Wnt-mediated down-regulation of Sp1 target genes by a transcriptional repressor Sp5.

scientific article

Wnt-mediated down-regulation of Sp1 target genes by a transcriptional repressor Sp5. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M605851200
P698PubMed publication ID17090534

P50authorSimone ScalabrinQ102352960
P2093author name stringStefan Krauss
Tomas Vacik
Cestmir Vlcek
Ondrej Machon
Zbynek Kozmik
Martin Speth
Naoko Fujimura
Dzung Diep
P2860cites workTargeting of p38 mitogen-activated protein kinases to MEF2 transcription factorsQ22010041
Identification of c-MYC as a target of the APC pathwayQ24310637
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cellsQ24314491
Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin geneQ24529898
Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulatorsQ24533307
Modification with SUMO. A role in transcriptional regulationQ24534589
Signaling disrupts mSin3A binding to the Mad1-like Sin3-interacting domain of TIEG2, an Sp1-like repressorQ24536316
A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3AQ24550902
Role for SUMO modification in facilitating transcriptional repression by BKLF.Q24556900
mBtd is required to maintain signaling during murine limb developmentQ24646954
Hyperactive Wnt signaling changes the developmental potential of embryonic lung endodermQ24791466
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cellsQ27860717
Generalized lacZ expression with the ROSA26 Cre reporter strainQ27860837
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanismQ28114789
Structure and localization on the X chromosome of the gene coding for the human filopodial protein moesin (MSN)Q28118901
The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancerQ28155884
Identification of a Wnt/Dvl/beta-Catenin --> Pitx2 pathway mediating cell-type-specific proliferation during developmentQ28216579
Something about SUMO inhibits transcriptionQ28266843
DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathwayQ28283034
Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryosQ28504476
Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with BrachyuryQ28508518
Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiationQ28584971
The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epitheliumQ28585080
Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalonQ28592524
SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localizationQ28612080
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathwayQ28640887
Regulation of cerebral cortical size by control of cell cycle exit in neural precursorsQ29615158
Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxietyQ29615160
WNT and beta-catenin signalling: diseases and therapiesQ29616159
De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skinQ29616492
Sin meets NuRD and other tails of repression.Q33789548
Genomic structure and chromosomal mapping of the human site-1 protease (S1P) geneQ33914052
The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1.Q34085341
Heat shock induces preferential translation of ERGIC-53 and affects its recycling pathwayQ34338424
Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stressQ34401927
SP1-binding elements, within the common metaxin-thrombospondin 3 intergenic region, participate in the regulation of the metaxin geneQ34612272
Analysis of the promoter region of the gene encoding NAD-dependent methylenetetrahydrofolate dehydrogenase methenyltetrahydrofolate cyclohydrolaseQ35776284
Cell proliferation and expression of the transferrin receptor gene: promoter sequence homologies and protein interactionsQ36215672
Groucho-dependent and -independent repression activities of Runt domain proteinsQ36572515
Structure and expression of the mouse necdin gene. Identification of a postmitotic neuron-restrictive core promoterQ36790661
Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancersQ38317305
Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulationQ38328801
Characterization and promoter analysis of the mouse nestin geneQ38341421
Multiple and essential Sp1 binding sites in the promoter for transforming growth factor-beta type I receptorQ38343374
The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning.Q38514669
Stat5 and Sp1 regulate transcription of the cyclin D2 gene in response to IL-2.Q38525465
Expression of SRG3, a core component of mouse SWI/SNF chromatin-remodeling complex, is regulated by cooperative interactions between Sp1/Sp3 and Ets transcription factorsQ40351281
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humansQ40490424
The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoterQ40697650
Characterization of the promoter region of the human RFP geneQ40939055
Multiple Sp1 binding sites in the cardiac/slow twitch muscle sarcoplasmic reticulum Ca2+-ATPase gene promoter are required for expression in Sol8 muscle cellsQ41217259
Active repression mechanisms of eukaryotic transcription repressorsQ41223932
A novel DNA element mediates transcription of Nkx2.1 by Sp1 and Sp3 in pulmonary epithelial cellsQ41720996
Efficient expansion and gene transduction of mouse neural stem/progenitor cells on recombinant fibronectinQ45250040
Forebrain-specific promoter/enhancer D6 derived from the mouse Dach1 gene controls expression in neural stem cellsQ45887375
Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancerQ46367561
Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formationQ47378942
Characterization of the chicken CTCF genomic locus, and initial study of the cell cycle-regulated promoter of the geneQ48019090
Structure and expression of the human Na,K-ATPase beta 2-subunit geneQ48039232
Structure of the gene encoding the mouse pituitary adenylate cyclase-activating polypeptide receptorQ48069730
The cellular fate of cortical progenitors is not maintained in neurosphere culturesQ48778732
The mouse enhancer element D6 directs Cre recombinase activity in the neocortex and the hippocampus.Q52126582
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectTrans-acting transcription factor 5Q21989198
P304page(s)1225-1237
P577publication date2006-11-06
P1433published inJournal of Biological ChemistryQ867727
P1476titleWnt-mediated down-regulation of Sp1 target genes by a transcriptional repressor Sp5.
P478volume282

Reverse relations

cites work (P2860)
Q36197089A WNT/p21 circuit directed by the C-clamp, a sequence-specific DNA binding domain in TCFs
Q83224710A genome-wide view of the de-differentiation of central nervous system endothelial cells in culture
Q28119037A human neurodevelopmental model for Williams syndrome
Q36883186A novel role for the tumour suppressor Nitrilase1 modulating the Wnt/β-catenin signalling pathway
Q36837854Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate
Q35049668Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities
Q47214639Amphioxus Sp5 is a member of a conserved Specificity Protein complement and is modulated by Wnt/β-catenin signalling
Q60907378An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra
Q90324945CD147 (EMMPRIN) controls malignant properties of breast cancer cells by interdependent signaling of Wnt and JAK/STAT pathways
Q41729839Canonical Wnt signaling modulates Tbx1, Eya1, and Six1 expression, restricting neurogenesis in the otic vesicle
Q34202927Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling
Q33815439Conservation and diversification of an ancestral chordate gene regulatory network for dorsoventral patterning
Q37575507Early Transcriptional Changes Induced by Wnt/β-Catenin Signaling in Hippocampal Neurons
Q39019544Ectopic activation of the canonical wnt signaling pathway affects ectodermal patterning along the primary axis during larval development in the anthozoan Nematostella vectensis
Q35063567Expression and functional analysis of Dkk1 during early gonadal development.
Q34652756FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis.
Q28579892Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction
Q41854867In vitro differentiation of mouse embryonic stem cells into neurons of the dorsal forebrain
Q33516228Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2.
Q36323609Investigation of TBR1 Hemizygosity: Four Individuals with 2q24 Microdeletions
Q57098343Malic Enzyme 1 (ME1) is pro-oncogenic in Apc mice
Q42153574Modeling neural crest induction, melanocyte specification, and disease-related pigmentation defects in hESCs and patient-specific iPSCs
Q41953333Mouse IDGenes: a reference database for genetic interactions in the developing mouse brain
Q44242344Role of Sp5 as an essential early regulator of neural crest specification in xenopus
Q49642709Screening of Potential Genes and Transcription Factors of Postoperative Cognitive Dysfunction via Bioinformatics Methods
Q36770583Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription
Q49443460Sp5 negatively regulates the proliferation of HCT116 cells by upregulating the transcription of p27.
Q45930399Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium.
Q35146881TGF-β-activated kinase 1 (TAK1) signaling regulates TGF-β-induced WNT-5A expression in airway smooth muscle cells via Sp1 and β-catenin
Q35645574The Nf2 tumor suppressor regulates cell-cell adhesion during tissue fusion
Q42380166The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells.
Q27022615The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue
Q34341527The cortical hem regulates the size and patterning of neocortex
Q35063692Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons
Q28587201Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus
Q37514374Transcriptional profiling of Wnt3a mutants identifies Sp transcription factors as essential effectors of the Wnt/β-catenin pathway in neuromesodermal stem cells
Q36127847Transcriptome response to heat stress in a chicken hepatocellular carcinoma cell line
Q90382654Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis
Q38113139Wnt and lithium: a common destiny in the therapy of nervous system pathologies?
Q48568086Wnt/β-catenin signaling regulates sequential fate decisions of murine cortical precursor cells

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