Stochastic loss of silencing of the imprinted Ndn/NDN allele, in a mouse model and humans with prader-willi syndrome, has functional consequences

scientific article

Stochastic loss of silencing of the imprinted Ndn/NDN allele, in a mouse model and humans with prader-willi syndrome, has functional consequences is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PGEN.1003752
P932PMC publication ID3764186
P698PubMed publication ID24039599
P5875ResearchGate publication ID256613985

P50authorDick SwaabQ2682716
Françoise MuscatelliQ52097093
Valéry MatarazzoQ56844964
Francoise WatrinQ63436657
Rachel WevrickQ46130607
P2093author name stringLaurent Bezin
Ulrich Zechner
Unga Unmehopa
Fabienne Schaller
François J Michel
Matthias Linke
Femke Dijkstra
Severine Corby
Keith Dudley
Anne Rieusset
Beatrice Georges
Jocelyn Bischof
Monique Bloemsma
P2860cites workA modified and improved method for bisulphite based cytosine methylation analysisQ24544058
The Prader-Willi syndrome murine imprinting center is not involved in the spatio-temporal transcriptional regulation of the Necdin geneQ24808766
Pairing of homologous regions in the mouse genome is associated with transcription but not imprinting statusQ27301083
The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouseQ28249408
The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal regionQ28253418
Evidence for genetic modifiers of postnatal lethality in PWS-IC deletion miceQ80809786
Review of 64 cases of death in children with Prader-Willi syndrome (PWS)Q80832115
The association between oxytocin receptor gene polymorphism (OXTR) and trait empathyQ83492124
Analysis of imprinted genes in subjects with Prader-Willi syndrome and chromosome 15 abnormalitiesQ93949736
Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome.Q49155367
Prader-Willi syndrome.Q51826464
Expression of the Prader-Willi gene Necdin during mouse nervous system development correlates with neuronal differentiation and p75NTR expression.Q52097061
Sequence-based bioinformatic prediction and QUASEP identify genomic imprinting of the KCNK9 potassium channel gene in mouse and humanQ56982001
Neuronal histamine production remains unaltered in Parkinson's disease despite the accumulation of Lewy bodies and Lewy neurites in the tuberomamillary nucleusQ57821060
Relaxation of imprinting in Prader-Willi syndromeQ62712526
Allelic discrimination using fluorogenic probes and the 5' nuclease assayQ74618454
Detection of specific polymerase chain reaction product by utilizing the 5'----3' exonuclease activity of Thermus aquaticus DNA polymeraseQ28291219
Absence of Ndn, encoding the Prader-Willi syndrome-deleted gene necdin, results in congenital deficiency of central respiratory drive in neonatal miceQ28505055
Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survivalQ28508839
Disruption of the mouse necdin gene results in early post-natal lethalityQ28587922
Environmental epigenomics and disease susceptibilityQ29547452
Genomic imprinting: parental influence on the genomeQ29616227
Highly efficient modification of bacterial artificial chromosomes (BACs) using novel shuttle vectors containing the R6Kgamma origin of replicationQ31120342
Sensory defects in Necdin deficient mice result from a loss of sensory neurons correlated within an increase of developmental programmed cell deathQ33264123
Sex-specific expression of the X-linked histone demethylase gene Jarid1c in brainQ33348587
Explaining inter-individual variability in phenotype: is epigenetics up to the challenge?Q33691436
Variability in gene expression underlies incomplete penetranceQ33717980
Spatial, temporal and interindividual epigenetic variation of functionally important DNA methylation patterns.Q33959408
Necdin protects embryonic motoneurons from programmed cell deathQ34017758
Prader-Willi Syndrome: Obesity due to Genomic ImprintingQ34229319
Prader-Willi syndrome and autism spectrum disorders: an evolving storyQ35680723
The secret language of destiny: stress imprinting and transgenerational origins of diseaseQ36005293
Loss of imprinting and cancerQ36687286
Insights into the regulation of protein abundance from proteomic and transcriptomic analysesQ36846022
Genomic imprinting effects in a compromised in utero environment: implications for a healthy pregnancyQ37625351
Neurodevelopmental disorders involving genomic imprinting at human chromosome 15q11-q13.Q37715376
Development of the eating behaviour in Prader-Willi Syndrome: advances in our understanding.Q37777323
Regulatory mechanisms and networks couple the different phases of gene expressionQ37901668
A survey of tissue-specific genomic imprinting in mammalsQ38028387
Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samplesQ38331031
Establishment and maintenance of DNA methylation patterns in mouse Ndn: implications for maintenance of imprinting in target genes of the imprinting center.Q39458709
Transient homologous chromosome pairing marks the onset of X inactivationQ40327289
Methylation profiles of DXPas34 during the onset of X-inactivationQ40834879
Regulated noise in the epigenetic landscape of development and diseaseQ41514448
Unexpected expression of orexin-B in basal conditions and increased levels in the adult rat hippocampus during pilocarpine-induced epileptogenesis.Q42499632
Necdin-deficient mice do not show lethality or the obesity and infertility of Prader-Willi syndromeQ43512902
Necdin plays a role in the serotonergic modulation of the mouse respiratory network: implication for Prader-Willi syndromeQ46755443
Selective loss of imprinting in the placenta following preimplantation development in cultureQ47232748
Evidence for a role of the chemorepellent semaphorin III and its receptor neuropilin-1 in the regeneration of primary olfactory axons.Q48346569
Sleep-related breathing disorders in prepubertal children with Prader-Willi syndrome and effects of growth hormone treatmentQ48489602
The mouse Necdin gene is expressed from the paternal allele only and lies in the 7C region of the mouse chromosome 7, a region of conserved synteny to the human Prader-Willi syndrome regionQ48575791
Increased melanin concentrating hormone receptor type I in the human hypothalamic infundibular nucleus in cachexiaQ49112851
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue9
P921main subjectPrader–Willi syndromeQ594013
P304page(s)e1003752
P577publication date2013-09-05
P1433published inPLOS GeneticsQ1893441
P1476titleStochastic loss of silencing of the imprinted Ndn/NDN allele, in a mouse model and humans with prader-willi syndrome, has functional consequences
P478volume9

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cites work (P2860)
Q55015001Application of droplet digital PCR in the analysis of genome integration and organization of the transgene in BAC transgenic mice.
Q39381468Cellular and disease functions of the Prader-Willi Syndrome gene MAGEL2.
Q42351562Clinical phenotypes of MAGEL2 mutations and deletions
Q35504751DNA methylation differences between in vitro- and in vivo-conceived children are associated with ART procedures rather than infertility
Q53424114Early-onset epileptic encephalopathy and severe developmental delay in an association with de novo double mutations in NF1 and MAGEL2.
Q37715275Genomic imprinting in development, growth, behavior and stem cells
Q35729124Imprinting genes associated with endometriosis
Q37690666Natural breaking of the maternal silence at the mouse and human imprinted Prader-Willi locus: A whisper with functional consequences.
Q47230157Necdin shapes serotonergic development and SERT activity modulating breathing in a mouse model for Prader-Willi syndrome.
Q64094464Preclinical Testing in Translational Animal Models of Prader-Willi Syndrome: Overview and Gap Analysis
Q35784896Reactivation of maternal SNORD116 cluster via SETDB1 knockdown in Prader-Willi syndrome iPSCs
Q92546825Screening for rare epigenetic variations in autism and schizophrenia
Q47706180The Prader-Willi syndrome proteins MAGEL2 and necdin regulate leptin receptor cell surface abundance through ubiquitination pathways