Development of broadly neutralizing antibodies from autologous neutralizing antibody responses in HIV infection

scientific article

Development of broadly neutralizing antibodies from autologous neutralizing antibody responses in HIV infection is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/COH.0000000000000057
P3181OpenCitations bibliographic resource ID3789110
P932PMC publication ID4068799
P698PubMed publication ID24662931

P50authorPenny MooreQ55079169
Lynn MorrisQ70377150
P2093author name stringCynthia A. Derdeyn
P2860cites workHIV-1 superinfection in women broadens and strengthens the neutralizing antibody responseQ21090490
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Co-evolution of a broadly neutralizing HIV-1 antibody and founder virusQ27644501
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Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep SequencingQ27671696
Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2Q27675879
Viral Escape from Neutralizing Antibodies in Early Subtype A HIV-1 Infection Drives an Increase in Autologous Neutralization BreadthQ27676728
Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibodyQ27677011
Rational HIV Immunogen Design to Target Specific Germline B Cell ReceptorsQ27677104
Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 NeutralizationQ27677117
The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV AntibodiesQ27680688
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Broad neutralization coverage of HIV by multiple highly potent antibodiesQ29615361
Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responsesQ37718722
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Broadly neutralizing antibodies against HIV-1: templates for a vaccineQ38065391
Vaccine design: emerging concepts and renewed optimismQ38087785
Genetic characteristics of HIV-1 subtype C envelopes inducing cross-neutralizing antibodiesQ43611862
Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginningQ46683819
A sweet surprise for HIV broadly neutralizing antibodiesQ85389317
Escape from autologous neutralizing antibodies in acute/early subtype C HIV-1 infection requires multiple pathwaysQ33504599
Limited neutralizing antibody specificities drive neutralization escape in early HIV-1 subtype C infectionQ33504604
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Characteristics of the earliest cross-neutralizing antibody response to HIV-1.Q33798076
Isolation of a monoclonal antibody that targets the alpha-2 helix of gp120 and represents the initial autologous neutralizing-antibody response in an HIV-1 subtype C-infected individualQ33912373
Infection by discordant strains of HIV-1 markedly enhances the neutralizing antibody response against heterologous virusQ34120140
Broadly neutralizing antiviral antibodiesQ34323311
Evolution of cross-neutralizing antibody specificities to the CD4-BS and the carbohydrate cloak of the HIV Env in an HIV-1-infected subjectQ34478071
The B cell response is redundant and highly focused on V1V2 during early subtype C infection in a Zambian seroconverterQ34485260
Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbsQ34539819
Analysis of V2 antibody responses induced in vaccinees in the ALVAC/AIDSVAX HIV-1 vaccine efficacy trialQ34562259
Genome-wide association study on the development of cross-reactive neutralizing antibodies in HIV-1 infected individualsQ34571277
Chimeric HIV-1 envelope glycoproteins with potent intrinsic granulocyte-macrophage colony-stimulating factor (GM-CSF) activityQ34658136
Potent and broad neutralization of HIV-1 subtype C by plasma antibodies targeting a quaternary epitope including residues in the V2 loopQ34742533
An HIV-1 envelope glycoprotein trimer with an embedded IL-21 domain activates human B cellsQ34796885
Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypesQ35034268
The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infectionQ35076717
Targeting HIV-1 envelope glycoprotein trimers to B cells by using APRIL improves antibody responsesQ35826171
Longitudinal analysis of early HIV-1-specific neutralizing activity in an elite neutralizer and in five patients who developed cross-reactive neutralizing activityQ35826458
Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine designQ35868076
Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope proteinQ36131738
The development of CD4 binding site antibodies during HIV-1 infectionQ36155396
B-lymphocyte dysfunction in chronic HIV-1 infection does not prevent cross-clade neutralization breadth.Q36171833
Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escapeQ36388754
Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodiesQ36750045
Multiple pathways of escape from HIV broadly cross-neutralizing V2-dependent antibodiesQ36760049
Evolution of broadly cross-reactive HIV-1-neutralizing activity: therapy-associated decline, positive association with detectable viremia, and partial restoration of B-cell subpopulationsQ37254327
Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors.Q37318213
Breadth of neutralizing antibody response to human immunodeficiency virus type 1 is affected by factors early in infection but does not influence disease progressionQ37356036
HIV-1 envelope glycoprotein signatures that correlate with the development of cross-reactive neutralizing activity.Q37360774
The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expressionQ37409232
Diverse recombinant HIV-1 Envs fail to activate B cells expressing the germline B cell receptors of the broadly neutralizing anti-HIV-1 antibodies PG9 and 447-52D.Q37644030
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
P304page(s)210-6
P577publication date2014-05-01
P1433published inCurrent Opinion in HIV and AIDSQ15724409
P1476titleDevelopment of broadly neutralizing antibodies from autologous neutralizing antibody responses in HIV infection
P478volume9