Preliminary data suggestive of a novel translational approach to mesothelioma treatment: imatinib mesylate with gemcitabine or pemetrexed

scientific article

Preliminary data suggestive of a novel translational approach to mesothelioma treatment: imatinib mesylate with gemcitabine or pemetrexed is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1136/THX.2006.069872
P932PMC publication ID2117287
P698PubMed publication ID17311837
P5875ResearchGate publication ID6493576

P50authorCamillo PortaQ37393105
P2093author name stringGiovanni Gaudino
Luciano Mutti
Dario Barbone
Sara Busacca
Pietro Bertino
Serena Germano
Sabrina Pinato
Roberto Favoni
Giancarlo Tassi
P2860cites workThe European mesothelioma epidemicQ24650064
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysQ25939005
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumorQ27824804
Prospects for phosphoinositide 3-kinase inhibition as a cancer treatmentQ28188301
Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cellsQ28279744
Receptor tyrosine kinase and phosphoinositide-3 kinase signaling in malignant mesotheliomaQ33220994
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosomeQ33336718
SV40 replication in human mesothelial cells induces HGF/Met receptor activation: a model for viral-related carcinogenesis of human malignant mesotheliomaQ33946963
Drug synergism: its detection and applicationsQ34337018
Platelet-derived growth factor receptors: a therapeutic target in solid tumorsQ34461490
Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model.Q34589774
An overview of targeted treatments in cancerQ35544746
The spectrum of Kit (CD117) immunoreactivity in lung and pleural tumors: a study of 96 cases using a single-source antibody with a review of the literatureQ35746576
Moving beyond chemotherapy: novel cytostatic agents for malignant mesotheliomaQ35839893
Pleural mesothelioma: little evidence, still time to do trialsQ35903121
Targeted cancer therapyQ35953128
Statistical analysis of drug combinations for synergismQ36155427
New agents in the management of advanced mesothelioma.Q36179396
Platelet-derived growth factor (PDGF) and glial tumorigenesisQ36247732
c-Kit is not expressed in malignant mesotheliomaQ38451233
Role of epidermal growth factor receptor degradation in gemcitabine-mediated cytotoxicity.Q40200594
FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance.Q40371743
Biological and immunological aspects of malignant mesotheliomaQ40476744
Selective activation of insulin receptor substrate-1 and -2 in pleural mesothelioma cells: association with distinct malignant phenotypes.Q40502632
Imatinib inhibits proliferation of Ewing tumor cells mediated by the stem cell factor/KIT receptor pathway, and sensitizes cells to vincristine and doxorubicin-induced apoptosis.Q40593401
Effect of imatinib mesylate on neuroblastoma tumorigenesis and vascular endothelial growth factor expressionQ40601630
STI571 enhances the therapeutic index of epothilone B by a tumor-selective increase of drug uptakeQ40632066
The presence of simian-virus 40 sequences in mesothelioma and mesothelial cells is associated with high levels of vascular endothelial growth factorQ40755750
The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growthQ40859298
Differential expression of platelet derived growth factor-beta in malignant mesothelioma: a clue to future therapies?Q41072033
Regulation of differential expression of platelet-derived growth factor alpha- and beta-receptor mRNA in normal and malignant human mesothelial cell linesQ41229288
Vascular endothelial growth factor is an autocrine growth factor in human malignant mesotheliomaQ43558001
Evidence for phosphatidylinositol 3-kinase-Akt-p7S6K pathway activation and transduction of mitogenic signals by platelet-derived growth factor in meningioma cellsQ44150480
Limited efficacy of imatinib mesylate in malignant mesothelioma: a phase II trialQ46541600
SV40-dependent AKT activity drives mesothelial cell transformation after asbestos exposure.Q53854583
Human peritoneal mesothelial cells produce many cytokines (granulocyte colony-stimulating factor [CSF], granulocyte-monocyte-CSF, macrophage-CSF, interleukin-1 [IL-1], and IL-6) and are activated and stimulated to grow by IL-1Q67802477
Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571Q74083395
Immunohistochemical analysis still has a limited role in the diagnosis of malignant mesothelioma. A study of thirteen antibodiesQ74317144
Hepatocyte growth factor/scatter factor stimulates chemotaxis and growth of malignant mesothelioma cells through c-met receptorQ74428792
Platelet-derived growth factor (PDGF) BB acts as a chemoattractant for human malignant mesothelioma cells via PDGF receptor beta-integrin alpha3beta1 interactionQ77746897
Malignant pleural mesotheliomaQ80200957
Chemotherapy for malignant pleural mesothelioma: past results and recent developmentsQ80355524
Negative results of an Italian Group for Mesothelioma (G.I.Me.) pilot study of single-agent imatinib mesylate in malignant pleural mesotheliomaQ83197781
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectimatinibQ177094
P304page(s)690-695
P577publication date2007-02-20
P1433published inThoraxQ7796158
P1476titlePreliminary data suggestive of a novel translational approach to mesothelioma treatment: imatinib mesylate with gemcitabine or pemetrexed
P478volume62

Reverse relations

cites work (P2860)
Q36988077A Phase I clinical trial of the combination of imatinib and paclitaxel in patients with advanced or metastatic solid tumors refractory to standard therapy.
Q37070229Advances in the systemic therapy of malignant pleural mesothelioma
Q38004067Anti-angiogenic therapies for malignant pleural mesothelioma
Q36874759Fowlpox-based survivin vaccination for malignant mesothelioma therapy
Q37449036Future developments in the management of malignant pleural mesothelioma
Q51823843Immunotherapy advances for mesothelioma treatment.
Q37672887Increasing dietary selenium elevates reducing capacity and ERK activation associated with accelerated progression of select mesothelioma tumors
Q38706374Inhibition of the platelet-derived growth factor receptor beta (PDGFRB) using gene silencing, crenolanib besylate, or imatinib mesylate hampers the malignant phenotype of mesothelioma cell lines.
Q34293068Investigational approaches for mesothelioma
Q37529848Malignant pleural mesothelioma: current treatments and emerging drugs.
Q38019747Malignant pleural mesothelioma: from the bench to the bedside.
Q26800042Mesothelioma treatment: Are we on target? A review
Q33890499Novel systemic therapy against malignant pleural mesothelioma
Q52672878Overexpressed genes in malignant pleural mesothelioma: implications in clinical management.
Q39380409PDGF-D/PDGF-ββ receptor-regulated chemotaxis of malignant mesothelioma cells
Q33442594Phase I Trial of Cediranib in combination with cisplatin and pemetrexed in chemo naive patients with unresectable malignant pleural mesothelioma (SWOG S0905).
Q37367634Phase I trial of cisplatin, pemetrexed, and imatinib mesylate in chemonaive patients with unresectable malignant pleural mesothelioma
Q36337646Phase II study of cediranib in patients with malignant pleural mesothelioma: SWOG S0509
Q36159154Preclinical studies identify novel targeted pharmacological strategies for treatment of human malignant pleural mesothelioma
Q37873380Review on clinical trials of targeted treatments in malignant mesothelioma
Q37992694Systemic treatment of malignant pleural mesothelioma
Q52672891Target therapy: new drugs or new combinations of drugs in malignant pleural mesothelioma.
Q37734455Translational therapies for malignant pleural mesothelioma.
Q57469068p53 modeling as a route to mesothelioma patients stratification and novel therapeutic identification

Search more.