Altering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation

scientific article

Altering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.181.1.271
P932PMC publication ID2191829
P698PubMed publication ID7807007
P5875ResearchGate publication ID15392214

P2093author name stringT Manser
K A Vora
P2860cites workSingle-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
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Structural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-foldQ33646218
Stepwise intraclonal maturation of antibody affinity through somatic hypermutationQ33664973
Germ line variable regions that match hypermutated sequences in genes encoding murine anti-hapten antibodiesQ33960151
Protein evolution on rugged landscapesQ34296709
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Germinal centers and antibody production in bone marrowQ36171770
Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune responseQ36229997
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The mechanism of antigenic stimulation of primary and secondary clonal precursor cellsQ36271704
Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusionsQ36302303
Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J geneQ36354162
The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary responseQ36354168
Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyteQ36356890
Hybridoma proteins expressing the predominant idiotype of the antiazophenylarsonate response of A/J miceQ36357540
Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutationQ36361415
Antigen-driven B cell differentiation in vivoQ36361955
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cellsQ36362440
Sequencing heavy- and light-chain variable genes of single B-hybridoma cells by total enzymatic amplificationQ37156660
Somatic recombination of heavy chain variable region transgenes with the endogenous immunoglobulin heavy chain locus in miceQ37275566
The evolution of B-cell clonesQ37928297
The efficiency of antibody affinity maturation: can the rate of B-cell division be limiting?Q37953676
Structural characterization of idiotopes by using antibody variants generated by site-directed mutagenesisQ38340444
Structural characterization of H chain-associated idiotopes of anti-p-azophenylarsonate monoclonal antibodiesQ38340718
Recurrent somatic mutations in mouse antibodies to p-azophenylarsonate increase affinity for haptenQ38345434
Might gene conversion be the mechanism of somatic hypermutation of mammalian immunoglobulin genes?Q38622353
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The dynamic nature of the antibody repertoireQ39545231
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Timing, genetic requirements and functional consequences of somatic hypermutation during B-cell development.Q39658899
Evolutionary and somatic selection of the antibody repertoire in the mouse.Q39682090
Cell Selection by Antigen in the Immune ResponseQ39985236
The immune response to a simple antigenic determinantQ40048013
The maintenance and regulation of the humoral immune response: persisting antigen and the role of follicular antigen-binding dendritic cells as accessory cellsQ40300507
Differentiation of the secondary B-lymphocyte repertoire: the germinal center reactionQ40673767
Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sectionsQ40874465
Intraclonal generation of antibody mutants in germinal centresQ41172275
The amino acid residues at the VH-D-JH junctions affect the affinity of anti-p-azophenylarsonate antibodiesQ41263547
Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.Q41380981
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Limits on heavy chain junctional diversity contribute to the recurrence of an antibody variable regionQ41951245
The BALB/c secondary response to the Sb site of influenza virus hemagglutinin. Nonrandom silent mutation and unequal numbers of VH and Vk mutationsQ42812230
Germinal centers develop oligoclonallyQ43487651
Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigensQ43603650
Towards a general theory of adaptive walks on rugged landscapesQ47593883
Maturation of the immune response in germinal centersQ48194763
Somatic hypermutation of an immunoglobulin transgene in kappa transgenic miceQ48348716
Influence of Clonal Selection on the Expression of Immunoglobulin Variable Region GenesQ48384664
ANTIGENS IN IMMUNITY. IV. CELLULAR LOCALIZATION OF 125-I- AND 131-I-LABELLED FLAGELLA IN LYMPH NODESQ50267219
Molecular characterization of single memory B cells.Q52099258
Relationship of germinal centers in lymphoid tissue to immunologic memory. VI. Transfer of B cell memory with lymph node cells fractionated according to their receptors for peanut agglutinin.Q52214183
Molecular events during maturation of the immune response to oxazoloneQ58019376
Somatic mutation and the maturation of immune response to 2-phenyl oxazoloneQ58019387
mIgM:mIgD ratios on B cells: mean mIgD expression exceeds mIgM by 10-fold on most splenic B cellsQ70467070
Affinity analysis of idiotype-positive and idiotype-negative Ars-binding hybridoma proteins and Ars-immune seraQ71714526
Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiationQ72117602
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcell differentiationQ210861
P304page(s)271-281
P577publication date1995-01-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleAltering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation
P478volume181

Reverse relations

cites work (P2860)
Q36368499Antigen-specific B cell memory: expression and replenishment of a novel b220(-) memory b cell compartment
Q42627701Disparity in the kinetics of onset of hypermutation in immunoglobulin heavy and light chains
Q73689109Evaluation of the role of the 3'alpha heavy chain enhancer [3'alpha E(hs1,2)] in Vh gene somatic hypermutation
Q41949877In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection.
Q40983825Life and death in germinal centers (redux).
Q73291744Maturation of an antibody response is governed by modulations in flexibility of the antigen-combining site
Q28585021Severe attenuation of the B cell immune response in Msh2-deficient mice
Q33959225Silent development of memory progenitor B cells
Q30435791Spontaneous autoimmunity in mice that carry an IghV partial transgene: a required arginine in VHCDR3.
Q42743187Taking advantage: high-affinity B cells in the germinal center have lower death rates, but similar rates of division, compared to low-affinity cells
Q52039310The roles of antibody variable region hypermutation and selection in the development of the memory B-cell compartment.
Q36376764The transcriptional promoter regulates hypermutation of the antibody heavy chain locus

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