Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection

scientific article published on October 1, 1992

Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1084/JEM.176.4.1137
P953full work available at URLhttps://europepmc.org/articles/PMC2119381
https://europepmc.org/articles/PMC2119381?pdf=render
P932PMC publication ID2119381
P698PubMed publication ID1402658

P50authorRonald LevyQ1758880
P2093author name stringT. T. Chen
A. D. Zelenetz
P2860cites workThe reciprocal partners of both the t(14; 18) and the t(11; 14) translocations involved in B-cell neoplasms are rearranged by the same mechanismQ70386283
DNA sequencing with chain-terminating inhibitorsQ22066207
A comprehensive set of sequence analysis programs for the VAXQ26778432
Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseQ26778460
A simple and very efficient method for generating cDNA librariesQ27860461
Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genesQ28259844
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cellsQ28294137
High efficiency transformation of E. coli by high voltage electroporationQ29615278
Somatic generation of antibody diversityQ29616439
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell deathQ29620000
Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual diseaseQ33586233
Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cellsQ33862904
Directional cloning of cDNA using a selectable SfiI cassetteQ33925817
Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouseQ34380142
Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partnersQ34614292
Follicular large cell lymphoma. An immunophenotype studyQ35836085
Histologic transformation of follicular lymphoma to diffuse lymphoma represents tumor progression by a single malignant B cellQ36229751
The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphomaQ36230378
BCL2 oncogene translocation is mediated by a chi-like consensusQ36231418
The monoclonality of human B-cell lymphomasQ36335226
Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutationQ36350233
Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomasQ36352177
Single cell origin of bigenotypic and biphenotypic B cell proliferations in human follicular lymphomasQ36354429
Clonal evolution of a follicular lymphoma: evidence for antigen selectionQ37120876
Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.Q37554227
The normal and malignant germinal centreQ40248654
Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locusQ41091501
Bcl-2/JH rearrangements in benign lymphoid tissues with follicular hyperplasiaQ41654748
Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.Q41714456
Translocation t(14;18) in B cell lymphomas as a cause for defective immunoglobulin productionQ41777162
bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferationQ41964290
Induction of proliferation of human follicular (B type) lymphoma cells by cognate interaction with CD4+ T cell clonesQ44670038
Expression of LFA-1 in non-Hodgkin's lymphomaQ46703919
Maturation of the immune response in germinal centersQ48194763
The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joiningQ48375088
Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.Q48377324
An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH.Q48413837
Bone marrow origin of a B-cell lymphoma.Q52251064
Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin's lymphoma.Q53435962
Evolutionary nucleotide replacements in DNAQ59075574
Three-dimensional structure of an antigen–antibody complex at 6 Å resolutionQ59081477
The role of clonal selection and somatic mutation in autoimmunityQ59082893
Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)Q59085244
Follicular non-Hodgkin's lymphoma cell adhesion to normal germinal centers and neoplastic follicles involves very late antigen-4 and vascular cell adhesion molecule-1Q67894725
Autoantibody activity of immunoglobulins isolated from B-cell follicular lymphomasQ67925562
Enhanced detection of the t(14;18) translocation in malignant lymphoma using pulsed-field gel electrophoresisQ67962252
Use of family specific leader region primers for PCR amplification of the human heavy chain variable region gene repertoireQ68066508
Direct sequence analysis of the 14q+ and 18q- chromosome junctions in follicular lymphomaQ68522830
Multiple recurrent genomic defects in follicular lymphoma. A possible model for cancerQ68918964
Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomasQ69406382
Comparative biochemical and genetic characterization of clonally related human B-cell lines secreting pathogenic anti-Pr2 cold agglutininsQ69832620
Involvement of the bcl-2 gene in human follicular lymphomaQ69870224
A clinical trial of anti-idiotype therapy for B cell malignancyQ69891840
Follicular low-grade non-Hodgkin's lymphoma: long-term outcome with or without tumor progressionQ69948335
Histologic progression in non-Hodgkin's lymphomaQ70212698
Differential expression of LFA-1 molecules in non-Hodgkin's lymphoma and lymphoid leukemiaQ70213375
Histologic conversion in the non-Hodgkin's lymphomasQ70325819
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectfollicular lymphomaQ123251
chromosomal translocationQ916504
gene rearrangementQ65350917
P304page(s)1137-1148
P577publication date1992-10-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleClonal expansion in follicular lymphoma occurs subsequent to antigenic selection
P478volume176

Reverse relations

cites work (P2860)
Q77589706A CD40 Signalosome anchored in lipid rafts leads to constitutive activation of NF-kappaB and autonomous cell growth in B cell lymphomas
Q41264930A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro
Q48082296A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q.
Q37314843A molecular analysis of biclonal follicular lymphoma: further evidence for bone marrow origin and clonal selection
Q72076148A submicroscopic interstitial deletion of chromosome 14 frequently occurs adjacent to the t(14;18) translocation breakpoint in human follicular lymphoma
Q34798677Apoptosis in lymphocytic leukemias and lymphomas
Q89823528B Cell Receptor Immunogenetics in B Cell Lymphomas: Immunoglobulin Genes as Key to Ontogeny and Clinical Decision Making
Q34059352B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression
Q37810118Biology and treatment of follicular lymphoma
Q41828070Burkitt's lymphomas express VH genes with a moderate number of antigen-selected somatic mutations.
Q39773710Can immunoglobulin C(H)1 constant region domain modulate antigen binding affinity of antibodies?
Q33350258Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities
Q36371091Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification.
Q36222868Clonal evolution of B cells in transformation from low- to high-grade lymphoma
Q48084578Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes
Q54657499Clonal selection in the bone marrow involvement of follicular lymphoma.
Q52004995Comparative Studies of Somatic and Ongoing Mutations in Immunoglobulin Heavy-Chain Variable Region Genes in Diffuse Large B-Cell Lymphomas of the Stomach and the Small Intestine
Q48067769Complete nucleotide sequence of Ig V genes in three cases of Burkitt lymphoma associated with AIDS.
Q52935530DNA sequence of immunoglobulin heavy chain variable region gene in thyroid lymphoma.
Q41522446Differentiation and apoptosis of human germinal center B-lymphocytes
Q40680069Diversity and somatic hypermutation of the Ig VHDJH, V kappa J kappa, and V lambda J lambda gene segments in lymphoma B cells: relevance to the origin of the neoplastic B cell clone.
Q36616139Effect of Helicobacter pylori eradication on ongoing mutation of immunoglobulin genes in gastric MALT lymphoma
Q35754463Establishment of a novel B cell clonality analysis using single-strand conformation polymorphism of immunoglobulin light chain messenger signals
Q35174152Etiology and pathogenesis of AIDS-related non-Hodgkin's lymphoma
Q35220375Follicular lymphoma in situ: clinical implications and comparisons with partial involvement by follicular lymphoma
Q37169915Follicular lymphoma of the thyroid gland
Q24677146Follicular lymphoma-like B cells in healthy individuals: a novel intermediate step in early lymphomagenesis
Q33927978Follicular lymphoma: still Six characters in search of an author?
Q38306094Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor.
Q31977172Immunoglobulin VH gene mutational analysis suggests that primary effusion lymphomas derive from different stages of B cell maturation
Q39809474Immunoglobulin gene sequence analysis to further assess B-cell origin of multiple myeloma
Q30826654In situ analysis of the variable heavy chain gene of an IgM/IgG-expressing follicular lymphoma: evidence for interfollicular trafficking of tumor cells.
Q36362440In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells
Q52904710Insight into Burkitt's lymphoma from immunoglobulin variable region gene analysis.
Q34476318Intraclonal diversity in follicular lymphoma analyzed by quantitative ultradeep sequencing of noncoding regions
Q61906757Intraclonal molecular heterogeneity suggests a hierarchy of pathogenetic events in Burkitt's lymphoma
Q35786734Lectins from opportunistic bacteria interact with acquired variable-region glycans of surface immunoglobulin in follicular lymphoma
Q41912026Molecular analysis of human immunoglobulin heavy chain variable genes (IgVH) in normal and malignant B cells
Q36243261Molecular characterization of IgA- and/or IgG-switched chronic lymphocytic leukemia B cells
Q34331092Molecular pathology of primary intraocular lymphoma
Q41756686Molecular pathways in low grade B-cell lymphoma.
Q74065767Molecular phenotype distinguishes two subsets of gastric low-grade mucosa-associated lymphoid tissue lymphomas
Q48069502New type of t(14;18) in a non-Hodgkin's lymphoma provides insight in molecular events in early B-cell differentiation.
Q52307938Optimal primer selection for clonality assessment by polymerase chain reaction analysis. III. Intermediate and high-grade B-cell neoplasms.
Q42583733Origin and migration of follicular lymphoma cells
Q42999023Pre-malignant and malignant lymphoproliferations in an HCV-infected type II mixed cryoglobulinemic patient are sequential phases of an antigen-driven pathological process
Q52578670Recurrent disruption of the Imu splice donor site in t(14;18) positive lymphomas: a potential molecular basis for aberrant downstream class switch recombination.
Q41931179Skewed T-cell receptor Vbeta8.2 expression in transgenic CD2-myc induced thymic lymphoma: a role for antigen stimulation in tumour development?
Q48037869Somatic hypermutation in normal and transformed human B cells
Q42678196Somatic hypermutation of immunoglobulin variable region genes: focus on follicular lymphoma and multiple myeloma
Q35552528Somatic hypermutation patterns in germinal center B cell malignancies
Q41040876Somatic hypermutations in the immunoglobulin genes of two new human lymphoma lines of lymphatic follicle origin
Q50930237Subversion of the Bcl-2 life/death switch in cancer development and therapy.
Q35750821Superantigen properties of a human sialoprotein involved in gut-associated immunity
Q26866936Targeting the Bcl-2 family for cancer therapy
Q35591695The Bcl-2 family: roles in cell survival and oncogenesis.
Q41329806The Somatic Hypermutation Activity of a Follicular Lymphoma Links to Large Insertions and Deletions of Immunoglobulin Genes
Q37831956The challenge of the microenvironment in B-cell lymphomas.
Q33922899The indispensable role of microenvironment in the natural history of low-grade B-cell neoplasms
Q34414672The occurrence and significance of V gene mutations in B cell-derived human malignancy
Q41467818Two acquired immunodeficiency syndrome-associated Burkitt's lymphomas produce specific anti-i IgM cold agglutinins using somatically mutated VH4-21 segments
Q35401680Ultradeep analysis of tumor heterogeneity in regions of somatic hypermutation
Q41404449VH gene expression in CD5 positive and CD5 negative B cell chronic lymphoid malignancies
Q58041799VH gene expression in hairy cell leukaemia