Transcriptional profiling of Wnt3a mutants identifies Sp transcription factors as essential effectors of the Wnt/β-catenin pathway in neuromesodermal stem cells

scientific article published on 24 January 2014

Transcriptional profiling of Wnt3a mutants identifies Sp transcription factors as essential effectors of the Wnt/β-catenin pathway in neuromesodermal stem cells is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...987018D
P356DOI10.1371/JOURNAL.PONE.0087018
P932PMC publication ID3901714
P698PubMed publication ID24475213
P5875ResearchGate publication ID259961282

P2093author name stringTerry P Yamaguchi
William C Dunty
Kenneth Campbell
Mark W L Kennedy
Ravindra B Chalamalasetty
P2860cites workIntestinal polyposis in mice with a dominant stable mutation of the beta-catenin geneQ24529898
mBtd is required to maintain signaling during murine limb developmentQ24646954
Sp8 is crucial for limb outgrowth and neuropore closureQ24683269
Two distinct sources for a population of maturing axial progenitorsQ28235278
Wnt-3a regulates somite and tailbud formation in the mouse embryoQ28504870
The bHLH regulator pMesogenin1 is required for maturation and segmentation of paraxial mesodermQ28505459
Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouseQ28507549
Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with BrachyuryQ28508518
Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) miceQ28509058
The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling programQ28511944
Inactivation of FGF8 in early mesoderm reveals an essential role in kidney developmentQ28585034
Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signalingQ28585925
Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6Q28589973
Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signalingQ28591110
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathwayQ28640887
Wnt-mediated down-regulation of Sp1 target genes by a transcriptional repressor Sp5.Q32874844
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cellsQ34149498
Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cellsQ34578176
Wnt signaling mediates self-organization and axis formation in embryoid bodiesQ34872357
T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification.Q35210431
Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterningQ35839230
Origin of stem cells in organogenesis.Q37341351
Wnt signaling and the polarity of the primary body axis.Q37652437
Wnt pathway regulation of embryonic stem cell self-renewalQ38041095
The way Wnt works: components and mechanism.Q38068918
The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning.Q38514669
Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish.Q38514802
Specification of the Anteroposterior Neural Axis through Synergistic Interaction of the Wnt Signaling Cascade withnogginandfollistatinQ38531394
Brachyury establishes the embryonic mesodermal progenitor nicheQ41193440
Canonical Wnt signaling dynamically controls multiple stem cell fate decisions during vertebrate body formationQ42496522
Regulation of canonical Wnt signaling by Brachyury is essential for posterior mesoderm formationQ43228969
Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancerQ46367561
The novel transcription factor gene Sp5 exhibits a dynamic and highly restricted expression pattern during mouse embryogenesisQ48377794
Redefining the progression of lineage segregations during mammalian embryogenesis by clonal analysis.Q51926154
Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs.Q51947004
Localised axial progenitor cell populations in the avian tail bud are not committed to a posterior Hox identity.Q51956205
Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation.Q51971087
Mouse Ripply2 is downstream of Wnt3a and is dynamically expressed during somitogenesis.Q51975063
Axial progenitors with extensive potency are localised to the mouse chordoneural hinge.Q52114147
Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development.Q52202953
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)e87018
P577publication date2014-01-24
P1433published inPLOS OneQ564954
P1476titleTranscriptional profiling of Wnt3a mutants identifies Sp transcription factors as essential effectors of the Wnt/β-catenin pathway in neuromesodermal stem cells
P478volume9

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cites work (P2860)
Q90201726A dorsal-ventral gradient of Wnt3a/β-catenin signals control hindgut extension and colon formation
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Q34012056Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks
Q92976612Greb1 is required for axial elongation and segmentation in vertebrate embryos
Q35568242Lineage tracing of neuromesodermal progenitors reveals novel Wnt-dependent roles in trunk progenitor cell maintenance and differentiation
Q34446339Mesogenin 1 is a master regulator of paraxial presomitic mesoderm differentiation
Q92450893Neuro-mesodermal progenitors (NMPs): a comparative study between pluripotent stem cells and embryo-derived populations
Q26795449Neuromesodermal progenitors and the making of the spinal cord
Q43673069Radial Extracorporeal Shock Wave Therapy Enhances the Proliferation and Differentiation of Neural Stem Cells by Notch, PI3K/AKT, and Wnt/β-catenin Signaling
Q90240319Sp2 promotes invasion and metastasis of hepatocellular carcinoma by targeting TRIB3 protein
Q36770583Sp5 and Sp8 recruit β-catenin and Tcf1-Lef1 to select enhancers to activate Wnt target gene transcription
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Q42380166The WNT target SP5 negatively regulates WNT transcriptional programs in human pluripotent stem cells.
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Q35828527Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth
Q91596741Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos
Q42025858Wnt/β-catenin and LIF-Stat3 signaling pathways converge on Sp5 to promote mouse embryonic stem cell self-renewal
Q35665935Wnt8a and Wnt3a cooperate in the axial stem cell niche to promote mammalian body axis extension
Q37002160Zfp703 Is a Wnt/β-Catenin Feedback Suppressor Targeting the β-Catenin/Tcf1 Complex

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