Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in Southern Africa

scientific article

Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in Southern Africa is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.01730-06
P932PMC publication ID1642599
P698PubMed publication ID16971434

P50authorVictoria R PolonisQ89151700
Cynthia A DerdeynQ94562588
Elwyn ChombaQ108185341
Kelli GreeneQ114434977
Salim Abdool KarimQ18161438
Bette KorberQ30505218
Carolyn WilliamsonQ70376235
Lynn MorrisQ70377150
Koleka MlisanaQ46535610
Beatrice H. HahnQ55293537
Jesus F Salazar-GonzalezQ57415418
David C. MontefioriQ63302725
P2093author name stringMing Zhang
Ming Li
Feng Gao
Yingying Li
James E Robinson
Kunxue Hong
Susan Allen
Eric Hunter
Joseph Mulenga
Julie M Decker
Cheswa Vwalika
Maria G Salazar
Miroslawa Bilska
Jintao Zhou
P2860cites workPatterns of amino acid variability in NSI-like and SI-like V3 sequences and a linked change in the CD4-binding domain of the HIV-1 Env proteinQ74029048
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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceQ24286950
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Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidatesQ27489000
Antibody domain exchange is an immunological solution to carbohydrate cluster recognitionQ27641517
Structural analysis of the epitope of the anti-HIV antibody 2F5 sheds light into its mechanism of neutralization and HIV fusionQ27641682
A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequencesQ27860580
Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120.Q28217208
Insensitivity of paediatric HIV-1 subtype C viruses to broadly neutralising monoclonal antibodies raised against subtype BQ28469023
CD4-Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: consequences for virus entry and neutralizationQ28646881
A conserved HIV gp120 glycoprotein structure involved in chemokine receptor bindingQ28646883
Antibody neutralization and escape by HIV-1Q29547345
Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDSQ29614260
Fast and sensitive multiple sequence alignments on a microcomputerQ29618252
Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibodyQ29618366
Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodiesQ29619015
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sitesQ29619017
Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.Q29619254
Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1.Q29622903
Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41.Q31016954
Biologic and genetic characterization of a panel of 60 human immunodeficiency virus type 1 isolates, representing clades A, B, C, D, CRF01_AE, and CRF02_AG, for the development and assessment of candidate vaccinesQ33780524
Characterization of human immunodeficiency virus type 1 (HIV-1) envelope variation and neutralizing antibody responses during transmission of HIV-1 subtype B.Q33780595
Selection for human immunodeficiency virus type 1 envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levelsQ33780649
Characterization of simian-human immunodeficiency virus envelope glycoprotein epitopes recognized by neutralizing antibodies from infected monkeysQ33785114
Sequential CD4-coreceptor interactions in human immunodeficiency virus type 1 Env function: soluble CD4 activates Env for coreceptor-dependent fusion and reveals blocking activities of antibodies against cryptic conserved epitopes on gp120.Q33794954
Characterization of V3 sequence heterogeneity in subtype C human immunodeficiency virus type 1 isolates from Malawi: underrepresentation of X4 variants.Q33816465
Increased neutralization sensitivity of CD4-independent human immunodeficiency virus variantsQ33850415
Recommendations for the design and use of standard virus panels to assess neutralizing antibody responses elicited by candidate human immunodeficiency virus type 1 vaccinesQ33911935
Understanding the genetic diversity of HIV-1.Q34087006
Diversity considerations in HIV-1 vaccine selectionQ34136023
Principal neutralizing domain of the human immunodeficiency virus type 1 envelope proteinQ34301897
A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1Q34306804
Regional clustering of shared neutralization determinants on primary isolates of clade C human immunodeficiency virus type 1 from South AfricaQ34332009
The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120.Q34341843
The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.Q34342352
A variable region 3 (V3) mutation determines a global neutralization phenotype and CD4-independent infectivity of a human immunodeficiency virus type 1 envelope associated with a broadly cross-reactive, primary virus-neutralizing antibody responseQ34357078
Prospects for vaccine protection against HIV-1 infection and AIDS.Q34542236
Evidence for potent autologous neutralizing antibody titers and compact envelopes in early infection with subtype C human immunodeficiency virus type 1Q34648079
The CCR5 and CXCR4 coreceptors are both used by human immunodeficiency virus type 1 primary isolates from subtype C.Q34781878
Defining the Protective Antibody Response for HIV-1Q35109054
Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor bindingQ35845976
Inter- and intraclade neutralization of human immunodeficiency virus type 1: genetic clades do not correspond to neutralization serotypes but partially correspond to gp120 antigenic serotypes.Q35853750
Multiple aligned sequence editor (MASE)Q67269453
A novel enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to HIV-1 envelope glycoproteins based on immobilization of viral glycoproteins in microtiter wells coated with concanavalin AQ68536789
Sexual behavior of HIV discordant couples after HIV counseling and testingQ73149539
Fine definition of a conserved CCR5-binding region on the human immunodeficiency virus type 1 glycoprotein 120Q73824497
Quantitative analysis of serum neutralization of human immunodeficiency virus type 1 from subtypes A, B, C, D, E, F, and I: lack of direct correlation between neutralization serotypes and genetic subtypes and evidence for prevalent serum-dependent iQ35853761
Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein.Q35857331
Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loopQ35893615
Change in coreceptor use correlates with disease progression in HIV-1--infected individualsQ36376800
Inhibition of virus attachment to CD4+ target cells is a major mechanism of T cell line-adapted HIV-1 neutralizationQ36380741
Antigenic conservation and immunogenicity of the HIV coreceptor binding siteQ36403587
Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoproteinQ36549382
Cryptic nature of envelope V3 region epitopes protects primary monocytotropic human immunodeficiency virus type 1 from antibody neutralizationQ36635390
Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infectionQ36647820
Mutational analysis of conserved N-linked glycosylation sites of human immunodeficiency virus type 1 gp41Q36694013
Genital tract reservoirsQ37446855
Resistance to V3-directed neutralization caused by an N-linked oligosaccharide depends on the quaternary structure of the HIV-1 envelope oligomerQ38359871
Absence of coreceptor switch with disease progression in human immunodeficiency virus infections in IndiaQ38935437
Macrophage tropism of human immunodeficiency virus type 1 and utilization of the CC-CKR5 coreceptor.Q38943221
The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infectionQ38949380
Effect of major deletions in the V1 and V2 loops of a macrophage-tropic HIV type 1 isolate on viral envelope structure, cell entry, and replicationQ39485916
Safety of multiple daily applications of COL-1492, a nonoxynol-9 vaginal gel, among female sex workers. COL-1492 Phase II Study GroupQ39547647
Comparison of the antibody repertoire generated in healthy volunteers following immunization with a monomeric recombinant gp120 construct derived from a CCR5/CXCR4-using human immunodeficiency virus type 1 isolate with sera from naturally infected iQ39549660
CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.Q39605077
Evaluation of antiviral drugs and neutralizing antibodies to human immunodeficiency virus by a rapid and sensitive microtiter infection assay.Q40191379
Perspective: hypothesis: serum IgG antibody is sufficient to confer protection against infectious diseases by inactivating the inoculumQ40538332
Epitope mapping and characterization of a novel CD4-induced human monoclonal antibody capable of neutralizing primary HIV-1 strainsQ40621073
Characterization and selection of HIV-1 subtype C isolates for use in vaccine developmentQ40663802
Characterization of CD4-induced epitopes on the HIV type 1 gp120 envelope glycoprotein recognized by neutralizing human monoclonal antibodiesQ40682865
A potent cross-clade neutralizing human monoclonal antibody against a novel epitope on gp41 of human immunodeficiency virus type 1.Q40757568
Immunization with recombinant canarypox vectors expressing membrane-anchored glycoprotein 120 followed by glycoprotein 160 boosting fails to generate antibodies that neutralize R5 primary isolates of human immunodeficiency virus type 1.Q40832863
CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.Q41151327
Differential role of V3-specific antibodies in neutralization assays involving primary and laboratory-adapted isolates of HIV type 1.Q41276031
A broadly neutralizing human monoclonal antibody against gp41 of human immunodeficiency virus type 1.Q41419602
An N-glycan within the human immunodeficiency virus type 1 gp120 V3 loop affects virus neutralizationQ43451743
HIV-1: nature's master of disguiseQ44031352
Induction of immune responses to HIV-1 by canarypox virus (ALVAC) HIV-1 and gp120 SF-2 recombinant vaccines in uninfected volunteers. NIAID AIDS Vaccine Evaluation GroupQ45752018
Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1. The National Institute of Allergy and Infectious Diseases AIDS Vaccine EvQ45771982
HIV-1 genomic RNA diversification following sexual and parenteral virus transmissionQ45873185
HIV vaccine design and the neutralizing antibody problemQ46474020
Envelope-constrained neutralization-sensitive HIV-1 after heterosexual transmissionQ47878972
A role for carbohydrates in immune evasion in AIDS.Q47982875
Genetic analysis of the complete gag and env genes of HIV type 1 subtype C primary isolates from South AfricaQ48332662
P433issue23
P407language of work or nameEnglishQ1860
P921main subjectSouthern AfricaQ27394
P304page(s)11776-11790
P577publication date2006-09-13
P1433published inJournal of VirologyQ1251128
P1476titleGenetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in Southern Africa
P478volume80

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Q37410770Mechanism of human immunodeficiency virus type 1 resistance to monoclonal antibody B12 that effectively targets the site of CD4 attachment
Q40290511Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.
Q42241364Mitigation of variation observed in a peripheral blood mononuclear cell (PBMC) based HIV-1 neutralization assay by donor cell pooling
Q30376865Molecular mechanisms of recombination restriction in the envelope gene of the human immunodeficiency virus
Q92147755Multimeric Epitope-Scaffold HIV Vaccines Target V1V2 and Differentially Tune Polyfunctional Antibody Responses
Q35129224Multimodality vaccination against clade C SHIV: partial protection against mucosal challenges with a heterologous tier 2 virus
Q30368471Mutations in HIV-1 envelope that enhance entry with the macaque CD4 receptor alter antibody recognition by disrupting quaternary interactions within the trimer.
Q36099045N-linked glycan modifications in gp120 of human immunodeficiency virus type 1 subtype C render partial sensitivity to 2G12 antibody neutralization
Q34109778Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41.
Q34304203Neutralisation of HIV-1 cell-cell spread by human and llama antibodies.
Q30537665Neutralization sensitivity of HIV-1 subtype B' clinical isolates from former plasma donors in China
Q47562235Neutralization tiers of HIV-1.
Q33382060Neutralization-sensitive R5-tropic simian-human immunodeficiency virus SHIV-2873Nip, which carries env isolated from an infant with a recent HIV clade C infection
Q35208657Neutralizing and other antiviral antibodies in HIV-1 infection and vaccination
Q33887693Neutralizing antibodies against HIV-1: can we elicit them with vaccines and how much do we need?
Q37519312Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine?
Q35857268Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection
Q34637968Neutralizing antibody responses in macaques induced by human immunodeficiency virus type 1 monovalent or trivalent envelope glycoproteins
Q27021279Origin of the transmitted virus in HIV infection: infected cells versus cell-free virus
Q41925528Owl monkey CCR5 reveals synergism between CD4 and CCR5 in HIV-1 entry
Q38659318Panels of HIV-1 Subtype C Env Reference Strains for Standardized Neutralization Assessments
Q47109778Patterns of conserved gp120 epitope presentation on attached HIV-1 virions
Q36281817Phenotypic Correlates of HIV-1 Macrophage Tropism
Q35192915Phenotypic and immunologic comparison of clade B transmitted/founder and chronic HIV-1 envelope glycoproteins
Q30402036Phylogenetic structure in African HIV-1 subtype C revealed by selective sequential pruning
Q36694846Pilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates
Q24635002Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals
Q36588632Postnatally-transmitted HIV-1 Envelope variants have similar neutralization-sensitivity and function to that of nontransmitted breast milk variants
Q34284855Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization
Q34742533Potent and broad neutralization of HIV-1 subtype C by plasma antibodies targeting a quaternary epitope including residues in the V2 loop
Q89592396Preclinical Optimization of gp120 Entry Antagonists as anti-HIV-1 Agents with Improved Cytotoxicity and ADME Properties through Rational Design, Synthesis, and Antiviral Evaluation
Q30374995Preclinical studies of human immunodeficiency virus/AIDS vaccines: inverse correlation between avidity of anti-Env antibodies and peak postchallenge viremia.
Q34551010Prime-boost immunization of rabbits with HIV-1 gp120 elicits potent neutralization activity against a primary viral isolate
Q35160124Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges
Q36974754Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C.
Q33640144R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models
Q34540352Rationally Designed Vaccines Targeting the V2 Region of HIV-1 gp120 Induce a Focused, Cross-Clade-Reactive, Biologically Functional Antibody Response.
Q34539819Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs
Q92288781Recombinant HIV-1 vaccine candidates based on replication-defective flavivirus vector
Q30657338Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth
Q36977750Reduced MyD88 dependency of ISCOMATRIX™ adjuvant in a DNA prime-protein boost HIV vaccine
Q36155365Refined identification of neutralization-resistant HIV-1 CRF02_AG viruses
Q36837815Relationship of HIV-1 and SIV envelope glycoprotein trimer occupation and neutralization
Q34357068Replication competent molecular clones of HIV-1 expressing Renilla luciferase facilitate the analysis of antibody inhibition in PBMC.
Q33961704Resistance to the CCR5 inhibitor 5P12-RANTES requires a difficult evolution from CCR5 to CXCR4 coreceptor use.
Q39723388Role of complex carbohydrates in human immunodeficiency virus type 1 infection and resistance to antibody neutralization
Q24650458Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component
Q41933070Screening of primary gp120 immunogens to formulate the next generation polyvalent DNA prime-protein boost HIV-1 vaccines
Q37370674Selection of HIV variants with signature genotypic characteristics during heterosexual transmission
Q40076041Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers
Q64979797Selective use of primate CD4 receptors by HIV-1.
Q58598623Sensitivity to Broadly Neutralizing Antibodies of Recently Transmitted HIV-1 Clade CRF02_AG Viruses with a Focus on Evolution over Time
Q36132706Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C.
Q36634965Short communication: HIV type 1 subtype C variants transmitted through the bottleneck of breastfeeding are sensitive to new generation broadly neutralizing antibodies directed against quaternary and CD4-binding site epitopes
Q39455602Single-chain Fv-based anti-HIV proteins: potential and limitations
Q37084521Soluble CD4 broadens neutralization of V3-directed monoclonal antibodies and guinea pig vaccine sera against HIV-1 subtype B and C reference viruses
Q37510603Soluble HIV-1 envelope immunogens derived from an elite neutralizer elicit cross-reactive V1V2 antibodies and low potency neutralizing antibodies
Q34415389Specificity of the autologous neutralizing antibody response
Q36138144Standardized assessment of NAb responses elicited in rhesus monkeys immunized with single- or multi-clade HIV-1 envelope immunogens
Q90438646Stoichiometric Analyses of Soluble CD4 to Native-like HIV-1 Envelope by Single-Molecule Fluorescence Spectroscopy
Q27660384Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity
Q36364955Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity
Q27678493Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors
Q59359981Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120
Q90212036Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes
Q35947805Susceptibility of recently transmitted subtype B human immunodeficiency virus type 1 variants to broadly neutralizing antibodies
Q59351886Synthesis, Antiviral Activity, and Structure-Activity Relationship of 1,3-Benzodioxolyl Pyrrole-Based Entry Inhibitors Targeting the Phe43 Cavity in HIV-1 gp120
Q33664910Temporal analysis of HIV envelope sequence evolution and antibody escape in a subtype A-infected individual with a broad neutralizing antibody response
Q27000889The Antibody Response against HIV-1
Q40091554The HIV Genomic Incidence Assay Meets False Recency Rate and Mean Duration of Recency Infection Performance Standards
Q26786540The HIV glycan shield as a target for broadly neutralizing antibodies
Q35973578The Vaginal Acquisition and Dissemination of HIV-1 Infection in a Novel Transgenic Mouse Model Is Facilitated by Coinfection with Herpes Simplex Virus 2 and Is Inhibited by Microbicide Treatment.
Q34982698The breadth and potency of passively acquired human immunodeficiency virus type 1-specific neutralizing antibodies do not correlate with the risk of infant infection
Q36483346The c3-v4 region is a major target of autologous neutralizing antibodies in human immunodeficiency virus type 1 subtype C infection
Q30367176The challenges of eliciting neutralizing antibodies to HIV-1 and to influenza virus.
Q37283747The differential binding and activity of PRO 2000 against diverse HIV-1 envelopes.
Q35140408The genetic bottleneck in vertical transmission of subtype C HIV-1 is not driven by selection of especially neutralization-resistant virus from the maternal viral population
Q37036454The griffithsin dimer is required for high-potency inhibition of HIV-1: evidence for manipulation of the structure of gp120 as part of the griffithsin dimer mechanism
Q37667754The implications of patterns in HIV diversity for neutralizing antibody induction and susceptibility.
Q37333734The infectious molecular clone and pseudotyped virus models of human immunodeficiency virus type 1 exhibit significant differences in virion composition with only moderate differences in infectivity and inhibition sensitivity
Q35743210The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4(+) cells
Q40144203The mutable vaccine for mutable viruses
Q35076717The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection
Q34017550The presence of glutamine at position 315 but not epitope masking predominantly hinders HIV subtype C neutralization by the anti-V3 antibody B4e8.
Q37547702The selection of low envelope glycoprotein reactivity to soluble CD4 and cold during simian-human immunodeficiency virus infection of rhesus macaques.
Q33614365Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodies
Q36000722Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7
Q33826682Two N-linked glycosylation sites in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 regulate viral neutralization susceptibility to the human monoclonal antibody specific for the CD4 binding domain
Q35943810UCLA1, a synthetic derivative of a gp120 RNA aptamer, inhibits entry of human immunodeficiency virus type 1 subtype C
Q41932027Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes
Q37256661Utilization of immunoglobulin G Fc receptors by human immunodeficiency virus type 1: a specific role for antibodies against the membrane-proximal external region of gp41.
Q27332360Vaccination against heterologous R5 clade C SHIV: prevention of infection and correlates of protection
Q42204816Vaccine focusing to cross-subtype HIV-1 gp120 variable loop epitopes.
Q58591002Variable infectivity and conserved engagement in cell-to-cell viral transfer by HIV-1 Env from Clade B transmitted founder clones
Q34203163Variations in autologous neutralization and CD4 dependence of b12 resistant HIV-1 clade C env clones obtained at different time points from antiretroviral naïve Indian patients with recent infection
Q27676728Viral Escape from Neutralizing Antibodies in Early Subtype A HIV-1 Infection Drives an Increase in Autologous Neutralization Breadth
Q37240053Viral load and CD4+ T-cell dynamics in primary HIV-1 subtype C infection.
Q37333754Virus entry via the alternative coreceptors CCR3 and FPRL1 differs by human immunodeficiency virus type 1 subtype
Q38936957Vpx complementation of 'non-macrophage tropic' R5 viruses reveals robust entry of infectious HIV-1 cores into macrophages.
Q35192660epitopes immediately below the base of the V3 loop of gp120 as targets for the initial autologous neutralizing antibody response in two HIV-1 subtype B-infected individuals
Q33348658sCD4-17b bifunctional protein: extremely broad and potent neutralization of HIV-1 Env pseudotyped viruses from genetically diverse primary isolates

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