| scholarly article | Q13442814 |
| P819 | ADS bibcode | 1989PNAS...86.6191M |
| P356 | DOI | 10.1073/PNAS.86.16.6191 |
| P932 | PMC publication ID | 297803 |
| P698 | PubMed publication ID | 2762321 |
| P5875 | ResearchGate publication ID | 20394565 |
| P2093 | author name string | Perelson AS | |
| Macken CA | |||
| P2860 | cites work | Variable region framework differences result in decreased or increased affinity of variant anti-digoxin antibodies | Q33570587 |
| Stepwise intraclonal maturation of antibody affinity through somatic hypermutation | Q33664973 | ||
| Natural Selection and the Concept of a Protein Space | Q34233063 | ||
| Somatic evolution of variable region structures during an immune response | Q35595595 | ||
| Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin | Q36261566 | ||
| Single amino acid substitution altering antigen-binding specificity | Q36287596 | ||
| Point mutations cause the somatic diversification of IgM and IgG2a antiphosphorylcholine antibodies | Q36354592 | ||
| Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin | Q36355399 | ||
| Mutation drift and repertoire shift in the maturation of the immune response | Q39658890 | ||
| Somatic mutation and clonal expansion of B cells in an antigen-driven immune response. | Q41380981 | ||
| A computer model of evolutionary optimization | Q44041011 | ||
| Natural Selection versus Gene Uniqueness | Q44301995 | ||
| Towards a general theory of adaptive walks on rugged landscapes | Q47593883 | ||
| Somatic variants of murine immunoglobulin λ light chains | Q48403814 | ||
| A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody | Q48409127 | ||
| Generation of an antibody with enhanced affinity and specificity for its antigen by protein engineering | Q59062564 | ||
| P433 | issue | 16 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | protein evolution | Q59870539 |
| P1104 | number of pages | 5 | |
| P304 | page(s) | 6191-6195 | |
| P577 | publication date | 1989-08-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Protein evolution on rugged landscapes | |
| P478 | volume | 86 |
| Q43110160 | A model of substitution trajectories in sequence space and long-term protein evolution. |
| Q52330140 | Adaptive walks with noisy fitness measurements. |
| Q36364275 | Altering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation |
| Q90699093 | Analysis of statistical correlations between properties of adaptive walks in fitness landscapes |
| Q36354875 | Breaking evolutionary constraint with a tradeoff ratchet |
| Q51727267 | Combinatorial vector fields and the valley structure of fitness landscapes. |
| Q30344005 | Comparing folding codes in simple heteropolymer models of protein evolutionary landscape: robustness of the superfunnel paradigm. |
| Q42041571 | Deterministic and stochastic regimes of asexual evolution on rugged fitness landscapes |
| Q90743445 | Evolution in the light of fitness landscape theory |
| Q52251893 | Evolution of model proteins on a foldability landscape. |
| Q90414037 | Evolving generalists in switching rugged landscapes |
| Q22122004 | Fitness and its role in evolutionary genetics |
| Q42089613 | Fitness landscape of human immunodeficiency virus type 1 protease quasispecies |
| Q51610625 | Genome structure and the benefit of sex |
| Q33322521 | Heterogeneous adaptive trajectories of small populations on complex fitness landscapes |
| Q59867557 | Impact of epistasis and pleiotropy on evolutionary adaptation |
| Q31149925 | In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation |
| Q33730568 | Inferring fitness landscapes by regression produces biased estimates of epistasis. |
| Q21563795 | Local properties of Kauffman’s N - k model: A tunably rugged energy landscape |
| Q91555438 | Long-term evolution on complex fitness landscapes when mutation is weak |
| Q68323896 | Modelling neutral and selective evolution of protein folding |
| Q35542019 | Multiple adaptive substitutions during evolution in novel environments |
| Q34477455 | Mutational effects and population dynamics during viral adaptation challenge current models |
| Q57234288 | Optimizing epochal evolutionary search: population-size independent theory |
| Q43029371 | Patterns of adaptation in a laboratory evolved thermophilic enzyme |
| Q50914574 | Phase transition in random adaptive walks on correlated fitness landscapes. |
| Q33860729 | Protein evolution on partially correlated landscapes |
| Q56272110 | RNA folding and combinatory landscapes |
| Q52407559 | RNA multi-structure landscapes. A study based on temperature dependent partition functions. |
| Q28728760 | Real time forecasting of near-future evolution |
| Q41841727 | Repeat protein architectures predicted by a continuum representation of fold space. |
| Q42324334 | Selection Limits to Adaptive Walks on Correlated Landscapes |
| Q52386608 | Statistics of RNA melting kinetics. |
| Q28547894 | Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance |
| Q32062850 | Stepwise in vitro affinity maturation of Vitaxin, an alphav beta3-specific humanized mAb. |
| Q35172659 | The changing geometry of a fitness landscape along an adaptive walk |
| Q37399576 | The dynamics of adaptation on correlated fitness landscapes |
| Q34557604 | The effect of phenotypic plasticity on evolution in multipeaked fitness landscapes |
| Q73665014 | The foldability landscape of model proteins |
| Q22122021 | The genetic theory of adaptation: a brief history |
| Q37353497 | The genetics of adaptation for eight microvirid bacteriophages |
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