Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.

scientific article published on 31 May 2018

Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CHOM.2018.04.018
P932PMC publication ID6002614
P698PubMed publication ID29861171

P50authorBarton HaynesQ4865631
Mattia BonsignoriQ56808332
David EasterhoffQ89359808
Kevin WieheQ89359811
Munir AlamQ89520930
Wilton B WilliamsQ89520935
P2093author name stringThomas B Kepler
R Ryan Meyerhoff
William J Faison
Todd Bradley
Kevin O Saunders
Connor Hart
P2860cites workbNAber: database of broadly neutralizing HIV antibodiesQ24567758
Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individualsQ24635002
Related Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationQ27000758
Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic AntibodyQ27644415
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virusQ27644501
Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01Q27663293
Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 BindingQ27670829
Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2Q27675879
Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 NeutralizationQ27677117
Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class AntibodiesQ27679353
Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and GQ27704710
H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccinationQ28743596
Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope GlycoproteinQ29306052
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in ThailandQ29547531
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Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodiesQ29619015
Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput immunoglobulin sequencing dataQ30706182
Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman PrimatesQ33612459
Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodiesQ33614365
Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic HypermutationQ33654599
Stepwise intraclonal maturation of antibody affinity through somatic hypermutationQ33664973
Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1.Q33693391
Early development of broadly neutralizing antibodies in HIV-1-infected infantsQ33764917
Variants from the diverse virus population identified at seroconversion of a clade A human immunodeficiency virus type 1-infected woman have distinct biological propertiesQ33814773
Host controls of HIV broadly neutralizing antibody developmentQ39108769
Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infectionQ39278529
Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodiesQ40118226
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Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine DesignQ40679052
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Reconstructing a B-cell clonal lineage. I. Statistical inference of unobserved ancestorsQ41818598
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutationQ44486460
The nucleotide-replacement spectrum under somatic hypermutation exhibits microsequence dependence that is strand-symmetric and distinct from that under germline mutationQ44872484
Developing an HIV vaccineQ47852386
Immunologic memory to phosphocholine keyhole limpet hemocyanin. Recurrent mutations in the lambda 1 light chain increase affinity for antigenQ52079184
Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms.Q55487007
Monitoring and interpreting the intrinsic features of somatic hypermutationQ61628475
Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germlineQ34075820
Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodiesQ34114798
Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodiesQ34177732
Germinal centersQ34245271
Global panel of HIV-1 Env reference strains for standardized assessments of vaccine-elicited neutralizing antibodiesQ34392963
Immunoglobulin somatic hypermutationQ34638632
The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infectionQ35076717
Genetic and neutralization properties of subtype C human immunodeficiency virus type 1 molecular env clones from acute and early heterosexually acquired infections in Southern AfricaQ35140032
Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestorsQ35382871
Dynamics of B cells in germinal centresQ35446555
HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodiesQ35728947
CATNAP: a tool to compile, analyze and tally neutralizing antibody panelsQ35810109
Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophagesQ35826158
Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine designQ35868076
Ability to develop broadly neutralizing HIV-1 antibodies is not restricted by the germline Ig gene repertoireQ35883727
Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding SiteQ35943521
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogenQ35969973
Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.Q36112751
Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spotsQ36172034
Boosting of HIV envelope CD4 binding site antibodies with long variable heavy third complementarity determining region in the randomized double blind RV305 HIV-1 vaccine trial.Q36290038
Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 InfectionQ36444787
Antigenicity and immunogenicity of RV144 vaccine AIDSVAX clade E envelope immunogen is enhanced by a gp120 N-terminal deletionQ36559838
Molecular mechanisms of antibody somatic hypermutation.Q36747477
Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodiesQ36750045
HIV-1 Neutralizing Antibodies with Limited Hypermutation from an InfantQ37059216
Visualizing antibody affinity maturation in germinal centersQ37078589
Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineagesQ37221575
Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing AntibodiesQ37246321
HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing AntibodiesQ37293480
Immunologic Basis for Long HCDR3s in Broadly Neutralizing Antibodies Against HIV-1.Q38219407
Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody GenesQ38388195
Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor RepertoiresQ38747466
Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity MaturationQ38988188
P433issue6
P304page(s)759-765.e6
P577publication date2018-05-31
P1433published inCell Host & MicrobeQ5058153
P1476titleFunctional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.
P478volume23

Reverse relations

cites work (P2860)
Q95278620A facile technology for the high-throughput sequencing of the paired VH:VL and TCRβ:TCRα repertoires
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Q96122822Pandemic Preparedness: Developing Vaccines and Therapeutic Antibodies For COVID-19
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Q90044905VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage

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