Clinical studies of camptothecin and derivatives

scientific article published on January 1, 2003

Clinical studies of camptothecin and derivatives is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/S0099-9598(03)60001-5
P698PubMed publication ID14593855

P50authorJaap VerweijQ98683725
Alex SparreboomQ71780219
P2093author name stringOtto Soepenberg
P2860cites workCancer ResearchQ326097
Drug Metabolism and DispositionQ1261140
Journal of Pharmacology and Experimental TherapeuticsQ1500272
HaematologicaQ5638209
Phase II trial of topotecan as a 21-day continuous infusion in patients with advanced or metastatic adenocarcinoma of the pancreasQ77667993
Phase II trial of topotecan for the treatment of mesotheliomaQ77695228
More about: irinotecan-related cholinergic syndrome induced by coadministration of oxaliplatinQ77798696
Phase II trial of topotecan in advanced breast cancer: a Cancer and Leukemia Group B studyQ77854147
Phase II trial of 9-aminocamptothecin (NSC 603071) administered as a 120-hr continuous infusion weekly for three weeks in metastatic colorectal carcinomaQ78061392
A phase I study of irinotecan and infusional cisplatin with recombinant human granulocyte colony-stimulating factor support in the treatment of advanced non-small cell lung cancerQ93896546
Important advances in oncologyQ27711194
Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNAQ27748892
A model for the mechanism of human topoisomerase IQ27748893
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trialQ28036747
A weekly regimen of cisplatin, paclitaxel and topotecan with granulocyte-colony stimulating factor support for patients with extensive disease small cell lung cancer: a phase II studyQ28364196
A phase I and pharmacokinetic study of intraperitoneal topotecanQ28366214
The domain organization of human topoisomerase IQ28910330
Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structuresQ28910447
Validation study of assay method for DX-8951 and its metabolite in human plasma and urine by high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometryQ30984313
Phase II trial of topotecan in patients with advanced, persistent, or recurrent uterine leiomyosarcomas: a Gynecologic Oncology Group StudyQ31431689
High-Performance liquid chromatographic analysis of lactone and hydroxy acid of new antitumor drug, DX-8951 (exatecan), in mouse plasmaQ32055895
Phase I and pharmacokinetic study of exatecan mesylate (DX-8951f): a novel camptothecin analogQ32073568
Irinotecan in the treatment of colorectal cancer: clinical overviewQ32073589
Lack of efficacy of topotecan in the treatment of metastatic or recurrent squamous carcinoma of the head and neck: an Eastern Cooperative Oncology Group Trial (E3393).Q32092717
Phase I and pharmacologic study of oral (PEG-1000) 9-aminocamptothecin in adult patients with solid tumorsQ33179163
Role of erythrocytes and serum proteins in the kinetic profile of total 9-amino-20(S)-camptothecin in humansQ33179201
Oral topoisomerase 1 inhibitors in adult patients: present and futureQ33180133
Modulation of camptothecin analogs in the treatment of cancer: a reviewQ33181805
The use of oral cytotoxic and cytostatic drugs in cancer treatmentQ33183187
Phase I and pharmacologic study of liposomal lurtotecan, NX 211: urinary excretion predicts hematologic toxicityQ33183439
Modulation of irinotecan metabolism by ketoconazoleQ33183940
Pharmacology of topoisomerase I inhibitors irinotecan (CPT-11) and topotecanQ33184156
Effects of St. John's wort on irinotecan metabolismQ33184162
Topotecan versus cyclophosphamide, doxorubicin, and vincristine for the treatment of recurrent small-cell lung cancerQ33328193
Phase I/pharmacokinetic study of the topoisomerase I inhibitor GG211 administered as a 21-day continuous infusion.Q33329060
A phase II clinical and pharmacological study of oral 9-nitrocamptothecin in patients with refractory epithelial ovarian, tubal or peritoneal cancer.Q33329288
Combination of oxaliplatin plus irinotecan in patients with gastrointestinal tumors: results of two independent phase I studies with pharmacokineticsQ33330597
Phase I and pharmacokinetic study of a daily times 5 short intravenous infusion schedule of 9-aminocamptothecin in a colloidal dispersion formulation in patients with advanced solid tumorsQ33330606
Activity and pharmacodynamics of 21-Day topotecan infusion in patients with ovarian cancer previously treated with platinum-based chemotherapy. New York Gynecologic Oncology GroupQ33330623
Lack of efficacy of 24-h infusional topotecan in platinum-refractory ovarian cancer: A Gynecologic Oncology Group trialQ33330937
Phase I and pharmacologic study of irinotecan administered as a 96-hour infusion weekly to adult cancer patientsQ33331346
A phase II study of 9-aminocamptothecin in patients with refractory breast cancerQ33331682
Phase II trial of topotecan in malignant melanomaQ73562813
Phase II trial of 9-aminocamptothecin administered as a 72-hour continuous infusion in metastatic colorectal carcinomaQ73585200
Enhanced cytogenetic and antitumor effects by 9-nitrocamptothecin and antineoplasticsQ73812598
Sensitive high-performance liquid chromatographic method for the determination of the lactone form and the lactone plus hydroxy-acid forms of the new camptothecin derivative DX-8951 in human plasma using fluorescence detectionQ73814722
Population pharmacokinetic model for topotecan derived from phase I clinical trialsQ73900863
A phase II trial of topotecan in esophageal carcinoma: a Southwest Oncology Group study (SWOG 9339)Q73905129
Phase II trial of topotecan in advanced gastric cancer: a Southwest Oncology Group studyQ73916903
A phase II study of topotecan administered five times daily in patients with advanced gastric cancerQ73927027
Severe CPT-11 toxicity in patients with Gilbert's syndrome: two case reportsQ73948201
Irinotecan-related cholinergic syndrome induced by coadministration of oxaliplatinQ74121312
Phase II trial of aminocamptothecin (9-AC/DMA) in patients with advanced squamous cell head and neck cancerQ74222602
Phase I and pharmacologic study of 9-aminocamptothecin colloidal dispersion formulation given as a 24-hour continuous infusion weekly times four every 5 weeksQ74329812
Plasma and cerebrospinal fluid pharmacokinetics of 9-aminocamptothecin (9-AC), irinotecan (CPT-11), and SN-38 in nonhuman primatesQ74469116
Combined irinotecan and oxaliplatin plus granulocyte colony-stimulating factor in patients with advanced fluoropyrimidine/leucovorin-pretreated colorectal cancerQ74593436
Phase I and pharmacokinetic trial of oral irinotecan administered daily for 5 days every 3 weeks in patients with solid tumorsQ74611892
Pharmacokinetics of cisplatin in combined cisplatin and 5-fluorouracil therapy: a comparative study of three different schedules of cisplatin administrationQ74616350
Phase I clinical and pharmacokinetic study of oral 9-aminocamptothecin (NSC-603071)Q74628254
A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinomaQ74635392
A risk-benefit assessment of irinotecan in solid tumoursQ74692829
Potent and broad antitumor effects of DX-8951f, a water-soluble camptothecin derivative, against various human tumors xenografted in nude miceQ74824090
Secondary leukemias induced by topoisomerase-targeted drugsQ77333785
The development of combination therapy involving camptothecins: a review of preclinical and early clinical studiesQ77395185
Unexpected hepatotoxicities in patients with non-Hodgkin's lymphoma treated with irinotecan (CPT-11) and etoposideQ77401717
O-glucuronidation, a newly identified metabolic pathway for topotecan and N-desmethyl topotecanQ77417368
Secondary leukemia following high cumulative doses of etoposide in patients treated for advanced germ cell tumorsQ77435869
Topotecan in previously treated advanced urothelial carcinoma: an ECOG phase II trialQ77665238
International Commission for Protection Against Environmental Mutagens and Carcinogens. Mutagenicity and carcinogenicity of topoisomerase-interactive agentsQ40391405
Topoisomerase inhibitors. A review of their therapeutic potential in cancerQ40499871
Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sitesQ40530650
Phase I and pharmacokinetic study of paclitaxel and irinotecan for patients with advanced non-small cell lung cancerQ40575774
Phase ii comparator study of oral versus intravenous topotecan in patients with chemosensitive small-cell lung cancerQ40606324
Phase I and pharmacokinetic study of the camptothecin analog DX-8951f administered as a 30-minute infusion every 3 weeks in patients with advanced cancer.Q40611414
Clinical phase II study and pharmacological evaluation of rubitecan in non-pretreated patients with metastatic colorectal cancer-significant effect of food intake on the bioavailability of the oral camptothecin analogueQ40648032
Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapyQ40659621
Phase II study of intravenous topotecan as a 5-day infusion for refractory epithelial ovarian carcinomaQ40669502
Clinical evidence for topotecan-paclitaxel non--cross-resistance in ovarian cancerQ40715776
A phase I clinical and pharmacokinetic study of the topoisomerase I inhibitor topotecan (SK&F 104864) given as an intravenous bolus every 21 daysQ40731233
Point mutations in the topoisomerase I gene in patients with non-small cell lung cancer treated with irinotecanQ40751042
Phase I and pharmacologic study of 9-aminocamptothecin colloidal dispersion formulation in patients with refractory or relapsed acute leukemiaQ40804661
Topoisomerase I inhibitors: topotecan and irenotecanQ40807397
Oral chemotherapy: rationale and future directionsQ40851033
Clinical pharmacokinetics of irinotecanQ40880283
Patient preferences for oral versus intravenous palliative chemotherapyQ40915962
Homocamptothecin, an E-ring-modified camptothecin analogue, generates new topoisomerase I-mediated DNA breaks.Q40916716
Characterization of a human small-cell lung cancer cell line resistant to a new water-soluble camptothecin derivative, DX-8951fQ40978962
Topoisomerase II inhibitors induce DNA double-strand breaks at a specific site within the AML1 locusQ41119522
The clinical status of irinotecan (CPT-11), a novel water soluble camptothecin analogue: 1996.Q41163991
Irinotecan. A review of its pharmacological properties and clinical efficacy in the management of advanced colorectal cancerQ41188377
The promoter region of the human type-I-DNA-topoisomerase gene. Protein-binding sites and sequences involved in transcriptional regulationQ41517482
Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell lineQ41597979
Topoisomerase I inhibitors: review and updateQ41634169
Effects of CPT-11 in combination with other anti-cancer agents in cultureQ41639325
Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activityQ41704097
Effect of topoisomerase modulators on cisplatin cytotoxicity in human ovarian carcinoma cellsQ41752714
The effect of increasing topotecan infusion from 30 minutes to 4 hours on the duration of exposure in cerebrospinal fluidQ43542620
Sequence effect of irinotecan and fluorouracil treatment on pharmacokinetics and toxicity in chemotherapy-naive metastatic colorectal cancer patientsQ43693197
Biorecognizable HPMA copolymer-drug conjugates for colon-specific delivery of 9-aminocamptothecinQ43698387
A phase II trial of 9-aminocaptothecin (9-AC) as a 120-h infusion in patients with non-small cell lung cancerQ43740784
Phase I clinical and pharmacogenetic trial of irinotecan and raltitrexed administered every 21 days to patients with cancerQ43766558
A randomised trial of oral versus intravenous topotecan in patients with relapsed epithelial ovarian cancerQ43828848
A phase II study of 9-nitrocamptothecin in patients with advanced pancreatic adenocarcinomaQ43836493
Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancerQ43850218
Phase I clinical and pharmacologic trial of intravenous estramustine phosphateQ43886340
Phase II trial of 9-nitrocamptothecin (RFS 2000) for patients with metastatic cutaneous or uveal melanomaQ43922127
Phase I study of carboplatin, irinotecan and docetaxel on a divided schedule with recombinant human granulocyte colony stimulating factor support in patients with stage IIIB or IV non-small cell lung cancerQ44015246
Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.Q44044782
Urinary and fecal excretion of topotecan in patients with malignant solid tumoursQ44058880
Clinical pharmacokinetics of irinotecan and its metabolites: a population analysisQ44083716
Novel 20-carbonate linked prodrugs of camptothecin and 9-aminocamptothecin designed for activation by tumour-associated plasminQ44088576
Osteosarcomas and adult soft tissue sarcomas: Is there a place for high LET radiation therapy?Q44182595
Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemiaQ44461372
Phase I and pharmacokinetic study of intraperitoneal topotecanQ46043090
Re: Irinotecan-related cholinergic syndrome induced by coadministration of oxaliplatinQ47842166
Irinotecan therapy in adults with recurrent or progressive malignant gliomaQ48207492
Pharmacokinetic and pharmacodynamic evaluation of the topoisomerase inhibitor irinotecan in cancer patients.Q50950480
Mutagenic properties of topoisomerase-targeted drugs.Q52531966
Isolation and structural confirmation of N-desmethyl topotecan, a metabolite of topotecan.Q53715458
The pharmacokinetics of topotecan and its carboxylate form following separate intravenous administration to the dog.Q53963181
Clinical, pharmacokinetic and biological studies of topotecan.Q54036451
A phase II and pharmacokinetic study of weekly 72-h topotecan infusion in patients with platinum-resistant and paclitaxel-resistant ovarian carcinoma.Q54041945
Topoisomerase I-mediated antiproliferative activity of enantiomerically pure fluorinated homocamptothecins.Q54049254
A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo.Q54167076
Activity of topotecan, a new topoisomerase I inhibitor, against human tumor colony-forming units in vitroQ54255888
Antitumor effect of DX-8951, a novel camptothecin analog, on human pancreatic tumor cells and their CPT-11-resistant variants cultured in vitro and xenografted into nude mice.Q54982736
Enhanced antitumor efficacy of a combination of CPT-11, a new derivative of camptothecin, and cisplatin against human lung tumor xenografts.Q55196356
Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2Q56864507
Identification and kinetics of a ?-glucuronide metabolite of SN-38 in human plasma after administration of the camptothecin derivative irinotecanQ59358959
Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancerQ61868290
Experimental studies on biochemical modulation targeting topoisomerase I and II in human tumor xenografts in nude miceQ67486552
Phase II trial of topotecan administered as a 21-day continuous infusion in previously untreated patients with stage IIIB and IV non-small-cell lung cancerQ33503990
Topotecan. A review of its potential in advanced ovarian cancerQ33504167
A phase I clinical and pharmacokinetic study of the new topoisomerase inhibitor GI147211 given as a 72-h continuous infusionQ33504409
A phase II study of 9-aminocamptothecin in advanced non-small-cell lung cancerQ33504516
Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2.Q33677099
Enhanced somatic mutation rates induced in stem cells of mice by low chronic exposure to ethylnitrosoureaQ33702163
The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndromeQ34057969
Secondary acute myelogenous leukemia and myelodysplasia without abnormalities of chromosome 11q23 following treatment of acute leukemia with topoisomerase II-based chemotherapyQ34288389
Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.Q34336896
Therapy-related acute lymphoblastic leukaemia with MLL rearrangements following DNA topoisomerase II inhibitors, an increasing problem: report on two new cases and review of the literature since 1992.Q34366002
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study GroupQ34511070
Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer.Q34754672
Phase I and pharmacologic study of irinotecan in combination with cisplatin for advanced lung cancerQ35977364
Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitorQ36135270
Phase I study of sequentially administered topoisomerase I inhibitor (irinotecan) and topoisomerase II inhibitor (etoposide) for metastatic non-small-cell lung cancerQ36431552
Topoisomerase I inhibitors: the relevance of prolonged exposure for present clinical developmentQ36431807
Oral topotecan: bioavailablity and effect of food co-administrationQ36620382
Phase I study of irinotecan and raltitrexed in patients with advanced gastrointestinal tract adenocarcinomaQ36621705
Topotecan, an active drug in the second-line treatment of epithelial ovarian cancer: results of a large European phase II studyQ36836814
Synergistic cytotoxicity of cisplatin and topotecan or SN-38 in a panel of eight solid-tumor cell lines in vitroQ36895601
Five days of oral topotecan (Hycamtin), a phase I and pharmacological study in adult patients with solid tumoursQ36899705
Topoisomerase-specific drug sensitivity in relation to cell cycle progressionQ36920787
Anti-tumour activity and toxicity of the new prodrug 9-aminocamptothecin glucuronide (9ACG) in miceQ37352745
Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomesQ37378223
Etoposide (VP-16-213)-induced gene alterations: potential contribution to cell deathQ37601249
Growth inhibitory effect of a new camptothecin analog, DX-8951f, on various drug-resistant sublines including BCRP-mediated camptothecin derivative-resistant variants derived from the human lung cancer cell line PC-6.Q38310198
A functional linker in human topoisomerase I is required for maximum sensitivity to camptothecin in a DNA relaxation assayQ38318734
A randomized phase II trial of two schedules of topotecan for the treatment of advanced stage non-small cell lung cancerQ33331774
Phase II evaluation of 24-h continuous infusion topotecan in recurrent, potentially platinum-sensitive ovarian cancer: A Gynecologic Oncology Group studyQ33331940
Second-line treatment of small-cell lung cancer with the camptothecin-derivative GI147211: a study of the EORTC Early Clinical Studies Group (ECSG).Q33332083
DX-8951f, a hexacyclic camptothecin analog, on a daily-times-five schedule: a phase I and pharmacokinetic study in patients with advanced solid malignanciesQ33333842
Activity and toxicity of GI147211 in breast, colorectal and non-small-cell lung cancer patients: an EORTC-ECSG phase II clinical studyQ33334181
Phase II trial of 9-aminocamptothecin as a 72-h infusion in cutaneous T-cell lymphomaQ33339001
A phase I and pharmacologic study of 9-aminocamptothecin administered as a 120-h infusion weekly to adult cancer patientsQ33339212
Phase I-II study of irinotecan combined with mitomycin-C in patients with advanced gastric cancerQ33341045
Randomized phase II study of irinotecan plus mitomycin C vs. oxaliplatin plus mitomycin C in patients with advanced fluoropyrimidine/leucovorin-pretreated colorectal cancerQ33341120
Weekly chemotherapy with carboplatin, docetaxel and irinotecan in advanced non-small-cell-lung cancer: a phase II studyQ33342696
Multicentre phase II and pharmacokinetic study of RFS2000 (9-nitro-camptothecin) administered orally 5 days a week in patients with glioblastoma multiformeQ33343042
Phase I study of weekly CPT-11 (irinotecan)/docetaxel in patients with advanced solid tumorsQ33343374
Dose-escalation study of weekly irinotecan and daily carboplatin with concurrent thoracic radiotherapy for unresectable stage III non-small cell lung cancerQ33343743
Phase II study of weekly irinotecan and carboplatin for refractory or relapsed small-cell lung cancerQ33344308
Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitorQ33350574
Phase I and pharmacologic study of irinotecan and etoposide with recombinant human granulocyte colony-stimulating factor support for advanced lung cancerQ33487960
Phase I clinical and pharmacokinetic study of topotecan administered by a 24-hour continuous infusionQ33488685
Phase I Clinical and Pharmacology Study of Topotecan Given Daily for 5 Consecutive Days to Patients With Advanced Solid Tumors, With Attempt at Dose Intensification Using Recombinant Granulocyte Colony-Stimulating FactorQ33489257
Phase I trial of low-dose continuous topotecan infusion in patients with cancer: an active and well-tolerated regimenQ33492322
Phase I and pharmacological study of the new topoisomerase I inhibitor GI147211, using a daily x 5 intravenous administrationQ33495553
Phase II study of topotecan in patients with advanced non-small-cell lung cancer previously untreated with chemotherapyQ33495774
Pharmacokinetics and pharmacodynamics of topotecan given on a daily-times-five schedule in phase II clinical trials using a limited-sampling procedureQ33495882
Phase II study of topotecan in patients with recurrent malignant glioma. National Clinical Institute of Canada Clinical Trials GroupQ33496743
A phase I study of irinotecan and infusional cisplatin for advanced non-small-cell lung cancerQ33498400
Phase I-II study of irinotecan hydrochloride combined with cisplatin in patients with advanced gastric cancerQ33498653
Phase I and pharmacologic study of oral topotecan administered twice daily for 21 days to adult patients with solid tumorsQ33498657
The bioavailability of oral GI147211 (GG211), a new topoisomerase I inhibitorQ33500497
9-Aminocamptothecin by 72-hour continuous intravenous infusion is inactive in the treatment of patients with 5-fluorouracil-refractory colorectal carcinoma.Q33500679
Phase II trial to topotecan in hepatocellular carcinoma: a Southwest Oncology Group studyQ33500972
Evaluation of topotecan in resistant and relapsing multiple myeloma: a Southwest Oncology Group studyQ33501662
Phase II evaluation of topotecan in patients with advanced colorectal cancer. A Southwest Oncology Group trial (SWOG 9241).Q33502171
Phase II and dose-escalation with or without granulocyte colony-stimulating factor study of 9-aminocamptothecin in relapsed and refractory lymphomasQ33503047
Phase I trial of 9-aminocamptothecin in children with refractory solid tumors: a Pediatric Oncology Group studyQ33503056
Combination of irinotecan and etoposide for treatment of refractory or relapsed small-cell lung cancerQ33503969
CPT-11 in combination with cisplatin for advanced non-small-cell lung cancerQ67504713
Phase I Study of Weekly Intravenous Infusions of CPT-11, a New Derivative of Camptothecin, in the Treatment of Advanced Non-Small-Cell Lung CancerQ68252500
DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenograftsQ69360455
Localization of the active type I DNA topoisomerase gene on human chromosome 20q11.2-13.1, and two pseudogenes on chromosomes 1q23-24 and 22q11.2-13.1.Q69362155
DNA topoisomerasesQ70095180
Report of the Cancer Therapy Evaluation Program monitoring plan for secondary acute myeloid leukemia following treatment with epipodophyllotoxinsQ70616408
Topotecan in colorectal cancer: a phase II study of the EORTC early clinical trials groupQ70970931
Phase I and pharmacologic studies of topotecan in patients with impaired hepatic functionQ71093671
Phase I and pharmacologic study of 9-aminocamptothecin given by 72-hour infusion in adult cancer patientsQ71121113
Phase II study of topotecan in patients with extensive-stage small-cell carcinoma of the lung: an Eastern Cooperative Oncology Group TrialQ71261842
Phase II study of topotecan in metastatic hormone-refractory prostate cancerQ71321842
Phase II and pharmacologic study of topotecan administered as a 21-day continuous infusion to patients with colorectal cancerQ71572036
Phase II trial of topotecan in advanced or metastatic adenocarcinoma of the pancreasQ71574198
A phase II trial of topotecan in patients with previously untreated pancreatic cancerQ71579235
Phase I study of irinotecan and cisplatin with granulocyte colony-stimulating factor support for advanced non-small-cell lung cancerQ71604258
Pharmacokinetics and pharmacodynamics of irinotecan during a phase II clinical trial in colorectal cancer. Pharmacology and Molecular Mechanisms Group of the European Organization for Research and Treatment of CancerQ71692731
Phase I and pharmacologic study of topotecan in patients with impaired renal functionQ71861177
Phase II study of irinotecan and etoposide in patients with metastatic non-small-cell lung cancerQ71975354
Phase I study of CPT-11 and etoposide in patients with refractory solid tumorsQ72098386
Clinical studies of irinotecan alone and in combination with cisplatinQ72149455
Antitumor effect of liposome-incorporated camptothecin in human malignant xenograftsQ72252535
Phase II study of topotecan in metastatic non-small-cell lung cancerQ72256259
Topoisomerase I inhibition: a new target or new missiles?Q72327065
Pharmacokinetics and pharmacodynamics of topotecan administered daily for 5 days every 3 weeksQ72368989
Phase I and pharmacokinetic trial of weekly CPT-11Q72576855
Phase I and pharmacokinetics study of topotecan, a new topoisomerase I inhibitorQ72609210
Enzymes that push DNA aroundQ73037272
Comparison of DX-8951f and topotecan effects on tumor colony formation from freshly explanted adult and pediatric human tumor cellsQ73044019
Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecanQ73088375
Effects of extended chronic exposures on endogenous and transgenic loci: implications for low-dose extrapolationsQ73102506
Phase I and pharmacokinetic study of irinotecan administered as a low-dose, continuous intravenous infusion over 14 days in patients with malignant solid tumorsQ73181530
Dose escalation of CPT-11 in combination with oxaliplatin using an every two weeks schedule: a phase I study in advanced gastrointestinal cancer patientsQ73356010
Topotecan, a new active drug in the second-line treatment of small-cell lung cancer: a phase II study in patients with refractory and sensitive disease. The European Organization for Research and Treatment of Cancer Early Clinical Studies Group andQ73368715
A phase II study of topotecan in patients with recurrent head and neck cancer. Identification of an active new agentQ73376814
Phase I study of a weekly infusion of irinotecan hydrochloride (CPT-11) and a 14-day continuous infusion of etoposide in patients with lung cancer: JCOG trial 9408Q73392354
Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancerQ73443071
P407language of work or nameEnglishQ1860
P304page(s)1-50
P577publication date2003-01-01
P1433published inThe alkaloids. Chemistry and biologyQ26842446
P1476titleClinical studies of camptothecin and derivatives
P478volume60

Reverse relations

Q45220663Molecular characterization of two anthranilate synthase alpha subunit genes in Camptotheca acuminatacites workP2860

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