Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy

scientific article

Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1167/IOVS.07-0112
P8608Fatcat IDrelease_zblirofesbbs3cecbb4hqyixpy
P698PubMed publication ID17962481
P5875ResearchGate publication ID5884362

P50authorAntónio Francisco AmbrósioQ38326805
Tetsuya TerasakiQ39391558
José Cunha-VazQ40347268
Ermelindo LealQ46592352
P2093author name stringAyyakkannu Manivannan
John V Forrester
José Cunha-Vaz
Ken-Ichi Hosoya
António Francisco Ambrósio
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectdiabetic retinopathyQ631361
P304page(s)5257-5265
P577publication date2007-11-01
P1433published inInvestigative Ophthalmology Visual ScienceQ6060707
P1476titleInducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy
P478volume48

Reverse relations

cites work (P2860)
Q3460029012/15-Lipoxygenase-derived lipid metabolites induce retinal endothelial cell barrier dysfunction: contribution of NADPH oxidase
Q50516135670 nm red light preconditioning supports Müller cell function: evidence from the white light-induced damage model in the rat retina.
Q89976199A New Human Blood-Retinal Barrier Model Based on Endothelial Cells, Pericytes, and Astrocytes
Q36249969Absence of DJ-1 causes age-related retinal abnormalities in association with increased oxidative stress
Q50095639Aflibercept in the treatment of diabetic macular edema: a review and consensus paper
Q37873482Anti-inflammatory therapy for diabetic retinopathy.
Q41285088Arginase as a mediator of diabetic retinopathy
Q46813458Atorvastatin-mediated protection of the retina in a model of diabetes with hyperlipidemia
Q43230861Beneficial effect of docosahexanoic acid and lutein on retinal structural, metabolic, and functional abnormalities in diabetic rats
Q39727356Beneficial effects of a novel RAGE inhibitor on early diabetic retinopathy and tactile allodynia.
Q42123271Blockade of vascular endothelial growth factor receptor 1 prevents inflammation and vascular leakage in diabetic retinopathy.
Q34919840CD40 promotes the development of early diabetic retinopathy in mice
Q37599453CaMKII regulates pericyte loss in the retina of early diabetic mouse
Q28584295Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes
Q34355343Candesartan attenuates diabetic retinal vascular pathology by restoring glyoxalase-I function
Q36145936Caspase-14: a novel caspase in the retina with a potential role in diabetic retinopathy.
Q36477301Clocking in on diabetic retinopathy
Q60045483Colony-stimulating factor 1 receptor inhibition prevents disruption of the blood-retina barrier during chronic inflammation
Q27007111Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases
Q38115020Could donor multipotent mesenchymal stromal cells prevent or delay the onset of diabetic retinopathy?
Q33791268Danhong Huayu Koufuye Prevents Diabetic Retinopathy in Streptozotocin-Induced Diabetic Rats via Antioxidation and Anti-Inflammation.
Q26799423Dexamethasone intravitreal implant in the treatment of diabetic macular edema
Q28577516Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: implication in the development of retinopathy
Q26749438Diabetic Macular Edema
Q58579972Diabetic Retinopathy: A complex pathophysiology requiring novel therapeutic strategies
Q26765466Diabetic Retinopathy: Animal Models, Therapies, and Perspectives
Q33713517Diabetic macular edema: new concepts in patho-physiology and treatment
Q39451009Diabetic retinopathy: Breaking the barrier
Q37184611Effect of Endomorphins on HUVECs Treated by ox-LDL and Its Related Mechanisms.
Q47124297Efficacy of a Fatty Acids Dietary Supplement in a Polyethylene Glycol-Induced Mouse Model of Retinal Degeneration
Q34433667Endothelial progenitor dysfunction in the pathogenesis of diabetic retinopathy: treatment concept to correct diabetes-associated deficits
Q34077613Etiology and treatment of the inflammatory causes of cystoid macular edema
Q34047929Evaluation of leukocyte-endothelial interactions in retinal diseases
Q34790591Expression of thrombospondin-1 modulates the angioinflammatory phenotype of choroidal endothelial cells
Q33701506Folic Acid Treatment Normalizes NOS‐Dependence of Vascular Tone in the Metabolic Syndrome
Q26824541Functions of Müller cell-derived vascular endothelial growth factor in diabetic retinopathy
Q52903973Genistein Treatment Confers Protection against Gliopathy and Vasculopathy of the Diabetic Retina in Rats.
Q31083347Heme oxygenase-1 protects retinal endothelial cells against high glucose- and oxidative/nitrosative stress-induced toxicity
Q39262816High glucose-induced proteome alterations in retinal pigmented epithelium cells and its possible relevance to diabetic retinopathy
Q38707676Histone HIST1H1C/H1.2 regulates autophagy in the development of diabetic retinopathy
Q26781909Immunopathogenic Background of Pars Planitis
Q34603026Inducible nitric oxide synthase gene deficiency counteracts multiple manifestations of peripheral neuropathy in a streptozotocin-induced mouse model of diabetes
Q38746963Induction of oxidative and nitrosative stresses in human retinal pigment epithelial cells by all-trans-retinal
Q37911285Inflammation and diabetic retinal microvascular complications
Q37884176Inflammation in diabetic retinopathy
Q34615514Intracavernous delivery of a designed angiopoietin-1 variant rescues erectile function by enhancing endothelial regeneration in the streptozotocin-induced diabetic mouse
Q55427105Intravitreal Bevacizumab Injection Attenuates Diabetic Retinopathy in Adult Rats with Experimentally Induced Diabetes in the Early Stage.
Q91362432Intravitreal injection of adenosine A2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice
Q41992574Loss of CD40 attenuates experimental diabetes-induced retinal inflammation but does not protect mice from electroretinogram defects
Q33645320Loss of synaptic connectivity, particularly in second order neurons is a key feature of diabetic retinal neuropathy in the Ins2Akita mouse
Q36410673Marrow-derived cells regulate the development of early diabetic retinopathy and tactile allodynia in mice
Q37096570Mechanisms of leukocyte migration across the blood-retina barrier
Q37658598Modes of Retinal Cell Death in Diabetic Retinopathy
Q34082890Müller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage
Q39948735Müller cells do not influence leukocyte adhesion to retinal endothelial cells
Q39416208Negative regulators of angiogenesis: important targets for treatment of exudative AMD.
Q46709448Neuropeptide Y stimulates retinal neural cell proliferation--involvement of nitric oxide
Q35071239Neurovascular interaction and the pathophysiology of diabetic retinopathy
Q37722105Niaspan inhibits diabetic retinopathy‑induced vascular inflammation by downregulating the tumor necrosis factor‑α pathway
Q28083676Nitric oxide and reactive oxygen species in the pathogenesis of preeclampsia
Q38845903Nitric oxide in the pathophysiology of retinopathy: evidences from preclinical and clinical researches
Q28730878Ocular application of the kinin B1 receptor antagonist LF22-0542 inhibits retinal inflammation and oxidative stress in streptozotocin-diabetic rats
Q29248994Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Diabetic Retinopathy
Q49746282Panton-Valentine Leukocidin Colocalizes with Retinal Ganglion and Amacrine Cells and Activates Glial Reactions and Microglial Apoptosis
Q87843427Participation of the extrinsic cholinergic innervation in the action of nitric oxide on the ovarian steroidogenesis in the first proestrous in rats
Q36104687Plasma Kallikrein-Kinin System as a VEGF-Independent Mediator of Diabetic Macular Edema
Q34575640Preconditioning with endoplasmic reticulum stress mitigates retinal endothelial inflammation via activation of X-box binding protein 1.
Q37526773Pro-inflammatory cytokines downregulate Hsp27 and cause apoptosis of human retinal capillary endothelial cells
Q36839005Promise of endothelial progenitor cell for treatment of diabetic retinopathy
Q34335696Protection of blood retinal barrier and systemic vasculature by insulin-like growth factor binding protein-3.
Q64251542Protective effect of myricetin derivatives from against hydrogen peroxide-induced stress in ARPE-19 cells
Q28564310Reduced gap junctional communication among astrocytes in experimental diabetes: contributions of altered connexin protein levels and oxidative-nitrosative modifications
Q43064763Reduction of inducible nitric oxide synthase via angiotensin receptor blocker prevents the oxidative retinal damage in diabetic hypertensive rats
Q38199105Regulation of claudins in blood-tissue barriers under physiological and pathological states
Q43442634Resveratrol blocks diabetes-induced early vascular lesions and vascular endothelial growth factor induction in mouse retinas
Q99561828Retinal Physiology and Circulation: Effect of Diabetes
Q42141781Retinal blood flow abnormalities following six months of hyperglycemia in the Ins2(Akita) mouse
Q37023057Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage
Q52731094Role of endoplasmic reticulum stress in 12/15-lipoxygenase-induced retinal microvascular dysfunction in a mouse model of diabetic retinopathy.
Q41012127Role of inflammation in the pathogenesis of diabetic retinopathy
Q34014053Role of microglia adenosine A(2A) receptors in retinal and brain neurodegenerative diseases
Q33914624Scutellaria barbata attenuates diabetic retinopathy by preventing retinal inflammation and the decreased expression of tight junction protein
Q48270894Sitagliptin Attenuates Endothelial Dysfunction of Zucker Diabetic Fatty Rats: Implication of the Antiperoxynitrite and Autophagy
Q55317221Subtle thinning of retinal layers without overt vascular and inflammatory alterations in a rat model of prediabetes.
Q63435749Sweet Stress: Coping With Vascular Dysfunction in Diabetic Retinopathy
Q34237700TNF-α signals through PKCζ/NF-κB to alter the tight junction complex and increase retinal endothelial cell permeability
Q35005977TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis
Q51662239TOWARDS A TREATMENT FOR DIABETIC RETINOPATHY: Intravitreal Toxicity and Preclinical Safety Evaluation of Inducible Nitric Oxide Synthase Inhibitors.
Q64071750TRPV4 inhibition prevents increased water diffusion and blood-retina barrier breakdown in the retina of streptozotocin-induced diabetic mice
Q34972210Targeting Neovascularization in Ischemic Retinopathy: Recent Advances
Q36184164Tetramethylpyrazine Protects Retinal Capillary Endothelial Cells (TR-iBRB2) against IL-1β-Induced Nitrative/Oxidative Stress
Q92538952The CD40-ATP-P2X 7 Receptor Pathway: Cell to Cell Cross-Talk to Promote Inflammation and Programmed Cell Death of Endothelial Cells
Q48308877The Role of Microglia in Diabetic Retinopathy: Inflammation, Microvasculature Defects and Neurodegeneration.
Q33769452The effect of intravitreal bevacizumab on ocular blood flow in diabetic retinopathy and branch retinal vein occlusion as measured by laser speckle flowgraphy
Q40258168The effect of omega- 3 polyunsaturated fatty acids on endothelial tight junction occludin expression in rat aorta during lipopolysaccharide-induced inflammation
Q50798804The effect of ubiquinone and combined antioxidant therapy on oxidative stress markers in non-proliferative diabetic retinopathy: A phase IIa, randomized, double-blind, and placebo-controlled study.
Q35226462The kallikrein-kinin system in diabetic retinopathy
Q39244498The pathology associated with diabetic retinopathy.
Q37276042The promise of cell-based therapies for diabetic complications: challenges and solutions
Q33786878The tight junction associated signalling proteins ZO-1 and ZONAB regulate retinal pigment epithelium homeostasis in mice
Q42373000Therapeutic Effects of a Novel Agonist of Peroxisome Proliferator-Activated Receptor Alpha for the Treatment of Diabetic Retinopathy
Q36424494Triamcinolone acetonide prevents enhancement of hypoxia-induced neuronal and inducible nitric oxide synthases in the retinas of rats with oxygen-induced retinopathy
Q37121919Uveitic foveal atrophy: clinical features and associations
Q48768631VEGF production and signaling in Müller glia are critical to modulating vascular function and neuronal integrity in diabetic retinopathy and hypoxic retinal vascular diseases
Q53645908Vaccinium myrtillus extract prevents or delays the onset of diabetes--induced blood-retinal barrier breakdown.
Q34364177Validation of structural and functional lesions of diabetic retinopathy in mice
Q33625727Vascular dysfunction in retinopathy-an emerging role for arginase
Q36313749Vitreous levels of somatostatin in patients with chronic uveitic macular oedema
Q51266257Zerumbone, a Bioactive Sesquiterpene, Ameliorates Diabetes-Induced Retinal Microvascular Damage through Inhibition of Phospho-p38 Mitogen-Activated Protein Kinase and Nuclear Factor-κB Pathways.
Q47993537miR-15a/16 inhibits TGF-beta3/VEGF signaling and increases retinal endothelial cell barrier proteins

Search more.