and VAX003 vaccinesQ42230293
Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelopeQ46331384
Recombinant gp120 vaccine-induced antibodies inhibit clinical strains of HIV-1 in the presence of Fc receptor-bearing effector cells and correlate inversely with HIV infection rateQ46775963
Non-Neutralizing Antibodies Directed against HIV and Their FunctionsQ47139556
Human immunodeficiency virus type-1 (HIV-1) evades antibody-dependent phagocytosis.Q47215816
HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among VaccineesQ47547483
Functional Antibody Response Against V1V2 and V3 of HIV gp120 in the VAX003 and VAX004 Vaccine Trials.Q47555452
Reduced cell-associated DNA and improved viral control in macaques following passive transfer of a single anti-V2 monoclonal antibody and repeated SHIV challenges.Q51743315
High-resolution definition of humoral immune response correlates of effective immunity against HIV.Q55022148
Analysis of complement-mediated lysis of SIV and SIV-infected cells reveals sex differences in vaccine-induced immune responses in Rhesus macaquesQ56517281
Control of Heterologous Simian Immunodeficiency Virus SIV Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in MacaquesQ56517308
Partially Open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and FusionQ57283084
Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7Q57751823
Common helical V1V2 conformations of HIV-1 Envelope expose the α4β7 binding site on intact virionsQ58115616
V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC ActivityQ60959639
Vaccine-elicited antibodies mediate antibody-dependent cellular cytotoxicity correlated with significantly reduced acute viremia in rhesus macaques challenged with SIVmac251Q64378954
Route of immunization defines multiple mechanisms of vaccine-mediated protection against SIVQ91276841
Plasma IgG to linear epitopes in the V2 and V3 regions of HIV-1 gp120 correlate with a reduced risk of infection in the RV144 vaccine efficacy trialQ34374835
Vaccine-induced IgG antibodies to V1V2 regions of multiple HIV-1 subtypes correlate with decreased risk of HIV-1 infectionQ34402934
Identification of a new quaternary neutralizing epitope on human immunodeficiency virus type 1 virus particlesQ34406977
Rationally Designed Vaccines Targeting the V2 Region of HIV-1 gp120 Induce a Focused, Cross-Clade-Reactive, Biologically Functional Antibody Response.Q34540352
Analysis of V2 antibody responses induced in vaccinees in the ALVAC/AIDSVAX HIV-1 vaccine efficacy trialQ34562259
Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibodyQ34630446
Epitope mapping of conformational V2-specific anti-HIV human monoclonal antibodies reveals an immunodominant site in V2.Q34907398
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virionsQ35006601
Antibody to the gp120 V1/V2 loops and CD4+ and CD8+ T cell responses in protection from SIVmac251 vaginal acquisition and persistent viremiaQ35105449
Structure and immune recognition of trimeric pre-fusion HIV-1 Env.Q35142291
Dynamic antibody specificities and virion concentrations in circulating immune complexes in acute to chronic HIV-1 infectionQ35363127
Identification of antibody glycosylation structures that predict monoclonal antibody Fc-effector functionQ35600028
Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeysQ35729899
Identification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin ReceptorQ35857404
Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV ControlQ35888710
Short Communication: Virion Aggregation by Neutralizing and Nonneutralizing Antibodies to the HIV-1 Envelope GlycoproteinQ36294806
Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene familyQ36363231
Neutralization of human immunodeficiency virus type 1 by complement occurs by viral lysisQ36795915
Infectious virion capture by HIV-1 gp120-specific IgG from RV144 vaccineesQ36978671
Correlation of vaccine-elicited systemic and mucosal nonneutralizing antibody activities with reduced acute viremia following intrarectal simian immunodeficiency virus SIVmac251 challenge of rhesus macaquesQ37033311
Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategiesQ37184296
Contribution of nonneutralizing vaccine-elicited antibody activities to improved protective efficacy in rhesus macaques immunized with Tat/Env compared with multigenic vaccines.Q37347813
Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeysQ37355237
Rationally Designed Immunogens Targeting HIV-1 gp120 V1V2 Induce Distinct Conformation-Specific Antibody Responses in RabbitsQ37448281
Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.Q37625296
Enhanced FCGR2A and FCGR3A signaling by HIV viremic controller IgG.Q37646897
Monoclonal Antibodies Specific for the V2, V3, CD4-Binding Site, and gp41 of HIV-1 Mediate Phagocytosis in a Dose-Dependent MannerQ38719420
Plasticity and Epitope Exposure of the HIV-1 Envelope Trimer.Q38725480
Potent neutralization of primary HIV-1 isolates by antibodies directed against epitopes present in the V1/V2 domain of HIV-1 gp120.Q39357299
Purification, Characterization, and Immunogenicity of a Soluble Trimeric Envelope Protein Containing a Partial Deletion of the V2 Loop Derived from SF162, an R5-Tropic Human Immunodeficiency Virus Type 1 IsolateQ39484956
Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisitionQ39726192
Human monoclonal antibody 2909 binds to pseudovirions expressing trimers but not monomeric HIV-1 envelope proteinsQ39845715
Protection against HIV Acquisition in the RV144 TrialQ40137608
Nonneutralizing antibodies are able to inhibit human immunodeficiency virus type 1 replication in macrophages and immature dendritic cellsQ40274328
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 4.0 InternationalQ24082749
P433issue4
P921main subjectHIV vaccineQ1479804
human immunodeficiency virus infectious diseaseQ18556697
RNA virus infectious diseaseQ18967413
simian acquired immunodeficiency syndromeQ19000697
P304page(s)309-317
P577publication date2019-07-01
P1433published inCurrent Opinion in HIV and AIDSQ15724409
P1476titleVaccine-induced V1V2-specific antibodies control and or protect against infection with HIV, SIV and SHIV
P478volume14

Reverse relations

cites work (P2860)
Q93038056HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions
Q92689689Revisiting the Correlate of Reduced HIV Infection Risk in the Rv144 Vaccine Trial
Q92538999Update on Fc-Mediated Antibody Functions Against HIV-1 Beyond Neutralization
Q92478519V2-Specific Antibodies in HIV-1 Vaccine Research and Natural Infection: Controllers or Surrogate Markers

Search more.