Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation

scientific article

Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S1074-7613(03)00092-X
P698PubMed publication ID12753742
P5875ResearchGate publication ID240193696

P50authorDaniel F LeglerQ54858768
Olivier MicheauQ60314905
Jürg TschoppQ28320791
P2093author name stringMarie-Agnès Doucey
Claude Bron
P2860cites workRecruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signalingQ22253441
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector moleculeQ24290576
TAK1 is a ubiquitin-dependent kinase of MKK and IKKQ24291454
The NF-kappa B and I kappa B proteins: new discoveries and insightsQ24313579
TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathwaysQ24317441
The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activationQ24318742
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activityQ27860643
Lipid rafts and signal transductionQ28131735
Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptorsQ28139933
Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulationQ28141339
CD95's deadly mission in the immune systemQ28142072
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chainQ28142613
CD40 signaling in human dendritic cells is initiated within membrane raftsQ40430095
Molecular mechanisms of ceramide-mediated CD95 clusteringQ43642943
The antitumor ether lipid ET-18-OCH(3) induces apoptosis through translocation and capping of Fas/CD95 into membrane rafts in human leukemic cellsQ43819664
Restricted localization of the TNF receptor CD120a to lipid rafts: a novel role for the death domainQ43950694
Structure and origin of ordered lipid domains in biological membranes.Q52186070
Ceramide enables fas to cap and kill.Q52542714
CD95 Signaling via Ceramide-rich Membrane RaftsQ57371964
Apoptotic, non-apoptotic, and anti-apoptotic pathways of tumor necrosis factor signallingQ58435118
TNF is here to stay!Q61819239
The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activationQ73745042
A CD40 Signalosome anchored in lipid rafts leads to constitutive activation of NF-kappaB and autonomous cell growth in B cell lymphomasQ77589706
TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90Q28203709
The TNF and TNF receptor superfamilies: integrating mammalian biologyQ28203717
Death receptors: signaling and modulationQ28280897
LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activationQ28281516
A protein related to a proteasomal subunit binds to the intracellular domain of the p55 TNF receptor upstream to its 'death domain'Q28292545
Modulation of life and death by the TNF receptor superfamilyQ28295043
A neutral sphingomyelinase resides in sphingolipid-enriched microdomains and is inhibited by the caveolin-scaffolding domain: potential implications in tumour necrosis factor signallingQ28363285
Raft-partitioning of the ubiquitin ligases Cbl and Nedd4 upon IgE-triggered cell signalingQ28573083
TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40Q28610812
Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domainQ29614381
The death domain kinase RIP mediates the TNF-induced NF-kappaB signalQ29617727
Structure and function of sphingolipid- and cholesterol-rich membrane raftsQ29618518
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activationQ29618715
Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell deathQ29620021
Lipid domain structure of the plasma membrane revealed by patching of membrane componentsQ29620204
Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisonsQ30658935
Tumor necrosis factor receptor and Fas signaling mechanisms.Q33652491
An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytesQ33757511
SUMO, ubiquitin's mysterious cousinQ33939449
The differential miscibility of lipids as the basis for the formation of functional membrane rafts.Q34067848
Activation-induced cell deathQ34282369
Signal transduction by tumor necrosis factor and its relativesQ34341941
Aggregation of lipid rafts accompanies signaling via the T cell antigen receptorQ36326042
Differential signaling and tumor necrosis factor receptor-associated factor (TRAF) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1).Q36369236
NF-kappaB signals induce the expression of c-FLIP.Q39460566
CD40 and LMP-1 both signal from lipid rafts but LMP-1 assembles a distinct, more efficient signaling complexQ39645275
Molecular ordering of the initial signaling events of CD95.Q39676008
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
membrane raftQ424178
TNFQ18032037
P304page(s)655-664
P577publication date2003-05-01
P1433published inImmunityQ6005457
P1476titleRecruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation
P478volume18

Reverse relations

cites work (P2860)
Q28287278A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions
Q33818158A differential role for endocytosis in receptor-mediated activation of Nox1.
Q36089051A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways
Q37728850A20: from ubiquitin editing to tumour suppression
Q24301284AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation
Q37273750Active uptake of dendritic cell-derived exovesicles by epithelial cells induces the release of inflammatory mediators through a TNF-alpha-mediated pathway
Q46909234Acute ethanol treatment modulates Toll-like receptor-4 association with lipid rafts
Q34707087Age-dependent accumulation of ubiquitinated 2',3'-cyclic nucleotide 3'-phosphodiesterase in myelin lipid rafts
Q37357098Altering the sphingolipid acyl chain composition prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalization
Q44976868An evolutionary conserved pathway of nuclear factor-kappaB activation involving caspase-mediated cleavage and N-end rule pathway-mediated degradation of IkappaBalpha
Q49790910An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation
Q40536268Analysis of human tumour necrosis factor receptor 1 dominant-negative mutants reveals a major region controlling cell surface expression
Q35886318Analysis of lipid-composition changes in plasma membrane microdomains
Q34973492Antagonistic TNF receptor one-specific antibody (ATROSAB): receptor binding and in vitro bioactivity
Q35023022Anti-inflammatory effect of targeted delivery of SOD to endothelium: mechanism, synergism with NO donors and protective effects in vitro and in vivo
Q35207610Apoptosis modulation as a promising target for treatment of systemic sclerosis
Q24537608BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway
Q38731779Brefeldin A-Inhibited Guanine Nucleotide-Exchange Factor 1 (BIG1) Governs the Recruitment of Tumor Necrosis Factor Receptor-Associated Factor 2 (TRAF2) to Tumor Necrosis Factor Receptor 1 (TNFR1) Signaling Complexes
Q52308826CADM1 is essential for KSHV-encoded vGPCR-and vFLIP-mediated chronic NF-κB activation.
Q40177590CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells
Q35083839Caveolae participate in tumor necrosis factor receptor 1 signaling and internalization in a human endothelial cell line
Q38979542Cell fate decisions regulated by K63 ubiquitination of tumor necrosis factor receptor 1.
Q64114610Cholesterol Sulfotransferase SULT2B1b Modulates Sensitivity to Death Receptor Ligand TNFα in Castration-Resistant Prostate Cancer
Q92263460Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling
Q36028155Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling
Q38530635Cloaked in ubiquitin, a killer hides in plain sight: the molecular regulation of RIPK1.
Q37715776Control of death receptor ligand activity by posttranslational modifications.
Q27657476Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin
Q33939106DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas.
Q24299573De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
Q42123656Death Receptor 5 Networks Require Membrane Cholesterol for Proper Structure and Function.
Q37257117Decrease in tumor necrosis factor-alpha receptor-associated death domain results from ubiquitin-dependent degradation in obstructive renal injury in rats
Q38822173Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.
Q36241231Deregulated TGF-beta signaling in leukemogenesis
Q39104729Dietary essential α-linolenic acid and linoleic acid differentially modulate TNFα-induced NFκB activity in FADS2-deficient HEK-293 cells
Q46418731Differential effects of lipoprotein lipase on tumor necrosis factor-alpha and interferon-gamma-mediated gene expression in human endothelial cells
Q33999606Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.
Q40540260Distinct mechanisms determine the patterns of differential activation of H-Ras, N-Ras, K-Ras 4B, and M-Ras by receptors for growth factors or antigen.
Q33585802Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNFalpha-induced inflammatory responses
Q39768159Dynamics of RASSF1A/MOAP-1 association with death receptors.
Q41932639Dynamics of mitochondrial raft-like microdomains in cell life and death.
Q35910540Effector CD4+ T cells generate intermediate caspase activity and cleavage of caspase-8 substrates
Q36687046Electrophilic nitro-fatty acids inhibit vascular inflammation by disrupting LPS-dependent TLR4 signalling in lipid rafts.
Q36732184Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death
Q33231442Extracellular TNFR1 release requires the calcium-dependent formation of a nucleobindin 2-ARTS-1 complex
Q52316878Factor VIIa induces anti-inflammatory signaling via EPCR and PAR1.
Q24320142Flotillin-2 expression in the human gut: from a cell model to human tissue in health and inflammatory bowel diseases
Q39724559Function of membrane rafts in viral lifecycles and host cellular response
Q24321317Functional analysis of the posttranslational modifications of the death receptor 6
Q33795250G-protein-coupled-receptor kinases mediate TNFα-induced NFκB signalling via direct interaction with and phosphorylation of IκBα.
Q90011228GIT1 regulates angiogenic factor secretion in bone marrow mesenchymal stem cells via NF-κB/Notch signalling to promote angiogenesis
Q49787949Ganglioside GM1 contributes to extracellular/intracellular regulation of insulin resistance, impairment of insulin signaling and down-stream eNOS activation, in human aortic endothelial cells after short- or long-term exposure to TNFα.
Q64254072Gangliosides Contribute to Vascular Insulin Resistance
Q28580654Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradation
Q99419127HRG switches TNFR1-mediated cell survival to apoptosis in Hepatocellular Carcinoma
Q37296344HSP70 interacts with TRAF2 and differentially regulates TNFalpha signalling in human colon cancer cells
Q90028528Herpes simplex virus 1 ICP6 impedes TNF receptor 1-induced necrosome assembly during compartmentalization to detergent-resistant membrane vesicles
Q35182251Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-κB inhibitor A20 and constitutive NF-κB signaling
Q36085601IAPs, RINGs and ubiquitylation
Q43125086Identification of a lysine-rich region of Fas as a raft nanodomain targeting signal necessary for Fas-mediated cell death.
Q37424031Impaired TNFalpha-induced A20 expression in E1A/Ras-transformed cells
Q35099711Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice
Q24312187Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
Q24309469Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation
Q35989359Inhibition of cytokine signaling in human retinal endothelial cells through modification of caveolae/lipid rafts by docosahexaenoic acid
Q39410061Inhibition of latent membrane protein 1 impairs the growth and tumorigenesis of latency II Epstein-Barr virus-transformed T cells.
Q36498514Inhibition of proinflammatory and innate immune signaling pathways by a cytomegalovirus RIP1-interacting protein
Q35951508Inhibition of toll-like receptor and cytokine signaling--a unifying theme in ischemic tolerance
Q35856781Interferon regulatory factor 7 is activated by a viral oncoprotein through RIP-dependent ubiquitination.
Q35150394Intracellular lipid flux and membrane microdomains as organizing principles in inflammatory cell signaling
Q36597952Intracellular signals and events activated by cytokines of the tumor necrosis factor superfamily: From simple paradigms to complex mechanisms.
Q41933362Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis
Q41189574JMJD8 is a positive regulator of TNF-induced NF-κB signaling
Q41830093LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages
Q37233180Life and death by death receptors
Q52553014Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death.
Q51323580Lipid Rafts Promote trans Fatty Acid-Induced Inflammation in Human Umbilical Vein Endothelial Cells.
Q34154684Lipid based therapy for ulcerative colitis-modulation of intestinal mucus membrane phospholipids as a tool to influence inflammation.
Q35101890Lipid raft redox signaling: molecular mechanisms in health and disease
Q26998351Lipid raft: A floating island of death or survival
Q37446112Lipid rafts and caveolin-1 coordinate interleukin-1beta (IL-1beta)-dependent activation of NFkappaB by controlling endocytosis of Nox2 and IL-1beta receptor 1 from the plasma membrane
Q36719287Lipid rafts determine clustering of STIM1 in endoplasmic reticulum-plasma membrane junctions and regulation of store-operated Ca2+ entry (SOCE)
Q38827777Lipid rafts in immune signalling: current progress and future perspective.
Q37665498Lipid rafts promote liver cancer cell proliferation and migration by up-regulation of TLR7 expression
Q36984127Localization of A20 to a lysosome-associated compartment and its role in NFkappaB signaling
Q24306882MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression
Q30490333Macrophage sphingomyelin synthase 2 deficiency decreases atherosclerosis in mice
Q33672489Many checkpoints on the road to cell death: regulation of Fas-FasL interactions and Fas signaling in peripheral immune responses
Q38078229Mechanisms regulating neutrophil survival and cell death.
Q37118254Membrane raft redox signalosomes in endothelial cells
Q26852802Membrane trafficking of death receptors: implications on signalling
Q37307064Microbial Degradation of Cellular Kinases Impairs Innate Immune Signaling and Paracrine TNFα Responses
Q40387341N-3 vs. n-6 fatty acids differentially influence calcium signalling and adhesion of inflammatory activated monocytes: impact of lipid rafts.
Q28271031NF-kappaB and the immune response
Q36964401NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies.
Q97636083NORE1A directs apoptotic switch of TNF signaling through reciprocal modulation of ITCH-mediated destruction of TNFRI and BAX
Q55440020On the modeling and analysis of the biological regulatory network of NF- $${\kappa }$$ κ B activation in HIV-1 infection
Q24652618PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination
Q92425057Palmitoylation is required for TNF-R1 signaling
Q39089524Piecing it together: Unraveling the elusive structure-function relationship in single-pass membrane receptors
Q40436916Proteasome inhibition induces TNFR1 shedding from human airway epithelial (NCI-H292) cells
Q90227518Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution
Q42661602RIP1 comes back to life as a cell death regulator in TNFR1 signaling
Q28288337RIP1, a kinase on the crossroads of a cell's decision to live or die
Q37774919Reactive oxygen species in TNFalpha-induced signaling and cell death.
Q40555067Receptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c-IAP1 and c-IAP2) in vitro
Q50100385Regulated intramembrane proteolysis: emergent role in cell signalling pathways
Q42810176Regulation of death complexes formation in tumor necrosis factor receptor signaling
Q37628447Regulation of death receptor signaling by the ubiquitin system
Q27690854Regulation of inflammatory and antiviral signaling by A20.
Q28262381Regulation of tumour necrosis factor signalling: live or let die
Q36017850Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: a mechanism for generation of soluble cytokine receptors
Q57372671Requirement of Oxidation-dependent CD40 Homodimers for CD154/CD40 Bidirectional Signaling
Q28476834Restoration of IFNγR subunit assembly, IFNγ signaling and parasite clearance in Leishmania donovani infected macrophages: role of membrane cholesterol
Q24559752Restoration of NF-kappaB activation by tumor necrosis factor alpha receptor complex-targeted MEKK3 in receptor-interacting protein-deficient cells
Q75356195Right place, right time
Q45345604Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation
Q24294081Role of GD3-CLIPR-59 association in lymphoblastoid T cell apoptosis triggered by CD95/Fas
Q38344567Role of mitochondrial raft-like microdomains in the regulation of cell apoptosis.
Q52622109Role of sphingomyelin synthesis in pulmonary endothelial cell cytoskeletal activation and endotoxin-induced lung injury.
Q36961046Roles of TRAF6 in CD40 signaling
Q49886934ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor
Q24294324Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase
Q29618714Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]
Q30493800Signaling components of redox active endosomes: the redoxosomes.
Q28512633Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death
Q29616428Signalling pathways of the TNF superfamily: a double-edged sword
Q91878626Soft extracellular matrix enhances inflammatory activation of mesenchymal stromal cells to induce monocyte production and trafficking
Q43166315Spatial compartmentalization of tumor necrosis factor (TNF) receptor 1-dependent signaling pathways in human airway smooth muscle cells. Lipid rafts are essential for TNF-alpha-mediated activation of RhoA but dispensable for the activation of the NF
Q28591973Spatial segregation of gamma-secretase and substrates in distinct membrane domains
Q41079635Spatial segregation of transport and signalling functions between human endothelial caveolae and lipid raft proteomes
Q35092629Specific elimination of effector memory CD4+ T cells due to enhanced Fas signaling complex formation and association with lipid raft microdomains
Q38963276Squalene synthase induces tumor necrosis factor receptor 1 enrichment in lipid rafts to promote lung cancer metastasis
Q41489885Subcellular domain-dependent molecular hierarchy of SFK and FAK in mechanotransduction and cytokine signaling
Q37073568Substrate specificity of gamma-secretase and other intramembrane proteases
Q33481328TNF-alpha-induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells.
Q83300040TNFR1 delivers pro-survival signals that are required for limiting TNFR2-dependent activation-induced cell death (AICD) in CD8+ T cells
Q37299479TNFR1 signaling kinetics: spatiotemporal control of three phases of IKK activation by posttranslational modification
Q40319830TRAIL-induced apoptosis in U-1242 MG glioma cells
Q36268329Targeting the Fas/Fas ligand pathway in cancer.
Q28190485The TNF receptor 1: a split personality complex
Q39308380The TNF-α/ROS/HIF-1-induced upregulation of FoxMI expression promotes HCC proliferation and resistance to apoptosis
Q37278043The TRAIL apoptotic pathway in cancer onset, progression and therapy
Q88862150The Tumor Necrosis Factor Family: Family Conventions and Private Idiosyncrasies
Q38255302The cell death response to enteropathogenic Escherichia coli infection
Q41839673The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability
Q92460121The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane
Q24683018The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games
Q40165317The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase and CD13/aminopeptidase N and modulates their endocytic pathways
Q36920268The role of TRADD in death receptor signaling
Q36295655The role of apoptosis in the development and function of T lymphocytes
Q24305510The role of receptor internalization in CD95 signaling
Q42323234The tumor necrosis factor receptor stalk regions define responsiveness to soluble versus membrane-bound ligand
Q28660873Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death
Q54708947Tumor necrosis factor alpha expression and protein levels after fluid percussion injury in rats: the effect of injury severity and brain temperature.
Q28575022Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain
Q39872674Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation
Q39296808U20 is responsible for human herpesvirus 6B inhibition of tumor necrosis factor receptor-dependent signaling and apoptosis
Q29616322Ubiquitin signalling in the NF-kappaB pathway
Q36399446Ubiquitin, TAK1 and IKK: is there a connection?
Q36819396Ubiquitin-mediated activation of TAK1 and IKK.
Q39318861Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB.
Q24530708Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity
Q39378876dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8.
Q46557485fat facets induces polyubiquitination of Imd and inhibits the innate immune response in Drosophila
Q36199812oxLDL and eLDL Induced Membrane Microdomains in Human Macrophages.
Q36674736γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling.

Search more.