| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2010PLoSO...515769F |
| P356 | DOI | 10.1371/JOURNAL.PONE.0015769 |
| P932 | PMC publication ID | 3012718 |
| P698 | PubMed publication ID | 21209906 |
| P5875 | ResearchGate publication ID | 49732317 |
| P50 | author | A. Gregory Matera | Q55154446 |
| P2093 | author name string | Jennifer L Fuentes | |
| Molly S Strayer | |||
| P2860 | cites work | Amyloid beta peptide toxicity in differentiated PC12 cells: calpain-calpastatin, caspase, and membrane damage | Q46625129 |
| An emerging picture of synapse formation: a balance of two opposing pathways | Q46757679 | ||
| Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy | Q46861362 | ||
| Survival motor neuron function in motor axons is independent of functions required for small nuclear ribonucleoprotein biogenesis. | Q47073257 | ||
| Intracellular Ca2+-dependent protease (CALPAIN) and its high-molecular-weight endogenous inhibitor (CALPASTATIN) | Q47301366 | ||
| Altered intracellular Ca2+ homeostasis in nerve terminals of severe spinal muscular atrophy mice. | Q47807997 | ||
| Purification and Characterization of a Calcium-Activated Neutral Protease from Monkey Brain and Its Action on Neuropeptides1 | Q48631663 | ||
| Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs | Q22121992 | ||
| Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component | Q24292040 | ||
| Gemin8 is required for the architecture and function of the survival motor neuron complex | Q24306053 | ||
| Coupled in vitro import of U snRNPs and SMN, the spinal muscular atrophy protein | Q24307701 | ||
| The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins | Q24316085 | ||
| The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis | Q24316121 | ||
| A novel nuclear structure containing the survival of motor neurons protein | Q24324247 | ||
| Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins. | Q24536283 | ||
| Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein. | Q24540057 | ||
| Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein | Q24600358 | ||
| Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex | Q24682443 | ||
| A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding | Q25938984 | ||
| SMN tudor domain structure and its interaction with the Sm proteins | Q27629094 | ||
| Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains | Q27652953 | ||
| Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin | Q27652954 | ||
| Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy | Q28137718 | ||
| The exon 2b region of the spinal muscular atrophy protein, SMN, is involved in self-association and SIP1 binding | Q28138530 | ||
| Muscle cachexia: current concepts of intracellular mechanisms and molecular regulation | Q28141769 | ||
| The calpain system | Q28185062 | ||
| SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets | Q28199238 | ||
| Determinants of the interaction of the spinal muscular atrophy disease protein SMN with the dimethylarginine-modified box H/ACA small nucleolar ribonucleoprotein GAR1 | Q28203025 | ||
| The SMN complex, an assemblyosome of ribonucleoproteins | Q28204829 | ||
| Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons? | Q28214361 | ||
| Spinal muscular atrophy | Q28251310 | ||
| A degron created by SMN2 exon 7 skipping is a principal contributor to spinal muscular atrophy severity | Q28274685 | ||
| Determination of peptide substrate specificity for mu-calpain by a peptide library-based approach: the importance of primed side interactions | Q28276503 | ||
| Genetic mapping of chronic childhood-onset spinal muscular atrophy to chromosome 5q11.2-13.3 | Q28280414 | ||
| Regulation of SMN protein stability | Q28304878 | ||
| The Ewing's sarcoma protein interacts with the Tudor domain of the survival motor neuron protein | Q28567835 | ||
| CaMPDB: a resource for calpain and modulatory proteolysis. | Q51713028 | ||
| Neuromuscular defects and breathing disorders in a new mouse model of spinal muscular atrophy. | Q51917443 | ||
| Involvement of calpains in the destabilization of the acetylcholine receptor clusters in rat myotubes. | Q52171980 | ||
| Gene for chronic proximal spinal muscular atrophies maps to chromosome 5q | Q59059683 | ||
| Neurofilament accumulation at the motor endplate and lack of axonal sprouting in a spinal muscular atrophy mouse model | Q61875385 | ||
| International SMA consortium meeting. (26-28 June 1992, Bonn, Germany) | Q67481178 | ||
| Cell-penetrating inhibitors of calpain block both membrane fusion and filamin cleavage in chick embryonic myoblasts | Q70721504 | ||
| Phosphorylation modulates calpain-mediated proteolysis and calmodulin binding of the 200-kDa and 160-kDa neurofilament proteins | Q70770912 | ||
| Molecular analysis of candidate genes on chromosome 5q13 in autosomal recessive spinal muscular atrophy: evidence of homozygous deletions of the SMN gene in unaffected individuals | Q70987146 | ||
| Importance of the ATP-ubiquitin-proteasome pathway in the degradation of soluble and myofibrillar proteins in rabbit muscle extracts | Q71742635 | ||
| An antisense oligodeoxyribonucleotide to m-calpain mRNA inhibits myoblast fusion | Q72017235 | ||
| Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates | Q72397802 | ||
| An exonic enhancer is required for inclusion of an essential exon in the SMA-determining gene SMN | Q73295491 | ||
| A role for polyproline motifs in the spinal muscular atrophy protein SMN. Profilins bind to and colocalize with smn in nuclear gems | Q73297574 | ||
| SMN oligomerization defect correlates with spinal muscular atrophy severity | Q74557706 | ||
| Spinal muscular atrophy and therapeutic prospects | Q79318646 | ||
| A comprehensive interaction map of the human survival of motor neuron (SMN) complex | Q79441366 | ||
| Gemin2 plays an important role in stabilizing the survival of motor neuron complex | Q79794565 | ||
| Nuclear calpain regulates Ca2+-dependent signaling via proteolysis of nuclear Ca2+/calmodulin-dependent protein kinase type IV in cultured neurons | Q80987899 | ||
| Hypomorphic Smn knockdown C2C12 myoblasts reveal intrinsic defects in myoblast fusion and myotube morphology | Q81340087 | ||
| SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN | Q81385781 | ||
| Spinal muscular atrophy: the RNP connection | Q82533240 | ||
| The spinal muscular atrophy gene product regulates neurite outgrowth: importance of the C terminus. | Q38304405 | ||
| A mouse model for spinal muscular atrophy | Q38316939 | ||
| Potential m-calpain substrates during myoblast fusion | Q38328892 | ||
| Epstein-Barr virus nuclear antigen 2 binds via its methylated arginine-glycine repeat to the survival motor neuron protein. | Q39741960 | ||
| Defective Ca2+ channel clustering in axon terminals disturbs excitability in motoneurons in spinal muscular atrophy | Q39751507 | ||
| Calpain small-1 modulates Akt/FoxO3A signaling and apoptosis through PP2A. | Q39912728 | ||
| Refined characterization of the expression and stability of the SMN gene products. | Q40089875 | ||
| Rapsyn interaction with calpain stabilizes AChR clusters at the neuromuscular junction. | Q40104987 | ||
| Phosphorylation regulates the activity of the SMN complex during assembly of spliceosomal U snRNPs. | Q40107820 | ||
| Two PEST-like motifs regulate Ca2+/calpain-mediated cleavage of the CaVbeta3 subunit and provide important determinants for neuronal Ca2+ channel activity | Q40278911 | ||
| Distinct domains of the spinal muscular atrophy protein SMN are required for targeting to Cajal bodies in mammalian cells | Q40322744 | ||
| Overexpression of calpastatin inhibits L8 myoblast fusion | Q40420244 | ||
| Molecular and functional analysis of intragenic SMN1 mutations in patients with spinal muscular atrophy. | Q40484524 | ||
| m-Calpain implication in cell cycle during muscle precursor cell activation | Q40537812 | ||
| Involvement of survival motor neuron (SMN) protein in cell death | Q40698290 | ||
| Characterization of functional domains of the SMN protein in vivo | Q40778498 | ||
| Natural history in proximal spinal muscular atrophy. Clinical analysis of 445 patients and suggestions for a modification of existing classifications | Q40986555 | ||
| Correlation between severity and SMN protein level in spinal muscular atrophy | Q41102726 | ||
| Tudor domains in proteins that interact with RNA. | Q41361779 | ||
| Role of intracellular proteases in differentiation of L6 myoblast cells. | Q41484451 | ||
| Autolysis parallels activation of mu-calpain | Q42983783 | ||
| When is a deletion not a deletion? When it is converted | Q43105061 | ||
| The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy | Q43569750 | ||
| A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs | Q43803910 | ||
| Subcellular localization and in vivo subunit interactions of ubiquitous mu-calpain. | Q44319476 | ||
| Neuromuscular defects in a Drosophila survival motor neuron gene mutant. | Q44463867 | ||
| On the sequential determinants of calpain cleavage | Q44779399 | ||
| Reduced expression of nicotinic AChRs in myotubes from spinal muscular atrophy I patients. | Q45025568 | ||
| Degradation of survival motor neuron (SMN) protein is mediated via the ubiquitin/proteasome pathway | Q45036608 | ||
| Analysis of point mutations in the SMN1 gene in SMA patients bearing a single SMN1 copy. | Q45867775 | ||
| Calpain activates caspase-8 in neuron-like differentiated PC12 cells via the amyloid-beta-peptide and CD95 pathways. | Q45914574 | ||
| A role for complexes of survival of motor neurons (SMN) protein with gemins and profilin in neurite-like cytoplasmic extensions of cultured nerve cells. | Q46564145 | ||
| Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization | Q28576163 | ||
| Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons | Q28576647 | ||
| Identification and characterization of a spinal muscular atrophy-determining gene | Q29547495 | ||
| Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis | Q29547538 | ||
| Regulation of cell death: the calcium-apoptosis link | Q29615554 | ||
| PEST sequences and regulation by proteolysis | Q29616394 | ||
| A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy | Q29617367 | ||
| Direct interaction of the spinal muscular atrophy disease protein SMN with the small nucleolar RNA-associated protein fibrillarin | Q31003752 | ||
| Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick? | Q33785933 | ||
| Survival motor neuron gene transcript analysis in muscles from spinal muscular atrophy patients. | Q34302504 | ||
| Best practice guidelines for molecular analysis in spinal muscular atrophy | Q34314037 | ||
| Quantitative analyses of SMN1 and SMN2 based on real-time lightCycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy | Q34353103 | ||
| The survival motor neuron protein in spinal muscular atrophy | Q34435656 | ||
| Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly? | Q35003162 | ||
| SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins. | Q35641208 | ||
| Interaction of calpastatin with calpain: a review | Q35837217 | ||
| A Drosophila melanogaster model of spinal muscular atrophy reveals a function for SMN in striated muscle. | Q36118011 | ||
| When contractile proteins go bad: the sarcomere and skeletal muscle disease | Q36193679 | ||
| Calpains in muscle wasting. | Q36241898 | ||
| Regulating cell migration: calpains make the cut. | Q36243926 | ||
| Caspase and calpain function in cell death: bridging the gap between apoptosis and necrosis | Q36301734 | ||
| Intact satellite cells lead to remarkable protection against Smn gene defect in differentiated skeletal muscle. | Q36323505 | ||
| Calpain and synaptic function | Q36586276 | ||
| Chaperoning ribonucleoprotein biogenesis in health and disease | Q36777301 | ||
| Myofibrillar protein turnover: the proteasome and the calpains | Q36914804 | ||
| SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain | Q36934614 | ||
| Spinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexes | Q37033848 | ||
| Calpain 3, the "gatekeeper" of proper sarcomere assembly, turnover and maintenance | Q37039715 | ||
| Calpain-mediated signaling mechanisms in neuronal injury and neurodegeneration | Q37237452 | ||
| Survival motor neuron protein modulates neuron-specific apoptosis | Q37292520 | ||
| Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy | Q37294764 | ||
| Molecular control of mammalian myoblast fusion | Q37315586 | ||
| Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice | Q37352940 | ||
| Calpain-1 cleaves and activates caspase-7. | Q37375801 | ||
| KH-type splicing regulatory protein interacts with survival motor neuron protein and is misregulated in spinal muscular atrophy. | Q38296508 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P4510 | describes a project that uses | ImageJ | Q1659584 |
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | e15769 | |
| P577 | publication date | 2010-12-30 | |
| P1433 | published in | PLOS One | Q564954 |
| P1476 | title | Molecular determinants of survival motor neuron (SMN) protein cleavage by the calcium-activated protease, calpain | |
| P478 | volume | 5 |
| Q34490238 | A multi-exon-skipping detection assay reveals surprising diversity of splice isoforms of spinal muscular atrophy genes |
| Q26781368 | An eccentric calpain, CAPN3/p94/calpain-3 |
| Q34082155 | Assays for the identification and prioritization of drug candidates for spinal muscular atrophy |
| Q57459208 | Calpain Inhibition Increases SMN Protein in Spinal Cord Motoneurons and Ameliorates the Spinal Muscular Atrophy Phenotype in Mice |
| Q96685645 | Calpain system is altered in survival motor neuron-reduced cells from in vitro and in vivo spinal muscular atrophy models |
| Q31032498 | Coilin phosphomutants disrupt Cajal body formation, reduce cell proliferation and produce a distinct coilin degradation product |
| Q35715801 | Different Stability and Proteasome-Mediated Degradation Rate of SMN Protein Isoforms. |
| Q64055868 | Drug screening with human SMN2 reporter identifies SMN protein stabilizers to correct SMA pathology |
| Q28115047 | Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies |
| Q36460273 | Regulated specific proteolysis of the Cajal body marker protein coilin |
| Q27679173 | Solution structure of the core SMN–Gemin2 complex |
| Q38073714 | Spinal muscular atrophy and the antiapoptotic role of survival of motor neuron (SMN) protein |
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