Tegafur/uracil + calcium folinate in colorectal cancer: double modulation of fluorouracil

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Tegafur/uracil + calcium folinate in colorectal cancer: double modulation of fluorouracil is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1005989173
P356DOI10.2165/00003495-199958003-00011
P698PubMed publication ID10711845

P2093author name stringPazdur R
Hoff PM
Lassere Y
P2860cites workClinical evaluation of ftorafur (pyrimidine-deoxyribose n1-2'-furanidyl-5-fluorouracil)Q28342351
Effective surgical adjuvant therapy for high-risk rectal carcinomaQ33387384
Cancer statistics, 1998.Q34065873
Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinomaQ38207042
A review of the United States clinical experience of the fluoropyrimidine, ftorafur (NSC-148958).Q40260056
Experience with UFT in JapanQ40870630
Phase I trials of uracil-tegafur (UFT) using 5 and 28 day administration schedules: demonstration of schedule-dependent toxicitiesQ40927573
Phase ii evaluation of ftorafur in previously untreated colorectal cancer: A southwest oncology group studyQ41062449
Effect of coadministration of uracil or cytosine on the anti-tumor activity of clinical doses of 1-(2-tetrahydrofuryl)-5-fluorouracil and level of 5-fluorouracil in rodentsQ41079432
Pharmacokinetics of Leucovorin Metabolites in Human Plasma as a Function of Dose Administrated Orally and IntravenouslyQ41135720
Preoperative combined oral UFT plus leucovorin and radiation therapy for rectal cancerQ42666008
A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program StudyQ44583571
Analogs of pyrimidine nucleosides. I. N1-(alpha-furanidyl) derivatives of natural pyrimidine bases and their antimetabolitiesQ44663361
Phase II study of fluorouracil and its modulation in advanced colorectal cancer: a Southwest Oncology Group studyQ44664927
Phase I and pharmacokinetic study of oral UFT, a combination of the 5-fluorouracil prodrug tegafur and uracil.Q46052099
Uracil and tegafur modulated with leucovorin: an effective regimen with low toxicity for the treatment of colorectal carcinoma in the elderly. Oncopaz Cooperative Group.Q50956129
Impact of protracted venous infusion fluorouracil with or without interferon alfa-2b on tumor response, survival, and quality of life in advanced colorectal cancer.Q53639104
Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancerQ59647361
Effect of uracil and its derivatives on antitumor activity of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracilQ67448566
Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis ProjectQ68056139
Phase I-II studies of oral tegafur (ftorafur)Q70467257
A phase I and pharmacokinetic study of oral uracil, ftorafur, and leucovorin in patients with advanced cancerQ71032345
Efficacy of oral tegafur modulation by uracil and leucovorin in advanced colorectal cancer. A phase II studyQ71127386
Thymidylate synthase inhibition by an oral regimen consisting of tegafur-uracil (UFT) and low-dose leucovorin for patients with gastric cancerQ71422133
Activation of Ftorafue [R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil] to 5-fluorouracil and gamma-butyrolactoneQ71507649
[Concentration of 5-FU level in the tissue and blood of the patients with breast cancer by preoperative administration of UFT]Q71648639
Mechanism-based improvement in the therapeutic selectivity of 5-FU prodrug alone and under conditions of metabolic modulationQ71934546
Clinical application of biochemical modulation in cancer chemotherapy: biochemical modulation for 5-FUQ71934549
Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetaseQ72004501
A fixed-ratio combination of uracil and Ftorafur (UFT) with low dose leucovorin. An active oral regimen for advanced colorectal cancerQ72425285
Tegafur-uracil (UFT) plus folinic acid in advanced rectal cancerQ72430744
Fluorouracil plus levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: a final reportQ72525174
Phase II trial of uracil and tegafur plus oral leucovorin: an effective oral regimen in the treatment of metastatic colorectal carcinomaQ72816296
Phase I trial of uracil-tegafur (UFT) plus oral leucovorin: 14-day scheduleQ73504125
P921main subjectcolorectal cancerQ188874
fluorouracilQ238512
colorectal carcinomaQ25493920
P304page(s)77-83
P577publication date1999-01-01
P1433published inDrugsQ3040094
P1476titleTegafur/uracil + calcium folinate in colorectal cancer: double modulation of fluorouracil
P478volume58 Suppl 3

Reverse relations

cites work (P2860)
Q33370792A phase I dose-finding clinical pharmacokinetic study of an oral formulation of irinotecan (CPT-11) administered for 5 days every 3 weeks in patients with advanced solid tumours
Q36859180A phase II study of UFT with leucovorin administered as a twice daily schedule in the treatment of patients with metastatic colorectal cancer.
Q33859998Improving fluorouracil chemotherapy with novel orally administered fluoropyrimidines
Q33859915Oral alkylating agents for breast cancer therapy
Q33341415Oral tegafur/uracil
Q34979779Oxaliplatin: results in colorectal carcinoma.
Q47951123Screening of the structural, topological, and electronic properties of the functionalized Graphene nanosheets as potential Tegafur anticancer drug carriers using DFT method.
Q35041996TEGAFIRI is an effective alternative regimen for the management of recurrent or metastatic colorectal cancer

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