Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells

scientific article published on 16 November 2009

Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.0902452
P932PMC publication ID4106706
P698PubMed publication ID19917681
P5875ResearchGate publication ID38093532

P50authorUri HershbergQ46786828
P2093author name stringMark J Shlomchik
Mohamed Uduman
Steven H Kleinstein
Shannon M Anderson
Ann M Haberman
Yoram Louzoun
Ashraf Khalil
P2860cites workA role for DRAK2 in the germinal center reaction and the antibody responseQ24630648
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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunityQ28138855
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
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In vivo imaging of germinal centres reveals a dynamic open structureQ33271310
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FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigenQ33711133
Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytesQ33897729
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viabilityQ33921263
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Characterization of (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific germinal center B cells and antigen-binding B220- cells after primary NP challenge in mice.Q64988883
Antigen and helper T lymphocytes activate B lymphocytes by distinct signaling pathwaysQ70527053
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VARIATIONS IN AFFINITIES OF ANTIBODIES DURING THE IMMUNE RESPONSEQ76969494
Antigen drives very low affinity B cells to become plasmacytes and enter germinal centersQ77573886
T cell division and death are segregated by mutation of TCRbeta chain constant domainsQ80865270
Germinal centers still hold secretsQ81865040
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Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiationQ36228608
Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutininQ36261566
Follicular B helper T cells in antibody responses and autoimmunity.Q36302329
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cellsQ36362440
gp39-CD40 interactions are essential for germinal center formation and the development of B cell memoryQ36363299
Altering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiationQ36364275
Tracing the development of single memory-lineage B cells in a highly defined immune responseQ36366754
T helper cells in murine germinal centers are antigen-specific emigrants that downregulate Thy-1.Q36367277
Germinal center initiation, variable gene region hypermutation, and mutant B cell selection without detectable immune complexes on follicular dendritic cellsQ36368941
Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reducedQ36370154
Germinal-center organization and cellular dynamicsQ36459345
The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunityQ40402476
Cyclic re-entry of germinal center B cells and the efficiency of affinity maturationQ40858324
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Clone: a Monte-Carlo computer simulation of B cell clonal expansion, somatic mutation, and antigen-driven selectionQ41711157
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection.Q41949877
Antibody engineering for the analysis of affinity maturation of an anti-hapten response.Q42735546
Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic miceQ42947038
Intracellular determination of activated caspases (IDAC) by flow cytometry using a pancaspase inhibitor labeled with FITCQ44649501
B cells expressing Bcl-2 and a signaling-impaired BAFF-specific receptor fail to mature and are deficient in the formation of lymphoid follicles and germinal centersQ45140656
V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin.Q45852339
Imaging of germinal center selection events during affinity maturationQ46722429
Analysis of mutational lineage trees from sites of primary and secondary Ig gene diversification in rabbits and chickensQ47810397
Junctional amino acids determine the maturation pathway of an antibody.Q47923096
Targeted insertion of a variable region gene into the immunoglobulin heavy chain locusQ48091786
Maturation of the immune response in germinal centersQ48194763
Germ-line affinity and germ-line variable-region genes in the B cell responseQ48349365
Interplay between cell division and cell death during TCR triggering.Q50994677
CD19 regulates B cell maturation, proliferation, and positive selection in the FDC zone of murine splenic germinal centers.Q51991122
A division-linked mechanism for the rapid generation of Ig-secreting cells from human memory B cells.Q52008746
Identification of murine germinal center B cell subsets defined by the expression of surface isotypes and differentiation antigens.Q52026937
Quantification of cell turnover kinetics using 5-bromo-2'-deoxyuridine.Q52078949
Is rapid proliferation in B centroblasts linked to somatic mutation in memory B cell clones?Q52122457
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The dynamic structure of the germinal center.Q52992143
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)7314-7325
P577publication date2009-11-16
P1433published inJournal of ImmunologyQ3521441
P1476titleTaking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells
P478volume183

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cites work (P2860)
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Q42142851Activated germinal centre B cells undergo directed migration
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