scholarly article | Q13442814 |
P356 | DOI | 10.1200/JCO.1989.7.4.425 |
P698 | PubMed publication ID | 2926468 |
P2093 | author name string | J D Ahlgren | |
J G Fryer | |||
J J Lokich | |||
J J Gullo | |||
J A Philips | |||
P433 | issue | 4 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | metastatic colorectal carcinoma | Q108607277 |
fluorouracil | Q238512 | ||
P304 | page(s) | 425-432 | |
P577 | publication date | 1989-04-01 | |
P1433 | published in | Journal of Clinical Oncology | Q400292 |
P1476 | title | A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program Study | |
P478 | volume | 7 |
Q53513591 | 20th-century advances in drug therapy in oncology--Part I. |
Q74202035 | 5-Fluorouracil (5-FU) continuous intravenous infusion compared with bolus administration. Final results of a randomised trial in metastatic colorectal cancer |
Q41153872 | 5-Fluorouracil (5FU) with or without folinic acid (LV) in human colorectal cancer? multivariate meta-analysis of the literature |
Q43051297 | 5-Fluorouracil and folinic acid: interesting biochemistry or effective treatment? |
Q36810361 | 5-Fluorouracil by Protracted Venous Infusion: A Review of Recent Clinical Studies |
Q34253978 | 5-Fluorouracil derivatives: a patent review. |
Q40666128 | 5-Fluorouracil-cisplatin adducts with potential antitumor activity. |
Q33750445 | 5-fluorouracil pharmacokinetics: causes for variability and strategies for modulation in cancer chemotherapy |
Q28359288 | 5-fluorouracil steady state pharmacokinetics and outcome in patients receiving protracted venous infusion for advanced colorectal cancer |
Q77949174 | 5-methyltetrahydrofolate for biochemical modulation of fluorouracil (FU) in patients with advanced colorectal cancer: a randomized phase I-II study of two different FU administration schedules |
Q34127889 | A community-based multicenter trial of pharmacokinetically guided 5-fluorouracil dosing for personalized colorectal cancer therapy |
Q35993743 | A less toxic regimen of 5-fluorouracil and high-dose folinic acid for advanced gastrointestinal adenocarcinomas |
Q77533706 | A multistep therapy with subcutaneous low dose recombinant interleukin-2, 5-fluorouracil and leucovorin prolongs the response of metastatic colorectal cancer patients: a pilot study |
Q43000487 | A new pharmacological approach to gastrointestinal cancer at high risk of relapse based on maintenance of the cytostatic effect. |
Q44458772 | A new regimen for S-1 therapy aiming at adverse reaction mitigation and prolonged medication by introducing a 1-week drug-free interval after each 2-week dosing session: efficacy and feasibility in clinical practice |
Q73923794 | A phase I trial of 5-day chronomodulated infusion of 5-fluorouracil and 1-folinic acid in patients with metastatic colorectal cancer |
Q41963946 | A phase I trial of 5-fluorouracil, folinic acid, and alpha-2a-interferon in patients with metastatic colorectal carcinoma |
Q36136107 | A phase II randomised trial of 5-fluorouracil with or without interferon alpha-2a in advanced colorectal cancer |
Q34315576 | A phase II study of combined oral uracil and ftorafur with leucovorin for patients with squamous cell carcinoma of the head and neck |
Q73893876 | A phase II study of continuous infusional 5-fluorouracil (5-FU) and subcutaneous interleukin-2 (IL-2) in metastatic renal cancer |
Q36135201 | A phase II study of continuous-infusion 5-fluorouracil with cisplatin and epirubicin in inoperable pancreatic cancer |
Q36973778 | A phase II study of gefitinib, 5-fluorouracil, leucovorin, and oxaliplatin in previously untreated patients with metastatic colorectal cancer |
Q44715299 | A phase II study of intravenous exatecan mesylate (DX-8951f) administered daily for five days every three weeks to patients with metastatic adenocarcinoma of the colon or rectum |
Q36079784 | A phase II study of regional 5-fluorouracil infusion with intravenous folinic acid for colorectal liver metastases |
Q33489857 | A pilot study of mitomycin, cisplatin and continuous infusion 5-fluorouracil (MCF) in advanced non-small-cell lung cancer |
Q51546518 | A prospective analysis of 949 long-term central venous access catheters for ambulatory chemotherapy in patients with gastrointestinal malignancy. |
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Q43596239 | A randomised phase II study of oxaliplatin alone versus oxaliplatin combined with 5-fluorouracil and folinic acid (Mayo Clinic regimen) in previously untreated metastatic colorectal cancer patients |
Q36102819 | A randomized, phase II trial of standard triweekly compared with dose-dense biweekly capecitabine plus oxaliplatin plus bevacizumab as first-line treatment for metastatic colorectal cancer: XELOX-A-DVS (dense versus standard) |
Q48247027 | A rare case of non-immune hemolytic anemia in a patient with metastatic breast cancer treated with capecitabine |
Q77128596 | A review of GERCOD trials of bimonthly leucovorin plus 5-fluorouracil 48-h continuous infusion in advanced colorectal cancer: evolution of a regimen. Groupe d'Etude et de Recherche sur les Cancers de l'Ovaire et Digestifs (GERCOD) |
Q33783647 | AGA technical review on the epidemiology, diagnosis, and treatment of pancreatic ductal adenocarcinoma. American Gastroenterological Association |
Q54253599 | Activity of continuous-infusion 5-fluorouracil in patients with advanced colorectal cancer clinically resistant to bolus 5-fluorouracil. |
Q33490610 | Adjuvant chemotherapy for oesophagogastric cancer with epirubicin, cisplatin and infusional 5-fluorouracil (ECF): a Royal Marsden pilot study |
Q73308572 | Adjuvant radiotherapy and concomitant 5-fluorouracil by protracted venous infusion for resected pancreatic cancer |
Q38862820 | Advances in oral delivery of anti-cancer prodrugs |
Q44427270 | Advantage of post-operative oral administration of UFT (tegafur and uracil) for completely resected p-stage I-IIIa non-small cell lung cancer (NSCLC). |
Q36024905 | Altered deoxyuridine and thymidine in plasma following capecitabine treatment in colorectal cancer patients. |
Q41247362 | Alternating bolus and continuous infusion 5-fluorouracil: a strategy to overcome resistance to this fluoropyrimidine in advanced colorectal cancer patients. |
Q44541306 | Ambulatory chemotherapy |
Q28346767 | Apoptosis and p53 status predict the efficacy of postoperative administration of UFT in non-small cell lung cancer |
Q44360855 | Apoptosis in normal tissues induced by anti-cancer drugs |
Q41604531 | Attitudes and practice in the management of metastatic colorectal cancer in Britain. Colorectal Cancer Working Party of the UK Medical Research Council |
Q73155409 | Bimonthly high dose leucovorin and 5-fluorouracil 48-hour infusion with interferon-alpha-2a in patients with advanced colorectal carcinoma. Groupe d'Etude et de Recherche sur les Cancers de l'Ovaire et Digestifs (GERCOD) |
Q35976676 | Bioavailability and feasibility of subcutaneous 5-fluorouracil |
Q37080091 | Biochemical Basis for Circadian-Dependent Metabolism of Fluoropyrimidines |
Q77128658 | Bolus injection (2-4 min) versus short-term (10-20 min) infusion of 5-fluorouracil in patients with advanced colorectal cancer: a prospective randomised trial. Nordic Gastrointestinal Tumour Adjuvant Therapy Group |
Q80510550 | Cancers of the large bowel and hepatobiliary tract |
Q40409795 | Central venous access catheters. |
Q61868299 | Chemotherapy for advanced pancreatic cancer - some light at the end of the tunnel? |
Q78478993 | Chemotherapy for colorectal cancer |
Q40484654 | Chemotherapy in Colorectal Carcinoma |
Q77203325 | Chemotherapy in advanced pancreatic adenocarcinoma |
Q73526632 | Chronotherapy with 5-fluorouracil, folinic acid and carboplatin for metastatic colorectal cancer; an interesting therapeutic index in a phase II trial |
Q33343214 | Cisplatin, tegafur, and leucovorin: a moderately effective and minimally toxic outpatient neoadjuvant chemotherapy for locally advanced squamous cell carcinoma of the head and neck |
Q34084272 | Clinical development of eniluracil/fluorouracil: an oral treatment for patients with solid tumors |
Q42218659 | Clinical pharmacokinetics of etoposide during 120 hours continuous infusions in solid tumours |
Q68548263 | Clinical significance of monitoring serum levels of 5-fluorouracil by continuous infusion in patients with advanced colonic cancer |
Q67543146 | Colorectal cancer |
Q41579445 | Colorectal cancer--is there an alternative to 5-FU? |
Q93911723 | Colorectal cancer: treatment of advanced disease |
Q73093121 | Combination chemotherapy with navelbine and continuous infusion of 5-fluorouracil in metastatic, chemotherapy refractory breast cancer |
Q70611518 | Combination of daily 4-h infusion of 5-fluorouracil and cisplatin in the treatment of advanced head and neck squamous-cell carcinoma: a South-East European Oncology Group study |
Q36141244 | Combined effect of clinically relevant doses of emitefur, a new 5-fluorouracil derivative, and radiation in murine tumours |
Q44181002 | Combined irinotecan, oxaliplatin and 5-fluorouracil in patients with advanced colorectal cancer. a feasibility pilot study. |
Q72065579 | Comparison of 5-fluorouracil anabolite levels after intravenous bolus and continuous infusion |
Q71170198 | Comparison of costs for infusion versus bolus chemotherapy administration: analysis of five standard chemotherapy regimens in three common tumors--Part one. Model projections for cost based on charges |
Q44016718 | Comparison of survival, palliation, and quality of life with three chemotherapy regimens in metastatic colorectal cancer: a multicentre randomised trial |
Q73206714 | Complete response of a gastric primary after a short but toxic course of 'S-1' EORTC Early Clinical Studies Group |
Q35050277 | Complications of hepatic artery infusion: a review of 4580 reported cases |
Q34084250 | Conceptual changes in cancer chemotherapy: from an oral fluoropyrimidine prodrug, UFT, to a novel oral fluoropyrimidine prodrug, S-1, and low-dose FP therapy in Japan |
Q36079497 | Continuous 5-fluorouracil in the treatment of breast cancer |
Q67760115 | Continuous infusion of 5-fluorouracil in ovarian cancer patients refractory to cisplatin and carboplatin |
Q36081891 | Continuous infusion of 5-fluorouracil with alpha 2b interferon for advanced colorectal carcinoma |
Q40859631 | Continuous infusion of chemotherapy: focus on 5-fluorouracil and fluorodeoxyuridine |
Q73668731 | Cost-effectiveness of second-line treatment with irinotecan or infusional 5-fluorouracil in metastatic colorectal cancer |
Q35097713 | Curative treatment of gastric cancer: towards a multidisciplinary approach? |
Q45938898 | Current and emerging therapies for metastatic colorectal cancer: applying research findings to clinical practice. |
Q40423737 | Current chemotherapeutic possibilities in the treatment of colorectal cancer |
Q44607726 | Cutaneous Hand and Foot Toxicity Associated With Cancer Chemotherapy |
Q38242295 | Cytotoxic drugs for gastric and colorectal cancer |
Q38254307 | DNA synthesis inhibitors for the treatment of gastrointestinal cancer |
Q43578599 | Determination of microsatellite instability, p53 and K-RAS mutations in hepatic metastases from patients with colorectal cancer: relationship with response to 5-fluorouracil and survival |
Q40022137 | Development history and concept of an oral anticancer agent S-1 (TS-1): its clinical usefulness and future vistas |
Q33442997 | Development of new promising antimetabolite, DFP-11207 with self-controlled toxicity in rodents |
Q34427755 | Disease management considerations: disease management considerations |
Q41419015 | Dose intensity for bolus versus infusion chemotherapy administration: review of the literature for 27 anti-neoplastic agents |
Q36217005 | Dose-escalation phase I study in metastatic breast cancer patients with combination of paclitaxel and tegafur·uracil |
Q36079721 | Double modulation of 5-fluorouracil with interferon alpha 2a and high-dose leucovorin: a phase I and II study |
Q37104107 | Doxifluridine in advanced colorectal cancer |
Q36711475 | Drug treatment of colorectal cancer. Current status |
Q43777233 | E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo |
Q42768404 | Effect of Skimmed Milk on the Absorption and Metabolism of5-Fluorouracil (5-FU) in Animals. |
Q73128670 | Effect of consecutive lower-dose cisplatin in enhancement of 5-fluorouracil cytotoxicity in experimental tumor cells in vivo |
Q43230727 | Effect of dimethylnitrosamine-induced liver dysfunction on the pharmacokinetics of 5-fluorouracil after administration of S-1, an antitumour drug, to rats |
Q46864342 | Effectiveness of 5-fluoruracil and vinorelbine in patients who had received multi-treatments for metastatic breast cancer |
Q61868327 | Epirubicin, cisplatin, and protracted venous infusion of 5-fluorouracil for esophagogastric adenocarcinoma: Response, toxicity, quality of life, and survival |
Q41712943 | Establishing a programme for continuous ambulatory infusion chemotherapy |
Q46448482 | FOLFOX2 in the treatment of advanced colorectal cancer: a comparison between elderly and middle aged patients |
Q46750925 | Feasibility of measuring 5-fluorouracil catabolic potential by oral loading |
Q74646473 | First experience and technical aspects of isolated liver perfusion for extensive liver metastasis |
Q35629061 | First-line treatment strategies to improve survival in patients with advanced colorectal cancer |
Q74028608 | Five-day continuous infusion of 5-fluorouracil and pulsed folinic acid in patients with metastatic colorectal carcinoma: an effective second-line regimen |
Q47618482 | Gastrointestinal Tract Cancer Liaison Office: an attempt to organise clinical research in Europe |
Q73258129 | Gastrointestinal cancer in the elderly |
Q34325090 | Gastrointestinal malignancies |
Q35584405 | HFS-14, a specific quality of life scale developed for patients suffering from hand-foot syndrome |
Q72112446 | Hand-foot syndrome associated with liposome-encapsulated doxorubicin therapy |
Q44943214 | High-dose chronomodulated infusion of 5-fluorouracil (5-FU) and folinic acid (FA) (FF5-16) in advanced colorectal cancer patients |
Q41148056 | How to optimize the effect of 5-fluorouracil modulated therapy in advanced colorectal cancer |
Q77658442 | Immediate postoperative 5-FU does not decrease colonic anastomotic strength |
Q33859998 | Improving fluorouracil chemotherapy with novel orally administered fluoropyrimidines |
Q36821382 | Infusion pumps for systemic and intra-arterial chemotherapy of colorectal liver metastases. |
Q41419088 | Infusional 5-fluorouracil in the treatment of gastrointestinal cancers: the Royal Marsden Hospital experience |
Q40935423 | Interaction of alpha-interferon with chemotherapeutic agents: effects on cytotoxic drug metabolism and multiple drug resistance |
Q70655786 | Intermittent continuous intravenous infusion of 5-fluorouracil; a useful approach in disseminated colorectal cancer? |
Q41160084 | Intra-hepatic arterial drug delivery |
Q42619097 | Irinotecan in second-line treatment of metastatic colorectal cancer: improved survival and cost-effect compared with infusional 5-FU. |
Q86273560 | Kinetically guided neoadjuvant chemoradiotherapy based on 5-Fluorouracil in patients with locally advanced rectal cancer |
Q43557094 | Latent hematopoietic stem cell toxicity associated with protracted drug administration |
Q73481598 | Liver metastases from colorectal cancer |
Q28273580 | Local treatment of hand-foot syndrome with uridine/thymidine: in vitro appraisal on a human keratinocyte cell line HaCaT |
Q42285544 | Long-term survival after epirubicin, cisplatin and fluorouracil for gastric cancer: results of a randomized trial |
Q78111183 | Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery |
Q44458770 | Longterm control of advanced and recurrent gastric cancer (ARGC) by S-1. |
Q92839397 | Major innovations and clinical applications of disodium-levofolinate: a review of available preclinical and clinical data |
Q38081864 | Management of advanced colorectal cancer, Part 1. |
Q34788235 | Management of colorectal cancer. |
Q77621017 | Management of hepatic metastases from colorectal cancer: systemic chemotherapy |
Q36291303 | Mature results from three large controlled studies with raltitrexed ('Tomudex'). |
Q73597514 | Maximum tolerable doses of intravenous zidovudine in combination with 5-fluorouracil and leucovorin in metastatic colorectal cancer patients. Clinical evidence of significant antitumor activity and enhancement of zidovudine-induced DNA single strand |
Q52170109 | Mechanisms of Action and Modulation of Fluorouracil. |
Q41449440 | Mechanistic Model for Cancer Growth and Response to Chemotherapy |
Q70733006 | Metabolic basis of the synergistic antitumor activities of 5-fluorouracil and cisplatin in rodent tumor models in vivo |
Q35148795 | Metastatic colorectal cancer: systemic treatment in the new millennium |
Q67760095 | Multiple confirmatory trials. How can additional studies be of value? |
Q45275933 | New drugs for colorectal cancer (irinotecan, oxaliplatin, raltitrexed) meet expectations in routine practice: a single center's experience before and after their introduction |
Q35687709 | New oral drugs in older patients: a review of idarubicin in elderly patients. |
Q40742190 | Overexpression of pyrimidine nucleoside phosphorylase enhances the sensitivity to 5'-deoxy-5-fluorouridine in tumour cells in vitro and in vivo |
Q43634493 | Oxaliplatin and protracted continuous 5-fluorouracil infusion in patients with pretreated advanced colorectal carcinoma |
Q28364999 | Oxaliplatin and protracted venous infusion of 5-fluorouracil in patients with advanced or relapsed 5-fluorouracil pretreated colorectal cancer |
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Q33499176 | Oxaliplatin with high-dose leucovorin and 5-fluorouracil 48-hour continuous infusion in pretreated metastatic colorectal cancer |
Q34746001 | Oxaliplatin, folinic acid and 5-fluorouracil (folfox) in pretreated patients with metastatic advanced cancer. The GERCOD |
Q57693104 | Palliative chemotherapy for advanced or metastatic colorectal cancer. Colorectal Meta-analysis Collaboration |
Q44317716 | Palliative treatment for colorectal cancer |
Q34731381 | Personalized colon cancer care in 2010. |
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Q34402152 | Perspectives in cancer chemotherapy |
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Q28361226 | Phase II study of S-1, a novel oral fluorouracil, in advanced non-small-cell lung cancer |
Q55389497 | Phase II study on early start of chemotherapy after excising primary colorectal cancer with distant metastases (Pearl Star 02). |
Q35982309 | Phase II trial of UFT in advanced colorectal and gastric cancer |
Q33490481 | Phase II trial of intravenous melphalan in advanced colorectal carcinoma |
Q36604241 | Pilot study of the early start of chemotherapy after resection of primary colorectal cancer with distant metastases (Pearl Star 01). |
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Q37679097 | Protracted intravenous infusion of 5-fluorouracil in combination treatments. A review |
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