| scholarly article | Q13442814 |
| P819 | ADS bibcode | 1988PNAS...85.8206K |
| P356 | DOI | 10.1073/PNAS.85.21.8206 |
| P932 | PMC publication ID | 282396 |
| P698 | PubMed publication ID | 3263647 |
| P5875 | ResearchGate publication ID | 19891956 |
| P50 | author | Klaus Rajewsky | Q126992 |
| P2093 | author name string | Kocks C | |
| P2860 | cites work | Lambda Charon vectors (Ch32, 33, 34 and 35) adapted for DNA cloning in recombination-deficient hosts | Q43496848 |
| The T-cell-independent immune response to the hapten NP uses a large repertoire of heavy chain genes | Q46529670 | ||
| Sodium dodecyl sulfate electrophoresis of high molecular weight proteins in N, N'-diallyltartardiamide-cross-linked polyacrylamide slab gels | Q47326485 | ||
| Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses | Q48348065 | ||
| The molecular evolution of the immune response: idiotope-specific suppression indicates that B cells express germ-line-encoded V genes prior to antigenic stimulation | Q68809092 | ||
| Contributions of immunoglobulin heavy and light chains to antibody specificity for lysozyme and two haptens | Q69013232 | ||
| The predicted structure of immunoglobulin D1.3 and its comparison with the crystal structure | Q70300738 | ||
| Utilization of the biotin/avidin system to amplify the sensitivity of the enzyme-linked immunosorbent assay (ELISA) | Q71689200 | ||
| DNA sequencing with chain-terminating inhibitors | Q22066207 | ||
| Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 | Q25938983 | ||
| Rapid and efficient site-specific mutagenesis without phenotypic selection | Q27860608 | ||
| Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination | Q27860827 | ||
| Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter | Q29614259 | ||
| Supercoil sequencing: a fast and simple method for sequencing plasmid DNA | Q29618184 | ||
| A V region determinant (idiotope) expressed at high frequency in B lymphocytes is encoded by a large set of antibody structural genes | Q33939362 | ||
| Organization of the constant-region gene family of the mouse immunoglobulin heavy chain | Q34270140 | ||
| Three-dimensional structure of an antibody-antigen complex | Q34366479 | ||
| Three-dimensional structure of a complex of antibody with influenza virus neuraminidase | Q34393544 | ||
| Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase | Q35340408 | ||
| Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin | Q36261566 | ||
| Somatic diversification of immunoglobulins. | Q36266886 | ||
| Structural basis for the specificity of antibody–antigen reactions and structural mechanisms for the diversification of antigen-binding specificities | Q36946912 | ||
| Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation | Q37577496 | ||
| Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells | Q37618235 | ||
| Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line | Q37675025 | ||
| Molecular mechanisms of transmembrane signaling in B lymphocytes | Q38175922 | ||
| Antigen-binding myeloma proteins of mice | Q39482737 | ||
| Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response | Q39606535 | ||
| Timing, genetic requirements and functional consequences of somatic hypermutation during B-cell development. | Q39658899 | ||
| Evolutionary and somatic selection of the antibody repertoire in the mouse. | Q39682090 | ||
| A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines | Q39683818 | ||
| Cell Selection by Antigen in the Immune Response | Q39985236 | ||
| 7 Synthetic adaptors for cloning DNA | Q40293135 | ||
| Improved oligonucleotide site-directed mutagenesis using M13 vectors. | Q40470764 | ||
| 'Enhancer-constitutive' vectors for the expression of recombinant antibodies | Q40536510 | ||
| Somatic mutation and clonal expansion of B cells in an antigen-driven immune response. | Q41380981 | ||
| Sequence analysis of non-expressed immunoglobulin heavy chain loci in clonally related, somatically mutated hybridoma cells | Q41431804 | ||
| Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells. | Q41459613 | ||
| Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP | Q42573237 | ||
| Antibody engineering for the analysis of affinity maturation of an anti-hapten response. | Q42735546 | ||
| P433 | issue | 21 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | antibody | Q79460 |
| P304 | page(s) | 8206-8210 | |
| P577 | publication date | 1988-11-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Stepwise intraclonal maturation of antibody affinity through somatic hypermutation | |
| P478 | volume | 85 |
| Q30646098 | "Affinity maturation" of ligands for HCV-specific serum antibodies |
| Q36101141 | A Public Database of Memory and Naive B-Cell Receptor Sequences |
| Q42604824 | A human anti-insulin IgG autoantibody apparently arises through clonal selection from an insulin-specific "germ-line" natural antibody template. Analysis by V gene segment reassortment and site-directed mutagenesis |
| Q41264930 | A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro |
| Q42680119 | A human germ line antibody light chain with hydrolytic properties associated with multimerization status |
| Q24806189 | A surrogate-based approach for post-genomic partner identification |
| Q42142851 | Activated germinal centre B cells undergo directed migration |
| Q39022761 | Affinity maturation of an ERBB2-targeted SPECT imaging peptide by in vivo phage display |
| Q36364275 | Altering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation |
| Q57258540 | An explanation for the defect in secretion of IgM Mott cells and their predominant occurrence in the Ly-1 B cell compartment |
| Q52107714 | Antibodies of different human IgG subclasses show distinct patterns of affinity maturation after immunization with keyhole limpet haemocyanin. |
| Q52867245 | Biased immunoglobulin variable region gene expression by Ly-1 B cells due to clonal selection. |
| Q38863529 | Bos taurus ultralong CDR H3 antibodies. |
| Q36354162 | Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene |
| Q35180027 | Building Antibodies from their Genes |
| Q41002744 | Clonal selection and learning in the antibody system |
| Q42185336 | Clonal selection in the germinal centre by regulated proliferation and hypermutation |
| Q37340809 | Conformational inactivation induces immunogenicity of the receptor-binding pocket of a bacterial adhesin |
| Q36229997 | Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response |
| Q36020766 | Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection |
| Q33711133 | FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen |
| Q28294153 | Follicular dendritic cells and germinal centers |
| Q55356257 | Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development. |
| Q36231063 | Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response |
| Q39553791 | HUMORAL IMMUNITY. T cell help controls the speed of the cell cycle in germinal center B cells. |
| Q90788276 | IL-9 receptor signaling in memory B cells regulates humoral recall responses |
| Q41384865 | IgH and L chain variable region gene sequence analyses of twelve synovial tissue-derived B cell lines producing IgA, IgG, and IgM rheumatoid factors structure/function comparisons of antigenic specificity, V gene sequence, and Ig isotype. |
| Q30353709 | Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry. |
| Q46102109 | Immunoglobulin Gene Rearrangement and Expression in B-CLL. |
| Q31131763 | Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes |
| Q36512196 | Immunopaleontology reveals how affinity enhancement is achieved during affinity maturation of antibodies to influenza virus |
| Q36362440 | In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells |
| Q41888015 | In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance |
| Q38635983 | Innate immunity against molecular mimicry: Examining galectin-mediated antimicrobial activity |
| Q41934489 | Integrating B cell lineage information into statistical tests for detecting selection in Ig sequences |
| Q72722707 | Low antibody affinity restricted to the IgA isotype in IgA nephropathy |
| Q28589356 | M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice |
| Q42170932 | Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies |
| Q28592782 | Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally |
| Q80088736 | Models for antigen receptor gene rearrangement: CDR3 length |
| Q34250038 | Molecular characterization of a somatically mutated anti-DNA antibody bearing two systemic lupus erythematosus-related idiotypes |
| Q41864771 | Multi Step Selection in Ig H Chains is Initially Focused on CDR3 and Then on Other CDR Regions. |
| Q51926034 | Novel analysis of clonal diversification in blood B cell and bone marrow plasma cell clones in immunoglobulin light chain amyloidosis. |
| Q36263769 | Optimal Sequential Immunization Can Focus Antibody Responses against Diversity Loss and Distraction |
| Q33598442 | Optimality of mutation and selection in germinal centers |
| Q37868736 | Pathogenic anti-DNA antibodies in SLE: idiotypic families and genetic origins |
| Q43029371 | Patterns of adaptation in a laboratory evolved thermophilic enzyme |
| Q37106800 | Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability |
| Q40187080 | Primary humoral antibody response to Coxiella burnetii, the causative agent of Q fever |
| Q34296709 | Protein evolution on rugged landscapes |
| Q42691059 | Re-evaluating the recycling hypothesis in the germinal centre. |
| Q27678538 | Reshaping Antibody Diversity |
| Q74139589 | Role of BCR affinity in T cell dependent antibody responses in vivo |
| Q54937838 | Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies. |
| Q57295484 | Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation |
| Q98164941 | Sequential immunization induces strong and broad immunity against all four dengue virus serotypes |
| Q26829346 | Serological diagnosis of Epstein-Barr virus infection: Problems and solutions |
| Q41222940 | Somatic diversification of antibody responses |
| Q28510640 | Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern |
| Q33646218 | Structural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-fold |
| Q61312713 | Structural differences among monoclonal antibodies with distinct fine specificities and kinetic properties |
| Q47789160 | Synthetic human antibodies and a strategy for protein engineering |
| Q42743187 | Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells |
| Q59065258 | Targeted disruption of mu chain membrane exon causes loss of heavy-chain allelic exclusion |
| Q54608320 | Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. |
| Q35137494 | Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences. |
| Q43744211 | Testing the reverse transcriptase model of somatic mutation |
| Q48081907 | The 5' boundary of somatic hypermutation in a V kappa gene is in the leader intron |
| Q40561266 | The Transcription Factor AP4 Mediates Resolution of Chronic Viral Infection through Amplification of Germinal Center B Cell Responses. |
| Q40931206 | The clonogenic precursor cell in multiple myeloma |
| Q42015134 | The mutation patterns in B-cell immunoglobulin receptors reflect the influence of selection acting at multiple time-scales |
| Q36354168 | The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response |
| Q27624954 | The structural basis of repertoire shift in an immune response to phosphocholine |
| Q45190964 | The use of semi-automated EBV IgG avidity determination for the diagnosis of infectious mononucleosis |
| Q41544908 | What limits affinity maturation of antibodies in Xenopus--the rate of somatic mutation or the ability to select mutants? |
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