Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7

scientific article

Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1002686
P932PMC publication ID3364951
P698PubMed publication ID22693444
P5875ResearchGate publication ID225302002

P50authorBarton HaynesQ4865631
Michael P. BuschQ6833284
Sallie R PermarQ87955622
John C TiltonQ87983772
Michael R. BettsQ88295419
Shilpa IyerQ91778068
John C KappesQ92482518
Erica H ParrishQ114423041
Bhavna HoraQ114512865
Jennifer HopperQ114512867
Haitao DingQ114512868
Tatenda MahlokozeraQ114512869
Beatrice H. HahnQ55293537
Nicholas F ParrishQ56771203
Jesus F Salazar-GonzalezQ57415418
David C. MontefioriQ63302725
George M. ShawQ78514357
Christina OchsenbauerQ86991008
Craig B WilenQ38590407
P2093author name stringFeng Gao
Marion Vermeulen
Amit Kumar
Jennifer M Pfaff
Robert W Doms
Julie M Decker
Maria G Salazar
Anna Berg
Lauren B Banks
Sally Yuan
Charl Coleman
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A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactorsQ28118386
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A rev1-vpu polymorphism unique to HIV-1 subtype A and C strains impairs envelope glycoprotein expression from rev-vpu-env cassettes and reduces virion infectivity in pseudotyping assaysQ33653774
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Donor and recipient envs from heterosexual human immunodeficiency virus subtype C transmission pairs require high receptor levels for entryQ33769382
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HIV-1 resistance to CCR5 antagonists associated with highly efficient use of CCR5 and altered tropism on primary CD4+ T cellsQ33990552
The glycan shield of HIV is predominantly oligomannose independently of production system or viral clade.Q33999756
A signature in HIV-1 envelope leader peptide associated with transition from acute to chronic infection impacts envelope processing and infectivityQ34005516
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HIV-1 replication in the central nervous system occurs in two distinct cell types.Q34050421
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Identification of amino acid substitutions associated with neutralization phenotype in the human immunodeficiency virus type-1 subtype C gp120.Q34428738
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Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivityQ35101464
Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in Southern AfricaQ35140032
HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodiesQ35192641
Phenotypic and immunologic comparison of clade B transmitted/founder and chronic HIV-1 envelope glycoproteinsQ35192915
Role of donor genital tract HIV-1 diversity in the transmission bottleneckQ35558621
Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelopeQ35598496
Topographic distribution of homing receptors on B and T cells in human gut-associated lymphoid tissue: relation of L-selectin and integrin alpha 4 beta 7 to naive and memory phenotypesQ35765315
Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entryQ35784750
Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophagesQ35826158
The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytesQ36028490
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CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitroQ36377185
Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencingQ36540055
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Blocking of α4β7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaquesQ36952767
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The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infectionQ37273195
Heterosexual transmission of human immunodeficiency virus type 1 subtype C: Macrophage tropism, alternative coreceptor use, and the molecular anatomy of CCR5 utilization.Q37275049
Human immunodeficiency virus type 1 V1-to-V5 envelope variants from the chronic phase of infection use CCR5 and fuse more efficiently than those from early after infection.Q37356028
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P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P921main subjectHIVQ15787
HIV transmissionQ49029021
P304page(s)e1002686
P577publication date2012-05-31
P1433published inPLOS PathogensQ283209
P1476titleTransmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7
P478volume8

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