Combined inactivation of pRB and hippo pathways induces dedifferentiation in the Drosophila retina

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Combined inactivation of pRB and hippo pathways induces dedifferentiation in the Drosophila retina is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PGEN.1000918
P932PMC publication ID2858677
P698PubMed publication ID20421993
P5875ResearchGate publication ID43346185

P50authorMaxim V FrolovQ98569211
P2093author name stringElizaveta V Benevolenskaya
Battuya Bayarmagnai
Brandon N Nicolay
Nam Sung Moon
P2860cites workThe Hallmarks of CancerQ221226
Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye.Q52551521
A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila.Q52678751
Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcomaQ71093029
Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eyeQ41075838
Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironmentQ41883433
Warts is required for PI3K-regulated growth arrest, autophagy, and autophagic cell death in DrosophilaQ42277611
The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye.Q43546698
Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrousQ44264431
Extra-embryonic function of Rb is essential for embryonic development and viabilityQ44329398
Requirement for a functional Rb-1 gene in murine developmentQ44462954
Proliferation of functional hair cells in vivo in the absence of the retinoblastoma proteinQ45226460
The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiationQ45345527
The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenanceQ46327230
Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye.Q46421007
Differential splicing generates a nervous system—Specific form of drosophila neuroglianQ46607453
Expression of baculovirus P35 prevents cell death in DrosophilaQ46962065
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferationQ47070662
The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors.Q47072628
Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs.Q51113909
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth controlQ24299106
salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell linesQ28219379
Pocket proteins and cell cycle controlQ28245850
The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAPQ28266862
Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entryQ28509466
Stem cells, the molecular circuitry of pluripotency and nuclear reprogrammingQ29614416
Elucidation of a universal size-control mechanism in Drosophila and mammalsQ29618935
Effects of an Rb mutation in the mouseQ29619196
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesisQ29619200
The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosisQ29619851
hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and wartsQ29620457
Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a.Q33289781
Context-dependent requirement for dE2F during oncogenic proliferationQ33373668
The retinoblastoma tumor-suppressor gene, the exception that proves the ruleQ33562001
The retinoblastoma gene family in differentiation and development.Q33814317
Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in DrosophilaQ33916848
Expression of transcription factor E2F1 induces quiescent cells to enter S phaseQ34354875
The eyes absent gene: genetic control of cell survival and differentiation in the developing Drosophila eye.Q34360299
Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progressionQ34488948
Emerging roles of E2Fs in cancer: an exit from cell cycle controlQ35009182
senseless repression of rough is required for R8 photoreceptor differentiation in the developing Drosophila eyeQ35065549
Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in miceQ36388809
Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesisQ36453536
RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3Q36585506
Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talkQ36648414
In vivo regulation of Yorkie phosphorylation and localization.Q36663448
Polycomb/Trithorax response elements and epigenetic memory of cell identityQ36690774
The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor networkQ36743530
Hippo signaling in organ size controlQ36793377
The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone developmentQ37229099
The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservationQ37242218
Conserved functions of the pRB and E2F familiesQ37249375
A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosisQ38508876
Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppressionQ40018354
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
P304page(s)e1000918
P577publication date2010-04-22
P1433published inPLOS GeneticsQ1893441
P1476titleCombined inactivation of pRB and hippo pathways induces dedifferentiation in the Drosophila retina
P478volume6

Reverse relations

cites work (P2860)
Q34807689A kinase shRNA screen links LATS2 and the pRB tumor suppressor
Q34229724A shared role for RBF1 and dCAP-D3 in the regulation of transcription with consequences for innate immunity
Q42043326Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation.
Q93073871Changes in chromatin accessibility ensure robust cell cycle exit in terminally differentiated cells
Q35559970Characterization of the cell of origin for small cell lung cancer
Q37969685Conserved RB functions in development and tumor suppression
Q28742574Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit
Q34025442Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration
Q42141064Defining a new vision for the retinoblastoma gene: report from the 3rd International Rb Meeting
Q26750375Drosophila as a Potential Model for Ocular Tumors
Q43077312Gene expression profiling identifies different sub-types of retinoblastoma.
Q38359785How the cell cycle impacts chromatin architecture and influences cell fate
Q28543584Involvement of YAP, TAZ and HSP90 in contact guidance and intercellular junction formation in corneal epithelial cells
Q28709122Loss of RBF1 changes glutamine catabolism
Q38011006Maintaining differentiated cellular identity
Q41892098Organ size control is dominant over Rb family inactivation to restrict proliferation in vivo
Q30375159Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila
Q35672110Rb deficiency during Drosophila eye development deregulates EMC, causing defects in the development of photoreceptors and cone cells
Q38967241Regulation of cell polarity determinants by the Retinoblastoma tumor suppressor protein
Q38471080Regulators of pluripotency and their implications in regenerative medicine
Q42107143Sweet DREAMs for Hippo
Q27321236The BTB-zinc finger transcription factor abrupt acts as an epithelial oncogene in Drosophila melanogaster through maintaining a progenitor-like cell state
Q95645882The Hippo Pathway as a Driver of Select Human Cancers
Q30429628What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease
Q104070077What we know about cardiomyocyte dedifferentiation
Q90573437Yorkie and JNK revert syncytial muscles into myoblasts during Org-1-dependent lineage reprogramming
Q35319234mTORC1 maintains the tumorigenicity of SSEA-4(+) high-grade osteosarcoma

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