Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice.

scientific article

Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/ART.30257
P932PMC publication ID3379710
P698PubMed publication ID21305519
P5875ResearchGate publication ID49821418

P50authorDavid D. ChaplinQ42780504
P2093author name stringJun Li
William E Grizzle
Qi Wu
Hui-Chen Hsu
John D Mountz
John H Wang
Tanja Guentert
Cecil R Stockard
Godwin Job
Pingar Yang
Thuc-Vy L Le
P2860cites workRegeneration of the immunoglobulin heavy-chain repertoire after transient B-cell depletion with an anti-CD20 antibodyQ24817041
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cellsQ28509339
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzymeQ29547201
Signals that initiate somatic hypermutation of B cells in vitroQ31838852
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylationQ33226024
Production of a novel class of polyreactive pathogenic autoantibodies in BXD2 mice causes glomerulonephritis and arthritisQ33230561
Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune diseaseQ33361951
Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synoviumQ33399862
Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunityQ33694922
B cell targeted therapiesQ33709315
IL-17 activates the canonical NF-kappaB signaling pathway in autoimmune B cells of BXD2 mice to upregulate the expression of regulators of G-protein signaling 16.Q33767461
Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arraysQ34160196
Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritisQ34327451
Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 miceQ34729932
B cells as therapeutic targets for rheumatic diseasesQ35753658
AID: how does it aid antibody diversity?Q35800376
Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trialQ35993027
Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr miceQ36253581
AID in somatic hypermutation and class switch recombinationQ36389988
B cell targeted therapies in autoimmune diseasesQ36465513
Targeting of B cells in SLE: rationale and therapeutic opportunitiesQ36661154
Peripheral B cell subsetsQ36867717
Increased expression of activation-induced cytidine deaminase is associated with anti-CCP and rheumatoid factor in rheumatoid arthritisQ36908127
Anticytokine therapy impacting on B cells in autoimmune diseasesQ37433729
Walking the AID tightropeQ37677543
B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencersQ38348243
Mitochondria-dependent caspase-9 activation is necessary for antigen receptor-mediated effector caspase activation and apoptosis in WEHI 231 lymphoma cellsQ40739761
Critical role for mitochondria in B cell receptor-mediated apoptosisQ40911390
Differentiation and apoptosis of human germinal center B-lymphocytesQ41522446
Paracrine regulation of germinal center B cell adhesion through the c-met-hepatocyte growth factor/scatter factor pathwayQ41903686
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection.Q41949877
Safety and efficacy of rituximab in systemic lupus erythematosus: results from 136 patients from the French AutoImmunity and Rituximab registryQ42661986
Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cellsQ42743187
The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation processQ42944711
Overexpression of activation-induced cytidine deaminase in B cells is associated with production of highly pathogenic autoantibodiesQ44051064
Critical roles of activation-induced cytidine deaminase in the homeostasis of gut floraQ44218058
Serologic changes following B lymphocyte depletion therapy for rheumatoid arthritisQ44541019
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritisQ44616885
Hyper-IgM syndrome with putative dominant negative mutation in activation-induced cytidine deaminaseQ44621269
Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeksQ44774931
Defective Fas ligand-mediated apoptosis predisposes to development of a chronic erosive arthritis subsequent to Mycoplasma pulmonis infectionQ45880270
AID constrains germinal center size by rendering B cells susceptible to apoptosis.Q45991820
Activation-induced deaminase heterozygous MRL/lpr mice are delayed in the production of high-affinity pathogenic antibodies and in the development of lupus nephritisQ46485635
Control of idiotope expression by monoclonal anti-idiotope and idiotope-bearing antibodyQ52225605
Genetic Segregation of Spontaneous Erosive Arthritis and Generalized Autoimmune Disease in the BXD2 Recombinant Inbred Strain of MiceQ57982623
Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritisQ61628467
Somatic mutation of immunoglobulin V genes in vitroQ71095985
Development of Autoantibodies before the Clinical Onset of Systemic Lupus ErythematosusQ79171865
Antibodies against cyclic citrullinated peptide are associated with HLA-DR4 in simplex and multiplex polyarticular-onset juvenile rheumatoid arthritisQ81248173
Blockade of lymphotoxin pathway exacerbates autoimmune arthritis by enhancing the Th1 responseQ81300642
P4510describes a project that usesImageJQ1659584
P433issue7
P304page(s)2038-2048
P577publication date2011-07-01
P1433published inArthritis and RheumatismQ23929027
P1476titleInhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice
P478volume63

Reverse relations

cites work (P2860)
Q41684084Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes
Q38017761Activation induced deaminase: How much and where?
Q83390734Activation-induced cytidine deaminase catalytic domain as a target to eliminate pathogenic autoantibodies
Q28507678Altered Pattern of Immunoglobulin Hypermutation in Mice Deficient in Slip-GC Protein
Q48343851Association Between Serum MicroRNAs and Magnetic Resonance Imaging Measures of Multiple Sclerosis Severity
Q83860003Autoimmunity: Engineered AICDA balances B cells
Q40773152Cutting Edge: defective follicular exclusion of apoptotic antigens due to marginal zone macrophage defects in autoimmune BXD2 mice.
Q37714326Death Receptor 5–Targeted Depletion of Interleukin‐23–Producing Macrophages, Th17, and Th1/17 Associated With Defective Tyrosine Phosphatase in Mice and Patients With Rheumatoid Arthritis
Q37846094Epigenetic alterations in autoimmune rheumatic diseases
Q37692338Extension of the Germinal Center Stage of B Cell Development Promotes Autoantibodies in BXD2 Mice
Q35562921General Approach for Tetramer-Based Identification of Autoantigen-Reactive B Cells: Characterization of La- and snRNP-Reactive B Cells in Autoimmune BXD2 Mice
Q37284814IL-17RA Is Essential for Optimal Localization of Follicular Th Cells in the Germinal Center Light Zone To Promote Autoantibody-Producing B Cells
Q34060009IL-23 promotes TCR-mediated negative selection of thymocytes through the upregulation of IL-23 receptor and RORγt
Q36040281Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus
Q34098180Interleukin-21 promotes germinal center reaction by skewing the follicular regulatory T cell to follicular helper T cell balance in autoimmune BXD2 mice
Q36033318Iron inhibits activation-induced cytidine deaminase enzymatic activity and modulates immunoglobulin class switch DNA recombination
Q26853622Regulation of Aicda expression and AID activity
Q35175080Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells
Q42438365Separation of Function between Isotype Switching and Affinity Maturation In Vivo during Acute Immune Responses and Circulating Autoantibodies in UNG-Deficient Mice
Q41183432Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model

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