Protecting exons from deleterious R-loops: a potential advantage of having introns

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Protecting exons from deleterious R-loops: a potential advantage of having introns is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1029996655
P356DOI10.1186/1745-6150-2-11
P932PMC publication ID1863416
P698PubMed publication ID17459149
P5875ResearchGate publication ID6370337

P50authorDeng-Ke NiuQ50637620
P2860cites workPlease hold--the next available exon will be right with youQ83887943
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Exon tethering in transcription by RNA polymerase IIQ28302498
The natural history of group I intronsQ28303356
A unified theory of gene expressionQ29615022
Introns and the origin of nucleus-cytosol compartmentalizationQ29618633
In exponentially growing Saccharomyces cerevisiae cells, rRNA synthesis is determined by the summed RNA polymerase I loading rate rather than by the number of active genesQ30310526
mRNA-mediated intron losses: evidence from extraordinarily large exonsQ31155910
A high density of ancient spliceosomal introns in oxymonad excavatesQ33241069
The origin of introns and their role in eukaryogenesis: a compromise solution to the introns-early versus introns-late debate?Q33253857
Complex early genesQ33836616
Mechanisms of stationary phase mutation: a decade of adaptive mutationQ33847662
Genome-wide hypermutation in a subpopulation of stationary-phase cells underlies recombination-dependent adaptive mutationQ33886793
Mechanism of non-spliceosomal mRNA splicing in the unfolded protein response pathwayQ33891036
Spliceosomal introns in the deep-branching eukaryote Trichomonas vaginalisQ33930440
Selective forces for the origin of the eukaryotic nucleusQ33995072
A spliceosomal intron in Giardia lambliaQ34019814
Selection for short introns in highly expressed genesQ34140547
Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated RecombinationQ34267573
Crystal structure of a self-splicing group I intron with both exonsQ34324406
Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instabilityQ34442378
The biology of intron gain and loss.Q34467973
The evolution of spliceosomal introns: patterns, puzzles and progressQ34495531
Origins and evolution of spliceosomal intronsQ34580514
Selective and mutational patterns associated with gene expression in humans: influences on synonymous composition and intron presenceQ34645301
The tiny enslaved genome of a rhizarian algaQ34686911
Messenger RNA surveillance and the evolutionary proliferation of intronsQ35091311
Introns in gene evolutionQ35179945
Keeping RNA and DNA Apart during TranscriptionQ35550748
Minimal introns are not "junk".Q35786108
Why is transcription coupled to translation in bacteria?Q35921500
Mobile group II intronsQ35965810
Structural characterization of RNA polymerase II complexes arrested by a cyclobutane pyrimidine dimer in the transcribed strand of template DNA.Q36021428
Analysis of evolution of exon-intron structure of eukaryotic genesQ36173290
Growth inhibition mediated by excess negative supercoiling: the interplay between transcription elongation, R-loop formation and DNA topologyQ36371631
The role of transient hypermutators in adaptive mutation in Escherichia coliQ36384221
Cotranscriptional processes and their influence on genome stability.Q36538957
Intron-rich ancestorsQ36542186
Duplication-targeted DNA methylation and mutagenesis in the evolution of eukaryotic chromosomesQ36819409
Stationary-phase mutation in the bacterial chromosome: recombination protein and DNA polymerase IV dependenceQ37096423
Intron phylogeny: a new hypothesisQ37778081
Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae.Q39528577
The signature of selection mediated by expression on human genesQ40830000
Intracellular transcription of G-rich DNAs induces formation of G-loops, novel structures containing G4 DNAQ41023029
Did group II intron proliferation in an endosymbiont-bearing archaeon create eukaryotes?Q41978462
A stem-loop "kissing" model for the initiation of recombination and the origin of intronsQ43629561
Eukaryotic evolution: early origin of canonical introns.Q44143060
Introns: mighty elements from the RNA worldQ47293905
Hypervariable and highly divergent intron-exon organizations in the chordate Oikopleura dioicaQ47299262
Why do genes have introns? Recombination might add a new piece to the puzzle.Q52587080
Molecular biology: RNA lost in translation.Q53631052
A switch from high-fidelity to error-prone DNA double-strand break repair underlies stress-induced mutation.Q54478818
Over-representation of exonic splicing enhancers in human intronless genes suggests multiple functions in mRNA processingQ58866839
Human antisense genes have unusually short introns: evidence for selection for rapid transcriptionQ59303885
High Deleterious Genomic Mutation Rate in Stationary Phase of Escherichia coliQ60057535
mRNA processing and genomic instabilityQ63383462
Are introns in-series error-detecting sequences?Q71107670
Factors affecting ectopic gene conversion in miceQ74450777
Starvation in yeast increases non-adaptive mutationQ74609074
Transcription and translation are coupled in ArchaeaQ79609849
RNA displacement and resolution of the transcription bubble during transcription by T7 RNA polymeraseQ80531683
P304page(s)11
P577publication date2007-04-25
P1433published inBiology DirectQ1954915
P1476titleProtecting exons from deleterious R-loops: a potential advantage of having introns
P478volume2

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cites work (P2860)
Q35004875An overview of the introns-first theory
Q33924790Association of intron loss with high mutation rate in Arabidopsis: implications for genome size evolution
Q33857851Conservation in first introns is positively associated with the number of exons within genes and the presence of regulatory epigenetic signals
Q33350157DNA double-strand break repair and the evolution of intron density
Q33700757Evaluation of models of the mechanisms underlying intron loss and gain in Aspergillus fungi.
Q28757923Evidence against the energetic cost hypothesis for the short introns in highly expressed genes
Q30485377Exon definition as a potential negative force against intron losses in evolution
Q36387310Gene expression levels are correlated with synonymous codon usage, amino acid composition, and gene architecture in the red flour beetle, Tribolium castaneum
Q33829781Genome-wide functional analysis of human 5' untranslated region introns
Q33526480Molecular diversity of antimicrobial effectors in the oyster Crassostrea gigas
Q37043759Reverse transcriptase and intron number evolution
Q41728634Survey of group I and group II introns in 29 sequenced genomes of the Bacillus cereus group: insights into their spread and evolution
Q33904719Why eukaryotic cells use introns to enhance gene expression: splicing reduces transcription-associated mutagenesis by inhibiting topoisomerase I cutting activity.

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