| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.274.53.37908 |
| P698 | PubMed publication ID | 10608857 |
| P2093 | author name string | B M Jockusch | |
| H Jockusch | |||
| S Buchmeier | |||
| S Rathke-Hartlieb | |||
| J W Bartsch | |||
| M Rothkegel | |||
| T Giesemann | |||
| P433 | issue | 53 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | muscular atrophy | Q2844600 |
| spinal muscular atrophy | Q580290 | ||
| P304 | page(s) | 37908-37914 | |
| P577 | publication date | 1999-12-01 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | A role for polyproline motifs in the spinal muscular atrophy protein SMN. Profilins bind to and colocalize with smn in nuclear gems | |
| P478 | volume | 274 |
| Q36118011 | A Drosophila melanogaster model of spinal muscular atrophy reveals a function for SMN in striated muscle. |
| Q55056826 | A novel phosphorylation site mutation in profilin 1 revealed in a large screen of US, Nordic, and German amyotrophic lateral sclerosis/frontotemporal dementia cohorts. |
| Q37742489 | Actin complexes in the cell nucleus: new stones in an old field |
| Q37490813 | Actin filaments at the leading edge of cancer cells are characterized by a high mobile fraction and turnover regulation by profilin I. |
| Q48586550 | Active transport of the survival motor neuron protein and the role of exon-7 in cytoplasmic localization. |
| Q35629448 | Axonal-SMN (a-SMN), a protein isoform of the survival motor neuron gene, is specifically involved in axonogenesis. |
| Q47150601 | BDNF/trkB Induction of Calcium Transients through Cav2.2 Calcium Channels in Motoneurons Corresponds to F-actin Assembly and Growth Cone Formation on β2-Chain Laminin (221). |
| Q40778498 | Characterization of functional domains of the SMN protein in vivo |
| Q38058732 | Co-transcriptional nuclear actin dynamics |
| Q28206200 | Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system |
| Q36924719 | Congenital bone fractures in spinal muscular atrophy: functional role for SMN protein in bone remodeling |
| Q33760559 | Conserved genes act as modifiers of invertebrate SMN loss of function defects |
| Q47808364 | Disruption of SMN function by ectopic expression of the human SMN gene in Drosophila. |
| Q64119137 | Dissecting Motor Neuron Disease With |
| Q39092025 | Diverse role of survival motor neuron protein |
| Q28206060 | Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1 |
| Q42834536 | Expression and subcellular localization of two isoforms of the survival motor neuron protein in different cell types |
| Q34115635 | Fine-tuning of neuronal architecture requires two profilin isoforms |
| Q28586728 | Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis |
| Q81340087 | Hypomorphic Smn knockdown C2C12 myoblasts reveal intrinsic defects in myoblast fusion and myotube morphology |
| Q36914618 | Identification and characterization of the porcine (Sus scrofa) survival motor neuron (SMN1) gene: an animal model for therapeutic studies |
| Q26774987 | Is spinal muscular atrophy a disease of the motor neurons only: pathogenesis and therapeutic implications? |
| Q35567371 | Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding. |
| Q39936898 | Matrix-coated transwell-cultured TM4 sertoli cell testosterone-regulated gene expression mimics in vivo expression |
| Q90674893 | Molecular Factors Involved in Spinal Muscular Atrophy Pathways as Possible Disease-modifying Candidates |
| Q26752798 | Molecular Mechanisms of Neurodegeneration in Spinal Muscular Atrophy |
| Q35226376 | Molecular and cellular basis of spinal muscular atrophy |
| Q30994078 | Molecular determinants of survival motor neuron (SMN) protein cleavage by the calcium-activated protease, calpain |
| Q27008398 | Molecular insights on context-specific role of profilin-1 in cell migration |
| Q36676833 | Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity |
| Q24619298 | Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis |
| Q51744183 | Neurochondrin interacts with the SMN protein suggesting a novel mechanism for Spinal Muscular Atrophy pathology. |
| Q36013982 | Neurogenic and myogenic contributions to hereditary motor neuron disease |
| Q34217758 | Neuronal profilin isoforms are addressed by different signalling pathways |
| Q35842667 | Profilin 1 with the amyotrophic lateral sclerosis associated mutation T109M displays unaltered actin binding and does not affect the actin cytoskeleton |
| Q73348995 | Profilin I colocalizes with speckles and Cajal bodies: a possible role in pre-mRNA splicing |
| Q28511468 | Profilin I is essential for cell survival and cell division in early mouse development |
| Q24551149 | Profilin II is alternatively spliced, resulting in profilin isoforms that are differentially expressed and have distinct biochemical properties |
| Q35588789 | Profilin binding to poly-L-proline and actin monomers along with ability to catalyze actin nucleotide exchange is required for viability of fission yeast |
| Q42266661 | Profilin is associated with transcriptionally active genes |
| Q37582162 | Profilin-1 mutations are rare in patients with amyotrophic lateral sclerosis and frontotemporal dementia |
| Q33840295 | Proteomic assessment of a cell model of spinal muscular atrophy |
| Q34103656 | ROCK inhibition as a therapy for spinal muscular atrophy: understanding the repercussions on multiple cellular targets |
| Q34762623 | Repair of pre-mRNA splicing: prospects for a therapy for spinal muscular atrophy. |
| Q40276922 | Reversible, activity-dependent targeting of profilin to neuronal nuclei |
| Q24551044 | Self-association of coilin reveals a common theme in nuclear body localization |
| Q81303651 | Smn depletion alters profilin II expression and leads to upregulation of the RhoA/ROCK pathway and defects in neuronal integrity |
| Q37033848 | Spinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexes |
| Q24291073 | Spinal muscular atrophy disrupts the interaction of ZPR1 with the SMN protein |
| Q35990221 | Spinal muscular atrophy: the role of SMN in axonal mRNA regulation. |
| Q33785933 | Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick? |
| Q36602121 | Spliceosome integrity is defective in the motor neuron diseases ALS and SMA. |
| Q92577181 | Splicing Defects of the Profilin Gene Alter Actin Dynamics in an S. pombe SMN Mutant |
| Q33659236 | Structure and functions of profilins |
| Q35580842 | Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of profilin-1. |
| Q36368457 | Suppression of tumorigenicity in breast cancer cells by the microfilament protein profilin 1. |
| Q35970811 | Survival motor neuron affects plastin 3 protein levels leading to motor defects |
| Q30499358 | The COPI vesicle complex binds and moves with survival motor neuron within axons |
| Q93164519 | The Cytoskeleton as a Modulator of Aging and Neurodegeneration |
| Q89965003 | The Need for SMN-Independent Treatments of Spinal Muscular Atrophy (SMA) to Complement SMN-Enhancing Drugs |
| Q28204829 | The SMN complex, an assemblyosome of ribonucleoproteins |
| Q28254957 | The SMN structure reveals its crucial role in snRNP assembly |
| Q34699419 | The molecular bases of spinal muscular atrophy |
| Q38191624 | The multifaceted role of profilin-1 in adipose tissue inflammation and glucose homeostasis |
| Q64444095 | The role of survival motor neuron protein (SMN) in protein homeostasis |
| Q37220425 | Tumor suppressor activity of profilin requires a functional actin binding site |
| Q37342966 | Zebrafish survival motor neuron mutants exhibit presynaptic neuromuscular junction defects |
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