Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year

scientific article

Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2337/DIACARE.28.8.1936
P698PubMed publication ID16043735
P5875ResearchGate publication ID7701405

P50authorBo AhrénQ5544506
P2093author name stringAnja Schweizer
Giovanni Pacini
James E Foley
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectmetforminQ19484
cell functionQ95674809
patientQ181600
type 2 diabetesQ3025883
P304page(s)1936-1940
P577publication date2005-08-01
P1433published inDiabetes CareQ5270111
P1476titleImproved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year
P478volume28

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cites work (P2860)
Q38282880A review of newer treatment approaches for type-2 diabetes: Focusing safety and efficacy of incretin based therapy
Q37237442Accelerating drug development using biomarkers: a case study with sitagliptin, a novel DPP4 inhibitor for type 2 diabetes
Q53746829Add on DPP-4 inhibitor alogliptin alone or in combination with pioglitazone improved β-cell function and insulin sensitivity in metformin treated PCOS.
Q45250947Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes
Q26749089An Update on the Effect of Incretin-Based Therapies on β-Cell Function and Mass
Q26829445Assessment of pancreatic β-cell function: review of methods and clinical applications
Q37141727Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus
Q36575421Biologic actions and therapeutic potential of the proglucagon-derived peptides
Q33587783Challenges in achieving optimal glycemic control in type 2 diabetes patients with declining renal function: The Southeast Asia perspective
Q37825941Clinical evidence and mechanistic basis for vildagliptin's action when added to metformin
Q37984567Clinical pharmacokinetics and pharmacodynamics of vildagliptin
Q38106411Combination therapy of dipeptidyl peptidase-4 inhibitors and metformin in type 2 diabetes: rationale and evidence.
Q37991385Combination therapy with metformin plus vildagliptin in type 2 diabetes mellitus.
Q36835802Combination treatment in the management of type 2 diabetes: focus on vildagliptin and metformin as a single tablet
Q37056847Comparison of Vildagliptin and Pioglitazone in Korean Patients with Type 2 Diabetes Inadequately Controlled with Metformin
Q91638366DPP-4 Inhibition and the Path to Clinical Proof
Q27028127DPP-4 inhibition and islet function
Q36729115DPPIV inhibition: promising therapy for the treatment of type 2 diabetes
Q43207763Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload
Q49997164Difference between observed and predicted glycated hemoglobin at baseline and treatment response to vildagliptin-based dual oral therapy in patients with type 2 diabetes
Q34589793Dipeptidyl peptidase IV (DPP IV) inhibitors: A newly emerging drug class for the treatment of type 2 diabetes.
Q36892807Dipeptidyl peptidase IV inhibitors and the incretin system in type 2 diabetes mellitus
Q37900690Dipeptidyl peptidase-4 inhibitors and preservation of pancreatic islet-cell function: a critical appraisal of the evidence
Q30846870Dipeptidyl peptidase-4 inhibitors and the risk of heart failure: a systematic review and meta-analysis
Q35026483Dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes: safety, tolerability, and efficacy
Q37378498Dipeptidyl peptidase-IV inhibitor use associated with increased risk of ACE inhibitor-associated angioedema
Q55518630Effect of Linagliptin and Voglibose on metabolic profile in patients with Type 2 Diabetes: a randomized, double-blind, placebo-controlled trial.
Q42496887Effect of initial combination therapy with sitagliptin and metformin on β-cell function in patients with type 2 diabetes
Q51444165Effect of multiple oral doses of linagliptin on the steady-state pharmacokinetics of a combination oral contraceptive in healthy female adults: an open-label, two-period, fixed-sequence, multiple-dose study.
Q37439806Effect of the glucagon-like peptide-1 receptor agonist lixisenatide on postprandial hepatic glucose metabolism in the conscious dog
Q35442079Effect of vildagliptin on hepatic steatosis
Q64902975Effectiveness and Tolerability of Vildagliptin and the Single Pill Combination of Vildagliptin and Metformin in "Real-World" Management of Type 2 Diabetes Mellitus: The G-FORCE Study.
Q38832851Effectiveness of vildagliptin as add-on to metformin monotherapy among uncontrolled type 2 diabetes mellitus patients in a real-world setting
Q46567048Effects of addition of a dipeptidyl peptidase IV inhibitor to metformin on sirolimus-induced diabetes mellitus
Q36315963Effects of dipeptidyl peptidase-4 inhibitors on beta-cell function and insulin resistance in type 2 diabetes: meta-analysis of randomized controlled trials
Q38077284Effects of pioglitazone and vildagliptin on coagulation cascade in diabetes mellitus--targeting thrombogenesis
Q45985301Effects of saxagliptin on β-cell stimulation and insulin secretion in patients with type 2 diabetes.
Q37153711Efficacy and safety of combination therapy with vildagliptin and metformin versus metformin up-titration in Chinese patients with type 2 diabetes mellitus: study design and rationale of the vision study
Q51281907Efficacy and safety of combination therapy with vildagliptin and metformin versus metformin uptitration in Chinese patients with type 2 diabetes inadequately controlled with metformin monotherapy: a randomized, open-label, prospective study (VISION)
Q51489068Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy in patients with type 2 diabetes mellitus.
Q34044817Efficacy and safety of vildagliptin and voglibose in Japanese patients with type 2 diabetes: a 12-week, randomized, double-blind, active-controlled study
Q51478128Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes.
Q42955206Electrical stimulation of the isolated rat intestine in the presence of nutrient stimulus enhances glucagon-like peptide-1 release
Q46121472Expanding treatment options for type 2 diabetes: the old and the new.
Q46637836GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide, is a glucoregulatory peptide
Q37071183Glucokinase activators in diabetes management
Q36729110Hit and Lead identification: efficient practices for drug discovery
Q36640585How do different GLP-1 mimetics differ in their actions?
Q46140543Impact of incretin therapy on islet dysfunction: an underlying defect in the pathophysiology of type 2 diabetes
Q48277301Impact of insulin glargine and lixisenatide on β-cell function in patients with type 2 diabetes mellitus: A randomized open-label study
Q53272501Improved Insulin Secretion by Autologous Islet Transplantation, Compared to Oral Antidiabetic Agents, After Distal Pancreatectomy.
Q35928257Improved glucose regulation in type 2 diabetic patients with DPP-4 inhibitors: focus on alpha and beta cell function and lipid metabolism
Q38225693Incretins: their physiology and application in the treatment of diabetes mellitus.
Q36580608Inhibition of dipeptidylpeptidase IV activity as a therapy of type 2 diabetes
Q42477903Initial short‐term intensive insulin therapy as a strategy for evaluating the preservation of beta‐cell function with oral antidiabetic medications: a pilot study with sitagliptin
Q27649728Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formation
Q36613938Management of Type 2 diabetes: the role of incretin mimetics
Q24683764Mechanisms of action of glucagon-like peptide 1 in the pancreas
Q37867193Mechanisms of action of the dipeptidyl peptidase-4 inhibitor vildagliptin in humans
Q37941683Medicinal Chemistry and Applications of Incretins and DPP-4 Inhibitors in the Treatment of Type 2 Diabetes Mellitus
Q37262966Metformin therapy and clinical uses
Q37183979More choices than ever before: emerging therapies for type 2 diabetes
Q100526083Neopterin and biopterin levels and tryptophan degradation in patients with diabetes
Q39626084New aspects of an old drug: metformin as a glucagon-like peptide 1 (GLP-1) enhancer and sensitiser
Q37288741New drugs for type 2 diabetes mellitus: what is their place in therapy?
Q36812821Novel combination treatment of type 2 diabetes DPP-4 inhibition + metformin
Q51323275Observational study on dipeptidyl peptidase-4 inhibitors: a real-life analysis on 360 patients from the ASL VCO territory in Italy.
Q34592210Oral combination therapy: repaglinide plus metformin for treatment of type 2 diabetes
Q37260330Overview of glucagon-like peptide-1 analogs and dipeptidyl peptidase-4 inhibitors for type 2 diabetes.
Q58448401Pharmacodynamics of Vildagliptin in Patients With Type 2 Diabetes During OGTT
Q36793605Pharmacotherapy for the treatment of patients with type 2 diabetes mellitus: rationale and specific agents
Q34139048Pioglitazone and alogliptin combination therapy in type 2 diabetes: a pathophysiologically sound treatment
Q36960161Profile of vildagliptin in type 2 diabetes: efficacy, safety, and patient acceptability
Q36693199Rationale for dipeptidyl peptidase 4 inhibitors: a new class of oral agents for the treatment of type 2 diabetes mellitus
Q24235718Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus
Q24240522Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus
Q24244739Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus
Q34128612Saxagliptin for the treatment of type 2 diabetes mellitus: assessing cardiovascular data
Q40524112Saxagliptin improves glycaemic control and C-peptide secretion in latent autoimmune diabetes in adults (LADA).
Q38071007Second line therapy: type 2 diabetic subjects failing on metformin GLP-1/DPP-IV inhibitors versus sulphonylurea/insulin: for GLP-1/DPP-IV inhibitors
Q91991896Slope of change in HbA1c from baseline with empagliflozin compared with sitagliptin or glimepiride in patients with type 2 diabetes
Q26772081Systematic review and meta-analysis of efficacy and safety of combinational therapy with metformin and dipeptidyl peptidase-4 inhibitors
Q38682317Systematic review and meta-analysis of vildagliptin for treatment of type 2 diabetes.
Q37270524Targeting Incretins in Type 2 Diabetes: Role of GLP-1 Receptor Agonists and DPP-4 Inhibitors
Q37782506Targeting β-Cell Function Early in the Course of Therapy for Type 2 Diabetes Mellitus
Q36945116The DPP-4 inhibitor vildagliptin: robust glycaemic control in type 2 diabetes and beyond
Q88312476The Vildagliptin Experience - 25 Years Since the Initiation of the Novartis Glucagon-like Peptide-1 Based Therapy Programme and 10 Years Since the First Vildagliptin Registration
Q48713671The dipeptidyl peptidase IV inhibitor vildagliptin suppresses development of neuropathy in diabetic rodents: Effects on peripheral sensory nerve function, structure and molecular changes
Q35688754The fate of Beta-cells in type 2 diabetes and the possible role of pharmacological interventions
Q28273497The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
Q34329204The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives
Q35333042The metabolic serine hydrolases and their functions in mammalian physiology and disease
Q53242373The physiology of incretin hormones and the basis for DPP-4 inhibitors.
Q42575070The potential role of vildagliptin in the management and prevention of type 2 diabetes mellitus
Q36800624The role of vildagliptin in the management of type 2 diabetes mellitus
Q37840099The therapeutic potential of targeting the glucagon-like peptide-2 receptor in gastrointestinal disease
Q34750027Therapeutic Approaches for Preserving or Restoring Pancreatic β-Cell Function and Mass.
Q42010899Triple Combination Therapy Using Metformin, Thiazolidinedione, and a GLP-1 Analog or DPP-IV Inhibitor in Patients with Type 2 Diabetes Mellitus
Q42171281Type 2 diabetes comorbidities and treatment challenges: rationale for DPP-4 inhibitors
Q37161925Unmet needs among patients with type 2 diabetes and secondary failure to oral anti-diabetic agents
Q37857686Use of DPP-4 inhibitors in type 2 diabetes: focus on sitagliptin
Q36651661Vildagliptin
Q37623831Vildagliptin in clinical practice: a review of literature.
Q37428878Vildagliptin: a new oral treatment for type 2 diabetes mellitus
Q36847177Vildagliptin: a novel oral therapy for type 2 diabetes mellitus
Q37313418Vildagliptin: a review of its use in the management of type 2 diabetes mellitus.
Q87461871Vildagliptin: a review of its use in type 2 diabetes mellitus
Q37801906Vildagliptin: a review of its use in type 2 diabetes mellitus
Q33973990Vildagliptin: the evidence for its place in the treatment of type 2 diabetes mellitus
Q34068749Weight neutrality with the DPP-4 inhibitor, vildagliptin: Mechanistic basis and clinical experience
Q48269534When Metformin Is Not Enough: Pros and Cons of SGLT2 and DPP-4 Inhibitors as a Second Line Therapy
Q80204033[New approaches in obesity treatment: the gastrointestinal tract as an endocrine organ]
Q36947018beta-cell function and anti-diabetic pharmacotherapy

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