Phase I/pharmacokinetic study of the topoisomerase I inhibitor GG211 administered as a 21-day continuous infusion.

scientific article

Phase I/pharmacokinetic study of the topoisomerase I inhibitor GG211 administered as a 21-day continuous infusion. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1023/A:1008313011289
P698PubMed publication ID10355580

P2093author name stringC Twelves
S B Kaye
P J O'Dwyer
A McDonald
L Paz-Ares
L B Grochow
K Selinger
J P Stevenson
J Sludden
P Wissel
D DeMaria
P2860cites workActivity of topotecan, a new topoisomerase I inhibitor, against human tumor colony-forming units in vitroQ54255888
DNA topoisomerase I--targeted chemotherapy of human colon cancer in xenograftsQ69360455
DNA topoisomerasesQ70095180
Determination of GI147211 in human blood by HPLC with fluorescence detectionQ71489054
Phase II and pharmacologic study of topotecan administered as a 21-day continuous infusion to patients with colorectal cancerQ71572036
Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase IQ72538750
Phase II trial of topotecan as a 21-day continuous infusion in patients with advanced or metastatic adenocarcinoma of the pancreasQ77667993
Reporting results of cancer treatmentQ29620070
Phase I trial of low-dose continuous topotecan infusion in patients with cancer: an active and well-tolerated regimenQ33492322
Phase I and pharmacological study of the new topoisomerase I inhibitor GI147211, using a daily x 5 intravenous administrationQ33495553
The bioavailability of oral GI147211 (GG211), a new topoisomerase I inhibitorQ33500497
Continuous infusional topotecan in advanced breast and non-small-cell lung cancer: no evidence of increased efficacyQ33501194
DNA topoisomerase-targeting antitumor drugs can be studied in yeastQ33654182
A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program StudyQ44583571
P433issue3
P921main subjectpharmacokineticsQ323936
P304page(s)339-344
P577publication date1999-03-01
P1433published inAnnals of OncologyQ326122
P1476titlePhase I/pharmacokinetic study of the topoisomerase I inhibitor GG211 administered as a 21-day continuous infusion.
P478volume10

Reverse relations

cites work (P2860)
Q48354241Biologically active quinoline and quinazoline alkaloids part I.
Q37069556Cancer therapies utilizing the camptothecins: a review of the in vivo literature
Q33194418Clinical studies of camptothecin and derivatives
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Q37481337Novel camptothecin derivatives as topoisomerase I inhibitors
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Q34468628Perspectives on biologically active camptothecin derivatives
Q44813441Phase I and pharmacokinetic study of a low-clearance, unilamellar liposomal formulation of lurtotecan, a topoisomerase 1 inhibitor, in patients with advanced leukemia
Q61773324Recent developments in the clinical activity of topoisomerase-1 inhibitors

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