Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity.

scientific article published on 17 November 2017

Bacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity. is …
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scholarly articleQ13442814

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P819ADS bibcode2017NatCo...8.1601P
P356DOI10.1038/S41467-017-01640-Y
P932PMC publication ID5693931
P698PubMed publication ID29150603

P50authorIan A WilsonQ87680387
Ralph PantophletQ89306380
Paul KosmaQ41464649
P2093author name stringSasha Murrell
Caitlin Rempel
Dennis Chau
Naiomi Lu
Nino Trattnig
P2860cites workFew and far between: how HIV may be evading antibody avidityQ21090507
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The HIV glycan shield as a target for broadly neutralizing antibodiesQ26786540
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan ShieldQ27675032
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120Q27678306
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Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 TrimersQ37695592
A bacterial lipooligosaccharide that naturally mimics the epitope of the HIV-neutralizing antibody 2G12 as a template for vaccine design.Q38327409
Immunological Outcomes of Antibody Binding to Glycans Shared between Microorganisms and MammalsQ39013747
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HIV-1 Virus-Like Particles Bearing Pure Env Trimers Expose Neutralizing Epitopes but Occlude Nonneutralizing EpitopesQ39402539
Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin MiceQ39407795
Immune perturbations in HIV-1-infected individuals who make broadly neutralizing antibodiesQ40103798
Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.Q40290511
A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans.Q40606158
Affinity Dependence of the B Cell Response to Antigen: A Threshold, a Ceiling, and the Importance of Off-RateQ41027647
Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV.Q42215329
Human antibody expression in transgenic rats: comparison of chimeric IgH loci with human VH, D and JH but bearing different rat C-gene regionsQ44182322
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Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunityQ28378893
High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH regionQ28709119
9G4 autoreactivity is increased in HIV-infected patients and correlates with HIV broadly neutralizing serum activityQ28730532
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Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic toleranceQ33591736
Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman PrimatesQ33612459
Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffoldsQ33840789
Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP TrimersQ33907694
Oligosaccharide chains are trimmed during synthesis of the envelope glycoprotein of vesicular stomatitis virusQ33961274
The presence of glutamine at position 315 but not epitope masking predominantly hinders HIV subtype C neutralization by the anti-V3 antibody B4e8.Q34017550
The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120.Q34342352
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N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of functionQ34594978
Characterization of human class-switched polymeric (immunoglobulin M [IgM] and IgA) anti-human immunodeficiency virus type 1 antibodies 2F5 and 2G12.Q34781840
Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelopeQ34991017
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Cross Reactive Material 197 glycoconjugate vaccines contain privileged conjugation sitesQ35913681
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Rational chemical design of the carbohydrate in a glycoconjugate vaccine enhances IgM-to-IgG switchingQ36557966
Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice.Q36627503
A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120Q36748055
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Immune Tolerance Negatively Regulates B Cells in Knock-In Mice Expressing Broadly Neutralizing HIV Antibody 4E10Q37171251
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Immunization with Outer Membrane Vesicles Displaying Designer Glycotopes Yields Class-Switched, Glycan-Specific AntibodiesQ37425396
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P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectinfectivityQ1662346
alpha-D-Manp-(1->2)-alpha-D-Manp-(1->3)-alpha-D-ManpQ27139646
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAcQ27139648
P304page(s)1601
P577publication date2017-11-17
P1433published inNature CommunicationsQ573880
P1476titleBacterially derived synthetic mimetics of mammalian oligomannose prime antibody responses that neutralize HIV infectivity
P478volume8

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cites work (P2860)
Q89859143A convenient synthesis of short-chain α-(1 → 2) mannopyranosyl oligosaccharides
Q90677040Antibody responses to the HIV-1 envelope high mannose patch
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Q60908253Comparative antigenicity of thiourea- and adipic amide linked neoglycoconjugates containing modified oligomannose epitopes for the carbohydrate-specific anti-HIV antibody 2G12
Q92932606Comparisons of the antibody repertoires of a humanized rodent and humans by high throughput sequencing
Q92006841Cooperation between somatic mutation and germline-encoded residues enables antibody recognition of HIV-1 envelope glycans
Q63362961Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities
Q64983102Protein and Glycan Mimicry in HIV Vaccine Design.
Q94554546Serum alpha-mannosidase as an additional barrier to eliciting oligomannose-specific HIV-1-neutralizing antibodies
Q64099089Synthesis of an Undecasaccharide Featuring an Oligomannosidic Heptasaccharide and a Bacterial Kdo-lipid A Backbone for Eliciting Neutralizing Antibodies to Mammalian Oligomannose on the HIV-1 Envelope Spike
Q89936366The Impact of Sustained Immunization Regimens on the Antibody Response to Oligomannose Glycans

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